Tomorrow, TIDES Europe 2026 kicks off in Amsterdam! 🚀 I'm looking forward to joining the conversation and presenting Inverna Therapeutics' next-generation precision RNA therapeutics platform, built o...

Immunotherapy with checkpoint inhibitors has revolutionized cancer therapy and enabled considerable therapeutic advances for treating various diseases, including lung cancer. However, the molecular de...

A new study shows that lung tumors can disable a key immune-alarm gene without mutating its DNA and that the pattern tracks with how well patients respond to treatment.

A study published in Nature Communications reveals that alcohol-related liver disease traps damaged cells in a regenerative limbo, preventing recovery even after abstinence. Researchers from the University of Illinois Urbana-Champaign, Duke University, and the Chan Zuckerberg Biohub Chicago discovered that inflammation disrupts RNA splicing, causing cells to remain stuck between mature and progenitor states. This cellular dysfunction leads to liver failure as healthy cells overwork and fail to regenerate properly. The study highlights a key pathway involving ESRP2 protein deficiency and inflammatory signals, suggesting potential treatments targeting inflammation could restore liver repair. Findings may lead to diagnostic markers for alcohol-associated liver disease and therapies addressing RNA splicing defects. This research addresses the global issue of alcohol-induced liver mortality, which causes approximately 3 million deaths annually.

The eukaryotic transcriptome diversity arises largely from alternative splicing. One of the widely used high-throughput methods to study this diversity is RNA sequencing. RNA sequencing has become a c...

Fusarium graminearum, the causal agent of Fusarium head blight (FHB), poses a major threat to global food security by contaminating cereals with the mycotoxin deoxynivalenol (DON). Although transcript...

Lu et al. report that PCBP1 safeguards AARS2 alternative splicing in the heart, and that loss of PCBP1 disrupts AARS2 splicing, leading to infantile mitochondrial cardiomyopathy. Loss of cardiac PCBP1...