🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
September 19, 2025 at 5:04 PM
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
📖 Read more: lnkd.in/eahrVbMt
#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
Transcription factor SP1 in nasal epithelial cells aggravates allergic rhinitis by inducing FOXC1 changes in epithelial barrier integrity @jimmunol.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
August 29, 2025 at 4:25 PM
Transcription factor SP1 in nasal epithelial cells aggravates allergic rhinitis by inducing FOXC1 changes in epithelial barrier integrity @jimmunol.bsky.social
academic.oup.com/jimmunol/adv...
academic.oup.com/jimmunol/adv...
Regulatory motifs alone don’t explain tissue specificity. FOXC1 sites appear in most paralogs. Patterns likely reflect combinatorial motif turnover plus cis-regulatory context (promoters/enhancers), chromatin accessibility and locus architecture altered by duplications.
August 15, 2025 at 11:53 AM
Regulatory motifs alone don’t explain tissue specificity. FOXC1 sites appear in most paralogs. Patterns likely reflect combinatorial motif turnover plus cis-regulatory context (promoters/enhancers), chromatin accessibility and locus architecture altered by duplications.
Blockable offence – basal cell carcinoma's low response to immunotherapy is due to low HLA class I attenuated by epigenetic regulator FOXC1
📷 Tomonori Oka et al Mass General Hospital and @harvardmed.bsky.social in @cp-cellreports.bsky.social
➡️ bpod.org.uk/archive/2025...
📷 Tomonori Oka et al Mass General Hospital and @harvardmed.bsky.social in @cp-cellreports.bsky.social
➡️ bpod.org.uk/archive/2025...
June 24, 2025 at 8:46 AM
Blockable offence – basal cell carcinoma's low response to immunotherapy is due to low HLA class I attenuated by epigenetic regulator FOXC1
📷 Tomonori Oka et al Mass General Hospital and @harvardmed.bsky.social in @cp-cellreports.bsky.social
➡️ bpod.org.uk/archive/2025...
📷 Tomonori Oka et al Mass General Hospital and @harvardmed.bsky.social in @cp-cellreports.bsky.social
➡️ bpod.org.uk/archive/2025...
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets...
buff.ly
August 22, 2026 at 6:26 AM
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
Associated transcription factors of allergic rhinitis: SP1 aggravates nasal epithelial barrier damage
Abstract. Allergic rhinitis (AR) is a respiratory airway disorder characterized by inflammation and barrier dysfunction. The transcription factor specifici
ow.ly
December 9, 2025 at 4:03 PM
Data suggest that transcription factor specificity protein 1 (SP1) aggravates allergic rhinitis through the upregulation of forkhead box C1 (FOXC1), which reverses the protective effect of SP1 silencing on epithelial barrier damage. Read more online: ow.ly/cKOO50XFVik.
3/7 🔬Using single-cell transcriptomics as well as live-cell imaging of engineered hESCs, we measured individual gene expression histories and found that human endoderm arises from two distinct developmental trajectories: a direct path and an indirect one through a FOXC1+ progenitor state.
September 9, 2025 at 8:01 PM
3/7 🔬Using single-cell transcriptomics as well as live-cell imaging of engineered hESCs, we measured individual gene expression histories and found that human endoderm arises from two distinct developmental trajectories: a direct path and an indirect one through a FOXC1+ progenitor state.
Every time I run away from the foxc1 gene, I find myself circling back to it 🤣🤣🤣
May 6, 2025 at 1:00 PM
Every time I run away from the foxc1 gene, I find myself circling back to it 🤣🤣🤣
Based on its DNA-binding motif, this was a novel FOX transcription factor, & it was given the official name FOXP2. Prior literature had linked pathogenic variants in other FOX genes to a range of diseases. Our work suggested FOXP2 dysfunction as one potential cause of speech/language disorder. 16/n
October 4, 2025 at 3:14 PM
Based on its DNA-binding motif, this was a novel FOX transcription factor, & it was given the official name FOXP2. Prior literature had linked pathogenic variants in other FOX genes to a range of diseases. Our work suggested FOXP2 dysfunction as one potential cause of speech/language disorder. 16/n
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets...
buff.ly
August 22, 2026 at 10:44 PM
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
FOXC1 genindeki fazladan bir kopyanın genç yaşta görülen açık açılı glokom ile bağlantılı olduğu belirlendi. Çalışma, genetik testlerin özellikle ailesinde glokom öyküsü bulunan kişilerde erken teşhis için önemli olabileceğini gösterdiler.
May 8, 2026 at 9:32 AM
FOXC1 genindeki fazladan bir kopyanın genç yaşta görülen açık açılı glokom ile bağlantılı olduğu belirlendi. Çalışma, genetik testlerin özellikle ailesinde glokom öyküsü bulunan kişilerde erken teşhis için önemli olabileceğini gösterdiler.
