February 5, 2025 at 10:03 PM
To program a T cell to be a regulatory T cell requires the action of a transcription factor (a protein that turns genes on or off) called FoxP3. In 2001, Mary Brunkow and Fred Ramsdell identified that IPEX syndrome was caused by mutations in FoxP3:
rdcu.be/eJHEr
rdcu.be/eJHEr
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics - The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
rdcu.be
October 6, 2025 at 1:04 PM
To program a T cell to be a regulatory T cell requires the action of a transcription factor (a protein that turns genes on or off) called FoxP3. In 2001, Mary Brunkow and Fred Ramsdell identified that IPEX syndrome was caused by mutations in FoxP3:
rdcu.be/eJHEr
rdcu.be/eJHEr
ótima música www.youtube.com/watch?v=IpEX...
September 16, 2024 at 2:33 PM
ótima música www.youtube.com/watch?v=IpEX...
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
#ArtistFave15
#MusicChallenge
Counting down my 15 favorite songs by Alice In Chains
12. Angry Chair
www.youtube.com/watch?v=IpEX...
#MusicChallenge
Counting down my 15 favorite songs by Alice In Chains
12. Angry Chair
www.youtube.com/watch?v=IpEX...
Alice In Chains - Angry Chair (Official HD Video)
YouTube video by AliceInChainsVEVO
www.youtube.com
February 3, 2026 at 9:59 PM
#ArtistFave15
#MusicChallenge
Counting down my 15 favorite songs by Alice In Chains
12. Angry Chair
www.youtube.com/watch?v=IpEX...
#MusicChallenge
Counting down my 15 favorite songs by Alice In Chains
12. Angry Chair
www.youtube.com/watch?v=IpEX...
Dafür investiert die Kfw Ipex-Bank hingegen lieber 860 Millionen in den Bau einer Ammoniakfabrik in Topolobampo in Mexiko, inmitten eines Feuchtgebiets.. Prioritäten so wichtig
August 5, 2026 at 8:20 AM
Dafür investiert die Kfw Ipex-Bank hingegen lieber 860 Millionen in den Bau einer Ammoniakfabrik in Topolobampo in Mexiko, inmitten eines Feuchtgebiets.. Prioritäten so wichtig
Using a battery from a discarded vape, and an ipex connecter from an old router.
March 18, 2026 at 9:20 PM
Using a battery from a discarded vape, and an ipex connecter from an old router.
#MusicChallenge
#mARTch24
Day 29 - Doris Salcedo - Noviembre 6 y 7 (2002)
Angry Chair - Alice in Chains
www.youtube.com/watch?v=IpEX...
#mARTch24
Day 29 - Doris Salcedo - Noviembre 6 y 7 (2002)
Angry Chair - Alice in Chains
www.youtube.com/watch?v=IpEX...
March 29, 2024 at 2:09 PM
#MusicChallenge
#mARTch24
Day 29 - Doris Salcedo - Noviembre 6 y 7 (2002)
Angry Chair - Alice in Chains
www.youtube.com/watch?v=IpEX...
#mARTch24
Day 29 - Doris Salcedo - Noviembre 6 y 7 (2002)
Angry Chair - Alice in Chains
www.youtube.com/watch?v=IpEX...
Hey @wirecardtyp.bsky.social wie ist denn der neue Finanzminister so?
Wirecard: Staatssekretär Jörg Kukies schlug noch kurz vor Insolvenz Kredit der KFW-Tochter Ipex vor
Zwei Tage vor der Wirecard-Insolvenz wollte das Bundesfinanzministerium die staatseigene Ipex-Bank zu einem Kredit für den Finanzdienstleister drängen. Das belegen geheime E-Mails, die dem SPIEGEL vor...
www.spiegel.de
November 7, 2024 at 7:52 AM
Hey @wirecardtyp.bsky.social wie ist denn der neue Finanzminister so?
