Neue Influenza-H3N2-Subklade breitet sich aus
„Noch hat die Grippewelle in Deutschland nicht begonnen. Dagegen laufen in mehreren Ländern der Nordhalbkugel bereits deutliche Influenzawellen. Sie werden überwiegend durch eine neue H3N2-Subklade, die als »Subklade K« bezeichnet …
„Noch hat die Grippewelle in Deutschland nicht begonnen. Dagegen laufen in mehreren Ländern der Nordhalbkugel bereits deutliche Influenzawellen. Sie werden überwiegend durch eine neue H3N2-Subklade, die als »Subklade K« bezeichnet …
November 21, 2025 at 4:16 PM
Neue Influenza-H3N2-Subklade breitet sich aus
„Noch hat die Grippewelle in Deutschland nicht begonnen. Dagegen laufen in mehreren Ländern der Nordhalbkugel bereits deutliche Influenzawellen. Sie werden überwiegend durch eine neue H3N2-Subklade, die als »Subklade K« bezeichnet …
„Noch hat die Grippewelle in Deutschland nicht begonnen. Dagegen laufen in mehreren Ländern der Nordhalbkugel bereits deutliche Influenzawellen. Sie werden überwiegend durch eine neue H3N2-Subklade, die als »Subklade K« bezeichnet …
⚠️ BREAKING:
WHO Warns as New Influenza A(H3N2) Subclade K Spreads Globally
The World Health Organization has warned of the spread of new influenza A(H3N2) subclade K across the European Union, East Asia, and parts of North America.
WHO Warns as New Influenza A(H3N2) Subclade K Spreads Globally
The World Health Organization has warned of the spread of new influenza A(H3N2) subclade K across the European Union, East Asia, and parts of North America.
December 17, 2025 at 5:26 PM
⚠️ BREAKING:
WHO Warns as New Influenza A(H3N2) Subclade K Spreads Globally
The World Health Organization has warned of the spread of new influenza A(H3N2) subclade K across the European Union, East Asia, and parts of North America.
WHO Warns as New Influenza A(H3N2) Subclade K Spreads Globally
The World Health Organization has warned of the spread of new influenza A(H3N2) subclade K across the European Union, East Asia, and parts of North America.
For those who have been led to believe that this year’s flu vaccine doesn’t work, this isn’t the case.
ER visits and hospital admissions are reduced by 72–75% in children and adolescents, and by 32–39% in adults.
pmc.ncbi.nlm.nih.gov/articles/PMC...
ER visits and hospital admissions are reduced by 72–75% in children and adolescents, and by 32–39% in adults.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K
Influenza A(H3N2) subclade K (J.2.4.1) has dominated the 2025/26 season start in England. Post-infection ferret antisera raised against northern hemisphere 2025/26 vaccine strains showed reduced reactivity to subclade K viruses in England, aligning ...
pmc.ncbi.nlm.nih.gov
January 1, 2026 at 11:38 PM
For those who have been led to believe that this year’s flu vaccine doesn’t work, this isn’t the case.
ER visits and hospital admissions are reduced by 72–75% in children and adolescents, and by 32–39% in adults.
pmc.ncbi.nlm.nih.gov/articles/PMC...
ER visits and hospital admissions are reduced by 72–75% in children and adolescents, and by 32–39% in adults.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Not quite:
H3N2, subclade K
H3N2, subclade K
December 31, 2025 at 2:10 AM
Not quite:
H3N2, subclade K
H3N2, subclade K
Moreover, the most critical advantage of the mRNA tech is the speed at which it can be produced. Under a properly functioning regulatory apparatus, when we got surprised with H3N2 subclade K, we could have had an updated vaccine within ~2 months.
February 11, 2026 at 12:15 AM
Moreover, the most critical advantage of the mRNA tech is the speed at which it can be produced. Under a properly functioning regulatory apparatus, when we got surprised with H3N2 subclade K, we could have had an updated vaccine within ~2 months.
The “super flu” behind outbreaks in the US and UK is a new variant of influenza A H3N2, subclade K. Existing vaccines appear to be insufficiently effective against the virus. www.wired.com/story/what-i...
What Is the ‘Super Flu’ That Is Spreading in Europe and the United States?
The “super flu” behind outbreaks in the US and UK is a new variant of influenza A H3N2, subclade K. Existing vaccines appear to be insufficiently effective against the virus.
www.wired.com
January 2, 2026 at 10:03 AM
The “super flu” behind outbreaks in the US and UK is a new variant of influenza A H3N2, subclade K. Existing vaccines appear to be insufficiently effective against the virus. www.wired.com/story/what-i...
