oral HPV, P. gingivalis and F. nucleatum correlates with worse survival in patients with HNSCC. The cancer samples also carried much heavier bacterial loads than the non-cancer controls. In some cases, counts were 100 to 1,000 times higher. One of the more notable parts of the study was what the
May 4, 2026 at 4:08 PM
oral HPV, P. gingivalis and F. nucleatum correlates with worse survival in patients with HNSCC. The cancer samples also carried much heavier bacterial loads than the non-cancer controls. In some cases, counts were 100 to 1,000 times higher. One of the more notable parts of the study was what the
Researchers led by Henry Daniell of the School of Dental Medicine at the University of Pennsylvania report that extracts from a bioengineered chewing gum can significantly lower levels of three microbes associated with head and neck squamous cell cancer (HNSCC)
• www.dental.upenn.edu/news-events/...
• www.dental.upenn.edu/news-events/...
May 4, 2026 at 4:01 PM
Researchers led by Henry Daniell of the School of Dental Medicine at the University of Pennsylvania report that extracts from a bioengineered chewing gum can significantly lower levels of three microbes associated with head and neck squamous cell cancer (HNSCC)
• www.dental.upenn.edu/news-events/...
• www.dental.upenn.edu/news-events/...
The results, published in Scientific Reports, point to a potential low-cost and accessible treatment approach.
NOTE: It leaves healthy oral bacteria UNTOUCHED.
YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
🧪🧵⬇️
NOTE: It leaves healthy oral bacteria UNTOUCHED.
YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
🧪🧵⬇️
May 4, 2026 at 4:02 PM
The results, published in Scientific Reports, point to a potential low-cost and accessible treatment approach.
NOTE: It leaves healthy oral bacteria UNTOUCHED.
YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
🧪🧵⬇️
NOTE: It leaves healthy oral bacteria UNTOUCHED.
YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
🧪🧵⬇️
School of Dental Medicine tested extracts from a bioengineered chewing gum against oral samples from patients with head and neck squamous cell carcinoma, or HNSCC. The gum is built from lablab bean powder and carried two active ingredients, FRIL, a naturally antiviral protein, and protegrin-1, an
May 4, 2026 at 4:03 PM
School of Dental Medicine tested extracts from a bioengineered chewing gum against oral samples from patients with head and neck squamous cell carcinoma, or HNSCC. The gum is built from lablab bean powder and carried two active ingredients, FRIL, a naturally antiviral protein, and protegrin-1, an
antimicrobial peptide. Together, they sharply cut levels of three microbes linked to these cancers. These microbes are human papilloma virus, known as HPV, and the bacteria Porphyromonas gingivalis and Fusobacterium nucleatum. That matters because HNSCC is a common cancer that forms in the lining of
May 4, 2026 at 4:03 PM
antimicrobial peptide. Together, they sharply cut levels of three microbes linked to these cancers. These microbes are human papilloma virus, known as HPV, and the bacteria Porphyromonas gingivalis and Fusobacterium nucleatum. That matters because HNSCC is a common cancer that forms in the lining of
antimicrobial and anticancer activity. This was to see whether the gum could also suppress the bacteria tied to tumor growth and poor survival. Researchers used oral samples from patients with HNSCC as well as samples from non-cancer participants. Rather than relying only on DNA or RNA amplification
May 4, 2026 at 4:05 PM
antimicrobial and anticancer activity. This was to see whether the gum could also suppress the bacteria tied to tumor growth and poor survival. Researchers used oral samples from patients with HNSCC as well as samples from non-cancer participants. Rather than relying only on DNA or RNA amplification
which cannot tell living microbes from dead ones, they cultured live bacteria AND used ELISA to measure viral material. This let them focus on the pathogens still present and potentially active. HPV turned up in all 14 saliva samples from HNSCC patients tested at one site, and viral levels were far
