hypertonic pelvic floor
hypertonic um... throat muscles?
hypertonic um... throat muscles?
May 30, 2025 at 11:15 PM
hypertonic pelvic floor
hypertonic um... throat muscles?
hypertonic um... throat muscles?
ERJ Open Research: Treatment of patients with bronchiectasis with hypertonic saline or carbocisteine does not significantly reduce sputum viscoelastic properties and biomarker levels or alter bacterial community composition https://bit.ly/4r2X2KA
September 27, 2026 at 2:45 PM
ERJ Open Research: Treatment of patients with bronchiectasis with hypertonic saline or carbocisteine does not significantly reduce sputum viscoelastic properties and biomarker levels or alter bacterial community composition https://bit.ly/4r2X2KA
girls love immersing themselves in hypertonic solutions
December 12, 2025 at 6:21 AM
girls love immersing themselves in hypertonic solutions
You mean the Hypertonic Lion Tamer?
April 5, 2025 at 1:32 AM
You mean the Hypertonic Lion Tamer?
it's wild how badly people dose hypertonic therapy
60 ml of 23% is equivalent to ~500 ml 3%, so this article makes no coherent sense
best approach: figure out the sodium change you want and calculate the hypertonic dose
math sets you free from dozens of contradictory consensus statements #EMIMCC
60 ml of 23% is equivalent to ~500 ml 3%, so this article makes no coherent sense
best approach: figure out the sodium change you want and calculate the hypertonic dose
math sets you free from dozens of contradictory consensus statements #EMIMCC
February 11, 2026 at 9:15 PM
it's wild how badly people dose hypertonic therapy
60 ml of 23% is equivalent to ~500 ml 3%, so this article makes no coherent sense
best approach: figure out the sodium change you want and calculate the hypertonic dose
math sets you free from dozens of contradictory consensus statements #EMIMCC
60 ml of 23% is equivalent to ~500 ml 3%, so this article makes no coherent sense
best approach: figure out the sodium change you want and calculate the hypertonic dose
math sets you free from dozens of contradictory consensus statements #EMIMCC
hypertonic pelvic floor be like
December 31, 2025 at 5:07 AM
hypertonic pelvic floor be like
the jet of hypertonic liquid hits the back of your nasal passages like an orbitoclast, sending your already reeling consciousness into a sea of roiling white
July 18, 2026 at 5:16 AM
the jet of hypertonic liquid hits the back of your nasal passages like an orbitoclast, sending your already reeling consciousness into a sea of roiling white
me when someone puts my cells inside of a hypertonic liquid
December 25, 2025 at 12:28 AM
me when someone puts my cells inside of a hypertonic liquid
Popped into the Co-op after the gym to buy a hypertonic recovery drink and a super enhanced sports snack.
February 20, 2026 at 7:33 PM
Popped into the Co-op after the gym to buy a hypertonic recovery drink and a super enhanced sports snack.
Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm. Full phase 3 MARCH trial results: https://nej.md/3PUyHdA
#CCR26 | @criticalcarereviews.com
#CCR26 | @criticalcarereviews.com
June 10, 2026 at 10:20 AM
Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm. Full phase 3 MARCH trial results: https://nej.md/3PUyHdA
#CCR26 | @criticalcarereviews.com
#CCR26 | @criticalcarereviews.com
Got another one
Hypertonic Saline vs Joey Chesnut’s 70 hot dog consumption containing over 55 grams (!) of sodium
Hypertonic Saline vs Joey Chesnut’s 70 hot dog consumption containing over 55 grams (!) of sodium
Anyone want to help write a grant for a RCT I have planned?
Which dissociates better: Ketamine vs Blitzy’s explanation of ilioinguinal nerve irritation from a renal stone caught at the pelvic inlet
Because the blank stare I got was fairly epic
Which dissociates better: Ketamine vs Blitzy’s explanation of ilioinguinal nerve irritation from a renal stone caught at the pelvic inlet
Because the blank stare I got was fairly epic
July 7, 2025 at 10:36 PM
Got another one
Hypertonic Saline vs Joey Chesnut’s 70 hot dog consumption containing over 55 grams (!) of sodium
Hypertonic Saline vs Joey Chesnut’s 70 hot dog consumption containing over 55 grams (!) of sodium
So... looks like a possible 'fix' could be 4-6 weeks of abstinence and daily pelvic floor relaxation exercises (breathing, light stretching, reverse kegels, certain yoga poses). If my pelvic floor has become hypertonic and constricting nerves.... looks like no nut September and then some I guess?
September 11, 2026 at 3:05 AM
So... looks like a possible 'fix' could be 4-6 weeks of abstinence and daily pelvic floor relaxation exercises (breathing, light stretching, reverse kegels, certain yoga poses). If my pelvic floor has become hypertonic and constricting nerves.... looks like no nut September and then some I guess?
Dopamine and sodium appetite!
Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.
Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.
Rapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite https://www.biorxiv.org/content/10.64898/2026.07.16.738888v1
July 22, 2026 at 3:53 PM
Dopamine and sodium appetite!
Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.
Sodium appetite causes a 'sign change' in the taste of hypertonic NaCl solutions. We've previously shown that generation of the appetite recruits phasic dopamine to the taste of NaCl; here we show the 'derecruitment' process during satiation.
amazingly, this worked! If syntaxin RNAi cells are cut in hypertonic media, they don’t die!
