You know GABA as an inhibitor, but that’s not all! We found that tonic GABAergic signaling, mediated by SST-interneurons and alpha5-type receptors, paradoxically facilitates dendritic calcium signals! www.sciencedirect.com/science/arti...
SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors
Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…
www.sciencedirect.com
May 12, 2026 at 3:42 PM
You know GABA as an inhibitor, but that’s not all! We found that tonic GABAergic signaling, mediated by SST-interneurons and alpha5-type receptors, paradoxically facilitates dendritic calcium signals! www.sciencedirect.com/science/arti...
"Our results suggest that adult autistic individuals have baseline retinal hyper-responsivity to single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals"
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder
Alterations in γ-aminobutyric acid (GABA) have been implicated in sensory differences in individuals with autism spectrum disorder (ASD). Visual signals are initially processed in the retina, and in t...
www.jneurosci.org
November 22, 2024 at 11:07 PM
"Our results suggest that adult autistic individuals have baseline retinal hyper-responsivity to single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals"
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas
https://go.nature.com/434f4ns
https://go.nature.com/434f4ns
GABAergic neuron-to-glioma synapses in diffuse midline gliomas - Nature
Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.
go.nature.com
February 20, 2025 at 7:12 AM
Nature research paper: GABAergic neuron-to-glioma synapses in diffuse midline gliomas
https://go.nature.com/434f4ns
https://go.nature.com/434f4ns
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
February 19, 2025 at 9:41 PM
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
Dying:
'a GABAergic benzodiazepine drug manufactured in the Saturnian pharmaceutical factories'
'a GABAergic benzodiazepine drug manufactured in the Saturnian pharmaceutical factories'
November 22, 2024 at 9:40 PM
Dying:
'a GABAergic benzodiazepine drug manufactured in the Saturnian pharmaceutical factories'
'a GABAergic benzodiazepine drug manufactured in the Saturnian pharmaceutical factories'
Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
go.nature.com/4oF4v2G
go.nature.com/4oF4v2G
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.
go.nature.com
August 12, 2025 at 10:36 AM
Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
go.nature.com/4oF4v2G
go.nature.com/4oF4v2G
New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...
Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility
While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...
www.biorxiv.org
June 30, 2025 at 5:55 PM
New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Distinct dendritic integration strategies control dynamics of inhibition in the neocortex
Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…
www.sciencedirect.com
July 3, 2025 at 10:12 AM
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
oh and as a believer in harm reduction and all, I feel obliged to inform you that while he's correct that quaaludes are non narcotic (they're considered a methaqualone, a gabaergic sedative-hypnotic), they ARE addictive lol, as are all mood-affecting psychotropic substances afaik
September 7, 2026 at 12:12 AM
oh and as a believer in harm reduction and all, I feel obliged to inform you that while he's correct that quaaludes are non narcotic (they're considered a methaqualone, a gabaergic sedative-hypnotic), they ARE addictive lol, as are all mood-affecting psychotropic substances afaik
#FluorescenceFriday Location of different classes of GABAergic interneurons derived from the medial ganglionic eminence in the mouse brain. Identified using the 10X Xenium platform, with @odrake.bsky.social and Jasper Heinsbroek.
September 18, 2026 at 10:15 PM
#FluorescenceFriday Location of different classes of GABAergic interneurons derived from the medial ganglionic eminence in the mouse brain. Identified using the 10X Xenium platform, with @odrake.bsky.social and Jasper Heinsbroek.
Nature research paper: Transcriptomic and spatial organization of telencephalic GABAergic neurons
go.nature.com/43fLcE5
go.nature.com/43fLcE5
Transcriptomic and spatial organization of telencephalic GABAergic neurons - Nature
Long-distance migration and dispersion is a common characteristic of nearly all classes of telencephalic GABAergic neurons, which diversify extensively after birth in the cortex and striatum, but show limited postnatal changes in the septum, preoptic area and pallidum.
go.nature.com
November 8, 2025 at 12:24 PM
Nature research paper: Transcriptomic and spatial organization of telencephalic GABAergic neurons
go.nature.com/43fLcE5
go.nature.com/43fLcE5
Happy to share the newest study from our lab, led by superstar postdoc Dr. Rodrigo Campos Cardoso, where we resolve the infralimbic cortex GABAergic circuits of fear extinction: tinyurl.com/38vvr2my
February 10, 2026 at 12:44 PM
Happy to share the newest study from our lab, led by superstar postdoc Dr. Rodrigo Campos Cardoso, where we resolve the infralimbic cortex GABAergic circuits of fear extinction: tinyurl.com/38vvr2my
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability
Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...
www.science.org
December 12, 2025 at 7:46 AM
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science www.science.org/doi/10.1126/...
