New study by Fu et al. 2025 shows HSPB8 acts as a tumor suppressor in prostate cancer
Low HSPB8 levels promote growth via PI3K–AKT–mTOR signaling.
Read the full article here → 📖 buff.ly/SgGOApa
#HSPB8 #CancerResearch #MFM13
Low HSPB8 levels promote growth via PI3K–AKT–mTOR signaling.
Read the full article here → 📖 buff.ly/SgGOApa
#HSPB8 #CancerResearch #MFM13
Frontiers | Recognition of HSPB8 as a potential therapeutic target for prostate cancer
Prostate cancer poses a serious burden on men’s quality of life. Identifying novel biomarkers for therapeutic development and prognostic prediction has long ...
buff.ly
November 24, 2025 at 6:03 PM
New study by Fu et al. 2025 shows HSPB8 acts as a tumor suppressor in prostate cancer
Low HSPB8 levels promote growth via PI3K–AKT–mTOR signaling.
Read the full article here → 📖 buff.ly/SgGOApa
#HSPB8 #CancerResearch #MFM13
Low HSPB8 levels promote growth via PI3K–AKT–mTOR signaling.
Read the full article here → 📖 buff.ly/SgGOApa
#HSPB8 #CancerResearch #MFM13
HSPB8 regulates CTP synthase filaments to couple nucleotide metabolism and autophagy in tumors https://www.biorxiv.org/content/10.64898/2026.02.10.704981v1
February 11, 2026 at 4:30 PM
HSPB8 regulates CTP synthase filaments to couple nucleotide metabolism and autophagy in tumors https://www.biorxiv.org/content/10.64898/2026.02.10.704981v1
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation https://www.biorxiv.org/content/10.1101/2025.01.28.635368v1
January 31, 2025 at 3:52 AM
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation https://www.biorxiv.org/content/10.1101/2025.01.28.635368v1
New study by Xiaolong Chen et al. reveals new roles for HSPB8 in gallbladder cancer 🧬
HSPB8 was identified among key genes linked to immune protection via tertiary lymphoid structures.
#HSPB8 #MFM13 #HeatShockProteins #CancerResearch
📖
HSPB8 was identified among key genes linked to immune protection via tertiary lymphoid structures.
#HSPB8 #MFM13 #HeatShockProteins #CancerResearch
📖
buff.ly
November 21, 2025 at 6:01 PM
New study by Xiaolong Chen et al. reveals new roles for HSPB8 in gallbladder cancer 🧬
HSPB8 was identified among key genes linked to immune protection via tertiary lymphoid structures.
#HSPB8 #MFM13 #HeatShockProteins #CancerResearch
📖
HSPB8 was identified among key genes linked to immune protection via tertiary lymphoid structures.
#HSPB8 #MFM13 #HeatShockProteins #CancerResearch
📖
🚨 New study: #HSPB8 delays aggregation of TDP43—key in #ALS & #FTD
Could this small heat shock protein, known from rare myopathies, be a therapeutic lead for broader neurodegeneration?
From niche to novel target?
www.biorxiv.org/content/10.1...
#CureHSPB8 #Neurodegeneration #RareDisease
Could this small heat shock protein, known from rare myopathies, be a therapeutic lead for broader neurodegeneration?
From niche to novel target?
www.biorxiv.org/content/10.1...
#CureHSPB8 #Neurodegeneration #RareDisease
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation
The loss of cellular proteostasis through aberrant stress granule formation is implicated in neurodegenerative diseases. Stress granules are formed by biomolecular condensation involving protein-prote...
www.biorxiv.org
April 26, 2025 at 12:59 AM
🚨 New study: #HSPB8 delays aggregation of TDP43—key in #ALS & #FTD
Could this small heat shock protein, known from rare myopathies, be a therapeutic lead for broader neurodegeneration?
From niche to novel target?
www.biorxiv.org/content/10.1...