May 4, 2026 at 4:05 PM
which cannot tell living microbes from dead ones, they cultured live bacteria AND used ELISA to measure viral material. This let them focus on the pathogens still present and potentially active. HPV turned up in all 14 saliva samples from HNSCC patients tested at one site, and viral levels were far
Testing a new treatment approach for HNSCC – ECOG-ACRIN Cancer Research Group
@eaonc.bsky.social
oncodaily.com/blog/hnscc-2...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #HNSCC
@eaonc.bsky.social
oncodaily.com/blog/hnscc-2...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #HNSCC
Testing a new treatment approach for HNSCC - ECOG-ACRIN Cancer Research Group - OncoDaily
Testing a new treatment approach for HNSCC - ECOG-ACRIN Cancer Research Group / cancer, ECOG-ACRIN Cancer Research Group, Head and Neck Cancer Awareness
oncodaily.com
April 16, 2025 at 9:31 PM
Testing a new treatment approach for HNSCC – ECOG-ACRIN Cancer Research Group
@eaonc.bsky.social
oncodaily.com/blog/hnscc-2...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #HNSCC
@eaonc.bsky.social
oncodaily.com/blog/hnscc-2...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #HNSCC
In Clinical Cancer Research, read the Phase 1 Study: Tumoral and Systemic Immune Correlates of Response to Concurrent Pembrolizumab and Chemoradiotherapy in HNSCC (NCT02775812). buff.ly/7wmAjZm
October 2, 2026 at 1:01 AM
In Clinical Cancer Research, read the Phase 1 Study: Tumoral and Systemic Immune Correlates of Response to Concurrent Pembrolizumab and Chemoradiotherapy in HNSCC (NCT02775812). buff.ly/7wmAjZm
Perineural Invasion Is Associated With function-evoked #pain and altered extracellular matrix in #patients with head and neck #squamous cell carcinoma 🔬 #cancerpain #Perineuralinvasion #HNSCC #FunctionevokedPain www.sciencedirect.com/science/arti...
Perineural Invasion Is Associated With Function-evoked Pain and Altered Extracellular Matrix in Patients With Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is painful, and perineural invasion (PNI) has been associated with the worst pain. Pain due to HNSCC is …
www.sciencedirect.com
March 11, 2025 at 4:56 PM
Perineural Invasion Is Associated With function-evoked #pain and altered extracellular matrix in #patients with head and neck #squamous cell carcinoma 🔬 #cancerpain #Perineuralinvasion #HNSCC #FunctionevokedPain www.sciencedirect.com/science/arti...
at one dose level. At the higher protegrin dose, BOTH bacteria were COMPLETELY ELIMINATED in those test samples. That dose was then used in the cancer-patient samples. In saliva and oral rinse from patients with HNSCC, the combination reduced P. gingivalis by 4 to 6 logs, or about 99.97% to 100%.
May 4, 2026 at 4:07 PM
at one dose level. At the higher protegrin dose, BOTH bacteria were COMPLETELY ELIMINATED in those test samples. That dose was then used in the cancer-patient samples. In saliva and oral rinse from patients with HNSCC, the combination reduced P. gingivalis by 4 to 6 logs, or about 99.97% to 100%.
🧬 CRISPR Treatment Shrinks Tumours
Scientists used CRISPR gene editing to remove a key gene from head & neck cancer cells, eliminating tumours in 50% of treated mice.
🔗 doi.org/10.1002/advs...
#SciComm 🧪 #Cancer #CRISPR
Scientists used CRISPR gene editing to remove a key gene from head & neck cancer cells, eliminating tumours in 50% of treated mice.
🔗 doi.org/10.1002/advs...
#SciComm 🧪 #Cancer #CRISPR
Targeted CRISPR/Cas9 Lipid Nanoparticles Elicits Therapeutic Genome Editing in Head and Neck Cancer
αEGFR-t-SOX2-cLNPs achieved specific delivery to tumor cells, resulting in 90% tumor growth inhibition of HNSCC-bearing mice. This response is sustained for 12 weeks, with 50% of the mice showing tum....
doi.org
March 13, 2025 at 9:18 PM
🧬 CRISPR Treatment Shrinks Tumours
Scientists used CRISPR gene editing to remove a key gene from head & neck cancer cells, eliminating tumours in 50% of treated mice.
🔗 doi.org/10.1002/advs...
#SciComm 🧪 #Cancer #CRISPR
Scientists used CRISPR gene editing to remove a key gene from head & neck cancer cells, eliminating tumours in 50% of treated mice.
