#onlywithHCR: @degrainger.bsky.social, @oliverastone.bsky.social, and their team reveal that lymphatic endothelial cells arise from specialized progenitors. #HCRimaging helped them to visualize endothelial progenitors in whole-mount mouse embryos.
Learn more: www.nature.com/articles/s44...
Learn more: www.nature.com/articles/s44...
March 28, 2025 at 4:30 PM
#onlywithHCR: @degrainger.bsky.social, @oliverastone.bsky.social, and their team reveal that lymphatic endothelial cells arise from specialized progenitors. #HCRimaging helped them to visualize endothelial progenitors in whole-mount mouse embryos.
Learn more: www.nature.com/articles/s44...
Learn more: www.nature.com/articles/s44...
#onlywithHCR: Morales et al. explore the hidden world of bacterial–fungal interactions (BFI). Using #HCRimaging, the team overcame key barriers in detecting endohyphal bacteria and visualized bacterial presence within fungal structures.
Explore the full findings here: tinyurl.com/ya5vpy66
Explore the full findings here: tinyurl.com/ya5vpy66
June 20, 2025 at 5:00 PM
#onlywithHCR: Morales et al. explore the hidden world of bacterial–fungal interactions (BFI). Using #HCRimaging, the team overcame key barriers in detecting endohyphal bacteria and visualized bacterial presence within fungal structures.
Explore the full findings here: tinyurl.com/ya5vpy66
Explore the full findings here: tinyurl.com/ya5vpy66
#onlywithHCR: LaBelle et al. reveal that cell–cell collisions are drivers of the dispersal of endodermal cells in zebrafish embryos. With #HCRtechnology, they observed epha2a expression, finding that endodermal cells undergo RhoA-dependent, active repulsion-type CIL.
Read more: tinyurl.com/mrx934sc
Read more: tinyurl.com/mrx934sc
December 12, 2025 at 6:50 PM
#onlywithHCR: LaBelle et al. reveal that cell–cell collisions are drivers of the dispersal of endodermal cells in zebrafish embryos. With #HCRtechnology, they observed epha2a expression, finding that endodermal cells undergo RhoA-dependent, active repulsion-type CIL.
Read more: tinyurl.com/mrx934sc
Read more: tinyurl.com/mrx934sc
#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain.
🦟 Read more: tinyurl.com/2rtk4bz2
🦟 Read more: tinyurl.com/2rtk4bz2
November 7, 2025 at 5:17 PM
#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain.
🦟 Read more: tinyurl.com/2rtk4bz2
🦟 Read more: tinyurl.com/2rtk4bz2
#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins.
Read more: tinyurl.com/4bwm599u
Read more: tinyurl.com/4bwm599u
August 22, 2025 at 5:00 PM
#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins.
Read more: tinyurl.com/4bwm599u
Read more: tinyurl.com/4bwm599u
#onlywithHCR: A study by Guillotin et al. reveals how different grass species evolved distinct traits, driven by specialized cell types. #HCRimaging was used to visualize gene expression patterns, uncovering how cell types evolved through gene module recruitment.
Learn more: tinyurl.com/peny8r64
Learn more: tinyurl.com/peny8r64
April 4, 2025 at 4:30 PM
#onlywithHCR: A study by Guillotin et al. reveals how different grass species evolved distinct traits, driven by specialized cell types. #HCRimaging was used to visualize gene expression patterns, uncovering how cell types evolved through gene module recruitment.
Learn more: tinyurl.com/peny8r64
Learn more: tinyurl.com/peny8r64
#onlywithHCR: Moriano-Gutierrez et al. uncovered how the bacterial small RNA SsrA enables Vibrio fischeri to maintain a stable symbiosis with its squid host, Euprymna scolopes. By using HCR™ imaging, they visualized how SsrA is packaged into outer membrane vesicles.
