#STAT3
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yanivelkouby.bsky.social
Now out from our lab in @currentbiology.bsky.social!

An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization

www.cell.com/current-biol...
November 26, 2025 at 7:01 PM
krhornberger.bsky.social
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
STAT3 is an attractive therapeutic target for cancer and other human diseases. We have previously reported the discovery of potent, selective, and efficacious PROTAC STAT3 degraders SD-36 and SD-91. I...
pubs.acs.org
November 22, 2024 at 1:19 PM
bernhardzdarsky.bsky.social
‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social

#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...
October 15, 2025 at 2:53 PM
science.org
Researchers in #ScienceSignaling have shown how the metabolism of glucose drives #ColorectalCancer by activating a growth-fueling signaling pathway—and shown that targeting this pathway can shrink tumors in mice. https://scim.ag/4aMsGr1 #ColorectalCancerAwarenessMonth
Glucose metabolism sustains aberrant STAT3 signaling in colorectal cancer through glycosylated local signaling factors
Reducing glucose availability may effectively restrict STAT3-driven growth in colorectal tumors.
scim.ag
March 4, 2026 at 4:10 PM
labwaggoner.bsky.social
@biorxivpreprint.bsky.social STAT3 operates as an inflammation-dependent transcriptional switch @josephsunlab.bsky.social @simongrassmann.bsky.social @mskcancercenter.bsky.social
www.biorxiv.org/content/10.1...
September 30, 2025 at 2:07 AM
labwaggoner.bsky.social
The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development
www.nature.com/articles/s41...
@naturecomms.bsky.social
February 2, 2025 at 5:38 PM
nature.com
Nature research paper: STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

https://go.nature.com/4dhenKu
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature
Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.
go.nature.com
May 19, 2025 at 9:40 AM
insight.jci.org
Adding a new perspective to STAT3 gain-of-function variants: doi.org/10.1172/jci....
Henrickson & team discover STAT3 GOF drives CD8+ T cell dysfunction, in part through a dysregulated purinergic axis, which is partially restored by targeted JAK inhibitor therapy.
September 21, 2026 at 8:01 PM
thomasbchadwick.bsky.social
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer - Nature Immunology
Here, the authors show that signal transducer and activator of transcription 3 (STAT3) has dual functions in small cell lung cancer as its deletion inhibited primary tumor growth but boosted metastati...
www.nature.com
November 23, 2024 at 7:48 AM
labwaggoner.bsky.social
Cytokine IL-6 drives STAT3/NF-κB signaling to increase USP24 expression, which promotes PD-1 deubiquitination and stabilization
www.science.org/doi/10.1126/...
April 16, 2025 at 7:36 PM
aargoetti.bsky.social
1/7 I’m excited to share our paper, describing the majority of my PhD, now published in
@naturecomms.bsky.social
!
We present how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response in human cells. A 🧵

www.nature.com/articles/s41...
January 12, 2025 at 3:52 PM
soserio.bsky.social
La donna socialmente gradita è una donna silenziosa, che diletta con qualunque arte, tranne quella oratoria (Michela Murgia, “Stai zitta”)

Michi, ieri non siamo stat3 zitt3 ✊🏻 ❤️

#passeggiatarrabbiata #nudm #nonunadimeno #nonunadipiù #transfemminismo #michelamurgia
April 6, 2025 at 6:42 AM
c0nc0rdance.bsky.social
I still have nightmares of JAK-STAT pathway diagrams with missing labels I was required to fill in.
Signaling cross-talk between JAK/STAT and other pathways. (1) STAT3-p300- SMAD1 forms a complex to induce astrocyte differentiation; (2) JAK1 binds to TGFβRI and activates STAT3; (3) TGF-β also activates STAT3 via SMAD-dependent manner. (4) STAT3 inhibits SMAD3–SMAD4 complex formation and suppress SMAD3-DNA binding; (5) SMAD3 inhibits STAT3 activation via recruiting PIAS3 to STAT3; (6) TGF-β blocks IL-12 mediated JAK2 and TYK2 tyrosine phosphorylation; (7) Notch signaling suppresses JAK/STAT activation by interfering with STAT translocation to the DNA domain, and signals of JAK/STAT inhibited Notch signaling conversely. (8) Hes proteins directly bind to STAT3 and induce phosphorylation by recruiting JAK2; (9) STAT5 direct interacts with PI3K; (10) STAT5 upregulates the expression of p85α (Pik3r1), p110α (Pik3ca), and AKT1; (11) STAT3 drives the hyperacetylation of RelA via interacting with p300; (12) cyclooxygenase-2, IL-17, IL-21, and IL-23 encoded by NF-κB activate STAT3; (13) NF-κB preceded ISGF3 (a complex containing STAT1, STAT2, and IRF9 subunits) at the Nos2 promoter, thus regulating nitric oxide synthase expression; (14) IRF9-STAT1-STAT2 trimeric complex induce gene expression; (15) STAT1 regulates IRF8 synthesis; (16) STAT5 suppresses IRF8 activity; (17) STAT1 and IRF1 synergistic induce IFNγ-induced gene transcription; (18) IRF8 increases IFNγ-induced gene transcription mediated by STAT1 and IRF1. Created with BioRender.com
March 2, 2026 at 1:03 PM
labwaggoner.bsky.social
Dysregulated purinergic signaling axis plays an important role in CD8+ T cell dysregulation in STAT3 GOF
doi.org/10.1101/2024...
@sarahhenrickson.bsky.social
December 16, 2024 at 3:38 AM
frenchdcsociety.bsky.social
Reprograming DC with PROTAC STAT3 degraders to enhance anti-tumor immunity !

