#FNAIT
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rarediseaseadvisor.bsky.social
New research into prenatally diagnosed intracranial hemorrhage (#ICH) presented at the 2025 @isuog.bsky.social World Congress revealed fetal and neonatal alloimmune thrombocytopenia (#FNAIT) as one of the identifiable causes.

Read more: https://bit.ly/42EEDue

#RareSky #MedSky
FNAIT Identified as a Notable Cause in Some Cases of Prenatal Intracranial Hemorrhage
FNAIT was identified as one of the potential causes of nonobvious prenatal intracranial hemorrhage discovered using ultrasound and MRI.
bit.ly
September 24, 2025 at 5:54 PM
bloodjournals.hematology.org
In pursuit of FNAIT biomarkers: αVβ3 specificity falls short buff.ly/5JILtNZ #hemesky
November 12, 2025 at 7:01 PM
ericawood.bsky.social
Beautiful day at Albert Park Lake, as part of Run for Rui, raising money for research into fetomaternal/neonatal alloimmune thrombocytopenia, #FNAIT.
Funds will support the vital work of the Australian NAIT Registry.
Please support us if you can!
sleapys-foundation.grassrootz.com/run-for-rui
January 31, 2026 at 2:48 AM
hematologyadvisor.bsky.social
Reversal of recurrent pregnancy loss associated with CIUE was achieved through an immunosuppressive protocol directed at antibody-mediated alloimmunity, a mechanism closely related to that seen in #FNAIT. From @frontiersin.bsky.social and @rarediseaseadvisor.bsky.social.

https://bit.ly/4ixvbzs
Immune-Modulating Therapy Achieves Successful Pregnancies in CIUE With FNAIT-Like Injury
Chronic histiocytic intervillositis of unknown etiology in the context of FNAIT-like fetal-specific anti-HLA responses responded to a transplant-derived immunosuppressive regimen.
bit.ly
December 7, 2025 at 6:37 PM
bloodjournals.hematology.org
🎙️ Just published a new episode of Blood Podcast: HLH-like toxicities after CAR-T and Structure-Function Relationships of FNAIT. Have a listen:
HLH-like toxicities after CAR-T and Structure-Function Relationships of FNAIT
In this week's episode, Blood editor Dr. Laura Michaelis interviews Drs....
bloodpodcast.transistor.fm
August 6, 2026 at 4:00 PM
jdhl18.bsky.social
In pursuit of FNAIT biomarkers: αVβ3 specificity falls short
ashpublications.org/blood/articl...
In pursuit of FNAIT biomarkers: αVβ3 specificity falls short
In this issue of Blood, Oosterhoff et al1 revisit a widely cited hypothesis: that maternal alloantibodies directed preferentially against integrin αVβ3, ra
ashpublications.org
April 3, 2026 at 7:52 AM
rarediseaseadvisor.bsky.social
Artificial intelligence (#AI) is gaining traction in transfusion medicine, including applications relevant to fetal and neonatal alloimmune thrombocytopenia (#FNAIT). Study in Vox Sanguinis.

Learn more: https://bit.ly/404ndpl

#RareDisease #MedTech #TransfusionMedicine
Survey Shows AI Adoption Is Growing in Transfusion Medicine
Nearly half of ISBT members reported personal AI use, with most citing positive impact on transfusion medicine, including FNAIT.
bit.ly
March 3, 2026 at 10:21 PM
versitiresearch.bsky.social
Check out publication by VBRI Senior investigator Peter Newman and collaborators in pubmed.ncbi.nlm.nih.gov/39520801/
Antigen-specific immunotherapy for platelet alloimmune disorders - PubMed
Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) is a significant hematologic disorder arising from maternal immune responses to fetal platelet alloantigens, predominantly Human Platelet Antigen (HP...
pubmed.ncbi.nlm.nih.gov
December 18, 2024 at 6:32 PM
rarediseaseadvisor.bsky.social
Recruitment company @rarepatientvoice.bsky.social has more than 200,000 registered patients and family caregivers spanning rare, chronic and complex conditions.

