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docnessmonster.bsky.social
Gabapentin is widely prescribed for nerve pain, but it doesn’t work the same for everyone.

We studied actual human sensory neurons from donors and found that some responded strongly - and others hardly at all.
#fromlabtolife #neuroskyence #PainResearch 1/4
Alt text (expanded version for web or accessibility-focused platforms): Vertical infographic titled “Why Gabapentin Works Differently for Different People.” Section 1 explains that 10% of adults live with neuropathic pain and gabapentin doesn't help everyone. Section 2 shows that researchers used donated human dorsal root ganglia (DRG) neurons to study gabapentin’s effects, combining electrophysiology and RNA sequencing. Section 3 illustrates how gabapentin reduced excitability in some donors’ neurons but not others, and those differences matched gene expression profiles. Section 4 highlights how this could lead to more personalized pain treatment that adds life to the years of people living with chronic pain. Footer credits the donors and includes the study DOI
August 7, 2025 at 5:27 PM
docnessmonster.bsky.social
🧠 From Lab to Life
New research shows Tylenol may quiet pain at its source by blocking Nav1.7 and Nav1.8, sodium channels critical for pain signaling.
That’s a big deal for the most common active ingredient in U.S. meds. 1/4
#FromLabToLife #PainResearch #NeuroSkyence
Infographic titled “From Lab to Life.” The header reads: “Tylenol may quiet pain at its source by blocking Nav1.7 and Nav1.8—sodium channels critical for nerve signaling.” The left panel lists key findings: (1) Acetaminophen inhibits sodium currents in sensory neurons, (2) AM404—the active metabolite—blocks Nav1.7 and Nav1.8, (3) This may reduce neuronal excitability and pain. On the right, a simple neuron illustration shows AM404 blocking two sodium channels, labeled Nav1.7 and Nav1.8. The footer says: “That’s a big deal for the most common active ingredient in U.S. meds.” The citation at the bottom is: Proc Natl Acad Sci U.S.A. 2025 Jun 10;122(23):e2413811122. doi: 10.1073/pnas.2413811122. Epub 2025 Jun 4.
August 2, 2025 at 12:45 PM
britishneuro.bsky.social
Curious how worms, flies, zebrafish, mice, rats & human iPSCs are transforming neuroscience?

Learn from experts, gain insights & earn a certificate!
💸 From £30 (members)
👉 Register: bna.org.uk/events/ems-e...

#Neuroscience #BrainResearch #ModelOrganisms #BNAtraining #STEM #FromLabToLife
November 4, 2025 at 11:05 AM
docnessmonster.bsky.social
🧠From Lab To Life
Why do peripheral nerves suffer axonal loss in diabetes?

A study led by @dianatavf.bsky.social from the @tedpricethepainguy.bsky.social lab showed how inflammation leads to neural fibrosis in diabetic peripheral neuropathy! #PainResearch #Neuroskyence #FromLabToLife 1/
Infographic titled "From Lab To Life: How Diabetes Rewires the Peripheral Nervous System – And what that means for treatment?" It is divided into four sections. The first section, "The Challenge," explains that about 50% of diabetes patients develop diabetic peripheral neuropathy (DPN), which causes pain, numbness, and disability, and highlights the lack of understanding of nerve degeneration. The second section, "What they did?" describes how researchers collected human tibial and sural nerves and used spatial transcriptomics to map gene activity and track inflammation and mRNA transport. The third section, "What they found?" reports increased inflammation markers (IL6, IL1B, CXCL2) and fibrosis markers (TGF-B, Tenascin) in DPN nerves. The final section, "Why it matters?" emphasizes the potential for early intervention to prevent fibrosis and axonal loss, moving toward personalized care. Visuals include a leg with pain indicators and a nerve illustration showing inflammation. The study is credited to Tavares-Ferreira et al., J Clin Invest, 2025, with a DOI link.
August 22, 2025 at 3:14 PM
medchemexpress.bsky.social
🚂 Train tracks = destiny receptors
☁️ Clouds carry protein storms (inhibitor raindrops!)
✨ #BiochemistryInMotion keeps rolling
#SciencePoetry
#fromlabtolife #sciart #Molecularart #Inhibitors #TrainOfThought #trains_worldwide
July 30, 2025 at 5:49 AM
britishneuro.bsky.social
What first sparked your interest in #neuroscience?

At this year's Festive Symposium we’ll follow that spark – from synapse to society.

Join us: bna.org.uk/events/festi...

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#FromLabToLife #ResearchImpact
October 1, 2025 at 12:27 PM