#Genotype
JUST IN: USDA Confirms Detection of Bird Flu Genotype D1.1 in Nevada Dairy Cows.

This marks the first detection of this virus genotype in dairy cattle.

Previously, all detections in dairy cattle have been linked to HPAI H5N1 clade 2.3.4.4b, genotype B3.13.
February 6, 2025 at 1:37 AM
JUST IN: Arizona Reports H5N1 Genotype D1.1 In Maricopa County Dairy Herd.
February 14, 2025 at 10:19 PM
Dairy cows in Nevada found to be infected with Influenza H5N1 (bird flu) genotype D1.1, presumably contracted from wild birds. D1.1 genotype is different from the B3.13 genotype which is causing a multistate H5N1 outbreak in dairy cattle.
February 11, 2025 at 4:02 AM
This is a very concerning development: H5N1 clade 2.3.4.4b, genotype D1.1 detected in dairy cattle. The D1.1 genotype may be connected to more severe disease in humans.

www.aphis.usda.gov/news/program...
APHIS Confirms D1.1 Genotype in Dairy Cattle in Nevada | Animal and Plant Health Inspection Service
On January 31, 2025, the USDA Animal and Plant Health Inspection Service (APHIS) National Veterinary Services Laboratories (NVSL) confirmed by whole genome sequence the first detection of highly patho...
www.aphis.usda.gov
February 5, 2025 at 7:59 PM
BREAKING: Mexico's fatal H5N1 bird flu case involved D1.1 genotype.
April 17, 2025 at 11:58 PM
Wyoming H5N1 bird flu case uploads to GISAID

—PB2 E627K mutation detected

Partial sequence from a Wyoming patient confirms H5N1 D1.1 genotype with PB2 E627K

It’s a key adaptation for mammalian replication.
February 26, 2025 at 2:10 PM
My biological sex is female. It has changed

Phenotype is orders of magnitude more important than genotype for everything from discrimination to healthcare to sexuality

Chromosomes are meaningless and any law treating them as all sex is is wrong
April 16, 2025 at 11:50 AM
CDC just confirmed the first severe case of #H5N1 in the US in a patient in Louisiana. This virus seems to be the same genotype D1.1 that is spreading in birds at the moment (so not the cattle genotype B3.13) that severely sickened the teenager in Canada. #IDsky 🧪
December 18, 2024 at 4:16 PM
BREAKING: New H5N1 Variant Hits Ohio & Indiana 19M Birds Culled

A newly identified D1.3 genotype of H5N1 avian flu has spread across 84 farms, leading to the culling of over 19 million birds in under three months.
March 17, 2025 at 4:39 AM
Some concerning #H5N1 updates this past week that I am watching closely:
1/ Canada 🇨🇦: The human H5N1 infection (genotype D1.1) reported in BC is different from the strain infecting US dairy cows (genotype B3.13) but carries mutations that could enhance human/mammal infectivity.
November 17, 2024 at 1:40 PM
i think we should draw a grammatical distinction between

maid (profession, aesthetic, phenotype)
and
Maid (posthuman species, genotype)
March 28, 2025 at 12:28 AM
Genotype D1.1 of H5N1 confirmed in Nevada cattle, which is the one circulating in birds and not B3.13, causing the wider cattle epizootic in the U.S.

In other words, this is a second observed jump from birds into cows.

Keep rolling the dice, shall we?

www.feedstuffs.com/agribusiness...
New HPAI genotype found in Nevada dairy cows
APHIS confirms first detection of D1.1 genotype in dairy cattle through NMTS testing.
www.feedstuffs.com
February 5, 2025 at 7:31 PM
The only aspect of biological sex that humans can’t easily change is our genotype, and that’s why transphobes pretend genes are the gold standard for biological sex.

But most biologists don’t use genotype to determine an animal’s sex because: GENOTYPE IS NOT AN ACCURATE PREDICTOR OF SEX.
August 2, 2025 at 4:17 PM
4/ Genetic analysis confirmed the virus as HPAI H5N1, genotype D1.1, different from the previously identified B3.13 strain. Notably, this is the first time a different genotype has been detected in U.S. dairy cattle.
February 10, 2025 at 2:21 PM
BREAKING: Nevada confirms state's first human case of bird flu in a dairy worker.

Meanwhile One person in Louisiana died who had been hospitalized with the D1.1 genotype.
February 11, 2025 at 2:16 AM
The H5N1 is mutating and spreading.

The new D1.1 genotype, which is more dangerous to humans, has been found in dairy herds in Nevada.

The risk of an H5N1 pandemic is rising.
February 6, 2025 at 1:39 PM
I think "biological" just isn't a helpful word. Like, genotype is biological. Phenotype is biological. If they don't match, which one is biology?
July 11, 2025 at 2:34 PM
New development: this is the first detection of genotype D1.1 H5N1 virus in cattle. All cattle sequences to date were genotype B3.13 & were all descended from a single spillover.

New genotype means new introduction to cows from birds.
www.statnews.com/2025/02/05/u...
USDA milk testing shows different strain of H5N1 bird flu in Nevada dairy herds
The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain that has circulated in wild birds, making prospects for containment in cows appear dim.
www.statnews.com
February 5, 2025 at 8:31 PM
USDA confirms spillover of 2nd H5N1 avian flu genotype into dairy cattle

Detection of the D1.1. genotype, linked to two severe infections in people, came from the national milk testing program.

www.cidrap.umn.edu/a...
February 5, 2025 at 8:01 PM
i think this thing just called me a lesbian www.guidedtrack.com/programs/2dj...
August 10, 2026 at 3:52 AM
And while this sounds like good news, the H5N1 situation remains grim. There has been an explosion of human cases, both of this genotype (D1.1) and the cow genotype (B3.13). More sequences from humans is a trend we need to reverse—we need fewer humans infected, period.
December 27, 2024 at 1:27 AM
Carlson et al. build a mathematical model considering how genotype-by-environment interactions can maintain variation and parametrize their model to test its applicability to real mutualisms.

Read now ahead of print!
www.journals.uchicago.edu/doi/10.1086/...
How Genotype-by-Environment Interactions Can Maintain Variation in Mutualisms | The American Naturalist
Abstract Coevolution requires reciprocal genotype-by-genotype (G × G) interactions for fitness, which occur when the fitness of a genotype in one species depends on the genotype it interacts with in a...
www.journals.uchicago.edu
December 24, 2025 at 12:50 AM
CDC just confirmed the first severe case of #H5N1 in the US in a patient in Louisiana. This virus seems to be the same genotype D1.1 that is spreading in birds at the moment (so not the cattle genotype B3.13) that severely sickened the teenager in Canada.
December 18, 2024 at 4:09 PM
CORRECTION: Genotype D1.1 has been responsible for some (not most) human infections to date and most case have been mild. Genotype D1.1 has a mutation that may increase its ability to spread from animals to humans but does not seem to influence ability to spread from humans to humans.
February 11, 2025 at 5:10 AM