CDC flu data is back! I’m so happy I could cry. H3N2 is predominating, especially the new subclade K. This supports the emerging hypothesis that we will have a big flu season. More to come.
November 14, 2025 at 4:24 PM
CDC flu data is back! I’m so happy I could cry. H3N2 is predominating, especially the new subclade K. This supports the emerging hypothesis that we will have a big flu season. More to come.
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
February 20, 2026 at 9:29 PM
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
The "Super-K" flu strain (officially H3N2 subclade K) is a fast-spreading, highly mutated variant of the seasonal influenza A virus.
www.csiro.au/en/news/All/...
www.csiro.au/en/news/All/...
The rise of the ‘Super-K’ flu: what you need to know
A new H3N2 subclade is driving an unusually early flu season in Australia. Here is what makes it different, and what it means for you.
www.csiro.au
August 9, 2026 at 5:04 AM
The "Super-K" flu strain (officially H3N2 subclade K) is a fast-spreading, highly mutated variant of the seasonal influenza A virus.
www.csiro.au/en/news/All/...
www.csiro.au/en/news/All/...
Australian Influenza update:
It became clear during November that a unusual second wave of influenza is underway in Australia, driven by the new "clade K" (H3N2 clade 2a.3a.1, subclade K).
Tasmania, New South Wales and South Australia are currently the hardest-hit.
#Influenza #Australia
🧵
It became clear during November that a unusual second wave of influenza is underway in Australia, driven by the new "clade K" (H3N2 clade 2a.3a.1, subclade K).
Tasmania, New South Wales and South Australia are currently the hardest-hit.
#Influenza #Australia
🧵
December 7, 2025 at 7:41 AM
Australian Influenza update:
It became clear during November that a unusual second wave of influenza is underway in Australia, driven by the new "clade K" (H3N2 clade 2a.3a.1, subclade K).
Tasmania, New South Wales and South Australia are currently the hardest-hit.
#Influenza #Australia
🧵
It became clear during November that a unusual second wave of influenza is underway in Australia, driven by the new "clade K" (H3N2 clade 2a.3a.1, subclade K).
Tasmania, New South Wales and South Australia are currently the hardest-hit.
#Influenza #Australia
🧵
H3N2 preprint: there are concerns of a severe incoming influenza season due to the drifted H3N2 K clade. We at @psioxford.bsky.social analysed epi data and ran scenario models to see what we could discern about K clade transmission dynamics: zenodo.org/records/1770....
(1/18)
(1/18)
Evaluation of the epidemiological outlook of the influenza A/H3N2 clade K in England during the 2025-26 season
Key findings England is currently experiencing a high growth rate of infections caused by the influenza A/H3N2 K clade. Antigenic change from the previously dominant clade, a rapid selective sweep evi...
zenodo.org
November 25, 2025 at 1:51 PM
H3N2 preprint: there are concerns of a severe incoming influenza season due to the drifted H3N2 K clade. We at @psioxford.bsky.social analysed epi data and ran scenario models to see what we could discern about K clade transmission dynamics: zenodo.org/records/1770....
(1/18)
(1/18)
There's a new, really important preprint looking at how well the current seasonal flu vaccines induce antibodies against the current H3N2 variants (subclade K), driving the massive surge in infections.
Let's look 🧵
Let's look 🧵
Antibodies elicited by the 2025-2026 influenza vaccine in humans
A new H3N2 variant (named subclade K) possesses several key hemagglutinin substitutions and is circulating widely during the 2025-2026 influenza season. In this report, we completed experiments to det...
www.medrxiv.org
January 8, 2026 at 12:32 AM
There's a new, really important preprint looking at how well the current seasonal flu vaccines induce antibodies against the current H3N2 variants (subclade K), driving the massive surge in infections.
Let's look 🧵
Let's look 🧵
Australian Influenza update:
The unusual second wave of influenza is continuing in most states of Australia, driven by the clade K (H3N2 clade 2a.3a.1, subclade K) – "Kangaroo variant".
#Influenza #Australia
🧵
The unusual second wave of influenza is continuing in most states of Australia, driven by the clade K (H3N2 clade 2a.3a.1, subclade K) – "Kangaroo variant".
#Influenza #Australia
🧵
December 20, 2025 at 5:07 AM
Australian Influenza update:
The unusual second wave of influenza is continuing in most states of Australia, driven by the clade K (H3N2 clade 2a.3a.1, subclade K) – "Kangaroo variant".
