Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
September 6, 2025 at 1:33 AM
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
Is the placenta is a source of, or merely a niche for, blood-forming #hematopoietic #StemCells? This Primer explores a @plosbiology.org study showing that the placenta does not directly give rise to hematopoietic stem cells. 🧪 Paper: plos.io/4hl3qZF Primer: plos.io/40R1VeE
February 7, 2025 at 10:18 AM
Is the placenta is a source of, or merely a niche for, blood-forming #hematopoietic #StemCells? This Primer explores a @plosbiology.org study showing that the placenta does not directly give rise to hematopoietic stem cells. 🧪 Paper: plos.io/4hl3qZF Primer: plos.io/40R1VeE
Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding Gladys Poon
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution
The representation of driver mutations in preleukemic HSCs provides a window into
the somatic evolution that precedes AML. Here, Poon et al. isolate pHSCs from the
bone marrow of 16 patients with AML ...
www.cell.com
January 21, 2025 at 8:20 PM
Delighted to share our latest work exploring levels of selection operating during pre-cancerous evolution usng single-cell DNA sequencing of HSCs led by the outstanding Gladys Poon
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
¡NUEVO! Resumen Semanal:
youtu.be/HsCS-mpBNjw
Esta semana subo el resumen un día antes que mañana es 1 de Mayo. ¿Abascal lo celebra? ¿Qué es ser español? ¿Me conviene afiliarme al PP?
Te resuelvo estas y otras dudas en el vídeo
youtu.be/HsCS-mpBNjw
Esta semana subo el resumen un día antes que mañana es 1 de Mayo. ¿Abascal lo celebra? ¿Qué es ser español? ¿Me conviene afiliarme al PP?
Te resuelvo estas y otras dudas en el vídeo
Jueces del PP, prórroga de alquileres y los WhatsApp de Vox #ResumenSemanal 166 | Miguel Charisteas
YouTube video by Miguel Charisteas
youtu.be
April 30, 2026 at 6:43 PM
¡NUEVO! Resumen Semanal:
youtu.be/HsCS-mpBNjw
Esta semana subo el resumen un día antes que mañana es 1 de Mayo. ¿Abascal lo celebra? ¿Qué es ser español? ¿Me conviene afiliarme al PP?
Te resuelvo estas y otras dudas en el vídeo
youtu.be/HsCS-mpBNjw
Esta semana subo el resumen un día antes que mañana es 1 de Mayo. ¿Abascal lo celebra? ¿Qué es ser español? ¿Me conviene afiliarme al PP?
Te resuelvo estas y otras dudas en el vídeo
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
January 1, 2026 at 7:03 PM
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
rdcu.be/e3smG
rdcu.be/e3smG
February 11, 2026 at 11:43 AM
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
rdcu.be/e3smG
rdcu.be/e3smG
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Blocking ferroptosis to expand human HSCs
Nature Cell Biology - Haematopoietic stem cells (HSCs) are used in a variety of cellular therapies, but our ability to support these cells ex vivo remains technically challenging. A new study...
rdcu.be
December 1, 2025 at 4:57 PM
Truly enjoyed writing this piece about recent discoveries by @bloodgenes.bsky.social and colleagues about how we can improve HSC expansion & gene editing by blocking ferroptosis!
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
Our @natcellbio.nature.com N&V: rdcu.be/eR25t
Associated article: tinyurl.com/msf9x8fn
An experimental base editing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells (HSCs) from healthy macaques and persists over time after autologous HSC transplant, according to a new study in #ScienceTranslationalMedicine. https://scim.ag/4oCplzC
August 14, 2025 at 3:00 PM
An experimental base editing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells (HSCs) from healthy macaques and persists over time after autologous HSC transplant, according to a new study in #ScienceTranslationalMedicine. https://scim.ag/4oCplzC
¿Has visto ya el resumen semanal?
youtu.be/HsCS-mpBNjw
Alguien que te mime como la Justicia mima al PP, la prórroga de los alquileres, los WhatsApp de Vox para echar a Ortega Smith, jueces machistas, Leonor universitaria, escopetazos a Trump y alguna cosa más
youtu.be/HsCS-mpBNjw
Alguien que te mime como la Justicia mima al PP, la prórroga de los alquileres, los WhatsApp de Vox para echar a Ortega Smith, jueces machistas, Leonor universitaria, escopetazos a Trump y alguna cosa más
Jueces del PP, prórroga de alquileres y los WhatsApp de Vox #ResumenSemanal 166 | Miguel Charisteas
YouTube video by Miguel Charisteas
youtu.be
May 3, 2026 at 6:58 AM
¿Has visto ya el resumen semanal?
youtu.be/HsCS-mpBNjw
Alguien que te mime como la Justicia mima al PP, la prórroga de los alquileres, los WhatsApp de Vox para echar a Ortega Smith, jueces machistas, Leonor universitaria, escopetazos a Trump y alguna cosa más
youtu.be/HsCS-mpBNjw
Alguien que te mime como la Justicia mima al PP, la prórroga de los alquileres, los WhatsApp de Vox para echar a Ortega Smith, jueces machistas, Leonor universitaria, escopetazos a Trump y alguna cosa más
Congrats to Salma Merchant for Cell Stem Cell paper: the effects of fatty acid oxidation in hematopoietic stem cells are context dependent. FAO is not necessary in young HSCs, but becomes necessary during aging, and is deleterious when upregulated by a high fat diet.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet
Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.