Check out this latest feature from FNAIT Companion: https://bit.ly/4tvE1TM

#RareDiseaseMonth #RareDisease #MedSky #FNAIT
Rare Patient Voice rewards patients and caregivers for sharing their insights
Recruitment company Rare Patient Voice has more than 200,000 registered patients and family caregivers spanning rare, chronic and complex conditions.
bit.ly
February 9, 2026 at 3:47 PM
ypestis.bsky.social
HDFN. FNAIT. wAIHA. What is anybody saying
March 26, 2026 at 12:01 AM
femtechinsider.bsky.social
BillionToOne Launches Expanded Fetal Antigen Testing for HDFN and FNAIT femtechinsider.com/billiontoone...
February 11, 2026 at 9:57 AM
rarediseaseadvisor.bsky.social
#Prophylaxis with #IVIG remains the most effective intervention to prevent severe bleeding complications in #FNAIT, although pharmacologic inhibitors of placental IgG transport are under investigation and may supplant IVIG in the future.

Learn more: https://bit.ly/476owIJ

#RareDisease #MedSky
Prophylaxis With IVIG and Emerging Therapies Transform FNAIT Management
Immunoglobulin prophylaxis remains the most effective treatment to prevent severe FNAIT, although emerging drugs may soon replace it.
bit.ly
October 22, 2025 at 7:17 PM
jdhl18.bsky.social
HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins
ashpublications.org/blood/articl...
HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins
Key PointsAnti–HPA-1a antibodies exclusively recognizing integrin αvβ3 were not detected in maternal sera from patients with FNAIT.Anti–HPA-1a antibodies b
ashpublications.org
April 3, 2026 at 7:46 AM
peredalab.bsky.social
Maternal anti-HPA1a antibodies recognize Leu33 in the PSI domain of β3, causing fetal/neonatal alloimmune thrombocytopenia (FNAIT)
One such antibody, named 26.4, blocks αIIbβ3 from binding fibrinogen after thrombin stimulation; a key step in clot formation.
How does 26.4 bind the integrin?…
(2/9)
July 28, 2026 at 2:51 PM
rarediseaseadvisor.bsky.social
Red blood cell transfusions are dose-dependently associated with a higher risk of periventricular leukomalacia and retinopathy of prematurity.

Read here: https://bit.ly/4cd1oJV

#RareDisease #FNAIT #Ophthalmology #MedSky
RBC Transfusions Linked to Brain Injury in Preterm Infants
New research shows RBC transfusions are independently associated with brain injury in preterm infants, with risk increasing with each transfusion.
bit.ly
April 7, 2026 at 7:25 PM
rarediseaseadvisor.bsky.social
Researchers have designed a new genome-editing platform to functionally classify genetic variants associated with inherited platelet disorders such as fetal and neonatal alloimmune thrombocytopenia (#FNAIT). @ajhgnews.bsky.social

Read here: https://bit.ly/4r2zlSX

#RareDisease #MedSky
New Genome-Editing Platform for Classifying Genetic Variants Linked to Platelet Disorders
The system, known as CRIMSON HD, is applicable to CD34+ cell-derived blood lineages and has been optimized for assessing platelet-linked variants.
bit.ly
January 20, 2026 at 6:11 PM
drrichjlaw.bsky.social
Rallybio Announces Initiation of Phase 2 Clinical Trial of RLYB212. $RLYB. Congrats & good luck to the awesome Rallybio team! 🚀
investors.rallybio.com/news-release...
Rallybio Announces Initiation of Phase 2 Clinical Trial of RLYB212 | Rallybio
— Screening is Now Underway to Identify Pregnant Women at Higher Risk for HPA-1a Alloimmunization and FNAIT — NEW HAVEN, Conn. --(BUSINESS WIRE)--Nov. 21, 2024-- Rallybio Corporation (Nasdaq: RLYB), a...
investors.rallybio.com
November 21, 2024 at 1:52 PM
bloodyminded.bsky.social
Some might say the #MAIPA is the glorious pinnacle of immunohaematology testing, others would call it an abomination of an assay with too many antibodies and too many animals and too many crying haematology registrars on this episode. #hemesky #meded #goat