Read more: tinyurl.com/4fyuyjrp
Read more: tinyurl.com/4fyuyjrp
May 16, 2025 at 4:25 PM
#onlywithHCR: Moriano-Gutierrez et al. uncovered how the bacterial small RNA SsrA enables Vibrio fischeri to maintain a stable symbiosis with its squid host, Euprymna scolopes. By using HCR™ imaging, they visualized how SsrA is packaged into outer membrane vesicles.
Read more: tinyurl.com/4fyuyjrp
Read more: tinyurl.com/4fyuyjrp
#onlywithHCR: In a remarkable study, O’Gorman et al. explored how traits evolve in tandem in Astyanax mexicanus. The team mapped oca2 gene expression in hybrid fish—uncovering a shared molecular signature in pigmentation and sleep behavior.
Dive into the full story here: tinyurl.com/4uya4xzz
Dive into the full story here: tinyurl.com/4uya4xzz
July 11, 2025 at 4:30 PM
#onlywithHCR: In a remarkable study, O’Gorman et al. explored how traits evolve in tandem in Astyanax mexicanus. The team mapped oca2 gene expression in hybrid fish—uncovering a shared molecular signature in pigmentation and sleep behavior.
Dive into the full story here: tinyurl.com/4uya4xzz
Dive into the full story here: tinyurl.com/4uya4xzz
#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction.
Read the full study @nature.com: tinyurl.com/bp7dbsjx
Read the full study @nature.com: tinyurl.com/bp7dbsjx
Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators - Scientific Reports
Scientific Reports - Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators
tinyurl.com
December 5, 2025 at 6:27 PM
#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction.
Read the full study @nature.com: tinyurl.com/bp7dbsjx
Read the full study @nature.com: tinyurl.com/bp7dbsjx
#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm.
🔬 Read more: tinyurl.com/3mvj2wu2
🔬 Read more: tinyurl.com/3mvj2wu2
October 24, 2025 at 4:19 PM
#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm.
🔬 Read more: tinyurl.com/3mvj2wu2
🔬 Read more: tinyurl.com/3mvj2wu2
#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system.
Read more: tinyurl.com/3tpmf4v3
Read more: tinyurl.com/3tpmf4v3
October 17, 2025 at 4:58 PM
#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system.
Read more: tinyurl.com/3tpmf4v3
Read more: tinyurl.com/3tpmf4v3
#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis.
Read more here: tinyurl.com/mr3yfwzy
Read more here: tinyurl.com/mr3yfwzy
October 10, 2025 at 5:23 PM
#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis.
Read more here: tinyurl.com/mr3yfwzy
Read more here: tinyurl.com/mr3yfwzy
#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.
Read more: tinyurl.com/4dcxhs38
Read more: tinyurl.com/4dcxhs38
September 26, 2025 at 5:27 PM
#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats.
Read more: tinyurl.com/4dcxhs38
Read more: tinyurl.com/4dcxhs38
#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages.
Read more: tinyurl.com/yt4fycah
Read more: tinyurl.com/yt4fycah
September 19, 2025 at 5:06 PM
#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages.
Read more: tinyurl.com/yt4fycah
Read more: tinyurl.com/yt4fycah
#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development.
Read more: tinyurl.com/mrxru323
Read more: tinyurl.com/mrxru323
September 12, 2025 at 6:36 PM
#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development.
Read more: tinyurl.com/mrxru323
Read more: tinyurl.com/mrxru323
#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues.
Read more: tinyurl.com/pxs5jrcu
Read more: tinyurl.com/pxs5jrcu
September 5, 2025 at 5:30 PM
#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues.
Read more: tinyurl.com/pxs5jrcu
Read more: tinyurl.com/pxs5jrcu
#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies.
Read more: tinyurl.com/2t7zhfwn
Read more: tinyurl.com/2t7zhfwn
August 29, 2025 at 4:30 PM
#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies.
Read more: tinyurl.com/2t7zhfwn
Read more: tinyurl.com/2t7zhfwn
#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages.
Read more: genesdev.cshlp.org/content/37/3...
