SIFT: Syncmer-Informed Selection of Haplotypes for T2T Imputation https://www.biorxiv.org/content/10.64898/2026.11.09.765394v1
November 11, 2026 at 10:45 AM
SIFT: Syncmer-Informed Selection of Haplotypes for T2T Imputation https://www.biorxiv.org/content/10.64898/2026.11.09.765394v1
How to disappear?
New paper by wizard @lucalivraghi.bsky.social
Camouflage polymorphism explained by hyperdivergence of the ivory:mir-193 locus. Large haplotypes tune how moths hedge their bets on how to hide.
doi.org/10.1016/j.cu...
New paper by wizard @lucalivraghi.bsky.social
Camouflage polymorphism explained by hyperdivergence of the ivory:mir-193 locus. Large haplotypes tune how moths hedge their bets on how to hide.
doi.org/10.1016/j.cu...
November 4, 2026 at 2:14 PM
How to disappear?
New paper by wizard @lucalivraghi.bsky.social
Camouflage polymorphism explained by hyperdivergence of the ivory:mir-193 locus. Large haplotypes tune how moths hedge their bets on how to hide.
doi.org/10.1016/j.cu...
New paper by wizard @lucalivraghi.bsky.social
Camouflage polymorphism explained by hyperdivergence of the ivory:mir-193 locus. Large haplotypes tune how moths hedge their bets on how to hide.
doi.org/10.1016/j.cu...
For the Balearic Islands, R. assumptionis is particularly interesting: it occurs in Menorca and the Hyères Islands (France), and plastid data are consistent with the French haplotypes deriving from Menorcan populations.
#BOTLAND #Romulea #Genomics #Botany #Mediterranean
#BOTLAND #Romulea #Genomics #Botany #Mediterranean
November 7, 2026 at 8:52 AM
For the Balearic Islands, R. assumptionis is particularly interesting: it occurs in Menorca and the Hyères Islands (France), and plastid data are consistent with the French haplotypes deriving from Menorcan populations.
#BOTLAND #Romulea #Genomics #Botany #Mediterranean
#BOTLAND #Romulea #Genomics #Botany #Mediterranean
Phenotypic variation in divergent mitochondrial haplotypes in migratory three-spined stickleback https://www.biorxiv.org/content/10.64898/2026.11.04.764197v1
November 9, 2026 at 12:31 PM
Phenotypic variation in divergent mitochondrial haplotypes in migratory three-spined stickleback https://www.biorxiv.org/content/10.64898/2026.11.04.764197v1
Phenotypic variation in divergent mitochondrial haplotypes in migratory three-spined stickleback https://www.biorxiv.org/content/10.64898/2026.11.04.764197v1
November 9, 2026 at 12:31 PM
Phenotypic variation in divergent mitochondrial haplotypes in migratory three-spined stickleback https://www.biorxiv.org/content/10.64898/2026.11.04.764197v1
Check out our new paper on the genetics of moth camouflage! Excellent explainer thread by @evolvwing.bsky.social below. Check out the video for an overview of the study.
www.youtube.com/watch?v=ZL3k...
www.youtube.com/watch?v=ZL3k...
November 4, 2026 at 2:33 PM
Check out our new paper on the genetics of moth camouflage! Excellent explainer thread by @evolvwing.bsky.social below. Check out the video for an overview of the study.
www.youtube.com/watch?v=ZL3k...
www.youtube.com/watch?v=ZL3k...
Hylke developed a grass model and showed that by adding (non-DMI) agricultural fungicides such as SDHIs and QoIs, the triazole resistant TR34 and TR46 haplotypes in A. fumigatus are indirectly selected.
SDHI and QoI enriches pre-existing triazole-resistant alleles through genetic hitchhiking.
SDHI and QoI enriches pre-existing triazole-resistant alleles through genetic hitchhiking.
