G proteins inhibit CaV2.2 by selectively blocking VSDs I & IV, revealing the mechanism of presynaptic inhibition #ionchannels #CaV2.2 #Gproteins #neuroscience

🎉🎖️We congratulate 🌟Jesús Daniel Gómez-Zepeda (IDIBAPS, Barcelona, Spain) on winning the FEBS Letters #PosterPrize at the @biochemsoc.bsky.social meeting on small #Gproteins, recently held in Manchester, UK! 🎉👏👏👏

#SGP25 #Gproteins25

GBM Lunch on December 17, 12:30 PM (CET)
We’re excited to welcome Mikel Garcia-Marcos (Boston University) presenting: “The Secret Life of G Proteins”
Session chair: Tassula Proikas-Cezanne (@unituebingen.bsky.social)
Organized by the GBM Study Group Autophagy.
#GBMLunch #Autophagy #GProteins

Alfred G. Gilman was born #OTD in 1941. He won a #LaskerAward in 1989 for the discovery that #Gproteins carry signals that regulate vital processes within cells. 🧪 laskerfoundation.org/winners/sign...

The GPR174 modulates #immune homeostasis by engaging distinct #Gproteins. This study shows that hydration-mediated interactions stabilize the active-state conformation of #GPR174 & reshape its intracellular cavity by enabling selectivity @plosbiology.org 🧪 plos.io/4dsN81j

The GPR174 modulates #immune homeostasis by engaging distinct #Gproteins. This study shows that hydration-mediated interactions stabilize the active-state conformation of #GPR174 & reshape its intracellular cavity by enabling selectivity @plosbiology.org 🧪 plos.io/4dsN81j

The GPR174 modulates #immune homeostasis by engaging distinct #Gproteins. This study shows that hydration-mediated interactions stabilize the active-state conformation of #GPR174 & reshape its intracellular cavity by enabling selectivity @plosbiology.org 🧪 plos.io/4dsN81j

🎉 As we celebrate #TIBS50, we're highlighting #CitedClassics and revisiting the top cited article from each of the last 50 years!

Check out this one on #Gproteins from 1992 by John R. Hepler and Alfred G. Gilman!

Read it here 👉 www.sciencedirect.com/science/arti...