🔗 doi.org/10.1002/advs...
#SciComm 🧪 #Cancer #CRISPR
💥 #Cancer #Vaccines in combo IO are #HOT!! Wasn’t on Bsky 11/8 so posting now/@ #SITC2024 we reported tripling of response rate & progression-free survival #PFS in #HNSCC + COOL #TCR #LAG3 & #DarkMatter data @patrickhwumd.bsky.social @chrystalpaulos.bsky.social www.einpresswire.com/article/7584...
November 30, 2024 at 8:12 PM
💥 #Cancer #Vaccines in combo IO are #HOT!! Wasn’t on Bsky 11/8 so posting now/@ #SITC2024 we reported tripling of response rate & progression-free survival #PFS in #HNSCC + COOL #TCR #LAG3 & #DarkMatter data @patrickhwumd.bsky.social @chrystalpaulos.bsky.social www.einpresswire.com/article/7584...
Biyomühendislikle üretilmiş sakızdan elde edilen özlerin, baş ve boyun skuamöz hücreli kanseri (HNSCC) ile ilişkili olduğu bilinen üç mikroorganizmanın düzeylerini azalttığını ortaya koydu. Bu bulgular, daha etkili ve uygun maliyetli tedavilerin yolunu açıyor.
April 26, 2026 at 11:27 AM
Biyomühendislikle üretilmiş sakızdan elde edilen özlerin, baş ve boyun skuamöz hücreli kanseri (HNSCC) ile ilişkili olduğu bilinen üç mikroorganizmanın düzeylerini azalttığını ortaya koydu. Bu bulgular, daha etkili ve uygun maliyetli tedavilerin yolunu açıyor.
Heading 2 #AACR2025 #Chicago to talk about our work on combination #cancer #immunotherapy for #HNSCC & see what is exciting scientists from across the globe. Also looking forward to visiting @loyolachicago.bsky.social Cancer Center to talk with Prof. Michael Nishimura regarding: TCR #FinishCancer
April 25, 2025 at 1:12 PM
Heading 2 #AACR2025 #Chicago to talk about our work on combination #cancer #immunotherapy for #HNSCC & see what is exciting scientists from across the globe. Also looking forward to visiting @loyolachicago.bsky.social Cancer Center to talk with Prof. Michael Nishimura regarding: TCR #FinishCancer
The authors included RRIDs in their in Frontiers in Cell and Developmental Biology paper! Thanks for making your methods matter! #BetterScience #methodsmatter #OpenResearch
Frontiers | Piezo1 promotes EMT and tumor progression in HNSCC through a YAP1-Associated Galectin-1 axis
BackgroundHead and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy in which epithelial–mesenchymal transition (EMT) contributes to tumor pro...
doi.org
October 1, 2026 at 7:01 AM
The authors included RRIDs in their in Frontiers in Cell and Developmental Biology paper! Thanks for making your methods matter! #BetterScience #methodsmatter #OpenResearch
Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC https://www.biorxiv.org/content/10.64898/2026.09.24.753717v1
September 29, 2026 at 3:47 AM
Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC https://www.biorxiv.org/content/10.64898/2026.09.24.753717v1
#FGF9 #HNSCC #HeadandNeckSquamousCellCarcinima
High FGF9 HR=2.5⬇️HNSCC survival
7-gene NOTCH module score➡️
Survival
Immunosuppressive TME
Anti-PD-1 immunotherapy response (low NOTCH score 92%; high 8%)
Chemo sensitivity
#JStomatolOralMaxillofacSurg 2025
www.sciencedirect.com/science/arti...
High FGF9 HR=2.5⬇️HNSCC survival
7-gene NOTCH module score➡️
Survival
Immunosuppressive TME
Anti-PD-1 immunotherapy response (low NOTCH score 92%; high 8%)
Chemo sensitivity
#JStomatolOralMaxillofacSurg 2025
www.sciencedirect.com/science/arti...
