A new study explores how host immune pressure may shape HPV16 evolution, with implications for viral persistence and disease outcomes.
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
September 25, 2026 at 10:15 AM
A new study explores how host immune pressure may shape HPV16 evolution, with implications for viral persistence and disease outcomes.
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
#PersistentInfection of HPV requires genome maintenance and partitioning during cell division, but #LiveCellMonitoring tools were lacking. This study applies #ANCHOR technology to visualise HPV18 genome tethering, providing a tool for therapy development. ➡️bit.ly/3ITp8Yu
#IPVSPaperoftheWeek
#IPVSPaperoftheWeek
August 1, 2025 at 6:55 AM
#PersistentInfection of HPV requires genome maintenance and partitioning during cell division, but #LiveCellMonitoring tools were lacking. This study applies #ANCHOR technology to visualise HPV18 genome tethering, providing a tool for therapy development. ➡️bit.ly/3ITp8Yu
#IPVSPaperoftheWeek
#IPVSPaperoftheWeek
New study in Annals of Internal Medicine: anal cancer screening is cost-effective for MSM living with HIV aged 35+➡️ bit.ly/40VTakk
Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPV #HIV #CancerScreening
Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPV #HIV #CancerScreening
July 18, 2025 at 6:43 AM
New study in Annals of Internal Medicine: anal cancer screening is cost-effective for MSM living with HIV aged 35+➡️ bit.ly/40VTakk
Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPV #HIV #CancerScreening
Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPV #HIV #CancerScreening
Can HPV in semen affect fertility outcomes? This prospective cohort study examined HPV prevalence in infertile men and its potential impact on ART success. While no major effects were found, subtle trends suggest HPV status may still matter.
Read the paper👉bit.ly/3Tkt1aC
#IPVSPaperOfTheWeek
Read the paper👉bit.ly/3Tkt1aC
#IPVSPaperOfTheWeek
June 13, 2025 at 5:34 AM
Can HPV in semen affect fertility outcomes? This prospective cohort study examined HPV prevalence in infertile men and its potential impact on ART success. While no major effects were found, subtle trends suggest HPV status may still matter.
Read the paper👉bit.ly/3Tkt1aC
#IPVSPaperOfTheWeek
Read the paper👉bit.ly/3Tkt1aC
#IPVSPaperOfTheWeek
This multinational study found a positive association between higher monthly alcohol consumption and oral high-risk HPV (HR-HPV) infection among men, suggesting alcohol as a modifiable risk factor: pubmed.ncbi.nlm.nih.gov/42005087
Highlights are summarised below ⬇️
#IPVSPaperoftheWeek
Highlights are summarised below ⬇️
#IPVSPaperoftheWeek
June 26, 2026 at 6:33 AM
This multinational study found a positive association between higher monthly alcohol consumption and oral high-risk HPV (HR-HPV) infection among men, suggesting alcohol as a modifiable risk factor: pubmed.ncbi.nlm.nih.gov/42005087
Highlights are summarised below ⬇️
#IPVSPaperoftheWeek
Highlights are summarised below ⬇️
#IPVSPaperoftheWeek
Swedish registry data show that husbands of women with anogenital cancer face increased HPV-related tonsillar and base-of-tongue squamous cell carcinoma risk, rising over time and highest in men under age 50, indicating spousal clustering. ➡️ bit.ly/4p8kcyn
#IPVSPaperOfTheWeek
#IPVSPaperOfTheWeek
December 19, 2025 at 8:08 AM
Swedish registry data show that husbands of women with anogenital cancer face increased HPV-related tonsillar and base-of-tongue squamous cell carcinoma risk, rising over time and highest in men under age 50, indicating spousal clustering. ➡️ bit.ly/4p8kcyn
#IPVSPaperOfTheWeek
#IPVSPaperOfTheWeek
#BetaHPV49, linked to skin cancer, uses a splice site in E6 previously seen only in #highrisk alpha-HPV. This site regulates E6 levels and is essential for keratinocyte immortalisation, revealing similarities in #viralpathogenesis.
