going slug mode. mucinmaxxing. in my glycoprotein excretion era
June 2, 2025 at 6:47 PM
going slug mode. mucinmaxxing. in my glycoprotein excretion era
A Boa Constrictor brain-derived cell expressing a viral glycoprotein (magenta) and stained for actin (yellow) and DNA (white).
#FluorescenceFriday
#FluorescenceFriday
June 27, 2025 at 11:20 AM
A Boa Constrictor brain-derived cell expressing a viral glycoprotein (magenta) and stained for actin (yellow) and DNA (white).
#FluorescenceFriday
#FluorescenceFriday
Got a glycoprotein as a target for your binder design competition on Monday? Look no further ⬇️ we got you 😎 #glycotime 🧪🔥
Refreshed ReGlyco Filter in bioRxiv 🧪(doi.org/10.64898/202...) in view of the upcoming Protein Design Competition on Monday 28/09 🎉🔥
proteinbase.com/competitions...
Each week a new target and if it's a glycoprotein, glycoshape.org and ReGlyco Filter can help screen and optimise your binder design
proteinbase.com/competitions...
Each week a new target and if it's a glycoprotein, glycoshape.org and ReGlyco Filter can help screen and optimise your binder design
September 25, 2026 at 6:27 PM
Got a glycoprotein as a target for your binder design competition on Monday? Look no further ⬇️ we got you 😎 #glycotime 🧪🔥
Nature research paper: Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
go.nature.com/4urU3yb
go.nature.com/4urU3yb
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - Nature
Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.
go.nature.com
March 17, 2026 at 9:43 AM
Nature research paper: Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
go.nature.com/4urU3yb
go.nature.com/4urU3yb
Molecular organization of the New World arenavirus spike glycoprotein complex | @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...
www.nature.com
August 9, 2025 at 5:56 AM
Molecular organization of the New World arenavirus spike glycoprotein complex | @natmicrobiol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
vaccines also offer relatively short-lived immunity, requiring annual -or even more frequent- booster doses, making it harder to administer. Cornell researchers sought out to address these shortcomings with their new vaccine. Their modular technology can accommodate glycoprotein antigens from many
March 13, 2025 at 4:03 PM
vaccines also offer relatively short-lived immunity, requiring annual -or even more frequent- booster doses, making it harder to administer. Cornell researchers sought out to address these shortcomings with their new vaccine. Their modular technology can accommodate glycoprotein antigens from many
Celebrating 29k human followers of our 0 person island by sharing about local fish. Patagonia Toothfish, like other notothenioid fishes, are able to survive in freezing, ice-laden waters of the S. Ocean due to the presence of an antifreeze glycoprotein in blood. It doesn’t help against Weddell Seals
April 7, 2025 at 3:24 PM
Celebrating 29k human followers of our 0 person island by sharing about local fish. Patagonia Toothfish, like other notothenioid fishes, are able to survive in freezing, ice-laden waters of the S. Ocean due to the presence of an antifreeze glycoprotein in blood. It doesn’t help against Weddell Seals
Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...
Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology
Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...
www.nature.com
August 9, 2025 at 9:51 AM
Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...
Having spent years building a network on twitter, I'm reluctant to start over, but I hear good things...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
Mapping glycoprotein structure reveals Flaviviridae evolutionary history - Nature
Combined phylogenetic analyses and glycoprotein structure prediction across the Flaviviridae reveals divergent membrane fusion systems and provides insights into the complex evolutionary history withi...
www.nature.com
November 7, 2024 at 9:47 PM
Having spent years building a network on twitter, I'm reluctant to start over, but I hear good things...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
I'm a scientist, I study viruses. I'll start by sharing some cool stuff we recently with published @eddieholmes.bsky.social and @jonathonmifsud.bsky.social
www.nature.com/articles/s41...
An important and beautiful structure of the native dystrophin glycoprotein complex!.
December 11, 2024 at 8:42 PM
An important and beautiful structure of the native dystrophin glycoprotein complex!.
