#onlywithHCR: @degrainger.bsky.social, @oliverastone.bsky.social, and their team reveal that lymphatic endothelial cells arise from specialized progenitors. #HCRimaging helped them to visualize endothelial progenitors in whole-mount mouse embryos.

Learn more: www.nature.com/articles/s44...

Is stiffness alone enough to change chemical guidance cues? Embedding soft brain regions in stiff 3D gels incresed levels of chemical guidance cues (using #HCRimaging) compared with soft 3D gels.

JUST RELEASED: IZFS NewsSplash Issue 22 | Summer 2026! This issue highlights researchers in the zebrafish field, new discoveries, HCR images, and more from the #ZebrafishCommunity! Read more: www.izfs.org/newssplash/n...

#NewsSplash #zebrafish #HCRimaging #zebrafishresearch

#onlywithHCR: Morales et al. explore the hidden world of bacterial–fungal interactions (BFI). Using #HCRimaging, the team overcame key barriers in detecting endohyphal bacteria and visualized bacterial presence within fungal structures.

Explore the full findings here: tinyurl.com/ya5vpy66

Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠

🟣 Mettl3
⚪️ astrocytes
🟢 nuclei
🟠 rRNA

#onlywithHCR: A study by Guillotin et al. reveals how different grass species evolved distinct traits, driven by specialized cell types. #HCRimaging was used to visualize gene expression patterns, uncovering how cell types evolved through gene module recruitment.

Learn more: tinyurl.com/peny8r64

Thanks to the folks at @HCRimaging for their nifty HCR HiFi encoders: "quantitative signal amplification of
1˚ antibodies for same-isotype multiplexing"
🔑@DSHB_antibodies can be tagged as supernatant, allowing mulplx wo/purification --> here are 2 trusted IgG1s used together

The MI team will be at NSH! Stop by Booth #620 to talk about how our team can support your research goals.

Don’t miss our workshop, “Translating Spatial RNA Biomarkers into Point-of-Care Lateral Flow Assays,” for a look at adapting #HCRimaging for lateral flow detection.

🗓️ Sept. 29
🕤 9:15–10:15 AM

... plus see some nice work with @HCRimaging
on whole-mount chromogenic HCR in Xenopus on Sat.

Have you read the IZFS NewsSplash Issue 22 | Summer 2026? This issue highlights researchers in the zebrafish field, new discoveries, HCR images, and more from the #ZebrafishCommunity! Read it here: www.izfs.org/newssplash/n...

#NewsSplash #zebrafish #HCRimaging

A study from the Cepko Lab at Harvard used #HCRimaging to map gene expression in the developing chicken retina.

“HCR™ [imaging] allowed us to scale spatial validation across many genes and developmental stages with high sensitivity and consistency.” — Heer Joisher

Read more: tinyurl.com/mw9vrtew

Meet our team from April 19-22 at Booth #2017 and learn how the HCR™ platform is empowering real-world cancer research!

We’ll be sharing how researchers use #HCRimaging to get more out of every sample while producing data that stands up to real-world analysis in oncology.

See you at #AACR26!

Discover how the Xenopus pronephros serves as a powerful system for studying nephrogenesis and human kidney disorders, and learn how the Miller Lab uses #HCRimaging to map gene expression across nephron segments!

🗓️ Wednesday, April 1
🕤 8:00 AM PT / 10:00 AM CT

Register today: tinyurl.com/2hxemxss

#onlywithHCR: Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. Using #HCRimaging, they were able to observe the widespread gene expression changes across the birdsong sensorimotor circuit caused by deafening.

🔬Read the full story: tinyurl.com/3fb2hpps

#onlywithHCR: Schember et al. compared the regulatory landscapes of the single-minded (sim) gene in two divergent insects. Using #HCRimaging, their findings highlight the evolutionary rewiring of the gene regulatory network.

Read the full study here: journals.plos.org/plosgenetics...

#onlywithHCR: In a fascinating study, Lopez and Alward used #HCRimaging to visualize cyp19a1 (brain-specific aromatase) mRNA expression in A. burtoni, providing new insight into how androgen signaling may influence social behavior.

Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...

#onlywithHCR: Gray and Lovely leveraged #HCRimaging to fluorescently visualize rar and rxr mRNA in transgenic zebrafish embryos, revealing overlapping expression of multiple rar/rxr genes between 12–32 hours post-fertilization.

Read the full study here: tinyurl.com/5crp99fs