Babesia aktasi is a recently discovered species that is highly prevalent in native goats in Türkiye’s Mediterranean region. Although it does not induce clinical disease in local breeds, it causes severe illness in Saanen goats, manifesting with high fever, anemia, hemoglobinuria, and jaundice. Imidocarb dipropionate (IMDP) has been reported to be therapeutically effective against Babesia species. This study aimed to evaluate the therapeutic efficacy of IMDP and its ability to eliminate the parasite in experimentally infected Saanen goats. Twelve goats were assigned to treatment and control groups (n = 5 per group) and infected using fresh blood from two splenectomized donors. All goats developed clinical babesiosis, with parasitemia ranging from 3.8% to 22. Semi-nested PCR specific to B. aktasi was performed for 30 days post-treatment. Following treatment with IMDP (1.2 mg/kg), clinical signs resolved by the third and fourth days, and parasitemia became microscopically undetectable. However, one goat in the treatment group and four goats in the control group died shortly after infection. Hematological parameters (HCT, RBC, HB) decreased during infection but normalized in surviving animals. Notably, B. aktasi DNA remained detectable by PCR up to 30 days after treatment. These findings indicated that IMDP resolved clinical signs and eliminated microscopically detectable parasitemia; however, it may not completely eliminate the parasite at the molecular level in B. aktasi infections. The results of this study provide valuable information for optimizing therapeutic approaches and improving our understanding of treatment responses in new species B. aktasi.

Babesia aktasi is a recently discovered species that is highly prevalent in native goats in Türkiye’s Mediterranean region. Although it does not induce clinical disease in local breeds, it causes severe illness in Saanen goats, manifesting with high fever, anemia, hemoglobinuria, and jaundice. Imidocarb dipropionate (IMDP) has been reported to be therapeutically effective against Babesia species. This study aimed to evaluate the therapeutic efficacy of IMDP and its ability to eliminate the parasite in experimentally infected Saanen goats. Twelve goats were assigned to treatment and control groups (n = 5 per group) and infected using fresh blood from two splenectomized donors. All goats developed clinical babesiosis, with parasitemia ranging from 3.8% to 22. Semi-nested PCR specific to B. aktasi was performed for 30 days post-treatment. Following treatment with IMDP (1.2 mg/kg), clinical signs resolved by the third and fourth days, and parasitemia became microscopically undetectable. However, one goat in the treatment group and four goats in the control group died shortly after infection. Hematological parameters (HCT, RBC, HB) decreased during infection but normalized in surviving animals. Notably, B. aktasi DNA remained detectable by PCR up to 30 days after treatment. These findings indicated that IMDP resolved clinical signs and eliminated microscopically detectable parasitemia; however, it may not completely eliminate the parasite at the molecular level in B. aktasi infections. The results of this study provide valuable information for optimizing therapeutic approaches and improving our understanding of treatment responses in new species B. aktasi.

Un total de 26 activadoras y activadores promueven el movimiento en colonias, barrios y juntas auxiliares

Babesia ovis is a significant tick-borne parasite of sheep, capable of causing both acute disease and long-lasting, low-grade infections. Imidocarb dipropionate (IMDP) is commonly used against babesiosis, yet whether it can completely eliminate B. ovis remains uncertain. In this study, we examined whether the parasite persists after treatment and whether such residual infections can still be transmitted. Three sheep were experimentally infected, treated with IMDP once clinical signs appeared, and then monitored for 180 days by microscopy, nested PCR, and iELISA. Fever and microscopic parasitemia resolved soon after treatment, but nPCR intermittently detected parasite DNA for several weeks. By day 180, all treated sheep were negative by nPCR and microscopy, while two still showed detectable antibodies. Blood collected at this time was transfused into naïve sheep. Two of the three recipients showed nPCR positivity at scattered time points and later seroconverted while showing no clinical signs. In contrast, Rhipicephalus bursa ticks that fed on the treated donors neither acquired the parasite nor transmitted it to recipients, likely because post-treatment parasitemia remained below the acquisition threshold. Overall, these results indicate that IMDP controls clinical disease but may not fully clear B. ovis, allowing silent transmission through blood despite negative routine tests.

Babesia ovis is a significant tick-borne parasite of sheep, capable of causing both acute disease and long-lasting, low-grade infections. Imidocarb dipropionate (IMDP) is commonly used against babesiosis, yet whether it can completely eliminate B. ovis remains uncertain. In this study, we examined whether the parasite persists after treatment and whether such residual infections can still be transmitted. Three sheep were experimentally infected, treated with IMDP once clinical signs appeared, and then monitored for 180 days by microscopy, nested PCR, and iELISA. Fever and microscopic parasitemia resolved soon after treatment, but nPCR intermittently detected parasite DNA for several weeks. By day 180, all treated sheep were negative by nPCR and microscopy, while two still showed detectable antibodies. Blood collected at this time was transfused into naïve sheep. Two of the three recipients showed nPCR positivity at scattered time points and later seroconverted while showing no clinical signs. In contrast, Rhipicephalus bursa ticks that fed on the treated donors neither acquired the parasite nor transmitted it to recipients, likely because post-treatment parasitemia remained below the acquisition threshold. Overall, these results indicate that IMDP controls clinical disease but may not fully clear B. ovis, allowing silent transmission through blood despite negative routine tests.

Watercraft inspections, lake monitoring keep invasive mussels at bay in 2025

En el Pepe Chedraui (@pepechedrauimx @PueblaAyto ), el deporte nos une, nos activa y nos inspira

YouTube video by Evil Chicken

El Gobierno municipal, a través del IMDP y en colaboración con los Pericos de Puebla, llevó a niñas y niños de juntas auxiliares

El Gobierno municipal, a través del IMDP y en colaboración con los Pericos de Puebla, llevó a niñas y niños de juntas auxiliares

Con acciones como esta, el Pepe Chedraui (@pepechedrauimx @PueblaAyto ) reafirma su compromiso de construir una Puebla más activa

Esta estrategia busca generar una red en beneficio de la activación física y el deporte en colonias, barrios, unidades habitacionales y juntas auxiliares de la capital

El Pepe Chedraui (@pepechedrauimx @PueblaAyto ) impulsa la participación deportiva en colonias, juntas auxiliares y escuelas de Puebla capital

IMDP reafirma su compromiso con el bienestar de las y los ciudadanos

La actividad se desarrolló en el estadio Hermanos Serdán, dentro del marco del convenio de colaboración entre el IMDP 

Las inscripciones serán gratuitas para equipos de todo el municipio en categorías libre en ramas femenil y varonil Puebla, Pue., 18 de junio de 2025 - Con el firme compromiso de fortalecer la cultura deportiva e incentivar la participación ciudadana, el Gobierno de la Ciudad encabezado por el presidente municipal Pepe Chedraui, a través del Instituto Municipal del Deporte de Puebla (IMDP), bajo la dirección de Ricardo Zayas Gallardo, anunció el lanzamiento oficial del Torneo de Barrios de Voleibol 2025.

Las inscripciones serán gratuitas para equipos de todo el municipio en categorías libre en ramas femenil y varonil Puebla, Pue., 18 de junio de 2025 - Con el firme compromiso de fortalecer la cultura deportiva e incentivar la participación ciudadana, el Gobierno de la Ciudad encabezado por el presidente municipal Pepe Chedraui, a través del Instituto Municipal del Deporte de Puebla (IMDP), bajo la dirección de Ricardo Zayas Gallardo, anunció el lanzamiento oficial del Torneo de Barrios de Voleibol 2025.