#CureHSPB8 #Neurodegeneration #RareDisease
Could this small heat shock protein, known from rare myopathies, be a therapeutic lead for broader neurodegeneration?
From niche to novel target?
www.biorxiv.org/content/10.1...
#CureHSPB8 #Neurodegeneration #RareDisease
🔬 MFM13 vs CMT2L
CMT2L comes from HSPB8 mutations (K141N/K141T). It’s autosomal dominant with distal weakness, atrophy & sensory loss.
🔍 Unlike MFM13, CMT2L is axonal—nerve damage first.
🧪 Dx: symptoms, nerve studies + HSPB8 testing.
#HSPB8 #CMT2L #MFM13 #Neuromuscular #RareDisease
CMT2L comes from HSPB8 mutations (K141N/K141T). It’s autosomal dominant with distal weakness, atrophy & sensory loss.
🔍 Unlike MFM13, CMT2L is axonal—nerve damage first.
🧪 Dx: symptoms, nerve studies + HSPB8 testing.
#HSPB8 #CMT2L #MFM13 #Neuromuscular #RareDisease
December 4, 2025 at 6:04 PM
🔬 MFM13 vs CMT2L
CMT2L comes from HSPB8 mutations (K141N/K141T). It’s autosomal dominant with distal weakness, atrophy & sensory loss.
🔍 Unlike MFM13, CMT2L is axonal—nerve damage first.
🧪 Dx: symptoms, nerve studies + HSPB8 testing.
#HSPB8 #CMT2L #MFM13 #Neuromuscular #RareDisease
CMT2L comes from HSPB8 mutations (K141N/K141T). It’s autosomal dominant with distal weakness, atrophy & sensory loss.
🔍 Unlike MFM13, CMT2L is axonal—nerve damage first.
🧪 Dx: symptoms, nerve studies + HSPB8 testing.
#HSPB8 #CMT2L #MFM13 #Neuromuscular #RareDisease
🚀 Cure HSPB8 is officially launched! 🚀
We are the only patient advocacy group for HSPB8 Myopathy, a rare muscle-wasting disease. Our launch is featured in RARE Revolution Magazine!
🔗 Read more:
rarerevolutionmagazine.com/cure-hspb8-a...
#CureHSPB8 #RARERevolution #RareDisease #PatientAdvocacy
We are the only patient advocacy group for HSPB8 Myopathy, a rare muscle-wasting disease. Our launch is featured in RARE Revolution Magazine!
🔗 Read more:
rarerevolutionmagazine.com/cure-hspb8-a...
#CureHSPB8 #RARERevolution #RareDisease #PatientAdvocacy
February 17, 2025 at 1:12 PM
🚀 Cure HSPB8 is officially launched! 🚀
We are the only patient advocacy group for HSPB8 Myopathy, a rare muscle-wasting disease. Our launch is featured in RARE Revolution Magazine!
🔗 Read more:
rarerevolutionmagazine.com/cure-hspb8-a...
#CureHSPB8 #RARERevolution #RareDisease #PatientAdvocacy
We are the only patient advocacy group for HSPB8 Myopathy, a rare muscle-wasting disease. Our launch is featured in RARE Revolution Magazine!
🔗 Read more:
rarerevolutionmagazine.com/cure-hspb8-a...
#CureHSPB8 #RARERevolution #RareDisease #PatientAdvocacy
🔬 MFM13 vs. other HSPB8 diseases
dHMN is caused by HSPB8 missense mutations like K141N or K141T. It leads to progressive distal motor weakness and atrophy.
🔍 Unlike MFM13 (a primary muscle disease), dHMN is axonal—motor nerve damage comes first.
🧪 Diagnosis: symptoms, nerve studies + HSPB8 testing
dHMN is caused by HSPB8 missense mutations like K141N or K141T. It leads to progressive distal motor weakness and atrophy.
🔍 Unlike MFM13 (a primary muscle disease), dHMN is axonal—motor nerve damage comes first.