March 19, 2026 at 6:56 PM
#FGF9 #HNSCC #HeadandNeckSquamousCellCarcinima
High FGF9 HR=2.5⬇️HNSCC survival
7-gene NOTCH module score➡️
Survival
Immunosuppressive TME
Anti-PD-1 immunotherapy response (low NOTCH score 92%; high 8%)
Chemo sensitivity
#JStomatolOralMaxillofacSurg 2025
www.sciencedirect.com/science/arti...
High FGF9 HR=2.5⬇️HNSCC survival
7-gene NOTCH module score➡️
Survival
Immunosuppressive TME
Anti-PD-1 immunotherapy response (low NOTCH score 92%; high 8%)
Chemo sensitivity
#JStomatolOralMaxillofacSurg 2025
www.sciencedirect.com/science/arti...
Human Papilloma Virus does not fully inactivate p53 in HNSCC https://www.biorxiv.org/content/10.1101/2025.02.11.637252v1
February 15, 2025 at 12:50 AM
Human Papilloma Virus does not fully inactivate p53 in HNSCC https://www.biorxiv.org/content/10.1101/2025.02.11.637252v1
Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC https://www.biorxiv.org/content/10.64898/2026.09.24.753717v1
September 29, 2026 at 3:46 AM
Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC https://www.biorxiv.org/content/10.64898/2026.09.24.753717v1
#StressBreak
more than a third of felines who received treatment (35%) had their disease controlled
And the drug will likely be effective for humans with head and neck squamous cell carcinoma (HNSCC, which is notoriously deadly and difficult to treat), according to the research team.
more than a third of felines who received treatment (35%) had their disease controlled
And the drug will likely be effective for humans with head and neck squamous cell carcinoma (HNSCC, which is notoriously deadly and difficult to treat), according to the research team.
New Cancer Therapy for Cats ‘Could Save Human Lives’ Too
A new targeted treatment for cats with head and neck cancers may also help save human lives in the future, say scientists.
www.goodnewsnetwork.org
September 3, 2025 at 4:38 AM
#StressBreak
more than a third of felines who received treatment (35%) had their disease controlled
And the drug will likely be effective for humans with head and neck squamous cell carcinoma (HNSCC, which is notoriously deadly and difficult to treat), according to the research team.
more than a third of felines who received treatment (35%) had their disease controlled
And the drug will likely be effective for humans with head and neck squamous cell carcinoma (HNSCC, which is notoriously deadly and difficult to treat), according to the research team.
Delighted our team won best poster at #ESMORareCancers25 with work spearheaded by former PhD @LSJones4. Work coming out shortly in @SciReports #dmd #hnscc
March 21, 2025 at 8:49 PM
Delighted our team won best poster at #ESMORareCancers25 with work spearheaded by former PhD @LSJones4. Work coming out shortly in @SciReports #dmd #hnscc
New Paper Alert: KEYNOTE-689. Neoadjuvant and Adjuvant Pembrolizumab Improves Survival in Locally Advanced HNC
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #KEYNOTE-689 #HNC #HNSCC
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #KEYNOTE-689 #HNC #HNSCC
KEYNOTE-689: Pembrolizumab Boosts Survival in HNSCC
KEYNOTE-689 shows perioperative pembrolizumab significantly improves event-free survival in resectable head and neck cancer.
oncodaily.com
June 20, 2025 at 9:42 PM
New Paper Alert: KEYNOTE-689. Neoadjuvant and Adjuvant Pembrolizumab Improves Survival in Locally Advanced HNC
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #KEYNOTE-689 #HNC #HNSCC
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #KEYNOTE-689 #HNC #HNSCC
As the sun rises in Napoli excitement is growing as Day 2 of the 10th anniversary #cancer #immunotherapy #Bridge2024 is about to start. Today we cover @pancan.bsky.social @lungcancerresearch.bsky.social @kidneycancer.bsky.social #Gastric #GI #ovary #HNSCC & much more # @sitcancer.bsky.social
December 5, 2024 at 7:08 AM
As the sun rises in Napoli excitement is growing as Day 2 of the 10th anniversary #cancer #immunotherapy #Bridge2024 is about to start. Today we cover @pancan.bsky.social @lungcancerresearch.bsky.social @kidneycancer.bsky.social #Gastric #GI #ovary #HNSCC & much more # @sitcancer.bsky.social