#HfpEF
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mikejohansenmd.medsky.social
HFpEF looking at tirzepatide and ignoring the mediocre finerenone.
November 16, 2024 at 5:12 PM
erictopol.bsky.social
Another GLP-1 drug success. Tirzepatide in heart failure with preserved ejection fraction (HFpEF) with longer term follow-up than 2 previous trials with semaglutide
nejm.org/doi/full/10....
in people with BMI >30; no data yet for HFpEF in people without obesity
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM
Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...
nejm.org
November 16, 2024 at 3:12 PM
erinmichos.bsky.social
Here at the #WCIRDC2024 conference where I presented in #HFpEF and sex specific considerations for women. I shared a summary of this with #HCPLive . #CardioSky #WomensHeartHealth

www.hcplive.com/view/erin-mi...
Erin Michos, MD: HFpEF in Women and Sex-Specific Therapeutic Approaches
Erin Michos, MD examines unique HFpEF mechanisms for women and implications for sex-specific treatment.
www.hcplive.com
December 14, 2024 at 12:43 AM
jordybc.bsky.social
@freelyfiltered.bsky.social covering HFpEF! As it should be

w/ @hswapnil.bsky.social @captainchloride.bsky.social @brendonneuen.bsky.social (honorary filtrate) @kidneyboy.bsky.social
@medpeedskidneys.bsky.social
November 15, 2024 at 2:30 AM
annetkiraboc1.bsky.social
Breaking: In HFpEF patients with obesity, weekly tirzepatide injections significantly reduced CV death/worsening HF events and improved health status vs. placebo. A game-changer for managing HFpEF? #AHA24 @AHAscience #Cardiology
November 16, 2024 at 9:26 PM
robmentz.bsky.social
Nice coverage of SUMMIT @tctmd.bsky.social

Well-executed trial; large benefit w tirzepatide in HFpEF + obesity

Note sample size modest (731) & modest number of events (92)

@dranulala.bsky.social @jgrapsa.bsky.social @drmarthagulati.bsky.social #cardiosky

www.tctmd.com/news/summit-...
SUMMIT: Tirzepatide a ‘Huge Win’ for HFpEF Patients With Obesity
HF specialists agree these drugs will be key tools in fighting the obesity-related HFpEF epidemic. Hurdles and questions remain.
www.tctmd.com
November 20, 2024 at 5:44 PM
ajpcardio.bsky.social
🫀 Coronary microvascular dysfunction may be the key to preventing & treating HFpEF.

Learn how CMD influences pathophysiology & what it means for future care.

🔗 ow.ly/Hk0150VOQxi

#HFpEF #CMD #HeartFailure #Cardiology #CVDPrevention #CardioSky #MedSky
May 7, 2025 at 7:49 PM
nejm.org
Neha J. Pagidipati, MD, and Donald Lloyd-Jones, MD, discuss common symptoms of heart failure with preserved ejection fraction (HFpEF) and why they occur.

Watch “HFpEF Explained — Living with HFpEF,” part three in a three-part Double Take video miniseries, now available on our YouTube channel.
May 11, 2026 at 7:01 PM
nejm.org
Dr. Sanjiv Shah explains standard of care for HFpEF. Learn more in the Double Take video “HFpEF Explained — Managing HFpEF in Primary Care,” available on our YouTube channel.
May 8, 2026 at 4:01 PM
captainchloride.bsky.social
On the heels of this - just prescribed finerenone for HFpEF in clinic @hswapnil.bsky.social @jordybc.bsky.social
November 15, 2024 at 7:11 PM
tommyedwin.bsky.social
Wanna hear some bullshit?

Bcuz of my #heartfailure #HfpEF I suffer from low oxygen at higher elevations like Denver (💘) esp. at night. But my doctor can’t prescribe supplemental O2 for travel w/O a sleep test being done at the locations I’m traveling to. Stupid, eh?
September 28, 2026 at 12:22 AM
drmarthagulati.bsky.social
Our joint publication with @jcardfail.bsky.social & @ajpcardio.bsky.social is out!
Underpinnings of #HeartFailure With Preserved Ejection Fraction in Women - From Prevention to Improving Function
#HFpEF #CVPrev #CardioTwitter #womenshearthealth #heartmonth
📎 onlinejcf.com/article/S107...
February 18, 2025 at 5:25 PM
cardioobdoc.bsky.social
Epicardial Adipose Tissue is associated with adverse prognosis in patients with #HFpEF & #HFmrEF: A Multicenter Study

#CardioSky #MedSky
#JAHA
@ahajournals.bsky.social @drmarthagulati.bsky.social @vietheartpa.bsky.social
www.ahajournals.org/doi/10.1161/...
December 15, 2024 at 11:37 AM
smidtheart.bsky.social
We are less than 3 weeks away from the start of the #HFpEF Conference! There's still a few spots left, grab your seat now.
Registration🔗 hfpefsummit.org
February 28, 2025 at 9:39 PM
cardioobdoc.bsky.social
Dietary Interventions in #HFpEF:
A Scoping Review