Read more: genesdev.cshlp.org/content/37/3...
August 15, 2025 at 6:00 PM
#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages.
Read more: genesdev.cshlp.org/content/37/3...
Read more: genesdev.cshlp.org/content/37/3...
#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits.
Read more: tinyurl.com/4nrsm275
Read more: tinyurl.com/4nrsm275
August 8, 2025 at 5:00 PM
#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits.
Read more: tinyurl.com/4nrsm275
Read more: tinyurl.com/4nrsm275
#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity.
With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.
Read more: tinyurl.com/bdfadjnr
With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.
Read more: tinyurl.com/bdfadjnr
August 1, 2025 at 5:00 PM
#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity.
With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.
Read more: tinyurl.com/bdfadjnr
With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context.
Read more: tinyurl.com/bdfadjnr
#onlywithHCR: Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. Using #HCRimaging, they were able to observe the widespread gene expression changes across the birdsong sensorimotor circuit caused by deafening.
🔬Read the full story: tinyurl.com/3fb2hpps
🔬Read the full story: tinyurl.com/3fb2hpps
July 25, 2025 at 4:31 PM
#onlywithHCR: Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. Using #HCRimaging, they were able to observe the widespread gene expression changes across the birdsong sensorimotor circuit caused by deafening.
🔬Read the full story: tinyurl.com/3fb2hpps
🔬Read the full story: tinyurl.com/3fb2hpps
#onlywithHCR: Task et al. mapped the expression of all major chemosensory co-receptors in Drosophila melanogaster. This revealed that Ir25a is co-expressed with Orco, suggesting a more integrated receptor network.
Explore the full story here: elifesciences.org/articles/725...
Explore the full story here: elifesciences.org/articles/725...
July 18, 2025 at 5:01 PM
#onlywithHCR: Task et al. mapped the expression of all major chemosensory co-receptors in Drosophila melanogaster. This revealed that Ir25a is co-expressed with Orco, suggesting a more integrated receptor network.
Explore the full story here: elifesciences.org/articles/725...
Explore the full story here: elifesciences.org/articles/725...
#onlywithHCR: In a cross-species study, Guillotin et al. unveiled how domesticated grasses evolved distinct traits through fine-scale changes in root cell types, revealing orthologous gene markers and highlighting which cell types evolved rapidly.
Read the full story here: tinyurl.com/peny8r64
Read the full story here: tinyurl.com/peny8r64
June 27, 2025 at 5:31 PM
#onlywithHCR: In a cross-species study, Guillotin et al. unveiled how domesticated grasses evolved distinct traits through fine-scale changes in root cell types, revealing orthologous gene markers and highlighting which cell types evolved rapidly.
Read the full story here: tinyurl.com/peny8r64
Read the full story here: tinyurl.com/peny8r64
#onlywithHCR: Schember et al. compared the regulatory landscapes of the single-minded (sim) gene in two divergent insects. Using #HCRimaging, their findings highlight the evolutionary rewiring of the gene regulatory network.
Read the full study here: journals.plos.org/plosgenetics...
Read the full study here: journals.plos.org/plosgenetics...
June 13, 2025 at 6:36 PM
#onlywithHCR: Schember et al. compared the regulatory landscapes of the single-minded (sim) gene in two divergent insects. Using #HCRimaging, their findings highlight the evolutionary rewiring of the gene regulatory network.
Read the full study here: journals.plos.org/plosgenetics...
Read the full study here: journals.plos.org/plosgenetics...
#onlywithHCR: In a fascinating study, Lopez and Alward used #HCRimaging to visualize cyp19a1 (brain-specific aromatase) mRNA expression in A. burtoni, providing new insight into how androgen signaling may influence social behavior.
Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...
Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...
June 6, 2025 at 4:30 PM
#onlywithHCR: In a fascinating study, Lopez and Alward used #HCRimaging to visualize cyp19a1 (brain-specific aromatase) mRNA expression in A. burtoni, providing new insight into how androgen signaling may influence social behavior.
Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...
Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...