u shaped AND inverse u shaped!!!!! holy regional heterogeneity batman
these charts show the relationship between zip code-level average income and individual probability of voting for democrats in different regions of the country. one of my favorite group fo charts, lots of stories to unearth
November 3, 2025 at 10:03 AM
u shaped AND inverse u shaped!!!!! holy regional heterogeneity batman
It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...
Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning
During regeneration, tissues must translate transient cellular variability into stable
spatial organization. Tissue architecture generates a density-dependent window of
heterogeneity in the mechanosen...
www.cell.com
June 30, 2026 at 7:22 PM
It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
This platform has grown explosively since the election, but growth has slowed down the past few days. Should we be concerned?
No. A temporary plateau was inevitable given the heterogeneity of social media users. From my point of view Bluesky is already over the hump 1/
No. A temporary plateau was inevitable given the heterogeneity of social media users. From my point of view Bluesky is already over the hump 1/
November 26, 2024 at 8:06 PM
This platform has grown explosively since the election, but growth has slowed down the past few days. Should we be concerned?
No. A temporary plateau was inevitable given the heterogeneity of social media users. From my point of view Bluesky is already over the hump 1/
No. A temporary plateau was inevitable given the heterogeneity of social media users. From my point of view Bluesky is already over the hump 1/
in 2021 i bought a pair of pink and blue tie dye thigh highs and i wore them for exactly 5 minutes before learning something important about heterogeneity
September 25, 2026 at 2:20 PM
in 2021 i bought a pair of pink and blue tie dye thigh highs and i wore them for exactly 5 minutes before learning something important about heterogeneity
Academic research essentially on hold in 70 health fields like "gene regulation in cancer" and "tumor evolution, heterogeneity, and metastasis."
Wondering if your study section cancelled? I update this sheet daily. As of today, 56/124 study sections that should have met since Jan 2, 2025 have "not met as scheduled." docs.google.com/spreadsheets...
2025 Study section tracking
docs.google.com
February 26, 2025 at 11:04 PM
Academic research essentially on hold in 70 health fields like "gene regulation in cancer" and "tumor evolution, heterogeneity, and metastasis."
March 11, 2025 at 12:16 AM
Resistance to diversity and heterogeneity is definitionally weakness, as it is diversity and heterogeneity that is essential to the evolution of the species
Slack-jawed provincial cultists have held back humanity for thousands of years, and they are doing so still
This is the oldest story we have
Slack-jawed provincial cultists have held back humanity for thousands of years, and they are doing so still
This is the oldest story we have
June 21, 2025 at 11:55 PM
Resistance to diversity and heterogeneity is definitionally weakness, as it is diversity and heterogeneity that is essential to the evolution of the species
Slack-jawed provincial cultists have held back humanity for thousands of years, and they are doing so still
This is the oldest story we have
Slack-jawed provincial cultists have held back humanity for thousands of years, and they are doing so still
This is the oldest story we have
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 11:44 AM
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Addiction Neuroscience | Dopamine circuitry and heterogeneity in addiction | ScienceDirect.com by Elsevier
The heterogeneity of midbrain dopamine neurons is coming into focus. Distinct subtypes of dopamine neurons can be identified across the ventral tegmental area (VTA) and substantia nigra pars compacta ...
www.sciencedirect.com
January 19, 2026 at 2:11 PM
I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...
Props to @benstanley.eu for getting "Lego blocks" and "heterogeneity" into the same sentence
May 18, 2025 at 9:11 PM
Props to @benstanley.eu for getting "Lego blocks" and "heterogeneity" into the same sentence
New RESOURCE!
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria - Nature Microbiology
A comprehensive genomic analysis reveals species- and strain-level heterogeneity in carbohydrate utilization potential across bifidobacteria of human origin.
www.nature.com
July 16, 2025 at 11:31 AM
New RESOURCE!
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria
@arzamasovalex.bsky.social @drlarsbode.bsky.social Andrei Osterman, Jeff Gordon & co
#microbiomesky #microsky
www.nature.com/articles/s41...