🧪 Diagnosis: symptoms, nerve studies + HSPB8 testing
December 1, 2025 at 6:02 PM
🔬 MFM13 vs. other HSPB8 diseases
dHMN is caused by HSPB8 missense mutations like K141N or K141T. It leads to progressive distal motor weakness and atrophy.
🔍 Unlike MFM13 (a primary muscle disease), dHMN is axonal—motor nerve damage comes first.
🧪 Diagnosis: symptoms, nerve studies + HSPB8 testing
dHMN is caused by HSPB8 missense mutations like K141N or K141T. It leads to progressive distal motor weakness and atrophy.
🔍 Unlike MFM13 (a primary muscle disease), dHMN is axonal—motor nerve damage comes first.
🧪 Diagnosis: symptoms, nerve studies + HSPB8 testing
HSPB8 beyond MFM13 function!
Piccolella M., et al., published new article, entitled "FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer"!
Check out full publication buff.ly/c6bOwtd to learn more about HSPB8 functions in breast cancer.
Piccolella M., et al., published new article, entitled "FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer"!
Check out full publication buff.ly/c6bOwtd to learn more about HSPB8 functions in breast cancer.
FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer - Cell Communication and Signaling
Cell Communication and Signaling - Breast cancer (BC) is a widespread and heterogeneous disease in which autophagy plays an essential role in tumor development and progression. It has been...
buff.ly
March 17, 2026 at 5:02 PM
HSPB8 beyond MFM13 function!
Piccolella M., et al., published new article, entitled "FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer"!
Check out full publication buff.ly/c6bOwtd to learn more about HSPB8 functions in breast cancer.
Piccolella M., et al., published new article, entitled "FAK signaling pathways are modulated by HSPB8 and BAG3 in breast cancer"!
Check out full publication buff.ly/c6bOwtd to learn more about HSPB8 functions in breast cancer.
🎯 Want to test for HSPB8 (linked to MFM13 myopathy) in #Europe without ordering a full panel? 🧬 Single gene testing might be the right fit.
🔹 Centogene 🔹 BluePrint Genetics 🔹 GeneDx 🔹Amsterdam UMC 🔹Eurofins
Visit their website & search for HSPB8
#HSPB8 #MFM13 #GeneticTesting #Myopathy #RareDisease
🔹 Centogene 🔹 BluePrint Genetics 🔹 GeneDx 🔹Amsterdam UMC 🔹Eurofins
Visit their website & search for HSPB8
#HSPB8 #MFM13 #GeneticTesting #Myopathy #RareDisease
July 15, 2025 at 5:03 PM
🎯 Want to test for HSPB8 (linked to MFM13 myopathy) in #Europe without ordering a full panel? 🧬 Single gene testing might be the right fit.
🔹 Centogene 🔹 BluePrint Genetics 🔹 GeneDx 🔹Amsterdam UMC 🔹Eurofins
Visit their website & search for HSPB8
#HSPB8 #MFM13 #GeneticTesting #Myopathy #RareDisease
🔹 Centogene 🔹 BluePrint Genetics 🔹 GeneDx 🔹Amsterdam UMC 🔹Eurofins
Visit their website & search for HSPB8
#HSPB8 #MFM13 #GeneticTesting #Myopathy #RareDisease
The IIMCB and Cure MFM13 are developing a new mouse model 🐭 for MFM13 — an ultra-rare muscle disease caused by a mutation in the HSPB8 gene.
Using CRISPR/Cas9, researchers aim to uncover its biology and pave the way for new therapies 💊💙
See the video: tinyurl.com/3h56t42t
#RareDiseases #MFM13
Using CRISPR/Cas9, researchers aim to uncover its biology and pave the way for new therapies 💊💙
See the video: tinyurl.com/3h56t42t
#RareDiseases #MFM13
October 28, 2025 at 7:09 AM
The IIMCB and Cure MFM13 are developing a new mouse model 🐭 for MFM13 — an ultra-rare muscle disease caused by a mutation in the HSPB8 gene.
