#apaperaday Today's pick is by Martinez-Pizarro et al published in @narjournal.bsky.social Molecular Medicine, using antisense oligonucleotides (ASO) to increase inclusion of a microexon in the CPEB4 gene. Interesting because exon inclusion is more difficult than skipping DOI: 10.1093/narmme/ugaf035

📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬

🔍Find out more: academic.oup.com/narmolmed/pa...

👉Submit: mc.manuscriptcentral.com/narmme

#CallForPapers #Genomics #RareDiseases #NARMME

🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.

📖 doi.org/10.1093/narm...

#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine

🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication

🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration

Autoimmune diseases stem from the immune system’s “bad memory.” IgAim targets B cell antibodies to erase these, offering a new way to treat autoimmune diseases and B-cell leukemias.

Full text in NARMME: doi.org/10.1093/narm...

#Antibodies #Autoimmunediseases #Immunotherapy #Bleukemia #NARMolMed

🧬 IQ2 could be a new approach to treating visceral leishmaniasis (VL) via c-MYC gene silencing and immune cell reactivation!🥊

📖 Read in NARMME: doi.org/10.1093/narm...

#VisceralLeishmaniasis #KalaAzar #Parasitology #MolecularBiology #OAPublication

🧬 DM1 is a complex genetic disease affecting multiple body systems. A fast, reliable method to measure DMPK & MBNL1 proteins across diverse cell models is described in NARMME: doi.org/10.1093/narm...
@varechavala.bsky.social
#DM1Research #MyotonicDystrophy #MolecularBiology #OAPublication

#apaperaday Today's pick is from Nucleic Acid Research Molecular Medicines by Pena-Rasgado et al on a systematic analysis of which exons in the CFTR genes can be skipped to allow production of a functional protein. DOI: 10.1093/narmme/ugae017

#apaperaday Forced to work from home due to a lack of trains (to Yuzu's delight). The pick is from @narjournal.bsky.social molecular insights by Ottesen et al on a study of off target effects of a MOE/PS ASO (the title does not mention the name, but it is nusinersen). doi: 10.1093/narmme/ugag002

📣 New NARMME collection: Targeting & Harnessing Nucleic Acids for Therapeutic Discovery. Submit work on nucleic acid chemistry, delivery, mechanisms, safety, targeting & therapeutic applications. Info: lnkd.in/eipeJmaw Submit: lnkd.in/ej9GNs3B #DrugDiscovery #TherapeuticInnovation

Retinoic acid signaling via RAR agonists drives neural lineage formation. Transcriptomic analysis in stem cells and brain organoids revealed diverse neuronal subtypes, retina-like structures, and microglia.

Read the NARMME article here: doi.org/10.1093/narm...

#StemCells #VitaminA #RARAgonists

💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess

🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬

📖 doi.org/10.1093/narm...

#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication

💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.

📖 doi.org/10.1093/narm...

#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication

🐟 New in NARMME: malat1 in zebrafish triggers signaling for retinal repair guided by Notch, Wnt & TGF-β pathways. In mammals, TGF-β blocks regeneration revealing a key difference in healing potential.

🔗 doi.org/10.1093/narm...

#Zebrafish #RetinaRepair #Malat1 #MolecularBiology #NARMME #OpenAccess

🦟 New in NARMME: for the first time, microRNA in tsetse fly saliva carrying Trypanosoma brucei were profiled. Infected flies carry less diverse microRNAs, hinting roles in how the disease spreads.

🔗 doi.org/10.1093/narm...

#SleepingSickness #TsetseFly #MicroRNA #Trypanosomes #NARMME #OpenAccess