Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria https://www.biorxiv.org/content/10.64898/2026.09.29.755391v1
September 30, 2026 at 11:16 AM
Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria https://www.biorxiv.org/content/10.64898/2026.09.29.755391v1
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
January 30, 2025 at 3:40 AM
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems
Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
So excited to have our new paper out now!
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
December 31, 2024 at 4:39 PM
So excited to have our new paper out now!
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3
#innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social
PYROPTOSIS is a type of programmed cell death characterized by inflammatory cell lysis when gasdermin forms pores in the cell membrane
December 12, 2024 at 3:57 PM
PYROPTOSIS is a type of programmed cell death characterized by inflammatory cell lysis when gasdermin forms pores in the cell membrane
Inserting multiple copies of Gasdermin from Salamandra salamandra (the fire salamander) into a wolf to make Canis incendiaris, or the pyre wolf
splicing random eDNA from a peat bog into a wolf to make canis sphagnumis, or the quagmire wolf
Splicing pipeweed DNA into wolves to make canis hobbitus, or the shire wolf.
April 8, 2025 at 6:28 PM
Inserting multiple copies of Gasdermin from Salamandra salamandra (the fire salamander) into a wolf to make Canis incendiaris, or the pyre wolf
Gasdermin E couples mitochondrial stress to STING-driven neuronal pyroptosis during Chandipura virus encephalitis https://www.biorxiv.org/content/10.64898/2026.09.25.754282v1
September 27, 2026 at 10:16 AM
Gasdermin E couples mitochondrial stress to STING-driven neuronal pyroptosis during Chandipura virus encephalitis https://www.biorxiv.org/content/10.64898/2026.09.25.754282v1
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death
www.nature.com/articles/s41...
congrats @mitodynamics.bsky.social & team!!
www.nature.com/articles/s41...
congrats @mitodynamics.bsky.social & team!!
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology
Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...
www.nature.com
October 14, 2025 at 5:07 PM
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death
www.nature.com/articles/s41...
congrats @mitodynamics.bsky.social & team!!
www.nature.com/articles/s41...
congrats @mitodynamics.bsky.social & team!!
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
www.cell.com
January 1, 2025 at 1:03 PM
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Gasdermin D pore-laden pyroptotic vesicles transplant these pores on neighboring cell surfaces and propagate cell death to bystander cells @cellcellpress.bsky.social @vijayrathinam.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 31, 2024 at 8:23 PM
Gasdermin D pore-laden pyroptotic vesicles transplant these pores on neighboring cell surfaces and propagate cell death to bystander cells @cellcellpress.bsky.social @vijayrathinam.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin
C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent
GsdmC activation in intestin...
www.cell.com
July 22, 2025 at 3:26 PM
Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...
Nature research paper: CARD domains mediate anti-phage defence in bacterial gasdermin systems
https://go.nature.com/3CvoD3W
https://go.nature.com/3CvoD3W
CARD domains mediate anti-phage defence in bacterial gasdermin systems - Nature
Caspase recruitment domains (CARDs) are present in defence systems that protect bacteria against phage, where the bacterial CARD domain is essential for protease-mediated activation of bacterial gasdermins that promote cell death.
go.nature.com
January 30, 2025 at 4:14 PM
Nature research paper: CARD domains mediate anti-phage defence in bacterial gasdermin systems
https://go.nature.com/3CvoD3W
https://go.nature.com/3CvoD3W
Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
July 29, 2026 at 5:54 PM
Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
🚨 We are excited to share the first preprint of our lab !
We discovered an NADase enzymatic domain in bacterial immunity and in the human protein TEP1.
www.biorxiv.org/content/10.6...
We discovered an NADase enzymatic domain in bacterial immunity and in the human protein TEP1.
www.biorxiv.org/content/10.6...
A widespread NADase domain links bacterial immunity with human TEP1
Recent discoveries on bacterial immunity have revealed that several protein domains involved in anti-phage defense are conserved in eukaryotes, such as SIRim, TIR, PNP and gasdermin. Bacterial immune ...
www.biorxiv.org
September 8, 2026 at 10:15 AM
🚨 We are excited to share the first preprint of our lab !
We discovered an NADase enzymatic domain in bacterial immunity and in the human protein TEP1.
www.biorxiv.org/content/10.6...
We discovered an NADase enzymatic domain in bacterial immunity and in the human protein TEP1.
www.biorxiv.org/content/10.6...
Neuroinflammation affects the blood-brain barrier in many ways. This study from Yonsei University (Seoul) provides new insight into how peripheral LPS challenges the BBB doi.org/10.1038/s414... #BloodBrainBarrier #Cerebrovascular
Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice - Nature Communications
The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption durin...
doi.org
January 19, 2025 at 5:12 PM
Neuroinflammation affects the blood-brain barrier in many ways. This study from Yonsei University (Seoul) provides new insight into how peripheral LPS challenges the BBB doi.org/10.1038/s414... #BloodBrainBarrier #Cerebrovascular
Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!
symposia.smart.org.cn/sym/event/Fu...
symposia.smart.org.cn/sym/event/Fu...