Super work on @nature.com from Weiping Zou, Shaomeng Wang and coll. 👏👏

www.nature.com/articles/s41...
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity - Nature
Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours...
www.nature.com
May 16, 2025 at 12:08 PM
krhornberger.bsky.social
Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader
Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader
Signal transducer and activator of transcription 3 (STAT3) is a promising therapeutic target for human cancers and other human diseases. Herein, we report on the design, synthesis, and evaluation of n...
pubs.acs.org
April 28, 2026 at 10:35 AM
espinlab.bsky.social
The latest paper from the Espin lab is out! 🍾🎉

www.cell.com/cell-reports...
Synergistic cooperation between progranulin and Jak2/Stat3 signaling determines definitive myeloid cell fate
McCune et al. demonstrate that progranulin enforces myeloid fate by regulating JAK2/STAT3 and uncover functional differences between two embryonically derived macrophage populations. These findings pr...
www.cell.com
June 12, 2026 at 4:00 AM
cerebrodigital.net
Investigadores del CNIO liderados por Mariano Barbacid eliminaron tumores de páncreas en ratones usando tres fármacos que bloquean KRAS, EGFR y STAT3, evitando resistencia y logrando regresión completa en modelos preclínicos de adenocarcinoma ductal.

DOI: 10.1073/pnas.2523039122
January 29, 2026 at 3:22 PM
cp-cellstemcell.bsky.social
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling #stemcells
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling
Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days into post-implantation structures mimicking Carnegie stages 5–7 embryos, including gastrulation, with high morphological and molecular fidelity.
dlvr.it
September 16, 2025 at 7:09 PM
labwaggoner.bsky.social
STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
www.nature.com/articles/s41...
November 22, 2024 at 3:52 PM
mattmuscleguy.bsky.social
New #stemcellreports paper: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. #Myoblue tinyurl.com/yyjhn94p
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells
In this manuscript, Sacco, Caputo, and colleagues demonstrate that modulation of the JAK2/STAT3 signaling pathway during in vitro myogenic differentiation promotes expansion of PAX7+ SMPCs in multiple...
tinyurl.com
October 30, 2025 at 4:07 PM
rk70534.bsky.social
"Se state vedendo questo video, siamo stat3 intercettat3 illegalmente dalla Marina Militare israeliana. Adesso tocca a voi: bloccate tutto!

If you are watching this video, we have been intercepted by the Israeli Navy. Now it's your turn: block everything!"

www.instagram.com/reel/DPRyabU...

#Gaza
October 1, 2025 at 7:33 PM
grnfluoresceblg.bsky.social
#ISR_RNA25 #RNASky
Yael Nandel gutfreund on cytoplamic roles of lncRNA as protein binding
Talking about the work of @aargoetti.bsky.social
www.nature.com/articles/s41...
lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3 - Nature Communications
Long non-coding RNA (lncRNA) has diverse functions. Here the authors show that a lncRNA, NORAD, interacts with an immune transcription factor, STAT3, to facilitate STAT3 nuclear import and thereby mod...
www.nature.com
March 10, 2025 at 12:29 PM
profolus.com
A clinical trial involving pet cats with naturally occurring head and neck squamous cell carcinoma has produced promising early results for a therapeutic agent targeting the STAT3 transcription factor.
New Therapy for Cats With Head and Neck Cancer Could Help Humans - Profolus
A phase one trial in pet cats shows that a STAT3-targeted therapy can offer a translational path for human head and neck cancer treatment.
www.profolus.com
November 4, 2025 at 7:00 PM