#HDMEA
𝗟𝗮𝘀𝘁 𝗖𝗵𝗮𝗻𝗰𝗲 𝘁𝗼 𝗔𝗽𝗽𝗹𝘆 𝗳𝗼𝗿 𝘁𝗵𝗲 €𝟭𝟱,𝟬𝟬𝟬 𝗔𝘄𝗮𝗿𝗱!

Applications for the 𝟯𝗕𝗿𝗮𝗶𝗻 - 𝗠𝗮𝘀𝘀𝗶𝗺𝗼 𝗚𝗿𝗮𝘁𝘁𝗮𝗿𝗼𝗹𝗮 𝗔𝘄𝗮𝗿𝗱 close on 𝗢𝗰𝘁𝗼𝗯𝗲𝗿 𝟭, 𝟮𝟬𝟮𝟲.

Win €𝟭𝟱,𝟬𝟬𝟬 towards your neuroscience research!

Its easy, free and quick to apply for!
👉 www.3brain.com/the-3brain-m...

#ResearchFunding #3Brain #HDMEA
September 23, 2026 at 10:54 AM
𝗙𝗼𝗿𝗯𝗲𝗿𝗴𝗲𝗿, 𝗞𝗿𝗮𝗴𝗲𝗹𝘂𝗻𝗱 & 𝘁𝗵𝗲 𝗞𝗶𝗿𝘀𝗰𝗵𝘀𝘁𝗲𝗶𝗻 lab have developed a protocol which shows how to use CorePlate™ enabled 3D HD-MEAs (4,096 electrodes) to map how tumors disrupt brain networks. By tracking activity trajectories (CATs), they revealed lost functional connectivity in glioma models. #HDMEA #Cancer
February 12, 2026 at 9:44 AM
New organoid research shows SMA affects far more than motor neurons, revealing widespread CNS disruptions. Using CorePlate™ HD MEAs, researchers found reduced activity, glutamate hyperexcitability, and showed early ASO treatment can rescue function. Huge thanks to the team! #iPSC #HDMEA #3Brain
March 12, 2026 at 9:52 AM
Exploring drug screening with 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗗𝗲𝗹𝘁𝗮 & 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟮𝟰𝗪! We characterized a primary rat neuron dose-response under glutamatergic inhibition. High SNR from 1,024 electrodes/well gave tight error bars, revealing network activity shifts. #3Brain #HDMEA #HighThroughputScreening
June 3, 2026 at 12:09 PM
𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗯𝗮𝗹𝗮𝗻𝗰𝗲 𝗲𝘅𝗰𝗶𝘁𝗮𝘁𝗶𝗼𝗻 & 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗶𝗼𝗻?
A new study by 𝗖𝗿𝗼𝗰𝗰𝗼 et al. (𝗖𝗿𝗲𝗺𝗶𝘀𝗶 𝗟𝗮𝗯) uses stem cell-derived DT/VT populations on CorePlate™ to map how E/I ratios shape network dynamics. Vital research for understanding neurodevelopmental disorders.
#3Brain #HDMEA #electrophysiology
March 5, 2026 at 8:46 AM
Great to see this ALS research move from preprint to publication. The newly published work from Fiskum et al. In 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲 offers powerful new insight into how motor neurons are affected in ALS.

Congratulations to 𝗩𝗲𝗴𝗮𝗿𝗱 𝗙𝗶𝘀𝗸𝘂𝗺 and the 𝗜𝗼𝗮𝗻𝗻𝗮 𝗦𝗮𝗻𝗱𝘃𝗶𝗴 lab!

#ALS #HDMEA #iPSC
March 31, 2026 at 8:09 AM
Heading to The 𝟮𝟬𝟮𝟲 𝗦𝗣𝗦 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 in Montréal? Discover how 3Brain's CorePlate™ HD-MEA technology delivers high-resolution, label-free functional data for neuronal and cardiac safety screening, from iPSC-derived neurones to complex 3D organoids. Visit us at Booth #2.

#SPS2026 #3Brain #HDMEA
September 21, 2026 at 11:15 AM
Guess the Sample - Ep. 1

What biological sample made this recording? We downsampled an HD-MEA recording to mimic a low-density multi-well MEA. Can you ID the tissue?

If the data can't even tell you what it is, can it tell you how it works?

Reveal tomorrow. Drop your guess 👇

#Neuroscience #HDMEA
July 23, 2026 at 1:24 PM
💡Exciting NEUREKA Project news from Vassanelli & Poirazi Labs: A new IC method on HD-MEAs shows we can predict neuronal network causal architecture using spontaneous activity.
www.biorxiv.org/content/10.1...
#Neuroscience #HDMEA #NeuronalNetworks #FunctionalConnectivity
Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures
Dissociated neuronal cultures on High-Density Multi-Electrode Arrays (HD-MEAs) provide a controllable in vitro platform to systematically investigate the formation, development, and functioning of neu...
www.biorxiv.org
June 12, 2025 at 7:01 AM
Exciting new work in 𝘾𝙚𝙡𝙡 𝙍𝙚𝙥𝙤𝙧𝙩𝙨 𝙈𝙚𝙩𝙝𝙤𝙙𝙨! hiPSC-derived neuromuscular organoids (NMOs) recapitulate key features of cancer cachexia. CorePlate™ enabled whole NMO electrophysiology via 4,096 simultaneous recording electrodes. Congratulations to all authors!

#3Brain #HDMEA #Organoids
September 10, 2026 at 1:08 PM
How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlate™ enabled HD-MEAs.

