H3LL GAT3
Earlier this week — July 20th, to be precise — Hell Gate celebrated three years since we turned on the paywall and made our website into a legit NYC journalism outlet. This week, we're reliving our favorite and most notable stories/projects in the below thread. Join us and feel free to add your own!
July 24, 2025 at 6:04 PM
H3LL GAT3
We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state!
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Structural basis for selective inhibition of human GABA transporter GAT3
The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...
www.biorxiv.org
March 29, 2025 at 2:12 PM
We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state!
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY
Molecular basis of human GABA transporter 3 inhibition
Nature Communications - GABA transporters maintain GABA homeostasis and regulate synaptic signaling. Here, the authors determined the cryoEM structures of GABA transporter 3 (GAT3) in its apo form...
urldefense.com
April 23, 2025 at 9:37 PM
I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY
🔊 Welcome to the Gat3 Sapphire Room
📷 instagr.am/gat3studio
▶️ avid.com/pro-tools
#gat3studio #sapphireroom #eucon #dolbyatmos #avids1 #musicproduction #daw #avidprotools #protools #avid
📷 instagr.am/gat3studio
▶️ avid.com/pro-tools
#gat3studio #sapphireroom #eucon #dolbyatmos #avids1 #musicproduction #daw #avidprotools #protools #avid
January 23, 2025 at 9:00 PM
🔊 Welcome to the Gat3 Sapphire Room
📷 instagr.am/gat3studio
▶️ avid.com/pro-tools
#gat3studio #sapphireroom #eucon #dolbyatmos #avids1 #musicproduction #daw #avidprotools #protools #avid
📷 instagr.am/gat3studio
▶️ avid.com/pro-tools
#gat3studio #sapphireroom #eucon #dolbyatmos #avids1 #musicproduction #daw #avidprotools #protools #avid
The fact that Baldur's Gate 3 was actually just called that and not "Baldur's Gat3: Absolute Power" is fuckin miracle in 2024
March 23, 2024 at 11:00 AM
The fact that Baldur's Gate 3 was actually just called that and not "Baldur's Gat3: Absolute Power" is fuckin miracle in 2024
Grab a cup of tea and relax. Second stream of the day. Four floofs go on an adventure in Baldurs Gat3. Joined by @azrafox.bsky.social , @supersahama.bsky.social & @lazyfang.bsky.social . Let the madness begin 😇
September 14, 2023 at 5:48 PM
Grab a cup of tea and relax. Second stream of the day. Four floofs go on an adventure in Baldurs Gat3. Joined by @azrafox.bsky.social , @supersahama.bsky.social & @lazyfang.bsky.social . Let the madness begin 😇
1st One Out The Gat3 ; SNL ; www.youtube.com/watch?v=LFtI... ; www.setlist.fm/setlist/jack... ; www.setlist.fm/setlist/jack... ;
Jack White: Derecho Demonico (Live) - SNL
YouTube video by Saturday Night Live
www.youtube.com
April 8, 2026 at 12:34 AM
1st One Out The Gat3 ; SNL ; www.youtube.com/watch?v=LFtI... ; www.setlist.fm/setlist/jack... ; www.setlist.fm/setlist/jack... ;
Gat3. - Rodeo
By3.
rodeo.club
December 14, 2024 at 4:37 PM
You might read the series of posts of bsky.app/profile/gat3... , a Bulgarian who responded on the primary post and gives more personal insights to this matter.
It's similar with Bulgaria. Reasons are simple enough (not as much propaganda as other factors), but explaining the whole dynamic behind this would take a long series of posts.
May 19, 2025 at 12:07 PM
You might read the series of posts of bsky.app/profile/gat3... , a Bulgarian who responded on the primary post and gives more personal insights to this matter.
rofl
Just remember…
October 28, 2025 at 12:52 PM
May 23, 2026 at 12:44 AM
Structural basis for selective inhibition of human GABA transporter GAT3 https://www.biorxiv.org/content/10.1101/2025.03.27.645797v1
March 29, 2025 at 5:16 AM
Structural basis for selective inhibition of human GABA transporter GAT3 https://www.biorxiv.org/content/10.1101/2025.03.27.645797v1
Estamos ya en casa con nuestra segunda partida al Baldur's Gat3. He cambiado a mi guerrera semielfa por una monja gnoma. La primera se llamaba Candela porque repartía candela. Está se llama Dolores por el mismo motivo.
November 7, 2024 at 5:21 PM
Estamos ya en casa con nuestra segunda partida al Baldur's Gat3. He cambiado a mi guerrera semielfa por una monja gnoma. La primera se llamaba Candela porque repartía candela. Está se llama Dolores por el mismo motivo.
Libérez Ronny de sa cage ! Il est disponible à l'adoption à la SPA de Vesoul
➡️ https://l.ici.fr/GAT3
➡️ https://l.ici.fr/GAT3
February 9, 2026 at 1:48 PM
Libérez Ronny de sa cage ! Il est disponible à l'adoption à la SPA de Vesoul
➡️ https://l.ici.fr/GAT3
➡️ https://l.ici.fr/GAT3
Our inhibitor-bound inward-open GAT3 reveals the binding mode of SR-THAP and the structural determinants of selectivity. Our GABA-bound inward-occluded GAT3 reveals ion coordination and substrate recognition network with exciting distinction to that previously observed for the GAT1 subtype.