Discover iPEX: a breakthrough in spatial proteomics revealing untargeted protein locations at micrometer resolution using tissue expansion and MALDI imaging. PMID:41224995, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-09734-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion | Nature
The number of spatial omics technologies being developed is increasing1. However, a missing tool is one that can locate proteins in tissues in an untargeted manner at high spatial resolution and coverage. Here we present in situ imaging proteomics via expansion (iPEX), which integrates isotropic tissue magnification2 with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. iPEX provides scalable spatial resolution down to the micrometre scale and substantially increases the sensitivity of protein identification by 10–100-fold. Using the retina as a model, iPEX enabled the construction of spatial proteomic maps with high precision, the visualization of single-cell layers and extrasomatic structures and the identification of colocalized proteins. iPEX was readily applied to diverse tissues, including brain, intestine, liver and organoids, detecting 600–1,500 proteins at 1–5-µm effective pixel size. The application of iPEX to depict spatial proteomic maps in bra
doi.org
November 30, 2025 at 10:10 AM
January 17, 2025 at 10:11 AM
3/ They also uncovered the key protein FoxP3, which keeps those cells in check. When FoxP3 fails, it can cause a rare but severe autoimmune disease called IPEX syndrome.
👉 nobelprize.org/prizes/medicine/2025/press-release/
👉 nobelprize.org/prizes/medicine/2025/press-release/
October 9, 2025 at 5:55 PM
3/ They also uncovered the key protein FoxP3, which keeps those cells in check. When FoxP3 fails, it can cause a rare but severe autoimmune disease called IPEX syndrome.
👉 nobelprize.org/prizes/medicine/2025/press-release/
👉 nobelprize.org/prizes/medicine/2025/press-release/
#TheN0ughtie5
Day 6.
Lykke Li - A Little Bit (Sweden 2008)
Wiki tells me that ‘a snippet of the song was used in the commercial for Victoria's Secret Ipex bra starring Heidi Klum’. Every day is a school day.
Day 6.
Lykke Li - A Little Bit (Sweden 2008)
Wiki tells me that ‘a snippet of the song was used in the commercial for Victoria's Secret Ipex bra starring Heidi Klum’. Every day is a school day.
June 6, 2026 at 6:50 AM
#TheN0ughtie5
Day 6.
Lykke Li - A Little Bit (Sweden 2008)
Wiki tells me that ‘a snippet of the song was used in the commercial for Victoria's Secret Ipex bra starring Heidi Klum’. Every day is a school day.
Day 6.
Lykke Li - A Little Bit (Sweden 2008)
Wiki tells me that ‘a snippet of the song was used in the commercial for Victoria's Secret Ipex bra starring Heidi Klum’. Every day is a school day.
In 2003, the key breakthrough happened - groups lead by Sakaguchi, Ramsdell and Sasha Rudensky all demonstrated that FOXP3, the IPEX gene, was also the master transcription factor that made Tregs immunosuppressive. Suddenly everyone could study Tregs and manipulate their genetics.
October 6, 2025 at 11:21 AM
In 2003, the key breakthrough happened - groups lead by Sakaguchi, Ramsdell and Sasha Rudensky all demonstrated that FOXP3, the IPEX gene, was also the master transcription factor that made Tregs immunosuppressive. Suddenly everyone could study Tregs and manipulate their genetics.
Μπράβο Κυριάκο, ρεζίλι διεθνώς όχι μόνο εσύ μιάς και οι χυδαιότητές σου μας βαραίνουν όλους.
“Οι ναζιστές χρησιμοποίησαν ακριβώς τα ίδια επιχειρήματα που σήμερα επιχειρούνται να χρησιμοποιηθούν κατά της Βενεζουέλας"
Σε έστειλε αδιάβαστο..
www.news247.gr/kosmos/ipex-...
“Οι ναζιστές χρησιμοποίησαν ακριβώς τα ίδια επιχειρήματα που σήμερα επιχειρούνται να χρησιμοποιηθούν κατά της Βενεζουέλας"
Σε έστειλε αδιάβαστο..
www.news247.gr/kosmos/ipex-...
ΥΠΕΞ Βενεζουέλας: Να μελετήσει διεθνές δίκαιο ο Έλληνας πρωθυπουργός
Ο Ιβάν Γκιλ Πίντο δεν έκρυψε την οργή για τις δηλώσεις του Κυριάκου Μητσοτάκη.
www.news247.gr
January 4, 2026 at 8:23 PM
Μπράβο Κυριάκο, ρεζίλι διεθνώς όχι μόνο εσύ μιάς και οι χυδαιότητές σου μας βαραίνουν όλους.