www.bloodyminded.com.au/allepisodes/...
Episode 44 - MAIPA Madness | FNAIT & Platelet Testing — Bloody Minded
FOUR Antibodies. THREE Animals. TWO Crying Haem Registrars. ONE TEST - The MAIPA. Actually maybe more than two crying haem registrars. How many antibodies are too many antibodies to have inside...
www.bloodyminded.com.au
April 30, 2025 at 3:07 AM
currentmedscience.bsky.social
Findings underscore the importance of thyroid status in #AntenatalCare and suggest proactive screening to mitigate risks such as miscarriage and #FNAIT. #medsky

Read here: doi.org/10.1007/s115...

#currentmedicalscience #Immunology #MaternalHealth #ThyroidResearch #PregnancyCare
Thyroid Diseases Identified as an Independent Risk Factor for Platelet Antibody Positivity in Pregnant Women: A Single-Center Study from Southern China
August 10, 2026 at 1:45 PM
drmcpharma.bsky.social
Blood Podcast
HLH-like toxicities after CAR-T and Structure-Function Relationships of FNAIT
Blood Podcast · Episode
open.spotify.com
August 7, 2026 at 2:21 PM
leidenscience.bsky.social
Researchers in Leiden have captured detailed images showing how, in the rare pregnancy disorder FNAIT, antibodies produced by the mother can cause bleeding in foetuses. The findings could help pave the way for a test that identifies which babies are at risk

www.universiteitleiden.nl/en/news/2026...
August 4, 2026 at 7:38 AM
peredalab.bsky.social
By revealing how HPA-1a antibody 26.4 engages and blocks αIIbβ3, we can better understand how functional alterations of β3 integrins contribute, together with other factors, to the severity of FNAIT.
This opens the door to novel FNAIT diagnostics and targeted treatments

(8/9)
July 28, 2026 at 2:51 PM
sciencex.bsky.social
In FNAIT, maternal antibodies were imaged locking a platelet clotting protein in its inactive shape, directly showing how fetal platelets can fail to clump and bleeding risk can rise. doi.org/hcb6fz
Crystal-clear images reveal how pregnancy antibodies cause harm in babies
Using advanced electron microscopy, researchers in Leiden have captured detailed images showing how, in the rare pregnancy disorder FNAIT, antibodies produced by the mother can cause bleeding in fetuses.
medicalxpress.com
July 20, 2026 at 1:40 PM
medicalxpress.com.web.brid.gy
Crystal-clear images reveal how pregnancy antibodies cause harm in babies
Using advanced electron microscopy, researchers in Leiden have captured detailed images showing how, in the rare pregnancy disorder FNAIT, antibodies produced by the mother can cause bleeding in fetuses. The findings, published in Science Advances, could help pave the way for a test that identifies, during pregnancy, which babies are at greatest risk.
medicalxpress.com
July 20, 2026 at 2:36 PM
oncologynurseadv.bsky.social
#Nipocalimab, a monoclonal antibody that inhibits the neonatal FcRN, has shown early therapeutic potential in FNAIT, a rare antibody-mediated disorder of #pregnancy. Published in @rarediseaseadvisor.bsky.social.

https://bit.ly/4i7aoTc
Emerging FcRN Blockade May Transform Management of FNAIT
Intravenous immunoglobulin remains the standard of care for preventing thrombocytopenia and intracranial hemorrhage in FNAIT.
bit.ly
November 24, 2025 at 5:54 PM