HCN1 channels in GABAergic amygdalar neurons underpin male-biased aggressive behaviors https://www.biorxiv.org/content/10.1101/2024.12.07.627305v1
December 8, 2024 at 1:15 PM
HCN1 channels in GABAergic amygdalar neurons underpin male-biased aggressive behaviors https://www.biorxiv.org/content/10.1101/2024.12.07.627305v1
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex
Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…
www.sciencedirect.com
September 18, 2025 at 4:16 PM
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Nature research paper: Spatiotemporal clonal architecture of the newborn mouse forebrain
go.nature.com/4xRHqwU
go.nature.com/4xRHqwU
Spatiotemporal clonal architecture of the newborn mouse forebrain - Nature
Clonal barcoding across the newborn mouse forebrain reveals developmental principles whereby glutamatergic neurons and astrocytes remain locally derived, whereas widely dispersed GABAergic (γ-aminobutyric acid-producing) lineages link neurons with oligodendrocyte precursor cells.
go.nature.com
October 1, 2026 at 10:00 AM
Nature research paper: Spatiotemporal clonal architecture of the newborn mouse forebrain
go.nature.com/4xRHqwU
go.nature.com/4xRHqwU
Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy: doi.org/10.1016/j.ti...
Review on the diversity of GABAergic synapse organizer proteins
Review on the diversity of GABAergic synapse organizer proteins
January 12, 2025 at 6:54 PM
Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy: doi.org/10.1016/j.ti...
Review on the diversity of GABAergic synapse organizer proteins
Review on the diversity of GABAergic synapse organizer proteins
Microglia nurture young GABAergic interneurons by secreting IGF-1, a new study shows.
By Lauren Schenkman
www.thetransmitter.org/spectrum/mic...
By Lauren Schenkman
www.thetransmitter.org/spectrum/mic...
Microglia nurture young interneurons
The immune cells secrete a growth factor that “sets the supply of GABAergic interneurons in the developing brain.”…
www.thetransmitter.org
August 28, 2025 at 2:35 PM
Microglia nurture young GABAergic interneurons by secreting IGF-1, a new study shows.
By Lauren Schenkman
www.thetransmitter.org/spectrum/mic...
By Lauren Schenkman
www.thetransmitter.org/spectrum/mic...
Congrats to @neuroknox.bsky.social who received the NOA for her F31 fellowship today! 🎉
NEI will support her study on psychedelics, GABAergic cell types, and visual processing.
Follow her for updates 😀
NEI will support her study on psychedelics, GABAergic cell types, and visual processing.
Follow her for updates 😀
April 17, 2026 at 5:13 PM
Congrats to @neuroknox.bsky.social who received the NOA for her F31 fellowship today! 🎉
NEI will support her study on psychedelics, GABAergic cell types, and visual processing.
Follow her for updates 😀
NEI will support her study on psychedelics, GABAergic cell types, and visual processing.
Follow her for updates 😀
“Our results are consistent with the notion that individuals with ASD may have…
🌟 baseline retinal overactivity 🌟
to repetitive single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals.”
…cool cool cool.
🌟 baseline retinal overactivity 🌟
to repetitive single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals.”
…cool cool cool.
"Our results suggest that adult autistic individuals have baseline retinal hyper-responsivity to single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals"
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Oh so then the lights MIGHT actually BE brighter for us, y'say?
🫠
Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder
Alterations in γ-aminobutyric acid (GABA) have been implicated in sensory differences in individuals with autism spectrum disorder (ASD). Visual signals are initially processed in the retina, and in t...
www.jneurosci.org
May 25, 2025 at 3:13 AM
“Our results are consistent with the notion that individuals with ASD may have…
🌟 baseline retinal overactivity 🌟
to repetitive single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals.”
…cool cool cool.
🌟 baseline retinal overactivity 🌟
to repetitive single light flashes and that the GABAergic system modulates this retinal response differently in autistic and nonautistic individuals.”
…cool cool cool.
Excited to hear all about your GABAergic meditation routines, your glutamatergic morning energizers, your acetylcholine pre-workouts.
LET THE CHEMICAL MESSENGERS BE. LET THEM DO THEIR JOBS. go grift somewhere else I am BEGGING.
LET THE CHEMICAL MESSENGERS BE. LET THEM DO THEIR JOBS. go grift somewhere else I am BEGGING.
August 6, 2025 at 7:37 PM
Excited to hear all about your GABAergic meditation routines, your glutamatergic morning energizers, your acetylcholine pre-workouts.
LET THE CHEMICAL MESSENGERS BE. LET THEM DO THEIR JOBS. go grift somewhere else I am BEGGING.
LET THE CHEMICAL MESSENGERS BE. LET THEM DO THEIR JOBS. go grift somewhere else I am BEGGING.
I am so happy to share that our lab was awarded our first (!!!) R01, the Stephen Katz R01 through NIDA! This award will allow our lab to expand into the fields of reward and addiction, where we will examine the prefrontal GABAergic circuits of adaptive and maladaptive reward seeking! We're hiring!
April 10, 2025 at 4:46 PM
I am so happy to share that our lab was awarded our first (!!!) R01, the Stephen Katz R01 through NIDA! This award will allow our lab to expand into the fields of reward and addiction, where we will examine the prefrontal GABAergic circuits of adaptive and maladaptive reward seeking! We're hiring!
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 12:04 PM
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
new out in #nature two cancer neuroscience papers. Number two: www.nature.com/articles/s41...
GABAergic neuron-to-glioma synapses in diffuse midline gliomas - Nature
Functional, tumour-promoting GABAergic neuron-to-glioma synapses in diffuse midline gliomas are identified.
www.nature.com
February 20, 2025 at 8:29 AM
new out in #nature two cancer neuroscience papers. Number two: www.nature.com/articles/s41...