November 10, 2026 at 12:57 PM
Hylke developed a grass model and showed that by adding (non-DMI) agricultural fungicides such as SDHIs and QoIs, the triazole resistant TR34 and TR46 haplotypes in A. fumigatus are indirectly selected.
SDHI and QoI enriches pre-existing triazole-resistant alleles through genetic hitchhiking.
SDHI and QoI enriches pre-existing triazole-resistant alleles through genetic hitchhiking.
Here is where things got really interesting.
PacBio Revio sequencing on 8 specimens resolved the co-existence of several haplotypes.
We love these genotype-plots for SNP visualization
PacBio Revio sequencing on 8 specimens resolved the co-existence of several haplotypes.
We love these genotype-plots for SNP visualization
November 4, 2026 at 2:14 PM
Here is where things got really interesting.
PacBio Revio sequencing on 8 specimens resolved the co-existence of several haplotypes.
We love these genotype-plots for SNP visualization
PacBio Revio sequencing on 8 specimens resolved the co-existence of several haplotypes.
We love these genotype-plots for SNP visualization
How to explain these large blocks? Inversions. In fact, the 3 main haplotypes result from a sequence of 2 overlapping inversions. We think they’re quite old as they accumulated a lot of divergence. Maybe maintained by a flavor of balancing selection.
November 4, 2026 at 2:14 PM
How to explain these large blocks? Inversions. In fact, the 3 main haplotypes result from a sequence of 2 overlapping inversions. We think they’re quite old as they accumulated a lot of divergence. Maybe maintained by a flavor of balancing selection.
While those introgressed frequencies were moderate, we ran nf-selection, a combined test for positive selection. We did not find evidence of selection, so the introgressed haplotypes are likely freely interchangeable with near-neutral clinical effects.
github.com/fernanda-mir...
github.com/fernanda-mir...
November 6, 2026 at 12:45 AM
While those introgressed frequencies were moderate, we ran nf-selection, a combined test for positive selection. We did not find evidence of selection, so the introgressed haplotypes are likely freely interchangeable with near-neutral clinical effects.
github.com/fernanda-mir...
github.com/fernanda-mir...
But we also used introgression as a test of compatibility -if Neanderthal haplotypes occur at moderate frequencies those living individuals are unlikely to experience any differences in development. We found that POR, CYB5A , and SULT2A1 are introgressed but HSD3B2 and CYP17A1 are not.
November 6, 2026 at 12:45 AM
But we also used introgression as a test of compatibility -if Neanderthal haplotypes occur at moderate frequencies those living individuals are unlikely to experience any differences in development. We found that POR, CYB5A , and SULT2A1 are introgressed but HSD3B2 and CYP17A1 are not.
🧬New from Kingsmore & colleagues!
📄Scaling haplospecific antisense oligonucleotides from N-of-1 to broad use in genetic disease populations by diplotyping
#ASO
📄Scaling haplospecific antisense oligonucleotides from N-of-1 to broad use in genetic disease populations by diplotyping
#ASO
Scaling haplospecific antisense oligonucleotides from N-of-1 to broad use in genetic disease populations by diplotyping
Antisense oligonucleotides (ASOs) made for one individual’s extremely rare causal
variant usually cannot help others. We show that by designing ASOs against common
haplotypes rather than causal varian...
www.cell.com
November 5, 2026 at 6:45 PM
🧬New from Kingsmore & colleagues!