Using CRISPR/Cas9, researchers aim to uncover its biology and pave the way for new therapies 💊💙
See the video: tinyurl.com/3h56t42t
#RareDiseases #MFM13
Using CRISPR/Cas9, researchers aim to uncover its biology and pave the way for new therapies 💊💙
See the video: tinyurl.com/3h56t42t
#RareDiseases #MFM13
💙 As #RareDiseaseMonth ends, we honor the strength of the rare disease community. Let’s keep sharing stories, driving research, and building hope for conditions like #HSPB8 #Myopathy.
👉 Get involved: curehspb8.org/families/#Ge...
#CureHSPB8 #RareDiseaseAwareness
👉 Get involved: curehspb8.org/families/#Ge...
#CureHSPB8 #RareDiseaseAwareness
February 28, 2025 at 2:43 PM
💙 As #RareDiseaseMonth ends, we honor the strength of the rare disease community. Let’s keep sharing stories, driving research, and building hope for conditions like #HSPB8 #Myopathy.
👉 Get involved: curehspb8.org/families/#Ge...
#CureHSPB8 #RareDiseaseAwareness
👉 Get involved: curehspb8.org/families/#Ge...
#CureHSPB8 #RareDiseaseAwareness
Today, Dr. Ania Kordala & Sylwia Szwec represent Cure HSPB8 at PORT Wrocław to discuss models of cooperation between patient orgs & scientists.
🤝 Collaboration = stronger advocacy for #MFM13 patients.
#RareDisease #PatientAdvocacy #HSPB8
🤝 Collaboration = stronger advocacy for #MFM13 patients.
#RareDisease #PatientAdvocacy #HSPB8
September 12, 2025 at 5:05 PM
Today, Dr. Ania Kordala & Sylwia Szwec represent Cure HSPB8 at PORT Wrocław to discuss models of cooperation between patient orgs & scientists.
🤝 Collaboration = stronger advocacy for #MFM13 patients.
#RareDisease #PatientAdvocacy #HSPB8
🤝 Collaboration = stronger advocacy for #MFM13 patients.
#RareDisease #PatientAdvocacy #HSPB8
🎧 Ep. 3 = Journal Club time!
We dig into HSPB8: how do mutations lead to dHMN, CMT2L & myopathy? Based on Rashed et al.’s new review in IJMS.
🎧 buff.ly/IXA0lo4
🧬 #RareDisease #HSPB8 #Neuromuscular #JournalClub #Podcast
We dig into HSPB8: how do mutations lead to dHMN, CMT2L & myopathy? Based on Rashed et al.’s new review in IJMS.
🎧 buff.ly/IXA0lo4
🧬 #RareDisease #HSPB8 #Neuromuscular #JournalClub #Podcast
June 13, 2025 at 5:04 PM
🎧 Ep. 3 = Journal Club time!
We dig into HSPB8: how do mutations lead to dHMN, CMT2L & myopathy? Based on Rashed et al.’s new review in IJMS.
🎧 buff.ly/IXA0lo4
🧬 #RareDisease #HSPB8 #Neuromuscular #JournalClub #Podcast
We dig into HSPB8: how do mutations lead to dHMN, CMT2L & myopathy? Based on Rashed et al.’s new review in IJMS.
🎧 buff.ly/IXA0lo4
🧬 #RareDisease #HSPB8 #Neuromuscular #JournalClub #Podcast
New study highlights muscle degeneration patterns in patients with #HSPB8 gene mutations, linked to Rimmed Vacuolar #Myopathy. Findings could help improve diagnostics and targeted therapies for this rare condition. www.sciencedirect.com/science/arti...
