I can’t wait until his carbon stops footprinting.
June 15, 2025 at 3:21 PM
I can’t wait until his carbon stops footprinting.
Have a bill to block digital footprinting altogether or do what the EU does and force companies to require people to explicitly opt-into tracking cookies.
March 27, 2026 at 12:20 PM
Have a bill to block digital footprinting altogether or do what the EU does and force companies to require people to explicitly opt-into tracking cookies.
I hate when they try to resist footprinting ;P
September 22, 2024 at 11:57 PM
I hate when they try to resist footprinting ;P
There has been a couple of manuscripts released regarding transcription factor footprinting - or digital genomic footprinting (DGF) as we call it. I would like to put some of the claims, results and conclusions in context, since I have worked and published on this for ~15 years. 1/n
January 24, 2025 at 10:54 PM
There has been a couple of manuscripts released regarding transcription factor footprinting - or digital genomic footprinting (DGF) as we call it. I would like to put some of the claims, results and conclusions in context, since I have worked and published on this for ~15 years. 1/n
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
April 8, 2025 at 1:52 PM
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
Latest from @arnaudkr.bsky.social on TF cooperation at enhancers, liked the combination of single-molecule footprinting at ectopic vs endogenous loci in mESCs. Curious if the cumulative activation frequency model holds for other less proliferative/plastic cell types? www.nature.com/articles/s41...
Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency - Nature Genetics
This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...
www.nature.com
August 3, 2026 at 12:25 AM
Latest from @arnaudkr.bsky.social on TF cooperation at enhancers, liked the combination of single-molecule footprinting at ectopic vs endogenous loci in mESCs. Curious if the cumulative activation frequency model holds for other less proliferative/plastic cell types? www.nature.com/articles/s41...
Time for a short thread! We developed HiddenFoot, a biophysics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! www.biorxiv.org/content/10.1...
1/6
1/6
May 19, 2025 at 6:55 PM
Time for a short thread! We developed HiddenFoot, a biophysics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! www.biorxiv.org/content/10.1...
1/6
1/6
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
Single-molecule states link transcription factor binding to gene expression - Nature
A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...
www.nature.com
November 20, 2024 at 8:34 PM
Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...
🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...
May 17, 2025 at 5:00 PM
🚨 New preprint out! Do you think Single Molecule Footprinting and Fiber-seq are super cool but aren't sure how to unlock their full potential? HiddenFoot can help you: www.biorxiv.org/content/10.1...
Also check out @guidobarzaghi.bsky.social efforts to develop Footprintcharter, an unsupervised analysis framework for Single Molecule Footprinting data. Feedback on the Bioconductor package welcome! bit.ly/3EkRqJh
April 8, 2025 at 3:01 PM
Also check out @guidobarzaghi.bsky.social efforts to develop Footprintcharter, an unsupervised analysis framework for Single Molecule Footprinting data. Feedback on the Bioconductor package welcome! bit.ly/3EkRqJh
how are environmental consequences of AI accounted for? new research on quantification, footprinting, supply chains.. 31st Jan (paris/online) 👉🏼 cis.cnrs.fr/exploring-th... w/ @anavaldi.bsky.social @theolenoir.bsky.social @ludovico-rella.bsky.social @vgoujon.bsky.social @hugoesteca.bsky.social & more
cis.cnrs.fr
January 21, 2025 at 2:56 PM
how are environmental consequences of AI accounted for? new research on quantification, footprinting, supply chains.. 31st Jan (paris/online) 👉🏼 cis.cnrs.fr/exploring-th... w/ @anavaldi.bsky.social @theolenoir.bsky.social @ludovico-rella.bsky.social @vgoujon.bsky.social @hugoesteca.bsky.social & more
Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1
November 27, 2025 at 3:19 AM
Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1
I can’t wait until his carbon quits footprinting.
February 19, 2026 at 8:32 PM
I can’t wait until his carbon quits footprinting.
And into our companion computational method paper for details on FootprintCharter doi.org/10.1093/bioi...
FootprintCharter: unsupervised detection and quantification of footprints in single molecule footprinting data
AbstractSummary. Single molecule footprinting profiles the heterogeneity of TF occupancy at cis-regulatory elements across cell populations at unprecedente
doi.org
August 11, 2026 at 3:11 PM
And into our companion computational method paper for details on FootprintCharter doi.org/10.1093/bioi...