November 10, 2025 at 5:47 PM
amazingly, this worked! If syntaxin RNAi cells are cut in hypertonic media, they don’t die!
6. Bolus > infusion for hypertonic saline 🧂
If you are going to use hypertonic saline - for example, in conjunction with a proactive DDAVP strategy as discussed above - there is evidence to show that recurrent boluses are superior to a slow continuous infusion.
pubmed.ncbi.nlm.nih.gov/33104189/
If you are going to use hypertonic saline - for example, in conjunction with a proactive DDAVP strategy as discussed above - there is evidence to show that recurrent boluses are superior to a slow continuous infusion.
pubmed.ncbi.nlm.nih.gov/33104189/
Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial - PubMed
ClinicalTrials.org Identifier: NCT02887469.
pubmed.ncbi.nlm.nih.gov
January 24, 2025 at 2:04 PM
6. Bolus > infusion for hypertonic saline 🧂
If you are going to use hypertonic saline - for example, in conjunction with a proactive DDAVP strategy as discussed above - there is evidence to show that recurrent boluses are superior to a slow continuous infusion.
pubmed.ncbi.nlm.nih.gov/33104189/
If you are going to use hypertonic saline - for example, in conjunction with a proactive DDAVP strategy as discussed above - there is evidence to show that recurrent boluses are superior to a slow continuous infusion.
pubmed.ncbi.nlm.nih.gov/33104189/
Safe to give 3% hypertonic saline through a peripheral IV bit.ly/49t5GcI
Retrospective study w/ 216 administrations of 3% by PIV + only 8 minor complications
Bottom line: don’t delay 3% hypertonic administration for placement of a central line
youtube.com/shorts/M5AyB...
#EMIMCC
Retrospective study w/ 216 administrations of 3% by PIV + only 8 minor complications
Bottom line: don’t delay 3% hypertonic administration for placement of a central line
youtube.com/shorts/M5AyB...
#EMIMCC
Hypertonic Saline Via Peripheral IV #emergencymedicine #criticalcare
YouTube video by EMSwami
youtube.com
March 13, 2026 at 3:07 PM
Safe to give 3% hypertonic saline through a peripheral IV bit.ly/49t5GcI
Retrospective study w/ 216 administrations of 3% by PIV + only 8 minor complications
Bottom line: don’t delay 3% hypertonic administration for placement of a central line
youtube.com/shorts/M5AyB...
#EMIMCC
Retrospective study w/ 216 administrations of 3% by PIV + only 8 minor complications
Bottom line: don’t delay 3% hypertonic administration for placement of a central line
youtube.com/shorts/M5AyB...
#EMIMCC
a long time ago I used to knock normal saline for being hypertonic
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
April 8, 2025 at 1:42 AM
a long time ago I used to knock normal saline for being hypertonic
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
I want to set the record straight on this, I was wrong
NS & LR are *functionally* isotonic
to affect sodium concentration, you'd need to give an impossibly massive volume
full discussion here: emcrit.org/ibcc/fluid/#...
my body craves hypertonic saline
December 24, 2023 at 1:13 AM
my body craves hypertonic saline
Hypertonic saline to slowly decrease the sodium level, huh
January 18, 2024 at 6:38 PM
Hypertonic saline to slowly decrease the sodium level, huh
I have advice to offer my fellow stuffy nosers, my booged-up compatriots, my brethren who wake up feeling like they absorbed zero oxygen overnight: Saline spray. The super concentrated hypertonic shit. Head tilted ninety degrees and such a long deep spray that you feel like you jumped in a pool
September 30, 2025 at 1:14 AM
I have advice to offer my fellow stuffy nosers, my booged-up compatriots, my brethren who wake up feeling like they absorbed zero oxygen overnight: Saline spray. The super concentrated hypertonic shit. Head tilted ninety degrees and such a long deep spray that you feel like you jumped in a pool
you gotta be careful with overdoing that, tho. My hypertonic pelvic floor made it feel I’d Deleuze everything worth living for
Quit reading Hegel you need to read about Kegel bestie your pelvic floor is embarrassing
February 13, 2025 at 9:10 PM
you gotta be careful with overdoing that, tho. My hypertonic pelvic floor made it feel I’d Deleuze everything worth living for
(to the tune of super massive black hole) hypertonic pelvic wall
July 30, 2023 at 5:53 PM
(to the tune of super massive black hole) hypertonic pelvic wall
For a hypertonic solution, you need 1 teaspoon salt, 2 cups water or 1/2 teaspoon, 1 cup of water
September 28, 2026 at 1:09 AM
For a hypertonic solution, you need 1 teaspoon salt, 2 cups water or 1/2 teaspoon, 1 cup of water
I think a rational approach is to calculate the volume of hypertonic therapy needed to raise the [Na] by 3 mM using the Androgue-Madias equation
if the volume seems unreasonably high, round down (use judgement)
maybe not perfect but better than current norms of practice (esp for elevated ICP tx)
if the volume seems unreasonably high, round down (use judgement)
maybe not perfect but better than current norms of practice (esp for elevated ICP tx)
June 24, 2025 at 12:27 PM
I think a rational approach is to calculate the volume of hypertonic therapy needed to raise the [Na] by 3 mM using the Androgue-Madias equation
if the volume seems unreasonably high, round down (use judgement)
maybe not perfect but better than current norms of practice (esp for elevated ICP tx)
if the volume seems unreasonably high, round down (use judgement)
maybe not perfect but better than current norms of practice (esp for elevated ICP tx)