@proteintech.bsky.social's resource, RRID:AB_2880716, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #methodsmatter #STMpublishing
FOXC1 ameliorates the disease progression of psoriasis through transcriptional upregulation of SOCS3
doi.org
December 5, 2025 at 8:00 AM
@proteintech.bsky.social's resource, RRID:AB_2880716, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #reproducibility #methodsmatter #STMpublishing
The authors included RRIDs in their Molecular Therapy Oncology paper! Thanks for making your methods matter! #STMpublishing #OpenScience #RRID
hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells
doi.org
May 22, 2025 at 7:00 AM
The authors included RRIDs in their Molecular Therapy Oncology paper! Thanks for making your methods matter! #STMpublishing #OpenScience #RRID
new from the lab (this is a thread): we discovered that the human variant rs6190 has a double-edged effect on metabolic health:
1) in Science Advances, we report the rs6190 mechanism promoting insulin sensitivity, unveiling two muscle-specific pro-metabolic genes www.science.org/doi/10.1126/...
1) in Science Advances, we report the rs6190 mechanism promoting insulin sensitivity, unveiling two muscle-specific pro-metabolic genes www.science.org/doi/10.1126/...
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle
While discovering a metabolic SNP mechanism, myocyte-autonomous mechanisms of metabolic health are unveiled.
www.science.org
July 9, 2025 at 7:34 PM
new from the lab (this is a thread): we discovered that the human variant rs6190 has a double-edged effect on metabolic health:
1) in Science Advances, we report the rs6190 mechanism promoting insulin sensitivity, unveiling two muscle-specific pro-metabolic genes www.science.org/doi/10.1126/...
1) in Science Advances, we report the rs6190 mechanism promoting insulin sensitivity, unveiling two muscle-specific pro-metabolic genes www.science.org/doi/10.1126/...
The authors included RRIDs in their Science Advances paper! We value the author's support of reproducibility. #accelerateopenscience #ReproducibleResearch #accelerateopenscience
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle
doi.org
July 26, 2025 at 7:00 AM
The authors included RRIDs in their Science Advances paper! We value the author's support of reproducibility. #accelerateopenscience #ReproducibleResearch #accelerateopenscience
RRID:AB_2863808 was used by the authors of the Cell Communication and Signaling paper "FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restrictio…". Thank you for making your methods matter! #RRID #methodsmatter
doi.org
January 17, 2025 at 12:30 AM
RRID:AB_2863808 was used by the authors of the Cell Communication and Signaling paper "FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restrictio…". Thank you for making your methods matter! #RRID #methodsmatter
Other Fox TFs are sometimes assumed to be pioneers based on their shared DBD (which is similar to the linker histone), but it's not clear if they are. To investigate, we expressed a selection of Fox TFs in the shared chromatin environment of mES cells and measured binding with ChIP-exo. 3/n
October 28, 2023 at 11:40 PM
Other Fox TFs are sometimes assumed to be pioneers based on their shared DBD (which is similar to the linker histone), but it's not clear if they are. To investigate, we expressed a selection of Fox TFs in the shared chromatin environment of mES cells and measured binding with ChIP-exo. 3/n
Gene duplication involving FOXC1 has been linked to juvenile glaucoma in 20 individuals from 10 families, supporting the role of genetic testing for early detection and intervention. doi.org/hb2vsv
Gene duplication tied to juvenile glaucoma in 20 patients across 10 families
A major international study led by Flinders University has identified a genetic contributor to juvenile glaucoma. Published today in the journal JAMA Ophthalmology, the study marks another important step toward treating multiple forms of glaucoma with the support of genetic testing.
medicalxpress.com
May 7, 2026 at 5:20 PM
Gene duplication involving FOXC1 has been linked to juvenile glaucoma in 20 individuals from 10 families, supporting the role of genetic testing for early detection and intervention. doi.org/hb2vsv
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
August 11, 2026 at 6:48 PM
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
August 11, 2026 at 6:48 PM
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
August 11, 2026 at 7:00 PM
A compartment-adjustment framework reclassifies FOXC1 as a stromal-vascular readout in Luminal A breast cancer and recasts the basal-lineage "Centaur" signal as a tumour-population axis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
https://www.biorxiv.org/content/10.64898/2026.08.11.744143v1
The authors included RRIDs in their in eLife paper! We value the author's support of reproducibility. #OpenScience #OpenResearch #methodsmatter
Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival
Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
doi.org
July 13, 2026 at 7:01 AM
The authors included RRIDs in their in eLife paper! We value the author's support of reproducibility. #OpenScience #OpenResearch #methodsmatter
TGF-beta/OPTN/FOXC1/miR-200 axis regulates intraocular pressure dynamics in trabecular meshwork cells https://www.biorxiv.org/content/10.1101/2024.06.06.593675v1
TGF-beta/OPTN/FOXC1/miR-200 axis regulates intraocular pressure dynamics in trabecular meshwork cells https://www.biorxiv.org/content/10.1101/2024.06.06.593675v1
Glaucoma is the second leading cause of irreversible blindness globally, with elevated intraocular p
www.biorxiv.org
June 7, 2024 at 3:30 AM
TGF-beta/OPTN/FOXC1/miR-200 axis regulates intraocular pressure dynamics in trabecular meshwork cells https://www.biorxiv.org/content/10.1101/2024.06.06.593675v1