📄Scaling haplospecific antisense oligonucleotides from N-of-1 to broad use in genetic disease populations by diplotyping
#ASO
📄Scaling haplospecific antisense oligonucleotides from N-of-1 to broad use in genetic disease populations by diplotyping
#ASO
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Indel-Free Tandem Repeats Form k-Core Haplotype Connector Hubs and Dissolve Under Triplet Interruptions — Why do repeat-containing haplotypes without fixed insertions or deletions (Repeat+…
https://crvscience.com/labs/discoveries/popgen-tier3-repeat-kcore
🧬 Tier 3 Synthesis: How Indel-Free Tandem Repeats Form k-Core Haplotype Connector Hubs and Dissolve Under Triplet Interruptions — Why do repeat-containing haplotypes without fixed insertions or deletions (Repeat+…
https://crvscience.com/labs/discoveries/popgen-tier3-repeat-kcore
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Indel-Free Tandem Repeats Form k-Core Haplotype Connector Hubs and Dissolve Under Triplet Interruptions — Why do repeat-containing haplotypes without fixed insertions or deletions (Repeat+/Indel-) exhibit elevated flanking substitution rates (McDonald et …
crvscience.com
November 2, 2026 at 10:38 PM
CRV Science Labs ⚗️
🧬 Tier 3 Synthesis: How Indel-Free Tandem Repeats Form k-Core Haplotype Connector Hubs and Dissolve Under Triplet Interruptions — Why do repeat-containing haplotypes without fixed insertions or deletions (Repeat+…
https://crvscience.com/labs/discoveries/popgen-tier3-repeat-kcore
🧬 Tier 3 Synthesis: How Indel-Free Tandem Repeats Form k-Core Haplotype Connector Hubs and Dissolve Under Triplet Interruptions — Why do repeat-containing haplotypes without fixed insertions or deletions (Repeat+…
https://crvscience.com/labs/discoveries/popgen-tier3-repeat-kcore
Authors of @ajhgnews.bsky.social's latest article uncover how repeat length, sequence motifs, and shared haplotypes interact to shape human genetic variation and inform the interpretation of disease-associated loci: https://www.cell.com/ajhg/abstract/S0002-9297(26)00382-4 #ASHG #humangenetics
October 29, 2026 at 8:08 PM
Authors of @ajhgnews.bsky.social's latest article uncover how repeat length, sequence motifs, and shared haplotypes interact to shape human genetic variation and inform the interpretation of disease-associated loci: https://www.cell.com/ajhg/abstract/S0002-9297(26)00382-4 #ASHG #humangenetics
Haplotype-based fine-mapping of variant associations for complex traits
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
October 28, 2026 at 11:19 AM
Haplotype-based fine-mapping of variant associations for complex traits
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Pezo-Valderrama et al. analyzed the genomes of 71 present-day human individuals across 7 Patagonian locations to reveal widespread European admixture and postcontact selection favoring indigenous immune system haplotypes.
🔗️ academic.oup.com/gbe/article/...
#societyjournal #genome #evolution
🔗️ academic.oup.com/gbe/article/...
#societyjournal #genome #evolution
October 26, 2026 at 3:01 PM
Pezo-Valderrama et al. analyzed the genomes of 71 present-day human individuals across 7 Patagonian locations to reveal widespread European admixture and postcontact selection favoring indigenous immune system haplotypes.
🔗️ academic.oup.com/gbe/article/...
#societyjournal #genome #evolution
🔗️ academic.oup.com/gbe/article/...
#societyjournal #genome #evolution
4/ First, we assembled chromosome-level genomes of two wild plants from opposite ends of the Atlantic range. Both had a 19th chromosome (~34 Mb) that is not in AP13!
Hi-C and long-read depth confirmed it's real, with ~2 copies in one plant and ~4 in the other!
Hi-C and long-read depth confirmed it's real, with ~2 copies in one plant and ~4 in the other!
October 28, 2026 at 6:53 PM
4/ First, we assembled chromosome-level genomes of two wild plants from opposite ends of the Atlantic range. Both had a 19th chromosome (~34 Mb) that is not in AP13!
Hi-C and long-read depth confirmed it's real, with ~2 copies in one plant and ~4 in the other!
Hi-C and long-read depth confirmed it's real, with ~2 copies in one plant and ~4 in the other!
Two new COI haplotypes of the #invasive #bluecrab, Callinectes sapidus, have been found in Spain’s Guadalquivir Estuary, matching populations from the Gulf of Mexico and Brazil. They point to new possible introduction pathways into European waters.