www.cell.com
December 20, 2024 at 4:03 PM
Congrats to Salma Merchant for Cell Stem Cell paper: the effects of fatty acid oxidation in hematopoietic stem cells are context dependent. FAO is not necessary in young HSCs, but becomes necessary during aging, and is deleterious when upregulated by a high fat diet.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Is the placenta is a source of, or merely a niche for, blood-forming #hematopoietic #StemCells? This Primer explores a @plosbiology.org study showing that the placenta does not directly give rise to hematopoietic stem cells. 🧪 Paper: plos.io/4hl3qZF Primer: plos.io/40R1VeE
February 7, 2025 at 6:17 PM
Is the placenta is a source of, or merely a niche for, blood-forming #hematopoietic #StemCells? This Primer explores a @plosbiology.org study showing that the placenta does not directly give rise to hematopoietic stem cells. 🧪 Paper: plos.io/4hl3qZF Primer: plos.io/40R1VeE
☕️Wang et al. profile the #translatome of #hematopoietic #StemCells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal in HSCs.
👉🏿https://rdcu.be/ecb3W
bit.ly/3F6FsTS
👉🏿https://rdcu.be/ecb3W
bit.ly/3F6FsTS
SNORD113–114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery - Nature Cell Biology
Wang et al. profile the translatome of haematopoietic stem cells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal i...
bit.ly
March 4, 2025 at 10:41 PM
☕️Wang et al. profile the #translatome of #hematopoietic #StemCells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal in HSCs.
👉🏿https://rdcu.be/ecb3W
bit.ly/3F6FsTS
👉🏿https://rdcu.be/ecb3W
bit.ly/3F6FsTS
I'm making sure the hscs see the evidence against the puberty blocker ban. I will never give in! I will never stop trying to protect and save trans lives! 🏳️⚧️🏳️⚧️🏳️⚧️
October 18, 2024 at 4:02 PM
I'm making sure the hscs see the evidence against the puberty blocker ban. I will never give in! I will never stop trying to protect and save trans lives! 🏳️⚧️🏳️⚧️🏳️⚧️
🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology
della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...
www.nature.com
November 22, 2025 at 12:27 AM
🥂Congratulations to @bloodgenes.bsky.social & co for their new study in our journal enhancing the ex vivo expansion and in vivo reconstitution potential of human #hematopoietic #StemCells by inhibiting #ferroptosis . Where? @natcellbio.nature.com ofc!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stunning hematopoetic stem cell talk by Rob Signer (@signerlab.bsky.social) showing that mouse HSCs depend on a specific family of Arginine tRNAs! 🤯 #ASH24
December 8, 2024 at 1:19 AM
Stunning hematopoetic stem cell talk by Rob Signer (@signerlab.bsky.social) showing that mouse HSCs depend on a specific family of Arginine tRNAs! 🤯 #ASH24
☕Sankaran (@bloodgenes.bsky.social) & co augment the ex vivo expansion potential of human #hematopoietic #StemCells (HSCs) by inhibiting #ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity.
bit.ly/4pEAzU9
bit.ly/4pEAzU9
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells - Nature Cell Biology
della Volpe et al. augment the ex vivo expansion potential of human haematopoietic stem cells (HSCs) by inhibiting ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo ...
bit.ly
December 16, 2025 at 10:05 PM
☕Sankaran (@bloodgenes.bsky.social) & co augment the ex vivo expansion potential of human #hematopoietic #StemCells (HSCs) by inhibiting #ferroptosis with liproxstatin-1 or ferrostatin-1. Treated HSCs have enhanced in vivo repopulation capacity.
bit.ly/4pEAzU9
bit.ly/4pEAzU9
Our new review: Hematopoietic (stem) cells—The elixir of life? 🧐
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the hear....
febs.onlinelibrary.wiley.com
December 8, 2025 at 6:52 PM
Our new review: Hematopoietic (stem) cells—The elixir of life? 🧐
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
Rejuvenation of the blood system might also improve the health of other organs! #FEBS Letters
Link to final video: lengefeldlab.com?page_id=203
Please RT. Happy reading 😃
febs.onlinelibrary.wiley.com/doi/10.1002/...
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
May 21, 2025 at 3:44 PM
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
You mean every time she makes a major decision she has to bonk a handsome Scots crofter first? #TheArchers HSCs take cover!
February 28, 2026 at 2:10 PM
You mean every time she makes a major decision she has to bonk a handsome Scots crofter first? #TheArchers HSCs take cover!
☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - Nature Cell Biology
Single-cell transplantations of long-term haematopoietic stem cells (HSCs), in-depth phenotyping and mathematical modelling identify reconstitution kinetics as a unifying metric of HSC potency and ext...
www.nature.com
June 24, 2026 at 11:53 AM
☕Single-cell transplantations of long-term HSCs, in-depth phenotyping and mathematical modeling identify reconstitution kinetics as a unifying metric of HSC potency and extrinsic regulation as a driver of lineage bias. @simonhaas.bsky.social @milsommick.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
September 6, 2025 at 1:33 AM
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
Healing a broken heart
A vitamin A metabolite, 4-oxo-retinoic acid, can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long...
www.ie-freiburg.mpg.de
April 2, 2025 at 2:32 PM
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