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
June 6, 2025 at 6:56 AM
#BetaHPV49, linked to skin cancer, uses a splice site in E6 previously seen only in #highrisk alpha-HPV. This site regulates E6 levels and is essential for keratinocyte immortalisation, revealing similarities in #viralpathogenesis.
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
Read the paper 👉https://bit.ly/4dTHST5
#IPVSPaperOfTheWeek
HPV test results aren’t just "new infection vs clearance": many are reactivations or low-level persistence. A new #IPVS review urges framing as “HPV detected” vs “not detected” to better guide counseling, screening & vaccination.
Read more 👉https://bit.ly/4cUR09k
#IPVSPaperOfTheWeek
Read more 👉https://bit.ly/4cUR09k
#IPVSPaperOfTheWeek
May 2, 2025 at 6:57 AM
HPV test results aren’t just "new infection vs clearance": many are reactivations or low-level persistence. A new #IPVS review urges framing as “HPV detected” vs “not detected” to better guide counseling, screening & vaccination.
Read more 👉https://bit.ly/4cUR09k
#IPVSPaperOfTheWeek
Read more 👉https://bit.ly/4cUR09k
#IPVSPaperOfTheWeek
Nuclear K6A boosts #HPV16 oncogene expression via TEAD1, offering insight into #viral-gene-regulation, cervical cancer development, and cell-type-specific oncogenic susceptibility.
Read the paper➡️bit.ly/46qhcHK
#IPVSPaperoftheWeek
Read the paper➡️bit.ly/46qhcHK
#IPVSPaperoftheWeek
July 4, 2025 at 6:30 AM
Nuclear K6A boosts #HPV16 oncogene expression via TEAD1, offering insight into #viral-gene-regulation, cervical cancer development, and cell-type-specific oncogenic susceptibility.
Read the paper➡️bit.ly/46qhcHK
#IPVSPaperoftheWeek
Read the paper➡️bit.ly/46qhcHK
#IPVSPaperoftheWeek
Recent study in India found the presence of HPV58 and HPV59 in #oropharyngeal #cancer cases. The HPV burden at this site may expand beyond just HPV16/18. Tobacco and alcohol still remain important risk factors for this cancer.
📄 Read the paper: bit.ly/3Jl5aGm
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 Read the paper: bit.ly/3Jl5aGm
Paper highlights ⬇️
#IPVSPaperoftheWeek
August 22, 2025 at 6:44 AM
Recent study in India found the presence of HPV58 and HPV59 in #oropharyngeal #cancer cases. The HPV burden at this site may expand beyond just HPV16/18. Tobacco and alcohol still remain important risk factors for this cancer.
📄 Read the paper: bit.ly/3Jl5aGm
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 Read the paper: bit.ly/3Jl5aGm
Paper highlights ⬇️
#IPVSPaperoftheWeek
New study published in the JNCI: Journal of the National Cancer Institute on the risk of #HPV-related squamous cell carcinomas in 7936 survivors of autologous or allogeneic blood or marrow transplantation #openaccess: bit.ly/3RIvcUE
#HPV #IPVSPaperOfTheWeek
#HPV #IPVSPaperOfTheWeek
April 11, 2025 at 7:26 AM
New study published in the JNCI: Journal of the National Cancer Institute on the risk of #HPV-related squamous cell carcinomas in 7936 survivors of autologous or allogeneic blood or marrow transplantation #openaccess: bit.ly/3RIvcUE
#HPV #IPVSPaperOfTheWeek
#HPV #IPVSPaperOfTheWeek
This narrative review synthesizes evidence that HPV DNA, E6/E7 mRNA, and DNA methylation biomarkers reflect complementary stages of persistent HPV infection and may improve HPV-based screening and risk stratification.
🔗https://pubmed.ncbi.nlm.nih.gov/41899583/
#IPVSPaperoftheWeek
🔗https://pubmed.ncbi.nlm.nih.gov/41899583/
#IPVSPaperoftheWeek
July 31, 2026 at 8:23 AM
This narrative review synthesizes evidence that HPV DNA, E6/E7 mRNA, and DNA methylation biomarkers reflect complementary stages of persistent HPV infection and may improve HPV-based screening and risk stratification.
