#HowITreat
LightNews LightNews
jhumimmunity.org
How I Treat: Diagnostic clues and treatment for activated phosphoinositide 3-kinase delta syndrome. Hirokazu Kanegane @sciencetokyo_en, Dan Tomomasa, and Satoshi Okada propose “10 Warning Signs of APDS” for the early clinical detection of APDS:
rupress.org/jhi/article/...

#HowITreat #IEIs
August 3, 2026 at 8:45 PM
asnpublications.bsky.social
Broader screening, earlier diagnosis, and targeted treatment of Primary aldosteronism (PA) have the potential to prevent years of cardiovascular and kidney damage in patients with hypertension according to a new #HowITreat article in #ASNCJASN. kidney.pub/CJASN1165...
July 28, 2026 at 5:30 PM
jhumimmunity.org
How I Treat: #STAT3 hyper IgE syndrome. Clinical management guidelines proposed by Cliodhna Murray, Eyad Jannoud, Seraina Prader, and Bodo Grimbacher @uni-freiburg.de:
rupress.org/jhi/article/...

#HowITreat #InbornErrorsOfImmunity #IEIs
June 5, 2026 at 1:31 PM
rupress.org
Hyper IgE syndrome is a rare and syndromic primary #immunodeficiency. In @jhumimmunity.org, Murray et al. propose clinical management guidelines for this multisystem condition based on the experience and management of these patients in the last 25+ years. rupress.org/jhi/article/...
#HowITreat #IEIs
May 29, 2026 at 6:00 PM
jhumimmunity.org
Hyper IgE syndrome is a rare and syndromic primary #immunodeficiency. Murray, Grimbacher et al. propose clinical management guidelines for this multisystem condition based on the experience and management of these patients in the last 25+ years. rupress.org/jhi/article/...
#HowITreat #STAT3 #IEIs
May 29, 2026 at 5:45 PM
jhumimmunity.org
How I Treat: Immune dysregulation in #DownSyndrome. Melissa Gans (University of Miami Miller School of Medicine) and colleagues propose actionable insights:
rupress.org/jhi/article/...

#HowITreat #Autoimmunity #InbornErrorsOfImmunity
@bogunoviclab.bsky.social
May 11, 2026 at 7:30 PM
jhumimmunity.org
How I Treat: Haploinsufficiency of A20. A comprehensive clinical framework for diagnosing and managing HA20 from Jonathan Li, Kader Cetin Gedik, Daniella M. Schwartz and colleagues (University of Pittsburgh):
rupress.org/jhi/article/...

#HowITreat #raredisease #autoinflammatory #IEI #PIRD
May 11, 2026 at 1:31 PM
rupress.org
Using clinical vignettes, Melissa Gans et al. highlight the underlying mechanisms and potential treatments for immune dysregulation in #DownSyndrome. New in @jhumimmunity.org: rupress.org/jhi/article/...

#HowITreat #Autoimmunity #InbornErrorsOfImmunity
@bogunoviclab.bsky.social
May 4, 2026 at 6:02 PM
jhumimmunity.org
Using clinical vignettes, Melissa Gans et al. highlight the underlying mechanisms and potential treatments for immune dysregulation in #DownSyndrome. rupress.org/jhi/article/...

#HowITreat #Autoimmunity #InbornErrorsOfImmunity
@bogunoviclab.bsky.social
May 4, 2026 at 6:00 PM
rupress.org
HA20: an underrecognized #immunedysregulation disease affecting up to 1:14,000. In @jhumimmunity.org, Jonathan Li, Daniella M. Schwartz et al. cover diagnosis, #biomarker-guided therapy with IL-1/TNF/JAK inhibitors, and family screening: rupress.org/jhi/article/...

#HowITreat #raredisease
May 4, 2026 at 4:47 PM
jhumimmunity.org
HA20: an underrecognized #immunedysregulation disease affecting up to 1:14,000. Jonathan Li, Daniella M. Schwartz et al. cover diagnosis, #biomarker-guided therapy with IL-1/TNF/JAK inhibitors, and family screening: rupress.org/jhi/article/...