Symposia
symposia.smart.org.cn
February 5, 2026 at 2:56 AM
Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!
symposia.smart.org.cn/sym/event/Fu...
symposia.smart.org.cn/sym/event/Fu...
Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria https://www.biorxiv.org/content/10.64898/2026.09.29.755391v1
September 30, 2026 at 11:16 AM
Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria https://www.biorxiv.org/content/10.64898/2026.09.29.755391v1
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D @scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D
NEK7 phosphorylation amplifies NLRP3 activation.
www.science.org
January 3, 2025 at 7:31 PM
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D @scienceimmuno.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ⓕⓛⓨⓘⓝⓖ ⓔⓜⓑⓔⓡⓢ
🔥 🔥 🔥 🔥 🔥 🔥 🔥 🔥
ⓘⓝ ⓐ ⓦⓘⓛⓓⓕⓘⓡⓔ
new concept in the propagation of inflammatory cell death in severe inflammation and sepsis
extracellular vesicles released from dying cells contain gasdermin pores that can subsequently attack and initiate rapid apoptosis in bystander cells
🔥 PyroEVs 🔥
🔥 🔥 🔥 🔥 🔥 🔥 🔥 🔥
ⓘⓝ ⓐ ⓦⓘⓛⓓⓕⓘⓡⓔ
new concept in the propagation of inflammatory cell death in severe inflammation and sepsis
extracellular vesicles released from dying cells contain gasdermin pores that can subsequently attack and initiate rapid apoptosis in bystander cells
🔥 PyroEVs 🔥
Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden
pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell
death to bystander cells.
www.cell.com
January 26, 2025 at 12:57 PM
ⓕⓛⓨⓘⓝⓖ ⓔⓜⓑⓔⓡⓢ
🔥 🔥 🔥 🔥 🔥 🔥 🔥 🔥
ⓘⓝ ⓐ ⓦⓘⓛⓓⓕⓘⓡⓔ
new concept in the propagation of inflammatory cell death in severe inflammation and sepsis
extracellular vesicles released from dying cells contain gasdermin pores that can subsequently attack and initiate rapid apoptosis in bystander cells
🔥 PyroEVs 🔥
🔥 🔥 🔥 🔥 🔥 🔥 🔥 🔥
ⓘⓝ ⓐ ⓦⓘⓛⓓⓕⓘⓡⓔ
new concept in the propagation of inflammatory cell death in severe inflammation and sepsis
extracellular vesicles released from dying cells contain gasdermin pores that can subsequently attack and initiate rapid apoptosis in bystander cells
🔥 PyroEVs 🔥
☕Nguyen, Collier et al. find a #mitochondria – #lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate #pyroptosis.
bit.ly/4oF4Fqb
bit.ly/4oF4Fqb
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology
Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...
bit.ly
November 15, 2025 at 8:09 PM
☕Nguyen, Collier et al. find a #mitochondria – #lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate #pyroptosis.
bit.ly/4oF4Fqb
bit.ly/4oF4Fqb
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
(Cell Reports 43, 114728; September 24, 2024)
dlvr.it
July 4, 2026 at 11:24 PM
Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors - Nature Communications
‘Gasdermin-mediated pyroptosis can induce anti-tumor immune responses. Here the authors report a toolbox of gasdermin D variants for induction of pyroptosis, showing that, when combined with intratumo...
www.nature.com
December 30, 2024 at 11:52 PM
As my inaugural post on BlueSky, I’m happy to share the first cancer-related study from Pyrocellfluencers spearheaded by Sara Orehek.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
October 14, 2025 at 9:47 PM
Preview @cp-immunity.bsky.social
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis @nature.com www.nature.com/articles/s41...
August 3, 2026 at 6:17 PM
Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis @nature.com www.nature.com/articles/s41...
🙏 @natrevimmunol.bsky.social for highlighting our latest work demonstrating intercellular propagation of pyroptosis. rdcu.be/d6dAB
Gasdermin pores on extracellular vesicles spread cell death
Nature Reviews Immunology - A study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce pyroptotic cell death in bystander cells.
rdcu.be
January 14, 2025 at 6:00 PM
🙏 @natrevimmunol.bsky.social for highlighting our latest work demonstrating intercellular propagation of pyroptosis. rdcu.be/d6dAB
#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...
https://www.cell.com/cell/abstract/S0092-8674(24)01334-5
t.co
December 31, 2024 at 6:07 PM
#NoTimeToDie! @vijayrathinam.bsky.social Weight &co show @cp-cell.bsky.social that pyroptotic cells release extracellular vesicles which transplant gasdermin D #GSDMD pores to neighboring cells propagating cell death! t.co/XgU6jt15aF Free link to the paper 👉 authors.elsevier.com/a/1kMQgL7PXq...