🔗https://pubmed.ncbi.nlm.nih.gov/41899583/
#IPVSPaperoftheWeek
🔗https://pubmed.ncbi.nlm.nih.gov/41899583/
#IPVSPaperoftheWeek
A study by Giesbrecht et al. on wastewater testing reveals 24 circulating HPV types in Canada, including high-risk and vaccine-preventable types like HPV-16 and -18. A promising tool for public health surveillance. @umanitoba.bsky.social
➡️ bit.ly/44CnCRC
#IPVSPaperOfTheWeek
➡️ bit.ly/44CnCRC
#IPVSPaperOfTheWeek
July 11, 2025 at 7:17 AM
A study by Giesbrecht et al. on wastewater testing reveals 24 circulating HPV types in Canada, including high-risk and vaccine-preventable types like HPV-16 and -18. A promising tool for public health surveillance. @umanitoba.bsky.social
➡️ bit.ly/44CnCRC
#IPVSPaperOfTheWeek
➡️ bit.ly/44CnCRC
#IPVSPaperOfTheWeek
New phase 3 evidence from China shows that an E. coli-produced nine-valent HPV vaccine demonstrated high efficacy against persistent infection with five additional high-risk HPV types.
🔗 bit.ly/4qlveTc
#IPVSPaperoftheWeek
🔗 bit.ly/4qlveTc
#IPVSPaperoftheWeek
August 14, 2026 at 8:39 AM
New phase 3 evidence from China shows that an E. coli-produced nine-valent HPV vaccine demonstrated high efficacy against persistent infection with five additional high-risk HPV types.
🔗 bit.ly/4qlveTc
#IPVSPaperoftheWeek
🔗 bit.ly/4qlveTc
#IPVSPaperoftheWeek
New paper published in the JNCI: Journal of the National Cancer Institute on racial and ethnic heterogeneity in #HPV-related cancers by anatomical site 👉https://bit.ly/43hE5Kb
#IPVSPaperOfTheWeek #Epidemiology #HPVCancer
#IPVSPaperOfTheWeek #Epidemiology #HPVCancer
May 16, 2025 at 7:40 AM
New paper published in the JNCI: Journal of the National Cancer Institute on racial and ethnic heterogeneity in #HPV-related cancers by anatomical site 👉https://bit.ly/43hE5Kb
#IPVSPaperOfTheWeek #Epidemiology #HPVCancer
#IPVSPaperOfTheWeek #Epidemiology #HPVCancer
Large, long-term Swedish cohort study shows 1–2 doses of quadrivalent #HPVvaccine before age 15 protect against high-grade cervical lesions comparable to 3 doses.
📄 Full paper: bit.ly/4oR90au
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 Full paper: bit.ly/4oR90au
Paper highlights ⬇️
#IPVSPaperoftheWeek
August 15, 2025 at 7:21 AM
Large, long-term Swedish cohort study shows 1–2 doses of quadrivalent #HPVvaccine before age 15 protect against high-grade cervical lesions comparable to 3 doses.
📄 Full paper: bit.ly/4oR90au
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 Full paper: bit.ly/4oR90au
Paper highlights ⬇️
#IPVSPaperoftheWeek
New population-based study from Portugal shows that #HPVVaccination and long-standing screening are associated with substantial reductions in high-grade cervical lesions, particularly among younger women, alongside a shift in HPV genotype distribution.
🔗 bit.ly/3NZMf6x
#IPVSPaperoftheWeek
🔗 bit.ly/3NZMf6x
#IPVSPaperoftheWeek
March 27, 2026 at 8:11 AM
New population-based study from Portugal shows that #HPVVaccination and long-standing screening are associated with substantial reductions in high-grade cervical lesions, particularly among younger women, alongside a shift in HPV genotype distribution.
