#IL4→#STAT6
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jlbjournal.bsky.social
Young Jun Kang shows that mitochondrial phosphatase #PGAM5 negatively regulates #IL4-induced anti-inflammatory responses and metabolic reprogramming of #Macrophages by controlling #JAK1-#STAT6 signaling
Mitochondrial phosphatase PGAM5 negatively regulates the induction of anti-inflammatory macrophages
Mitochondrial phosphatase PGAM5 negatively regulates IL-4-induced anti-inflammatory responses and metabolic reprogramming of macrophages by controlling JAK
doi.org
September 30, 2026 at 4:07 PM
notreload.bsky.social
$NRIX +13.8% [Nurix licensed STAT6 degrader program (NX-3911) targeting inflammation to Sanofi for $127M total w/$465M+ milestones & royalties] ir.nurixtx.com/news-release...
Sanofi Exercises License Extension Option to Nurix’s STAT6 Program | Nurix Therapeutics, Inc.
STAT6 is a key transcription factor within the IL4/IL13 signaling pathways which act as drivers of inflammation in allergic conditions Nurix to receive a $15 million license extension fee from Sanofi ...
ir.nurixtx.com
June 2, 2025 at 4:44 PM
medchemexpress.bsky.social
📚MedChemExpress Digest | #JAKSTAT in #AutoimmuneDiseases
💊JAK inhibitors & cytokine antibodies offer safer, long-lasting remission vs. broad immunosuppressants.
🔹Cytokine → STAT: #IL12→#STAT4 | #IL4→#STAT6 | #IL6/#IL23→#STAT3 | #IL2→#STAT5
🔗https://ow.ly/eaHu50Xmfho
November 4, 2025 at 3:52 AM