#Fluvoxamine
Fluvoxamine Fails to Shorten COVID-19 Symptom Duration in Mild to Moderate Outpatients
www.ajmc.com/view/fluvoxa...
Fluvoxamine Fails to Shorten COVID-19 Symptom Duration in Mild to Moderate Outpatients
Study finds no benefit of fluvoxamine in shortening COVID-19 symptom duration among mild to moderate cases.
www.ajmc.com
December 8, 2024 at 4:13 PM
"Common antidepressant may ease long COVID’s crushing fatigue"

A clinical trial of 399 adults with long COVID in Brazil found that the antidepressant fluvoxamine significantly reduced fatigue and boosted quality of life compared to a placebo. Meanwhile, Metformin did not produce the same results.
Common antidepressant may ease long COVID’s crushing fatigue
A low-cost antidepressant may offer new hope for people struggling with long COVID fatigue. In a randomized clinical trial involving 399 adults, fluvoxamine significantly reduced fatigue and improved ...
www.sciencedaily.com
July 20, 2026 at 12:19 AM
1) 🇧🇷 A big trial from Brazil reports that the antidepressant fluvoxamine improved fatigue in Long Covid patients while the diabetes drug Metformin had no effect.

The effect of fluvoxamine unfortunately looks quite small and it's unclear if it is clinically significant.
April 1, 2026 at 8:36 AM
anyone on fluvoxamine for ocd?? any words of encouragement?? ߹𖥦߹
August 6, 2025 at 8:52 PM
ahhhh second day of fluvoxamine and swallowing is fucking weird dawg
July 2, 2025 at 1:20 PM
1) fluvoxamine is a serotonin reuptake Inhibitor but it's a bit different than other antidepressants because of its high affinity for sigma-1 receptors.

Would be interesting to have a replication study that not only compares fluvoxamine to placebo but another SSRI as well.
1) 🇧🇷 A big trial from Brazil reports that the antidepressant fluvoxamine improved fatigue in Long Covid patients while the diabetes drug Metformin had no effect.

The effect of fluvoxamine unfortunately looks quite small and it's unclear if it is clinically significant.
April 1, 2026 at 10:44 AM
Pills, Pills, Pills
September 4, 2025 at 7:17 PM
The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID

www.acpjournals.org/doi/10.7326/...

Critical discussion:
www.s4me.info/threads/the-...

Screenshot from latest Science for ME weekly update

#LongCovid
April 11, 2026 at 12:45 AM
I have OCD—not the euphemistic kind, clinically diagnosed.

The last time I tried to go off of my meds was a disaster, so much so that I ended up on emergency Valium to get through the day until I could get fully back on my fluvoxamine.
May 9, 2026 at 3:49 PM
ALL THE Fluvoxamine PLEASE! #LongCovid
"Common antidepressant may ease long COVID’s crushing fatigue"

A clinical trial of 399 adults with long COVID in Brazil found that the antidepressant fluvoxamine significantly reduced fatigue and boosted quality of life compared to a placebo. Meanwhile, Metformin did not produce the same results.
Common antidepressant may ease long COVID’s crushing fatigue
A low-cost antidepressant may offer new hope for people struggling with long COVID fatigue. In a randomized clinical trial involving 399 adults, fluvoxamine significantly reduced fatigue and improved ...
www.sciencedaily.com
July 21, 2026 at 3:39 AM
“Fluvoxamine showed consistent and meaningful benefits, and because it’s already widely used and well understood, it has clear potential for clinical use.

...the 60-day clinical trial showed a 99% probability that fluvoxamine outperformed the placebo for reducing fatigue symptoms."

#LongCovid
March 30, 2026 at 9:24 PM
lets take fluvoxamine together..!
November 15, 2025 at 3:42 AM
Study: The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID.

Published: 31 March 2026

www.acpjournals.org/doi/10.7326/...
The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial: Annals of Internal Medicine: Vol 179, No 5
Background: Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom. Objective: To assess the efficacy of fluvo...
www.acpjournals.org
July 20, 2026 at 12:19 AM
May i suggest a small dose of fluvoxamine?
September 25, 2026 at 9:45 PM
⚠️Quick Clarification⚠️

Some of you are mixing up the medication mentioned in my last post.

🔹Fluvoxamine (Luvox) – This is the one used in the long COVID fatigue trial

🔹Fluoxetine (Prozac) – This is a completely different medication
July 20, 2026 at 2:08 AM
***UPDATE on WashU Healthy Mind Lab FLUVOXAMINE LONG COVID RCT***
We have completed recruitment on our randomized clinical trial of fluvoxamine for treatment of long COVID, supported by the BALVI COVID FUND.
We expect we will be able to report results
~ March 1, 2025.
November 10, 2024 at 11:32 PM
An antidepressant called fluvoxamine reduces fatigue in people with long COVID, at least in the short term, according to a new study that tested the drug against a placebo.

Read more on the study: ow.ly/2wpC50YBcEC
March 31, 2026 at 1:43 PM
After reading about this in April I switched from Paxil (paroxetine) to fluvoxamine. I definitely sleep more. Simple stuff still knocks me down but maybe I recover faster? Would recommend trying for anyone with Long Covid, CFS, etc.
July 19, 2026 at 5:37 PM
lamictal, fluvoxamine, adderall, estrogen, weed, and therapy 😎
February 27, 2024 at 9:12 AM
i am super thankful for everyone who left comments talking about their experience!!! unfortunately, fluvoxamine was so difficult for me that I had to stop taking it and am back on zooloft ( ;´꒳`;)
anyone on fluvoxamine for ocd?? any words of encouragement?? ߹𖥦߹
August 26, 2025 at 5:56 PM
Health Day: "Fluvoxamine Improves Fatigue, QoL in Long COVID"

'Reduction in fatigue seen at day 60 and persisted to day 90 with fluvoxamine but not metformin'

www.healthday.com/healthpro-ne...
Fluvoxamine Improves Fatigue, QoL in Long COVID
FRIDAY, April 3, 2026 (HealthDay News) -- For patients with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), fluvoxamine seem
www.healthday.com
April 3, 2026 at 2:50 PM
A team at Amsterdam UMC will test fluvoxamine (an SSRI) as a treatment for #PostCOVID in a phase III RCT.

Fluvoxamine “may reduce PC symptoms because of its regulatory effect on the (neuro) immune system, the HPA axis and the tryptophan system.“

clinicaltrials.gov/study/NCT073...
January 26, 2026 at 1:53 PM
Study: The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial

Published: 31 March 2026

www.acpjournals.org/doi/10.7326/...
The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID: An Adaptive Randomized Trial: Annals of Internal Medicine: Vol 0, No 0
Background: Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom. Objective: To assess the efficacy of fluvo...
www.acpjournals.org
March 30, 2026 at 10:59 PM