#FOXP3
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altcdc.altgov.info
Time for a nerdy timeline palate cleanser: 🧬

This year’s Nobel Prize in Medicine went to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for discoveries about regulatory T cells and the Foxp3 gene -- the immune system’s built-in “brakes.”
October 6, 2025 at 8:18 PM
enirenberg.bsky.social
To program a T cell to be a regulatory T cell requires the action of a transcription factor (a protein that turns genes on or off) called FoxP3. In 2001, Mary Brunkow and Fred Ramsdell identified that IPEX syndrome was caused by mutations in FoxP3:
rdcu.be/eJHEr
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics - The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
rdcu.be
October 6, 2025 at 1:04 PM
immunoeditor.bsky.social
Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !
Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3
Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.
www.science.org
June 20, 2025 at 6:51 AM
gilman.bsky.social
Love this story about one of today's Nobel winners, Mary Brunkow.

(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)
October 6, 2025 at 1:35 PM
labwaggoner.bsky.social
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 @nature.com
www.nature.com/articles/s41...
March 27, 2025 at 3:13 AM
jibarrondo.bsky.social
Foxp3: The epigenetic engineer of regulatory T cell identity | Science Immunology www.science.org/doi/10.1126/... 🧪
Foxp3: The epigenetic engineer of regulatory T cell identity
The Foxp3 transcription factor integrates cell-intrinsic and environmental contexts with epigenetic programs to establish regulatory T cell identity.
www.science.org
May 22, 2026 at 7:30 PM
teiflab.bsky.social
Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites www.cell.com/molecular-ce...
▶️FoxP3 recognizes a variety of TnG repeat microsatellites
▶️FoxP3 multimers are ultrastable, can bridge 2–4 DNA duplexes
▶️Nucleosomes can facilitate FoxP3 assembly by inducing local DNA bending
Microsatellites are essential genomic components increasingly linked to transcriptional regulation. FoxP3, a transcription factor critical for regulatory T cell (Treg) development, recognizes TTTG repeat microsatellites by forming multimers along DNA. However, FoxP3 also binds a broader range of TnG repeats (n = 2–5), often at the edges of accessible chromatin regions. This raises questions about how FoxP3 adapts to sequence variability and the potential role of nucleosomes. Using cryoelectron microscopy and single-molecule analyses, we show that murine FoxP3 assembles into various distinct supramolecular structures, depending on DNA sequence. This structural plasticity enables FoxP3 to bridge 2–4 DNA duplexes, forming ultrastable structures that coordinate multiple genomic loci. Nucleosomes further facilitate FoxP3 assembly by inducing local DNA bending, creating a nucleus that recruits distal DNA elements through multiway bridging. Our findings thus reveal FoxP3’s unusual ability to shapeshift to accommodate evolutionarily dynamic microsatellites and its potential to reinforce chromatin boundaries and three-dimensional genomic architecture.
April 5, 2025 at 9:54 PM
sheencr.bsky.social
Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology
Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...
www.nature.com
June 4, 2025 at 7:30 AM
labwaggoner.bsky.social
Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3 @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3
Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.
www.science.org
June 7, 2025 at 3:35 AM
labwaggoner.bsky.social
Foxp3 confers long-term efficacy of CAR-T cells via metabolic reprogramming
www.cell.com/cell-metabol...
May 5, 2025 at 8:13 PM
ylepidemiologist.bsky.social
3/ They also uncovered the key protein FoxP3, which keeps those cells in check. When FoxP3 fails, it can cause a rare but severe autoimmune disease called IPEX syndrome.
👉 nobelprize.org/prizes/medicine/2025/press-release/
October 9, 2025 at 5:55 PM
margaritapk.bsky.social
Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function | Science Immunology www.science.org/doi/10.1126/...
Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function
Foxp3 integrates cell-intrinsic and environmental contexts with epigenetic programs to establish Treg cell molecular identity and function.
www.science.org
May 3, 2026 at 2:52 PM
immunoboys.bsky.social
Succinate induces Treg dysfunction by inhibiting succinyl-CoA generation. Succinyl-CoA is necessary for FOXP3 succinylation and protection of FOXP3 from proteasome degradation.

Wang et al – 2025 @natureportfolio.nature.com
www.nature.com/articles/s41...
June 28, 2025 at 5:21 PM
labwaggoner.bsky.social
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 2, 2025 at 7:37 PM
labwaggoner.bsky.social
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
www.cell.com/immunity/ful...
@cp-immunity.bsky.social @gladstoneinst.bsky.social
November 14, 2025 at 3:29 AM
labwaggoner.bsky.social
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
October 8, 2025 at 5:17 PM
lorenzadlung.com
🧬 Nach jahrelanger Arbeit fanden Brunkow und Ramsdell 2001 das verantwortliche Gen: FOXP3. Es steuert die Entwicklung der regulatorischen T-Zellen. Fehlende FOXP3-Funktion führt bei Mäusen und Menschen zu fatalen Autoimmunerkrankungen wie IPEX.

🕵 Damit war klar: ....

7/10
October 6, 2025 at 3:36 PM
daltmann.bsky.social
www.nature.com/articles/s41...
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 - Nature
The RBPJ–NCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.
www.nature.com
April 3, 2025 at 11:18 AM
lozanzi.bsky.social
#WeekendRead! #ToSuppressOrNotToSuppress! Van Der Veeken &co show @ Science Immunology that transient depletion of #Foxp3 doesn’t alter #Tregs under homeostasis but during inflammation continuous Foxp3 activity is necessary to actively suppress transcriptional programs!
Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3
Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.
www.science.org
June 8, 2025 at 2:57 PM
cyrilpedia.bsky.social
'Unexpectedly, we found the pronounced enrichment for RBPJ as a novel negative regulator of iTreg differentiation and FOXP3 expression with minimal effects in nTreg cells, highlighting the dependence on contextual cues and diverse avenues of #FOXP3 gene regulation'
#Immunology #Treg #Immunosky
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 - Nature
The RBPJ–NCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.
www.nature.com
April 2, 2025 at 10:02 PM
natimmunol.nature.com
Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation
October 6, 2025 at 3:37 PM
lozanzi.bsky.social
#WeekendRead! #ImmunometabolismPower! Wang, Fang &co show @natimmunol.nature.com that succiante is elevated in #IBD & exacerbates colitis by preventing the succinylation of FOXP3, leading to its ubiquitination & degradation, impairing Treg cell functions & favoring IL17 production!
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology
Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...
www.nature.com
June 7, 2025 at 3:06 PM
mellziland.bsky.social
Shimon Sakaguchi (Universidade de Osaka) descobriu em 1995 as células T reguladoras - aquele 'amigo com calma inexplicável' que expressa uma proteína especial: FOXP3.
October 7, 2025 at 12:41 AM
e-nox.net
It's time for #ArtAdventCalendar!

Going to try to make a new protein render each day. Today is FOXP3, which is involved in controlling the expression of numerous genes. Here shows as a domain-swapped dimer that is able to bridge two(!) strands of DNA.

More projects: e-nox.net/portfolio/

#SciArt
Illustration of the structure of the FOXP3 protein, here shown as a dimer (red translucent surface with ribbon structure visible inside) binding with two separate strands of DNA (glowing yellow)
December 1, 2025 at 4:45 PM
proteinimaging.bsky.social
Here you can see a cryoEM structure showing how FoxP3 multimers bridge two T4G repeat DNAs (PDB code: 9D2J)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #foxp3 #transcription #multimer #bridge #cryoem
May 23, 2026 at 10:01 AM