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thecovidinfoguy.bsky.social
Study: SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells

Published: 30 September 2025

academic.oup.com/narmolmed/ar...
SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells
Abstract. N6-Methyladenosine (m6A) is a key base modification that regulates RNA stability and translation during viral infection. While m6A methylation of
academic.oup.com
December 17, 2025 at 11:01 PM
ralfwittenbrink.bsky.social
zu validieren.
„Jetzt beginnen die Laborarbeiten, um die beobachteten Mechanismen zu bestätigen“, so der Forscher abschließend.«

Danke 🙏🏼 @toveharris.bsky.social für das Teilen der Studie.

academic.oup.com/narmolmed/ar...

www.miragenews.com/covid-19-alt...

agencia.fapesp.br/the-covid-19...
SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells
Abstract. N6-Methyladenosine (m6A) is a key base modification that regulates RNA stability and translation during viral infection. While m6A methylation of
academic.oup.com
December 17, 2025 at 5:56 PM
virussucks.com
The #SARSCoV2 virus will eventually modify and destroy your lungs.

You might feel fine, but are you?

academic.oup.com/narmolmed/ar...

SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells | NAR Molecular Medicine

#LongCOVID
December 18, 2025 at 5:15 PM
glowsticks.bsky.social

At last we've published in NAR Molecular Medicine the results of a project that began in 2015 in which we study how the dimerization of a bisbenzamidine DNA-binding agent influences its affinity and anti-leishmanial activity. #ChemSky

academic.oup.com/narmolmed/ad...
High-affinity A/T-rich DNA binding with a dimeric bisbenzamidine
Abstract. A bisbenzamidine DNA binding agent can be easily dimerized by alkylation of its terminal amidine groups to afford an extended minor groove binder
academic.oup.com
December 9, 2024 at 7:59 PM
mackinprof.bsky.social
My first post on Bluesky...

Perhaps skeletal muscle hypertrophy isn't all about muscle fibres? Check out our paper: Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

academic.oup.com/narmolmed/ar...
Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling
Abstract. A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeleta
academic.oup.com
December 22, 2024 at 2:48 PM
semirkin.bsky.social
Best holiday present: Our comprehensive review of triplex H-DNA has just come out in NAR Mol Medicine. I am indebted to two outstanding graduate students: Julia Hisey and Chiara Masnovo, whose enthusiasm, dedication and hard work made this review possible! academic.oup.com/narmolmed/ad...
Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease
Abstract. H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from chara
academic.oup.com
December 24, 2024 at 12:10 PM
narjournal.bsky.social
Autoimmune diseases stem from the immune system’s “bad memory.” IgAim targets B cell antibodies to erase these, offering a new way to treat autoimmune diseases and B-cell leukemias.

Full text in NARMME: doi.org/10.1093/narm...

#Antibodies #Autoimmunediseases #Immunotherapy #Bleukemia #NARMolMed
May 28, 2025 at 12:55 PM
lucbuee.bsky.social
Mapt mutations are found in brain disorders. Most of them are located in sequences encoding microtubule-binding domains. However, some are in the 5'UTR tau mRNAs. Understanding the effect of mutations in the amino-terminal part of tau and the role of N-truncated tau academic.oup.com/narmolmed/ar...
FTLD-MAPT mutations and short 5′UTR Tau mRNAs increase Tau translation
Abstract. Tau protein plays a central role in Alzheimer’s disease (AD) and other tauopathies. Tau proteins aggregate in degenerating neurons and their expr
academic.oup.com
January 11, 2025 at 11:33 AM
narjournal.bsky.social
📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬

🔍Find out more: academic.oup.com/narmolmed/pa...

👉Submit: mc.manuscriptcentral.com/narmme

#CallForPapers #Genomics #RareDiseases #NARMME
October 30, 2025 at 10:28 AM
drinfosec.bsky.social
Direct link to the research mentioned in the posts above:

SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells (Sept 30, 2025)
academic.oup.com/narmolmed/ar...

[ FREE PDF available ]
SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells
Abstract. N6-Methyladenosine (m6A) is a key base modification that regulates RNA stability and translation during viral infection. While m6A methylation of
academic.oup.com
December 18, 2025 at 8:54 PM
laurabreimann.bsky.social
Happy to share the publication of another collaboration with the Chekulaeva lab at @mdc-berlin.bsky.social. This work uses patient-derived iPSC models to study the molecular mechanisms of neurodegenerative diseases like ALS: academic.oup.com/narmolmed/ad...
Neuromuscular dysfunction in patient-derived FUSR244RR-ALS iPSC model via axonal downregulation of neuromuscular junction proteins
Abstract. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by the progressive degeneration of motor neurons, ultimately r
academic.oup.com
March 17, 2025 at 2:49 PM
romanzug.bsky.social
And there's this one!

academic.oup.com/narmolmed/ar...
A modular CRISPRa system for molecular therapy of FOXG1 syndrome
Abstract. To date, there is an unmet need for novel approaches that address haploinsufficiency disorders in a targeted and robust manner. Here, we develope
academic.oup.com
September 26, 2025 at 10:36 AM
indranilmalik.bsky.social
First paper from the lab published in NAR Molecular Medicine, led by grad student Subashani. Collaboration work with Dr. Rahul Kumar. Subashani created this database/tool: eVGeMdb. Use it for disease-specific modifiers, mechanisms/hypotheses, and therapeutic targets.
academic.oup.com/narmolmed/ar...
eVGeMdb: a manually curated database for experimentally validated genetic modifiers of neurodegenerative disorders
Abstract. Genetic modifiers are genes that, while not directly causing disease, can alter the onset, progression, severity, or specific phenotypes of a dis
academic.oup.com
January 17, 2026 at 3:05 AM
virussucks.com
Unfortunately, I felt extreme pain in my back after starting to sprint while on the antibiotics. Now I know why. The virus damages our lungs.

academic.oup.com/narmolmed/ar...

SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells | NAR Molecular Medicine
SARSCoV2 in vitro infection in human lung cells
December 18, 2025 at 4:16 PM
craigagoodman1.bsky.social
Sex-specific skeletal muscle gene expression responses to exercise reveal novel direct mediators of insulin sensitivity change
academic.oup.com/narmolmed/ar...
Sex-specific skeletal muscle gene expression responses to exercise reveal novel direct mediators of insulin sensitivity change
Abstract. Understanding how exercise improves whole-body insulin sensitivity (Si) involves complex molecular signaling. This study examines skeletal muscle
academic.oup.com
April 14, 2025 at 6:04 PM
jsabatino37.bsky.social
Understanding if specific EBV variants are associated with MS is an important, unanswered question.

Simple, but clever approach for beginning to answer this: academic.oup.com/narmolmed/ad...
EBV genome analysis in multiple sclerosis shows extensive viral diversity and links to autoimmunity
Abstract. Epstein–Barr virus (EBV) is a major risk factor for multiple sclerosis (MS), yet the contribution of specific viral variants remains unclear. Com
academic.oup.com
March 27, 2026 at 5:14 PM
waynestatechem.bsky.social
The Bhagwat Lab provides a fresh perspective on CSR (class-switch recombination) in the journal NAR Molecular Medicine.#wsuchemistry #chembio #chemistryindetroit #ChemSky

academic.oup.com/narmolmed/ar...
Nucleotide level mapping of uracils in murine heavy chain switch regions shows correlation between uracilation and positions of switch junctions created during class-switch recombination
Abstract. Introduction of uracils in specific regions within immunoglobulin genes by the activation-induced deaminase (AID) promotes mutations and double-s
academic.oup.com
July 14, 2025 at 5:27 PM
eriani-martinlab.bsky.social
Our latest study on Tau translation is online

#MAPT #Tau #Alzheimer

@ErianiLab

@LucBuee

academic.oup.com/narmolmed/ad...
FTLD-mapt mutations and short 5′UTR tau mRNAs increase tau translation
Abstract. Tau protein plays a central role in Alzheimer's disease (AD) and other Tauopathies. Tau proteins aggregate in degenerating neurons and its expres
academic.oup.com
December 11, 2024 at 4:01 PM
dm1myotonic.bsky.social
Spanish study: Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening academic.oup.com/narmolmed/ar...
Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening
Abstract. Myotonic dystrophy type I (DM1) is caused by CTG repeat expansions in the DMPK gene leading to mRNA toxicity and sequestration of the splicing re
academic.oup.com
November 19, 2025 at 1:58 PM
asoshnev.bsky.social
Don't post often but this is a good occasion: we wrote a huge review about mechanisms that preserve chromatin fidelity, and how its progressive degradation occurs in disease. Inspired by #oncohistones but mostly *not* about that. Bonus, snuck Horace into the title!
academic.oup.com/narmolmed/ar...
Aere perennius: how chromatin fidelity is maintained and lost in disease
Abstract. Multicellular organisms arise from a single genome template in the zygote, necessitating the cells of the developing embryo to up- and downregula
academic.oup.com
August 13, 2025 at 2:35 PM
The dynamics and strategy of RNA replication in astroviruses academic.oup.com/narmolmed/ar...
The dynamics and strategy of RNA replication in astroviruses
Abstract. Astroviruses are positive-sense single-stranded RNA viruses that cause significant disease across avian and mammalian hosts, yet their replicatio
academic.oup.com
April 20, 2026 at 9:24 PM
jenna-m-norton.bsky.social
This is pretty far afield from my area of expertise, so I can’t offer a very nuanced take off the cuff. The study is published in a peer reviewed journal. academic.oup.com/narmolmed/ar.... I’m not seeing red flags, but defer to others on the quality of the science.
SARS-CoV-2 reshapes m6A methylation in long noncoding RNAs of human lung cells
Abstract. N6-Methyladenosine (m6A) is a key base modification that regulates RNA stability and translation during viral infection. While m6A methylation of
academic.oup.com
December 21, 2025 at 4:53 AM
craigagoodman1.bsky.social
Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle
academic.oup.com/narmolmed/ar...
Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle
Abstract. Skeletal muscle aging is accompanied by deterioration in metabolic flexibility, neuromuscular connectivity, and structural integrity, all of whic
academic.oup.com
April 29, 2026 at 6:07 PM
varechavala.bsky.social
We may have weighted your favourite #DM1 model, so check our OA paper, if not... you can send you our protocol or send us your cells. 🧫 Andrea is busy testing treatments, but she may find a minute to look at yours. (She really likes using her weighing scales... 🤪)

academic.oup.com/narmolmed/ar...
Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening
Abstract. Myotonic dystrophy type I (DM1) is caused by CTG repeat expansions in the DMPK gene leading to mRNA toxicity and sequestration of the splicing re
academic.oup.com
November 19, 2025 at 2:14 PM