#Neuroscience #3Brain #Electrophysiology #HDMEA
January 8, 2026 at 12:55 PM
𝗕𝗹𝗼𝗰𝗸 et al. from the 𝗚𝗿𝗲𝘀𝗰𝗵𝗻𝗲𝗿 𝗹𝗮𝗯 utilised CorePlate™ HD-MEAs to show avian retinas feature saltatory conduction. Tracking spikes propagation along the axons, they found spikes can travel 4x faster than in rodents!
#Neuroscience #Electrophysiology #HDMEA #Retina
February 24, 2026 at 8:59 AM
How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlate™ 3D electrodes, the 𝗟𝗶𝘂 𝗟𝗮𝗯 recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids
January 29, 2026 at 9:10 AM
How do cortical and hippocampal neurons differ in their baseline firing and drug response? Our latest application note uses 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟲𝗪 and 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗔𝗹𝗽𝗵𝗮 to functionally screen both side by side with 𝗖𝘆𝗰𝗹𝗼𝘁𝗵𝗶𝗮𝘇𝗶𝗱𝗲 (𝗖𝗧𝗭). Check it out: resources.3brain.com/f1/downloads...
#HDMEA #Electrophysiology
April 13, 2026 at 8:51 AM
WORD 2026 - This year, we presented a scientific poster on CorePlate™ recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thank‑you to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys
February 11, 2026 at 8:47 AM
RECI 2026 is almost here! Join the 3Brain team to talk ion channels in neuronal cultures & organoids. Our CorePlate™ HD-MEA platforms give label-free access to spiking activity in primary & iPSC models. Catch Sercan Deniz's talk or visit our booth!
#Neuroscience #Electrophysiology #3brain #HDMEA
May 22, 2026 at 8:54 AM
𝗭𝗮𝗽𝗳𝗲 et al. used CorePlate™ to track the center of mass of current in the hippocampus. It’s not just data, it’s a way to see hidden synaptic interactions in high-res. As a bonus, the current source density (CSD) graphics are stunning!

#Electrophysiology #HDMEA #Hippocampus #NeuralCircuits
January 22, 2026 at 9:58 AM
New work from 𝗗𝘂𝗱𝗮 et al., 𝗣𝘂𝗹𝗹𝗲𝗿& 𝗚𝗿𝗲𝘀𝗰𝗵𝗻𝗲𝗿 shows displaced RGCs are fully integrated in the visual circuit. Using CorePlate™ HD‑MEAs, they mapped dRGC spatial + functional properties, revealing displaced sONα cells fill mosaic gaps and share the same role. Huge thanks to the team! #HDMEA #Retina
April 21, 2026 at 8:41 AM
𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 𝗶𝗻 𝗖𝗲𝗹𝗹‐𝗯𝗮𝘀𝗲𝗱 𝗦𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 2026 kicks off tomorrow in Gothenburg! Find us at booth #𝟰 or catch our poster with 𝗔𝘅𝗼𝗹 𝗕𝗶𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲 presented by 𝗦𝗲𝗿𝗰𝗮𝗻 𝗗𝗲𝗻𝗶𝘇 — see how CorePlate™ HD-MEA is bridging complex in vitro biology with robust functional insights. See you there! #3Brain #ELRIG #HDMEA #iPSC
May 5, 2026 at 12:29 PM
𝗧𝗵𝗲 𝟲𝘁𝗵 𝗠𝗮𝘀𝘀𝗶𝗺𝗼 𝗚𝗿𝗮𝘁𝘁𝗮𝗿𝗼𝗹𝗮 𝗔𝘄𝗮𝗿𝗱 𝗶𝘀 𝗼𝗽𝗲𝗻: €15,000 grant for an emerging scientist using HD-MEA to explore organoids and iPSC technologies as promising new NAMs for disease modelling and screening applications.

Full details and apply here: onlylinks.cc/ONFY

#3Brain #HDMEA #ResearchFunding
August 20, 2026 at 1:26 PM
𝗚𝘂𝗲𝘀𝘀 𝘁𝗵𝗲 𝗦𝗮𝗺𝗽𝗹𝗲. 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟰.

Final challenge! Can you guess this sample from the recording alone?

On low-density MEAs, very different preparations look nearly identical where most of the activity never gets measured.

What is it? Guess below. Reveal later this week.

#3Brain #neuroscience #HDMEA
August 10, 2026 at 12:36 PM
Guess the Sample Ep.3. This sample was a retina. The low-density recording gave only a limited view, making the tissue hard to identify. The CorePlate™ HD-MEA recording tells a different story: structure, activity patterns, and functional organisation, in far greater detail. #HDMEA #Neuroscience
August 6, 2026 at 9:25 AM
𝗚𝘂𝗲𝘀𝘀 𝘁𝗵𝗲 𝗦𝗮𝗺𝗽𝗹𝗲. 𝗘𝗽𝗶𝘀𝗼𝗱𝗲 𝟯.
What are we looking at? Hard to say from a low-density recording. Capture only a slice of the activity, and you lose the spatial picture - an incomplete view of what's really happening across the sample. Guess below & reveal later this week. #HDMEA #neuroscience
August 3, 2026 at 12:36 PM
Guess the Sample Ep.2. This sample is a primary hippocampal neuronal culture. Low-density recordings catch only a fraction of the activity. CorePlate™ HD-MEA's dense electrodes reveal the full picture: sharper connectivity analysis, clearer functional organisation. #3Brain #HDMEA #Electrophysiology
July 31, 2026 at 8:54 AM
Peel back the wells of CorePlate™ 96W and you'll find an HD-MEA beneath each one. 24,576 electrodes recording all 96 wells at once: neuronal & cardiac activity from 2D monolayers to organoids, at high resolution. See it live at ISSCR, booth 412.
#3Brain #HDMEA #ISSCR2026
July 9, 2026 at 2:57 PM