March 29, 2025 at 2:12 PM
Our inhibitor-bound inward-open GAT3 reveals the binding mode of SR-THAP and the structural determinants of selectivity. Our GABA-bound inward-occluded GAT3 reveals ion coordination and substrate recognition network with exciting distinction to that previously observed for the GAT1 subtype.
🔥 Working for the new Grammys!
📷 Gat3 Productions
▶️ avid.co/oe5o50WF50a
#grammys #gat3studio #makingmusic #musicproduction #daw #avidprotools #protools #avid #avidcreator
📷 Gat3 Productions
▶️ avid.co/oe5o50WF50a
#grammys #gat3studio #makingmusic #musicproduction #daw #avidprotools #protools #avid #avidcreator
August 21, 2025 at 4:04 PM
🔥 Working for the new Grammys!
📷 Gat3 Productions
▶️ avid.co/oe5o50WF50a
#grammys #gat3studio #makingmusic #musicproduction #daw #avidprotools #protools #avid #avidcreator
📷 Gat3 Productions
▶️ avid.co/oe5o50WF50a
#grammys #gat3studio #makingmusic #musicproduction #daw #avidprotools #protools #avid #avidcreator
„The Schoeps V4 has become one of my favourite vocal mics in the world and I have nearly every great vocal mic made. This is one serious and special microphone on vocals, but also on cello, acoustic instruments, and piano! ”
Glenn A Tabor III / Gat3 Studio
Glenn A Tabor III / Gat3 Studio
June 12, 2025 at 2:28 PM
„The Schoeps V4 has become one of my favourite vocal mics in the world and I have nearly every great vocal mic made. This is one serious and special microphone on vocals, but also on cello, acoustic instruments, and piano! ”
Glenn A Tabor III / Gat3 Studio
Glenn A Tabor III / Gat3 Studio
Our study will facilitate structure-based design of improved selective inhibitors targeting GAT3 for more efficient treatment of epilepsy and a range of other neurological disorders. We are grateful for the support from
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@DFF_raad
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@DFF_raad
March 29, 2025 at 2:12 PM
Our study will facilitate structure-based design of improved selective inhibitors targeting GAT3 for more efficient treatment of epilepsy and a range of other neurological disorders. We are grateful for the support from
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@DFF_raad
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@DFF_raad
Glycosomal ABC transporter 3 (GAT3) is associated with antileishmanial drug susceptibility in Leishmania infantum pubmed.ncbi.nlm.nih.gov/42700952/
September 6, 2026 at 9:33 AM
Glycosomal ABC transporter 3 (GAT3) is associated with antileishmanial drug susceptibility in Leishmania infantum pubmed.ncbi.nlm.nih.gov/42700952/
Réduire sa fenêtre alimentaire, une piste pour préserver les capacités cognitives ?
➡️ https://l.lindependant.fr/GAT3
➡️ https://l.lindependant.fr/GAT3
August 13, 2026 at 12:43 PM
Réduire sa fenêtre alimentaire, une piste pour préserver les capacités cognitives ?
➡️ https://l.lindependant.fr/GAT3
➡️ https://l.lindependant.fr/GAT3
How Astrocytes Keep Neural Teams in Sync https://neurosciencenews.com/astrocytes-gaba-neuron-29529/?B∙R∙AI∙N=http%3A%2F%2Fscitech.news #health #neuroscience #neuroscience
How Astrocytes Keep Neural Teams in Sync - Neuroscience News
A new study shows that astrocytes use a protein called Gat3 to manage ambient GABA levels, helping neurons work together to encode visual input.
neurosciencenews.com
July 27, 2025 at 3:22 AM
How Astrocytes Keep Neural Teams in Sync https://neurosciencenews.com/astrocytes-gaba-neuron-29529/?B∙R∙AI∙N=http%3A%2F%2Fscitech.news #health #neuroscience #neuroscience
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn – Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn - Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện #TanSonNhat #GaT3…
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn - Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện #TanSonNhat #GaT3…
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn – Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn - Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện #TanSonNhat #GaT3 #DuongTranQuocHoanCongHoa #GiaoThongTPHCM #KhanhThanh19_4 TP.HCM – Thành phố dự kiến chính thức đưa vào sử dụng tuyến đường nối Trần Quốc Hoàn - Cộng Hòa và nhà ga T3 sân bay Tân Sơn Nhất vào ngày 19-4 tới.
tiki.pro.vn
April 18, 2025 at 6:35 PM
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn – Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn - Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện #TanSonNhat #GaT3…
TP.HCM Sắp Khánh Thành Đường Nối Trần Quốc Hoàn - Cộng Hòa Và Nhà Ga T3 Sân Bay Tân Sơn Nhất: Lộ Trình Chi Tiết Cho Phương Tiện #TanSonNhat #GaT3…