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Single-cell mapping of regulatory DNA:Protein interactions
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...
biorxiv.org
January 2, 2025 at 9:10 PM
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
i really need to get back into writing poetry but a part of me is pissed that i might never write anything that goes as hard as "whalefall" went. like dude, "Footprinting beyond fossil record where blue bleeds abyssal"??? I've been rotation the phrase blue bleeds abyssal for years in my brain now
January 10, 2026 at 9:23 AM
i really need to get back into writing poetry but a part of me is pissed that i might never write anything that goes as hard as "whalefall" went. like dude, "Footprinting beyond fossil record where blue bleeds abyssal"??? I've been rotation the phrase blue bleeds abyssal for years in my brain now
Excited to finally unveil something I and a lot of other people in my community have been working on for some time now: community guidelines for hydroxyl radical protein footprinting experiments. Please take a look at the pre-print if this is an experiment that has ever interested you. 🧪
Recommendations and Considerations for Hydroxyl Radical Protein Footprinting - Mass Spectrometry
Protein oxidative ‘footprinting’— where obtaining structural information of proteins using hydroxyl radical labeling is detected with bottom-up proteomics mass spectrometry analysis—has evolved from a...
doi.org
April 15, 2025 at 6:01 PM
Excited to finally unveil something I and a lot of other people in my community have been working on for some time now: community guidelines for hydroxyl radical protein footprinting experiments. Please take a look at the pre-print if this is an experiment that has ever interested you. 🧪
“Large corporations shape norms to blame the individual. ‘Carbon footprinting’ is a term developed by British Petroleum to try to blame the individual, to say that the problem here isn’t about big fossil fuel companies, but about people, who need to change the way they use their cars and transport.”
June 24, 2025 at 5:25 AM
“Large corporations shape norms to blame the individual. ‘Carbon footprinting’ is a term developed by British Petroleum to try to blame the individual, to say that the problem here isn’t about big fossil fuel companies, but about people, who need to change the way they use their cars and transport.”
Beautiful single-molecule footprinting study from the Greenleaf and Bintu labs www.nature.com/articles/s41...
Single-molecule states link transcription factor binding to gene expression - Nature
A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...
www.nature.com
November 21, 2024 at 1:01 AM
Beautiful single-molecule footprinting study from the Greenleaf and Bintu labs www.nature.com/articles/s41...
Excited to see this out!
Using single-molecule footprinting, we showed that Pol II occupancy is lower at mouse than fly promoters. This low Pol II occupancy is explained by high Pol II turnover and low transcription initiation at mouse promoters.
Using single-molecule footprinting, we showed that Pol II occupancy is lower at mouse than fly promoters. This low Pol II occupancy is explained by high Pol II turnover and low transcription initiation at mouse promoters.
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
April 2, 2025 at 1:50 PM
Excited to see this out!
Using single-molecule footprinting, we showed that Pol II occupancy is lower at mouse than fly promoters. This low Pol II occupancy is explained by high Pol II turnover and low transcription initiation at mouse promoters.
Using single-molecule footprinting, we showed that Pol II occupancy is lower at mouse than fly promoters. This low Pol II occupancy is explained by high Pol II turnover and low transcription initiation at mouse promoters.
New for 2025 - Our Greener Trials Carbon Footprinting Drop-In Clinics!
January 17, 2025 at 12:32 PM
New for 2025 - Our Greener Trials Carbon Footprinting Drop-In Clinics!
DNS Dumpster is a free OSINT tool for passive DNS reconnaissance, widely used in cybersecurity for network footprinting and attack surface mapping.
dnsdumpster.com
dnsdumpster.com
March 11, 2025 at 2:56 AM
DNS Dumpster is a free OSINT tool for passive DNS reconnaissance, widely used in cybersecurity for network footprinting and attack surface mapping.
dnsdumpster.com
dnsdumpster.com
Don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.
April 8, 2025 at 3:52 PM
Don't forget to checkout our annex pre-print bit.ly/3EkRqJh for a sense on our new 💻 tool FootprintCharter, for the unsupervised footprint quantification from single molecule data. Available on Bioconductor at bit.ly/3XLe8RC.