Read on: doi.org/10.3897/BDJ....
Read on: doi.org/10.3897/BDJ....
New insights into the potential introduction pathways of Callinectes sapidus Rathbun, 1896 (Decapoda, Portunidae) in European waters
Two new COI haplotypes of the invasive Callinectes sapidus were reported for the first time in the western Iberian Peninsula and one of them in Europe, providing new insights into the origin of this s...
doi.org
October 26, 2026 at 11:18 AM
Two new COI haplotypes of the #invasive #bluecrab, Callinectes sapidus, have been found in Spain’s Guadalquivir Estuary, matching populations from the Gulf of Mexico and Brazil. They point to new possible introduction pathways into European waters.
Read on: doi.org/10.3897/BDJ....
Read on: doi.org/10.3897/BDJ....
A CYP21A2 case: TruPath MRJD reconstructed 4 CYP21 gene copies across 2 haplotypes. One carries the I2G splice variant; the other has a chimeric gene.
October 26, 2026 at 6:55 AM
A CYP21A2 case: TruPath MRJD reconstructed 4 CYP21 gene copies across 2 haplotypes. One carries the I2G splice variant; the other has a chimeric gene.
Conflicts and coalitions among selfish toxin-antidote elements shape the evolution of hyperdivergent haplotypes https://www.biorxiv.org/content/10.64898/2026.10.22.760680v1
October 24, 2026 at 3:30 AM
Conflicts and coalitions among selfish toxin-antidote elements shape the evolution of hyperdivergent haplotypes https://www.biorxiv.org/content/10.64898/2026.10.22.760680v1
Conflicts and coalitions among selfish toxin-antidote elements shape the evolution of hyperdivergent haplotypes https://www.biorxiv.org/content/10.64898/2026.10.22.760680v1
October 24, 2026 at 3:30 AM
Conflicts and coalitions among selfish toxin-antidote elements shape the evolution of hyperdivergent haplotypes https://www.biorxiv.org/content/10.64898/2026.10.22.760680v1
Prognostic Impact of ERAP1 Genetic Variants and Haplotypes in Cervical Cancer: Insights From TCGA-CESC and a Brazilian Patient Cohort pubmed.ncbi.nlm.nih.gov/42899476/
October 22, 2026 at 2:43 AM
Prognostic Impact of ERAP1 Genetic Variants and Haplotypes in Cervical Cancer: Insights From TCGA-CESC and a Brazilian Patient Cohort pubmed.ncbi.nlm.nih.gov/42899476/
Himito analyses mtDNA from long reads in one graph-based framework: it filters out reads from nuclear mitochondrial insertions (NUMTs), assembles the main haplotypes, calls variants and measures 5mC methylation.
October 20, 2026 at 6:18 PM
Himito analyses mtDNA from long reads in one graph-based framework: it filters out reads from nuclear mitochondrial insertions (NUMTs), assembles the main haplotypes, calls variants and measures 5mC methylation.
www.researchgate.net/publication/...
You could have found this yourself in about 2 minutes, but it’s clearly very important to you that it not be true.
It’s from the journal Human Immunology, October 2001.
You could have found this yourself in about 2 minutes, but it’s clearly very important to you that it not be true.
It’s from the journal Human Immunology, October 2001.
(PDF) HLA Genes in Palestinians The Origin of Palestinians and Their Genetic Relatedness With Other Mediterranean Populations
PDF | The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes.... | Find, read and cite all the research you ne...
www.researchgate.net
October 20, 2026 at 5:42 AM
www.researchgate.net/publication/...
You could have found this yourself in about 2 minutes, but it’s clearly very important to you that it not be true.
It’s from the journal Human Immunology, October 2001.
You could have found this yourself in about 2 minutes, but it’s clearly very important to you that it not be true.
It’s from the journal Human Immunology, October 2001.