#RareDisease #PatientAdvocacy
#RareDisease #PatientAdvocacy
61P Characteristics of muscle computed tomography in a family with HSPB8-related rimmed vacuolar myopathy
Mutations in HSPB8 (heat shock protein family B member 8) have been reported to cause rimmed vacuolar myopathy (RVM). However, there are few reports i…
www.sciencedirect.com
March 7, 2025 at 2:18 AM
New study highlights muscle degeneration patterns in patients with #HSPB8 gene mutations, linked to Rimmed Vacuolar #Myopathy. Findings could help improve diagnostics and targeted therapies for this rare condition. www.sciencedirect.com/science/arti...
#RareDisease #PatientAdvocacy
#RareDisease #PatientAdvocacy
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation https://www.biorxiv.org/content/10.1101/2025.01.28.635368v1
January 31, 2025 at 3:52 AM
Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation https://www.biorxiv.org/content/10.1101/2025.01.28.635368v1
Scientists exploring glaucoma found that blocking miR-126-5p in eye tissue cells helps them grow better and avoid damage under stress. This process boosts a protein called HSPB8, triggering helpful cellular signals. It's a step forward in understanding how to protect eyes from stress-related harm.
Silencing miR-126-5p protects trabecular meshwork cells against chronic oxidative injury by upregulating HSPB8 to activate PI3K/AKT pathway.
Published in Journal of molecular histology
doi.org
December 28, 2024 at 2:00 PM
Scientists exploring glaucoma found that blocking miR-126-5p in eye tissue cells helps them grow better and avoid damage under stress. This process boosts a protein called HSPB8, triggering helpful cellular signals. It's a step forward in understanding how to protect eyes from stress-related harm.
🚨 New Publication!
Du et al. (J. Virology) show that HSPB8/HSPB1 regulate SUMOylation during Japanese encephalitis virus replication.
🧬 Beyond MFM13 + CASA, these chaperones are also play role in host–pathogen interactions.
👉 buff.ly/N1tSkuL
#HSPB8 #Virology
Du et al. (J. Virology) show that HSPB8/HSPB1 regulate SUMOylation during Japanese encephalitis virus replication.
🧬 Beyond MFM13 + CASA, these chaperones are also play role in host–pathogen interactions.
👉 buff.ly/N1tSkuL
#HSPB8 #Virology
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5 | Journal of Virology
Japanese encephalitis virus (JEV) poses a severe global health threat, yet host factors regulating its replication remain poorly understood. Our study identifies ZNF33B as a critical host protein…
Asmjournals.asm.org
October 20, 2025 at 5:28 PM
🚨 New Publication!
Du et al. (J. Virology) show that HSPB8/HSPB1 regulate SUMOylation during Japanese encephalitis virus replication.
🧬 Beyond MFM13 + CASA, these chaperones are also play role in host–pathogen interactions.
👉 buff.ly/N1tSkuL
#HSPB8 #Virology
Du et al. (J. Virology) show that HSPB8/HSPB1 regulate SUMOylation during Japanese encephalitis virus replication.
🧬 Beyond MFM13 + CASA, these chaperones are also play role in host–pathogen interactions.
👉 buff.ly/N1tSkuL
#HSPB8 #Virology
RRID:Addgene_34710, was just reported to be used in "Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation". RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #reproducibility
doi.org
April 2, 2025 at 7:00 AM
RRID:Addgene_34710, was just reported to be used in "Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation". RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #reproducibility
(BioRxiv All) Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation: The loss of cellular proteostasis through aberrant stress granule formation is implicated in neurodegenerative… http://dlvr.it/THhLkN #BioRxiv #MassSpecRSS
January 31, 2025 at 6:05 AM
(BioRxiv All) Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation: The loss of cellular proteostasis through aberrant stress granule formation is implicated in neurodegenerative… http://dlvr.it/THhLkN #BioRxiv #MassSpecRSS
🧠 Oommenn et al. detail 12 genetically confirmed myofibrillar myopathy cases from South India. Most had DES mutations, but a standout case with #HSPB8 c.566_567del showed ptosis + limb-girdle weakness—an unreported phenotype.