#Influenza #Australia
🧵
The unusual second wave of influenza is continuing in most states of Australia, driven by the clade K (H3N2 clade 2a.3a.1, subclade K) – "Kangaroo variant".
#Influenza #Australia
🧵
So hey new virus mutation just dropped. If you have a horrible sore throat, fever that won't go down with NSAIDs, bad headaches, PLUS all the other symptoms of the flu, but are testing negative for COVID and Flu A&B on home tests?
You have Subclade K/H3N2. You have the flu and it will suck.
You have Subclade K/H3N2. You have the flu and it will suck.
December 30, 2025 at 6:30 PM
So hey new virus mutation just dropped. If you have a horrible sore throat, fever that won't go down with NSAIDs, bad headaches, PLUS all the other symptoms of the flu, but are testing negative for COVID and Flu A&B on home tests?
You have Subclade K/H3N2. You have the flu and it will suck.
You have Subclade K/H3N2. You have the flu and it will suck.
🚨New Pre-Print🚨
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
January 30, 2026 at 12:01 PM
🚨New Pre-Print🚨
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...
Our preprint examining the specificity of human antibodies that cross-react with subclade K H3N2 viruses was posted this morning on medRxiv. These studies have implications on what vaccine strains should be selected for next year’s influenza season. 1/
www.medrxiv.org/content/10.6...
www.medrxiv.org/content/10.6...
Mapping the specificity of H3N2 strain-specific and cross-reactive human neutralizing antibodies elicited by the 2025-2026 influenza vaccine
An H3N2 variant, named subclade K, continues to circulate widely during the 2025-2026 influenza season. This virus possesses a hemagglutinin (HA) protein that has eleven substitutions relative to the ...
www.medrxiv.org
February 22, 2026 at 4:14 PM
Our preprint examining the specificity of human antibodies that cross-react with subclade K H3N2 viruses was posted this morning on medRxiv. These studies have implications on what vaccine strains should be selected for next year’s influenza season. 1/
www.medrxiv.org/content/10.6...
www.medrxiv.org/content/10.6...
Since H3N2 subclade K differs from the H3N2 strain in the current influenza vaccine, there is concern the vaccine may be less effective against H3N2 this season.
So far early estimates from England show expected effectiveness against hospitalization (70-75% for children and 30-40% for adults)
So far early estimates from England show expected effectiveness against hospitalization (70-75% for children and 30-40% for adults)
December 18, 2025 at 1:57 AM
Since H3N2 subclade K differs from the H3N2 strain in the current influenza vaccine, there is concern the vaccine may be less effective against H3N2 this season.
So far early estimates from England show expected effectiveness against hospitalization (70-75% for children and 30-40% for adults)
So far early estimates from England show expected effectiveness against hospitalization (70-75% for children and 30-40% for adults)
...has undoubtedly caused people to wrongly skip it.
The 2025/26 flu vaccine has been shown to reduce pediatric hospitalizations by 72-75%.
The 2025/26 flu vaccine has been shown to reduce pediatric hospitalizations by 72-75%.
Early influenza virus characterisation and vaccine effectiveness in England in autumn 2025, a period dominated by influenza A(H3N2) subclade K
Influenza A(H3N2) subclade K (J.2.4.1) has dominated the 2025/26 season start in England. Post-infection ferret antisera raised against northern hemisphere 2025/26 vaccine strains showed reduced reactivity to subclade K viruses in England, aligning ...
pmc.ncbi.nlm.nih.gov
January 5, 2026 at 7:20 PM
...has undoubtedly caused people to wrongly skip it.
The 2025/26 flu vaccine has been shown to reduce pediatric hospitalizations by 72-75%.
The 2025/26 flu vaccine has been shown to reduce pediatric hospitalizations by 72-75%.
"..the first known human H5N5 infection has captured a good deal of attention, but the `other' flu story we've been following this week has been the rapid spread of a new seasonal H3N2 subcade (K) virus, which emerged in the Southern Hemisphere"
afludiary.blogspot.com/2025/11/cdc-...
afludiary.blogspot.com/2025/11/cdc-...
CDC FluView, ECDC CDT & Canada Announce Early H3N2 Subclade K Prevalence Numbers
Credit NIAID #18,947 Yesterday's announcement for the first known human H5N5 infection has captured a good deal of attention, but the `ot...
afludiary.blogspot.com
November 15, 2025 at 8:40 PM
"..the first known human H5N5 infection has captured a good deal of attention, but the `other' flu story we've been following this week has been the rapid spread of a new seasonal H3N2 subcade (K) virus, which emerged in the Southern Hemisphere"
afludiary.blogspot.com/2025/11/cdc-...
afludiary.blogspot.com/2025/11/cdc-...