New pre-print on heterogeneity- stability relationship led by @jsola.bsky.social: Using a long-term #RockyShore experiment we show substrate heterogeneity promotes stability via biodiversity and asynchrony, but simultaneously inhibits stabilising dominants. www.authorea.com/users/795647...
Counteracting cascades challenge the heterogeneity -- stability relationship
Spatial environmental heterogeneity is widely assumed to enhance ecological stability by promoting refugia, biodiversity, and asynchrony. Yet, we lack field experiments testing this fundamental relati...
www.authorea.com
November 27, 2024 at 5:26 AM
New pre-print on heterogeneity- stability relationship led by @jsola.bsky.social: Using a long-term #RockyShore experiment we show substrate heterogeneity promotes stability via biodiversity and asynchrony, but simultaneously inhibits stabilising dominants. www.authorea.com/users/795647...
Bacteriophage continue to have so much to teach us.
It's in our interest to understand how they work and impact human & environmental health.
New joint work led by @mariandm.bsky.social & @rantahan.bsky.social inferring single-cell latent period & burst size heterogeneity from population dynamics.
It's in our interest to understand how they work and impact human & environmental health.
New joint work led by @mariandm.bsky.social & @rantahan.bsky.social inferring single-cell latent period & burst size heterogeneity from population dynamics.
Inferring single-cell heterogeneity of bacteriophage lysis-associated life-history traits from population-scale dynamics
Theory-guided experiments reveal single-cell heterogeneity of lysis-associated bacteriophage traits from population scale data.
www.science.org
July 15, 2026 at 6:50 PM
Bacteriophage continue to have so much to teach us.
It's in our interest to understand how they work and impact human & environmental health.
New joint work led by @mariandm.bsky.social & @rantahan.bsky.social inferring single-cell latent period & burst size heterogeneity from population dynamics.
It's in our interest to understand how they work and impact human & environmental health.
New joint work led by @mariandm.bsky.social & @rantahan.bsky.social inferring single-cell latent period & burst size heterogeneity from population dynamics.
Maybe… maybe not.
Is there treatment effect HETEROgeneity?
Is there treatment effect HETEROgeneity?
March 8, 2025 at 2:27 PM
Maybe… maybe not.
Is there treatment effect HETEROgeneity?
Is there treatment effect HETEROgeneity?
A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪
February 1, 2025 at 9:36 PM
A study in Nature Cancer provides genetic evidence that intrinsic developmental heterogeneity can prime individual, lifelong cancer susceptibility. https://go.nature.com/3PZla0G #Medsky 🧪
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
May 21, 2025 at 5:17 PM
New @nature.com
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
An ingenious way to track DNA replication patterns at the single-cell level that leads to cell heterogeneity and daughter cells that can potentially give rise to cancer
www.nature.com/articles/s41...
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC - Nature
In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.
go.nature.com
March 12, 2025 at 7:34 PM
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
Specifically, he will employ two-way fixed effects models to remove unnecessary heterogeneity
if you're worried about the new inflation data today, don't worry, the new head of the bls will fix that going forward
August 12, 2025 at 1:47 PM
Specifically, he will employ two-way fixed effects models to remove unnecessary heterogeneity
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
biorxiv.org/content/10.110
biorxiv.org
July 23, 2025 at 9:43 PM
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.110
biorxiv.org/content/10.110
I have been reading all the "students these days" threads from various sides and I have an essay's worth of thoughts -- there's a lot of complexity and heterogeneity that is hard to communicate on social media. There are a couple of things I will say here though. 1/
November 29, 2025 at 4:20 PM
I have been reading all the "students these days" threads from various sides and I have an essay's worth of thoughts -- there's a lot of complexity and heterogeneity that is hard to communicate on social media. There are a couple of things I will say here though. 1/
I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma - Nature Biomedical Engineering
Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.
www.nature.com
December 10, 2024 at 3:28 PM
I am so excited to share the biggest (and best) part of my #PhD in @maxreichertmd.bsky.social lab
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...
We show how inter/intra-tumoral #heterogeneity impacts plasticity and treatment resistance by using #PDAC #organoids
@natureportfolio.bsky.social
www.nature.com/articles/s41...