#CardioSky #MedSky #JACCAdvances
www.jacc.org/doi/10.1016/...
@jaccjournals.bsky.social @csilvers.bsky.social @daniellebelardomd.bsky.social @dranulala.bsky.social @sjgreene-md.bsky.social @robmentz.bsky.social @vietheartpa.bsky.social
January 28, 2025 at 9:53 PM
drrajivsankar.bsky.social
SUMMIT Trial #AHA24 Tirzepatide for #HFpEF & obesity
❇️Double-blind placebo controlled RCT
❇️⬇️risk of a composite of CV☠️/worsening #heartfailure
❇️⬆️health status(KCCQ-CSS) in HFpEF & obesity www.nejm.org/doi/full/10.... #cardiosky @robmentz.bsky.social @carysbarton.bsky.social @poppybrooks.bsky.social
November 16, 2024 at 3:42 PM
imcrit.bsky.social
ICU Stories:

Elderly patient with multiple medical problems (HFpEF / A fib / HTN / PE / obesity etc) was admitted w CHF exacerbation. Improved w diuresis but developed left upper extremity edema; diagnosed with extensive DVT for which Interventional Radiology (IR) was consulted
March 22, 2025 at 6:59 PM
hancardiomd.bsky.social
How to diagnose heart failure with preserved ejection fraction
academic.oup.com/ehjcimaging/...
#CardioSky
#EchoFirst #HFpEF #EHJCVI
November 18, 2024 at 10:58 PM
cardioobdoc.bsky.social
Simultaneous or Rapid Initiation of Combination Therapy for #HFpEF

#CardioSky
jamanetwork.com/journals/jam...
@jama.com @vietheartpa.bsky.social @jimjanuzzi.bsky.social @sjgreene-md.bsky.social @hvanspall.bsky.social @anastasiasmihaili.bsky.social @psatishmd.bsky.social @jgrapsa.bsky.social
March 12, 2025 at 12:55 AM
erinmichos.bsky.social
So exciting! #SUMMIT trial, the first #HFpEF trial of incretin therapy with HF clinical outcomes as prespecified primary outcome. And #tirzepatide reduced CV death or worsening HF by significant 38%! Improvement in KCCQ quality of life by 7 pts, wt loss 12%, hsCRP reduction by 35%! #AHA24 #CardioSky
November 16, 2024 at 3:19 PM
load-dependent.eurosky.social
HFpEF is not a single disease but a highly heterogeneous syndrome, this might contribute to its development in a subset of patients, but we should be careful not to generalise too broadly to all HFpEF. #cardiosky
jaccjournals.bsky.social JACC Journals @jaccjournals.bsky.social · Aug 31
#HFpEF appears to develop as a result of changes in the biology of a person’s internal fat tissue, according to the #Adipokine Hypothesis, a new way of understanding how fat may impact the heart.

Get the details: https://bit.ly/45QzO3f

#JACC #ESCCongress #WCCardio #CardioSky
September 1, 2025 at 4:02 PM
sarahhudsonuk.bsky.social
Its back! Ten current papers for the curious cardiologist, including BP targets in T2DM, spiro post MI, left atrial appendage occlusion, coronary sinus reducer for angina, device detected AF & tirzepatide in HFpEF #CardioSky

1/11
November 18, 2024 at 10:24 PM
jama.com
In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but tirzepatide offered no additional benefit over semaglutide.

#ESCCongress #WCCardio

ja.ma/45EJlKy
Study design comparing Semaglutide and Tirzepatide in heart failure patients. It shows emulated trials and expanded populations with eligibility criteria for STEP-HFPEF DM and SUMMIT trials. Patient numbers are listed for each treatment group.
August 31, 2025 at 1:30 PM
drmarthagulati.bsky.social
Another great paper from @jcardfail.bsky.social on the efficacy of #GLP1RA in patient s with T2DM+Obesity & #HFpEF
December 12, 2024 at 7:10 AM
rickyturgeon.bsky.social
Updated prior NERDCAT summary of GLP1 receptor agonists in HFpEF with data from SUMMIT: nerdcat.org/studysummari...
#cardiosky #nephsky #medsky
How do people feel about the "incretin analog" terminology? Still feels clumsy to me
STEP-HFpEF & SUMMIT: Incretin analogs (semaglutide & tirzepatide) in patients with HF & ejection fraction >=45% & obesity, with or without diabetes — NERDCAT
Semaglutide articles Pooled analysis of STEP-HFpEF & STEP-HFpEF DM. Lancet 2024 STEP-HFpEF main paper. NEJM 2023;389:1069-84. STEP-HFpEF DM main paper. NEJM 2024;390:1394-407. S...
nerdcat.org
December 4, 2024 at 3:00 AM