A big addition to global #MFM data.
#RareDisease #Genetics #Neuromuscular
A big addition to global #MFM data.
#RareDisease #Genetics #Neuromuscular
July 10, 2025 at 5:05 PM
🧠 Oommenn et al. detail 12 genetically confirmed myofibrillar myopathy cases from South India. Most had DES mutations, but a standout case with #HSPB8 c.566_567del showed ptosis + limb-girdle weakness—an unreported phenotype.
A big addition to global #MFM data.
#RareDisease #Genetics #Neuromuscular
A big addition to global #MFM data.
#RareDisease #Genetics #Neuromuscular
🚨 Big news: Cure HSPB8 has received new 2025 funding from @volofoundation.bsky.social!
This support helps us expand research, grow our patient registry, and drive awareness for #HSPB8Myopathy. Grateful for partners who believe in science & impact! 💙
#CureHSPB8 #RareDiseasen #PatientAdvocacy
This support helps us expand research, grow our patient registry, and drive awareness for #HSPB8Myopathy. Grateful for partners who believe in science & impact! 💙
#CureHSPB8 #RareDiseasen #PatientAdvocacy
April 26, 2025 at 1:02 AM
🚨 Big news: Cure HSPB8 has received new 2025 funding from @volofoundation.bsky.social!
This support helps us expand research, grow our patient registry, and drive awareness for #HSPB8Myopathy. Grateful for partners who believe in science & impact! 💙
#CureHSPB8 #RareDiseasen #PatientAdvocacy
This support helps us expand research, grow our patient registry, and drive awareness for #HSPB8Myopathy. Grateful for partners who believe in science & impact! 💙
#CureHSPB8 #RareDiseasen #PatientAdvocacy
For many in the rare disease community, the journey starts with a search—not a treatment. It can take 5–7 years to get a diagnosis. This #RareDiseaseDay (Feb 28), we honor that pursuit & push for faster MFM13 diagnosis, new treatments, and stronger connections. #CureMFM13 #HSPB8
February 26, 2026 at 6:03 PM
For many in the rare disease community, the journey starts with a search—not a treatment. It can take 5–7 years to get a diagnosis. This #RareDiseaseDay (Feb 28), we honor that pursuit & push for faster MFM13 diagnosis, new treatments, and stronger connections. #CureMFM13 #HSPB8
Our 2025 Annual Report is out!
MFM13 is now officially recognized as a distinct disease entity - and that's just one of the last year's milestones. A mouse model, antibodies, community support progress - it's all in there.
Read the full report at curemfm13.org
#MFM13 #HSPB8 #RareDisease
MFM13 is now officially recognized as a distinct disease entity - and that's just one of the last year's milestones. A mouse model, antibodies, community support progress - it's all in there.
Read the full report at curemfm13.org
#MFM13 #HSPB8 #RareDisease
Cure MFM13 | Fighting Ultrarare Genetic Muscle Disorder
Dedicated to curing MFM13, an ultrarare genetic disorder marked by progressive muscle weakness. Supporting patients, families, and critical research.
curemfm13.org
March 5, 2026 at 6:02 PM
Our 2025 Annual Report is out!
MFM13 is now officially recognized as a distinct disease entity - and that's just one of the last year's milestones. A mouse model, antibodies, community support progress - it's all in there.
Read the full report at curemfm13.org
#MFM13 #HSPB8 #RareDisease
MFM13 is now officially recognized as a distinct disease entity - and that's just one of the last year's milestones. A mouse model, antibodies, community support progress - it's all in there.
Read the full report at curemfm13.org
#MFM13 #HSPB8 #RareDisease
Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy modulating therapy. #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.04.742148v1
https://www.biorxiv.org/content/10.64898/2026.08.04.742148v1
August 10, 2026 at 4:02 AM
Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy modulating therapy. #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.08.04.742148v1
https://www.biorxiv.org/content/10.64898/2026.08.04.742148v1