Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of f...

Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting c...

Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting c...

Blocking IL1RAP, a receptor that sits at a key control point in inflammatory signaling, can disrupt the tumor-driven inflammatory network that helps pancreatic cancer resist treatment, according to new research.

Read the full paper: Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion

Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of first-respo...

PTPδ, encoded by PTPRD, is implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPδ trans-synaptically interacts with multiple postsynaptic adhesion molecules, which involves its extracellular alternatively spliced mini-exons, meA and meB. While PTPδ-meA functions have been studied in vivo, PTPδ-meB has not been studied. Here, we report that, unlike homozygous PTPδ-meA-mutant mice, homozygous PTPδ-meB-mutant (Ptprd-meB–/–) mice show markedly reduced early postnatal survival. Heterozygous Ptprd-meB+/– male mice show behavioral abnormalities and decreased excitatory synaptic density and transmission in dentate gyrus granule cells (DG-GCs). Proteomic analyses identify decreased postsynaptic density levels of IL1RAP, a known trans-synaptic partner of meB-containing PTPδ. Accordingly, IL1RAP-mutant mice show decreased excitatory synaptic transmission in DG-GCs. Ptprd-meB+/– DG interneurons with minimal IL1RAP expre

New immunotherapy article from the lab (https://lnkd.in/ePBcqqdi): I am very pleased to highlight our latest publication, “IL1RAP antibody-drug conjugates potently target primary and metastatic disea...

A study led by researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) has found that mutations in blood-forming cells may explain the increased risk for leukemia and other blood disorders among first responders exposed to the 9/11 World Trade Center (WTC) disaster site and its toxic dust.

Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting cells and fibrosis while boosting the activity of cancer-fighting T cells. That could make chemotherapy and immunotherapy more effective.

Los anticuerpos dirigidos a la proteína IL1RAP pueden reducir la expresión de citocinas inflamatorias y marcadores de adhesión en las células endoteliales lo que

The FDA decision follows phase 2 CANFOUR trial data showing a 2-year survival rate of 35% in IL1RAP-high metastatic pancreatic ductal adenocarcinoma.

Leveraging advances in high-throughput plasma proteomics and machine learning, Adewale et al. identify an 11-protein biomarker panel that accurately distin

Abstract. Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of f...

“Our findings provide new insights into the long-term health impacts of environmental catastrophes, such as wildfires, and suggest targeted interventions for those affected by 9/11 or similar disaster...