“Οι ναζιστές χρησιμοποίησαν ακριβώς τα ίδια επιχειρήματα που σήμερα επιχειρούνται να χρησιμοποιηθούν κατά της Βενεζουέλας"
Σε έστειλε αδιάβαστο..
www.news247.gr/kosmos/ipex-...
“Οι ναζιστές χρησιμοποίησαν ακριβώς τα ίδια επιχειρήματα που σήμερα επιχειρούνται να χρησιμοποιηθούν κατά της Βενεζουέλας"
Σε έστειλε αδιάβαστο..
www.news247.gr/kosmos/ipex-...
February 6, 2025 at 9:53 AM
さまざまなAIをWindowsのローカルPCで動かせる「Run llama.cpp Portable Zip on Intel GPU with IPEX-LLM」がDeepSeekにも対応したことをIntelが発表
https://gigazine.net/news/20250309-run-llama-portable-zip/
https://gigazine.net/news/20250309-run-llama-portable-zip/
さまざまなAIをWindowsのローカルPCで動かせる「Run llama.cpp Portable Zip on Intel GPU with IPEX-LLM」がDeepSeekにも対応したことをIntelが発表
近年、高度な生成AIや大規模言語モデルが多数登場していますが、それらを動作させるには高価なGPUなど、相応の機器が必要となります。しかし、Intelが提供するPyTorch用エクステンションの「IPEX-LLM」では、Intel製ディスクリートGPUなどでGemmaやLlamaなどのAIを動作させることが可能です。今回、そんなIPEX-LLMがDeepSeek R1に対応したことをIntelが発表しました。
gigazine.net
March 9, 2025 at 4:01 AM
さまざまなAIをWindowsのローカルPCで動かせる「Run llama.cpp Portable Zip on Intel GPU with IPEX-LLM」がDeepSeekにも対応したことをIntelが発表
https://gigazine.net/news/20250309-run-llama-portable-zip/
https://gigazine.net/news/20250309-run-llama-portable-zip/
🧬 Nach jahrelanger Arbeit fanden Brunkow und Ramsdell 2001 das verantwortliche Gen: FOXP3. Es steuert die Entwicklung der regulatorischen T-Zellen. Fehlende FOXP3-Funktion führt bei Mäusen und Menschen zu fatalen Autoimmunerkrankungen wie IPEX.
🕵 Damit war klar: ....
7/10
🕵 Damit war klar: ....
7/10
October 6, 2025 at 3:36 PM
🧬 Nach jahrelanger Arbeit fanden Brunkow und Ramsdell 2001 das verantwortliche Gen: FOXP3. Es steuert die Entwicklung der regulatorischen T-Zellen. Fehlende FOXP3-Funktion führt bei Mäusen und Menschen zu fatalen Autoimmunerkrankungen wie IPEX.
🕵 Damit war klar: ....
7/10
🕵 Damit war klar: ....
7/10
Trading Resumed for $IPEX Inflection Point Aq V Ords A | at 13:34:22 ET on NASDAQ | 2026-09-25
September 25, 2026 at 5:38 PM
Trading Resumed for $IPEX Inflection Point Aq V Ords A | at 13:34:22 ET on NASDAQ | 2026-09-25
Angry Chair
youtube.com/watch?v=IpEX...
youtube.com/watch?v=IpEX...
YouTube
Share your videos with friends, family, and the world
youtube.com
September 16, 2024 at 4:39 AM
Angry Chair
youtube.com/watch?v=IpEX...
youtube.com/watch?v=IpEX...
Nature research paper: iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion
go.nature.com/4qRtP6F
go.nature.com/4qRtP6F
iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion - Nature
Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification rates in multiple tissue types.
go.nature.com
November 13, 2025 at 11:17 AM
Nature research paper: iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion
go.nature.com/4qRtP6F
go.nature.com/4qRtP6F
Trading Resumed for $IPEX Inflection Point Aq V Ords A | at 13:23:40 ET on NASDAQ | 2026-09-25
September 25, 2026 at 5:31 PM
Trading Resumed for $IPEX Inflection Point Aq V Ords A | at 13:23:40 ET on NASDAQ | 2026-09-25