#HowITreat #raredisease #autoinflammatory #IEI #PIRD
May 4, 2026 at 4:02 PM
bloodjournals.hematology.org
New issue of #Blood out now featuring Removal of anti-ABO B cells by bispecific antibody, Common variants influence #AML risk and prognosis, a new #howItreat and more. Explore here: ashpublications.org/blood/issue/...
April 23, 2026 at 5:42 PM
jhumimmunity.org
How I treat chronic granulomatous disease: Jennifer W. Leiding @jhu.edu, Michael D. Keller (Children’s National Hospital) and colleagues present their consensus approach to diagnosis and management of CGD. rupress.org/jhi/article/...

#HowITreat #InbornErrorsOfImmunity
April 23, 2026 at 1:45 PM
jhumimmunity.org
Leiding, Keller et al. present their practical guide to diagnosis and treatment of chronic granulomatous disease, including the first comprehensive clinical protocol for treatment of CGD. rupress.org/jhi/article/...

#HowITreat #InbornErrorsOfImmunity
April 16, 2026 at 4:00 PM
jhumimmunity.org
#HowITreat: Infections and #InbornErrorsOfImmunity—Prevention, diagnosis, and treatment. New practical advice from Alexandra Freeman @niaidnews.bsky.social, Beth Thielen @thie0149.bsky.social, and Tamara Pozos @childrensminnesota.bsky.social: rupress.org/jhi/article/...

@clinimmsoc.bsky.social
December 23, 2025 at 4:30 PM
jhumimmunity.org
Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...

#HowITreat
@clinimmsoc.bsky.social
December 16, 2025 at 7:58 PM
rupress.org
In @jhumimmunity.org, Freeman, Thielen @thie0149.bsky.social and Pozos provide practical advice on prevention, diagnosis, and management of infections in #InbornErrorsOfImmunity as well as management of common complications such as bronchiectasis. rupress.org/jhi/article/...

#HowITreat
December 16, 2025 at 7:15 PM
bloodjournals.hematology.org
Recent epidemiologic evidence suggest that the incidence of hospital-acquired venous thromboembolism among children in the United States has continued to rise over the past 20 years. buff.ly/Cfcvvv3 #hemesky #HowITreat #pediatrichematology
May 27, 2025 at 3:04 PM
bloodjournals.hematology.org
Platelet refractoriness describes a poor response to platelet transfusion, and conventional thinking has divided etiologies into 2 broad categories: immune and nonimmune. buff.ly/JEfMzzB #hemesky #transfusionmedicine #HowITreat
May 21, 2025 at 1:03 PM
bloodjournals.hematology.org
Patients with thrombocytopenia requiring ongoing platelet transfusion support may develop inadequate platelet count increments, referred to as platelet refractoriness, which further complicates their care. buff.ly/JEfMzzB #hemesky #transfusionmedicine #HowITreat #plateletsandthrombopoiesis
May 16, 2025 at 3:02 PM
bloodjournals.hematology.org
How I treat AML relapse after allogeneic HSCT buff.ly/2ihDGyE #hemesky #howitreat
May 14, 2025 at 12:02 PM
bloodjournals.hematology.org
Myelodysplastic syndromes/neoplasms are a widely heterogenous group of myeloid malignancies characterized by morphological dysplasia, a defective hematopoiesis, and recurrent genetic abnormalities. buff.ly/tRGezUI #hemesky #HowITreat #myeloidneoplasia
May 7, 2025 at 6:03 PM
bloodjournals.hematology.org
There is emergent evidence that molecular monitoring may identify an improvement in disease state translating to improved overall survival. buff.ly/IYtLqtS #hemesky #HowITreat #myeloidneoplasia
April 23, 2025 at 8:03 PM
bloodjournals.hematology.org
The treatment of myelofibrosis-associated anemia is complicated by a multifactorial pathobiology and a lack of therapies that result in normalization of the bone marrow and complete restoration of its function. buff.ly/1R198vd #hemesky #HowITreat #myeloidneoplasia
April 23, 2025 at 4:05 PM
bloodjournals.hematology.org
Constantly learning about the complex, heterogenous genotypic and phenotypic spectrum of these patients with a view to provide personalized treatment options, aiming to improve outcomes, quality of life, and ultimately a cure. buff.ly/TlNNq80 #hemesky #myeloidneoplasia #HowITreat
April 22, 2025 at 3:03 PM