A Surprise Flu Variant Threw Off the Vaccine. Get Ready for a Brutal Winter
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K. gizmodo.com/a-surprise-f...
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K. gizmodo.com/a-surprise-f...
A Surprise Flu Variant Threw Off the Vaccine. Get Ready for a Brutal Winter
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K.
gizmodo.com
November 17, 2025 at 5:21 AM
A Surprise Flu Variant Threw Off the Vaccine. Get Ready for a Brutal Winter
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K. gizmodo.com/a-surprise-f...
Scientists are warning that this winter's flu vaccine will be less effective against an emerging variant of H3N2 flu named subclade K. gizmodo.com/a-surprise-f...
Joseph Eastman is worth subscribing to.
“CDC delayed vaccine approval [against COVID] for high-risk children by roughly a month and has not announced a timeline for low-income children, despite rising pediatric hospitalizations.”
RFK playing god.
josepheastman.substack.com/p/daily-glob...
“CDC delayed vaccine approval [against COVID] for high-risk children by roughly a month and has not announced a timeline for low-income children, despite rising pediatric hospitalizations.”
RFK playing god.
josepheastman.substack.com/p/daily-glob...
Daily Global Pathogen Briefing: 10-2-2026
New wastewater report, US hits its second peak; new influenza A(H3N2)”subclade K”
josepheastman.substack.com
October 3, 2026 at 9:04 AM
Joseph Eastman is worth subscribing to.
“CDC delayed vaccine approval [against COVID] for high-risk children by roughly a month and has not announced a timeline for low-income children, despite rising pediatric hospitalizations.”
RFK playing god.
josepheastman.substack.com/p/daily-glob...
“CDC delayed vaccine approval [against COVID] for high-risk children by roughly a month and has not announced a timeline for low-income children, despite rising pediatric hospitalizations.”
RFK playing god.
josepheastman.substack.com/p/daily-glob...
“two subclades that spread widely over the last year (subclade K for H3N2 and D.3.1.1 for H1N1) are now spawning descendants with reduced neutralization by human sera.”
Honestly… this explains a lot.
Honestly… this explains a lot.
AFluDiary Blog `Preprint: Near real-time data on the human neutralizing antibody landscape to influenza virus in summer of 2026 shows antigenic advance of H3N2 subclade K region D mutants and H1N1 D.3.1.1 Sa mutants' afludiary.blogspot.com/2026/09/prep...
afludiary.blogspot.com
September 18, 2026 at 12:27 PM
“two subclades that spread widely over the last year (subclade K for H3N2 and D.3.1.1 for H1N1) are now spawning descendants with reduced neutralization by human sera.”
Honestly… this explains a lot.
Honestly… this explains a lot.
"despite high apparent transmissibility, there is no evidence to date of a clinical severity signal with K viruses."
A good piece by a great team.
www.eurosurveillance.org/content/10.2...
A good piece by a great team.
www.eurosurveillance.org/content/10.2...
Eurosurveillance | Extended influenza seasons in Australia and New Zealand in 2025 due to the emergence of influenza A(H3N2) subclade K viruses
In Australia and New Zealand, late outbreaks of an A(H3N2) variant virus termed subclade K extended the 2025 influenza season. Subclade K viruses were genetically and antigenically distinct from the 2025 vaccine A(H3N2) strain A/Croatia/10136RV/2023 (H3N2)-like virus and previously circulating subclade J viruses. Subclade K viruses have since been detected in over 34 countries and appear to have spread globally, except in South America. It is thus likely that they will further expand during the northern hemisphere winter 2025/26 season.
www.eurosurveillance.org
February 28, 2026 at 5:38 AM
"despite high apparent transmissibility, there is no evidence to date of a clinical severity signal with K viruses."
A good piece by a great team.
www.eurosurveillance.org/content/10.2...
A good piece by a great team.
www.eurosurveillance.org/content/10.2...
2. Watching the current scrambling response of many healthcare systems to H3N2 K, combined with the firmly embedded political and ideological resistance to masking, I can assure you all that if H5N1 goes human to human with a high CFR, we're in deep trouble as a species.
/end
/end
December 13, 2025 at 12:34 PM
2. Watching the current scrambling response of many healthcare systems to H3N2 K, combined with the firmly embedded political and ideological resistance to masking, I can assure you all that if H5N1 goes human to human with a high CFR, we're in deep trouble as a species.
/end
/end