Nature research paper: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
go.nature.com/4mZHupC
go.nature.com/4mZHupC
A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2 - Nature
A neutralizing nanobody specific to the prefusion conformation of herpes simplex virus glycoprotein B has cross-species activity and offers insights into virus neutralization, possible immunogens and an attractive avenue for antiviral interventions.
go.nature.com
September 9, 2025 at 1:24 PM
Nature research paper: A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2
go.nature.com/4mZHupC
go.nature.com/4mZHupC
Im like that of a glycolipid or glycoprotein the way i
October 6, 2025 at 1:42 AM
Im like that of a glycolipid or glycoprotein the way i
the same mRNA technology that powered the COVID-19 vaccines, but redirect it to fight a protein that promotes blood vessel growth in the retina. So, how does it work exactly? Researchers developed a vaccine that carries mRNA instructions for leucine-rich alpha-2-glycoprotein 1, or LRG1. The protein
March 29, 2026 at 4:06 PM
the same mRNA technology that powered the COVID-19 vaccines, but redirect it to fight a protein that promotes blood vessel growth in the retina. So, how does it work exactly? Researchers developed a vaccine that carries mRNA instructions for leucine-rich alpha-2-glycoprotein 1, or LRG1. The protein
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations
Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antib...
www.biorxiv.org
December 18, 2024 at 8:39 PM
In new study, we measure how all mutations to rabies G affect cell entry & antibody neutralization
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
Sheds light on constraints on type III fusion proteins, suggests ways to stabilize G vaccine antigens, and quantifies antibody robustness to rabies variation
www.biorxiv.org/content/10.1...
💥 Couldn’t be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro 🦠 H/T @paramyxologist.bsky.social + Lauren Henderson, Erica Ollmann Saphire Chris Benedict @natmicrobiol.nature.com www.nature.com/articles/s41...
The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells - Nature Microbiology
The gH-associated tropism and entry (GATE) complex consists of glycoprotein H, UL116 and UL141. This complex is abundant on human cytomegalovirus virions and enables entry into human endothelial cells...
www.nature.com
June 30, 2025 at 4:15 PM
💥 Couldn’t be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro 🦠 H/T @paramyxologist.bsky.social + Lauren Henderson, Erica Ollmann Saphire Chris Benedict @natmicrobiol.nature.com www.nature.com/articles/s41...
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes - Nature Biomedical Engineering
A microfluidics- and electron-microscopy-based method enables the characterization of polyclonal antibody responses to infection and vaccination.
www.nature.com
July 13, 2025 at 4:02 PM
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chimeric SARS-CoV-2 vaccine vectors stably incorporating the functional glycoprotein of VSV pubmed.ncbi.nlm.nih.gov/42781491/ #cryoem
September 25, 2026 at 4:07 PM
Chimeric SARS-CoV-2 vaccine vectors stably incorporating the functional glycoprotein of VSV pubmed.ncbi.nlm.nih.gov/42781491/ #cryoem
Nice work from @mclellanlab.bsky.social 👇🏼
"Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes"
www.cell.com/cell/fulltex...
"Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes"
www.cell.com/cell/fulltex...
Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes
Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.
www.cell.com
December 19, 2024 at 6:12 AM
Nice work from @mclellanlab.bsky.social 👇🏼
"Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes"
www.cell.com/cell/fulltex...
"Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes"
www.cell.com/cell/fulltex...
What’s more is that glycoprotein usage is not congruent with our Nidovirales polymerase (RdRp) phylogeny, suggesting a complex history of glycoprotein switching throughout this order.
December 17, 2024 at 4:10 AM
What’s more is that glycoprotein usage is not congruent with our Nidovirales polymerase (RdRp) phylogeny, suggesting a complex history of glycoprotein switching throughout this order.
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection.
pdb101.rcsb.org/motm...
pdb101.rcsb.org/motm...
PDB101: Molecule of the Month: RSV Fusion Glycoprotein
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection.
pdb101.rcsb.org
January 22, 2025 at 5:12 PM
Structures of the fusion glycoprotein from respiratory syncytial virus (RSV) were used to engineer effective vaccines to fight viral infection.
pdb101.rcsb.org/motm...
pdb101.rcsb.org/motm...
2 important #Nature papers on the structure of the dystrophin-glycoprotein (DGC) complex: tinyurl.com/29rnn6ua and tinyurl.com/2vmztm72
Structure and assembly of the dystrophin glycoprotein complex - Nature
A structural study of native dystrophin glycoprotein complex from mouse skeletal muscle reveals an extended tower-like architecture that provides multiple binding sites on both sides of the membr...
tinyurl.com
December 12, 2024 at 1:12 PM
2 important #Nature papers on the structure of the dystrophin-glycoprotein (DGC) complex: tinyurl.com/29rnn6ua and tinyurl.com/2vmztm72
High-resolution in situ structures of hantavirus glycoprotein tetramers pubmed.ncbi.nlm.nih.gov/41763200/ #cryoem
March 1, 2026 at 7:40 PM
High-resolution in situ structures of hantavirus glycoprotein tetramers pubmed.ncbi.nlm.nih.gov/41763200/ #cryoem