#nuclearspeckle
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natcellbio.nature.com
💫NEW by Berger & co: #NuclearSpeckle (NS) constituents have 2 expression states in #cancer correlating with patient survival & HIF-2α functional programs. HIF-2α mediates NS association of key genes activated in renal cancer.
rdcu.be/d56c7
www.nature.com/articles/s41...
Nuclear speckles regulate functional programs in cancer
Nature Cell Biology - This study reports that nuclear speckle constituents have two expression states in cancer correlating with patient survival and HIF-2α functional programs. HIF-2α...
rdcu.be
January 13, 2025 at 1:38 PM
pnas.org
Mysterious #NuclearSpeckles could unlock new answers in #KidneyCancer. In PNAS Journal Club: www.pnas.org/post/journal...

#GeneRegulation #p53 #NuclearSpeckle #cancer #CancerTherapy
A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring Harbor Laboratory).
February 3, 2025 at 8:08 PM
genesdev.bsky.social
RESEARCH PAPER: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2
By Begg, Tracey et al., and Kristen Lynch
➡️ https://genesdev.cshlp.org/content/40/15-16/1250.abstract

University of Pennsylvania Penn Medicine
#kinase #nuclearspeckle #RNA #RNAsplicing
August 11, 2026 at 6:00 PM
genesdev.bsky.social
🆕 ADVANCE ONLINE 🆕

RESEARCH PAPER: Coordination of nuclear RNA processing by speckle-localized kinase TAOK2
By Begg, Tracey et al., and Kristen Lynch
➡️ https://ow.ly/nbBO50ZoBpX

University of Pennsylvania Penn Medicine
#kinase #nuclearspeckle #RNA #RNAsplicing
July 22, 2026 at 3:00 PM
mol-biomed.bsky.social
#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...

#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets - Molecular Biomedicine
Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in mult...
doi.org
November 7, 2025 at 8:45 AM