Researchers have identified genetic variants linked to ovarian reserve and the rate of reproductive ageing, offering new insights into infertili… #Geneticvariants #Infertility #Menopause #Ovarianreserve #Reproductivegenetics

While many genetic variants have been associated with Parkinson’s disease, little is known about their underlying causal mechanisms. De-Paula et al. show t

A recent study has identified genetic factors that may influence the effectiveness of GLP-1 drugs, which are commonly used to treat obesity and type 2 diabetes. Researchers found that certain genetic variants can reduce the drugs' impact on weight loss and metabolic control. Patients like Mercedes, who tried multiple GLP-1 treatments without success, are now being considered for alternative therapies such as non-GLP-1 drugs or bariatric surgery. The study highlights the importance of genetic testing in personalized medicine, as approximately 10% of patients may experience reduced efficacy due to these variants. While the findings offer hope for tailored treatments, they also underscore the need for further research to address treatment resistance in obesity management. The research team, including experts in human genetics and metabolic disorders, emphasizes that resistance is not a failure of the drug but a biological variation that requires individualized approaches. This discovery could lead to more effective treatment strategies for patients who do not respond to standard GLP-1 therapies.

An Imperial-led study has highlighted how rare variants of a gene regulating the gut lining may increase the risk of MIS-C by up to four times.

Italfarmaco's oral HDAC inhibitor Duvyzat has been recommended for approval in the EU as a treatment for Duchenne muscular dystrophy (DMD).

The Pakistan Genome Resource compiles biobank data from 173,303 individuals with high familial relatedness, broadening the catalogue of human genetic variation and establishing a population-specific g...