🔗 bit.ly/3NZMf6x
#IPVSPaperoftheWeek
🔗 bit.ly/3NZMf6x
#IPVSPaperoftheWeek
New global analysis shows major inequities in #CervicalCancer screening and follow-up. Integrating #SelfCollection and #HPV point-of-care testing is a promising step toward equitable #Screening and #CancerControl. ➡️ bit.ly/46816Rx
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
September 5, 2025 at 6:42 AM
New global analysis shows major inequities in #CervicalCancer screening and follow-up. Integrating #SelfCollection and #HPV point-of-care testing is a promising step toward equitable #Screening and #CancerControl. ➡️ bit.ly/46816Rx
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
New study: DNA methylation testing on cervical biopsies found positivity only in high-grade (HSIL) lesions, tied to HPV16 and higher Ki-67 - all low-grade samples were negative. Could help stratify lesion risk.
🔗https://bit.ly/46u6T4e
#IPVSPaperOfTheWeek
🔗https://bit.ly/46u6T4e
#IPVSPaperOfTheWeek
August 28, 2026 at 1:54 PM
New study: DNA methylation testing on cervical biopsies found positivity only in high-grade (HSIL) lesions, tied to HPV16 and higher Ki-67 - all low-grade samples were negative. Could help stratify lesion risk.
🔗https://bit.ly/46u6T4e
#IPVSPaperOfTheWeek
🔗https://bit.ly/46u6T4e
#IPVSPaperOfTheWeek
New evidence from India: first-void urine HPV testing performs comparably to vaginal self-sampling & is highly acceptable to women — a feasible option for expanding cervical cancer screening in resource-limited settings.
📄 Read more: bit.ly/IPVSPaperoft...
#IPVSPaperoftheWeek
📄 Read more: bit.ly/IPVSPaperoft...
#IPVSPaperoftheWeek
July 10, 2026 at 6:34 AM
New evidence from India: first-void urine HPV testing performs comparably to vaginal self-sampling & is highly acceptable to women — a feasible option for expanding cervical cancer screening in resource-limited settings.
📄 Read more: bit.ly/IPVSPaperoft...
#IPVSPaperoftheWeek
📄 Read more: bit.ly/IPVSPaperoft...
#IPVSPaperoftheWeek
A global systematic review reveals most (148/194) countries have introduced HPV vaccination, but coverage among girls aged 9–14 remains far below target. Coverage is highest in upper-middle-income countries, indicating geographic disparities.
📄 bit.ly/4mWLVBF
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 bit.ly/4mWLVBF
Paper highlights ⬇️
#IPVSPaperoftheWeek
September 12, 2025 at 7:30 AM
A global systematic review reveals most (148/194) countries have introduced HPV vaccination, but coverage among girls aged 9–14 remains far below target. Coverage is highest in upper-middle-income countries, indicating geographic disparities.
📄 bit.ly/4mWLVBF
Paper highlights ⬇️
#IPVSPaperoftheWeek
📄 bit.ly/4mWLVBF
Paper highlights ⬇️
#IPVSPaperoftheWeek
A woman with an immune defect developed #betaHPV–integrated skin cancer. Stem-cell transplant restored T-cell function and cleared all HPV diseases — revealing the direct #carcinogenicity of β-HPV under immune deficiency. ➡️ bit.ly/3HwYRis
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
August 29, 2025 at 5:15 AM
A woman with an immune defect developed #betaHPV–integrated skin cancer. Stem-cell transplant restored T-cell function and cleared all HPV diseases — revealing the direct #carcinogenicity of β-HPV under immune deficiency. ➡️ bit.ly/3HwYRis
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
Paper highlights have been summarized ⬇️
#IPVSPaperoftheWeek
People with HIV are at higher risk for head and neck cancer.
Recent study found that HIV was associated with 43 % higher hazard of death for oropharyngeal cancer. Read the paper➡️bit.ly/46qm9QV Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPVResearch
Recent study found that HIV was associated with 43 % higher hazard of death for oropharyngeal cancer. Read the paper➡️bit.ly/46qm9QV Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPVResearch
July 25, 2025 at 8:49 AM
People with HIV are at higher risk for head and neck cancer.
Recent study found that HIV was associated with 43 % higher hazard of death for oropharyngeal cancer. Read the paper➡️bit.ly/46qm9QV Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPVResearch
Recent study found that HIV was associated with 43 % higher hazard of death for oropharyngeal cancer. Read the paper➡️bit.ly/46qm9QV Paper highlights have been summarized 👇
#IPVSPaperoftheWeek #HPVResearch
New hope for penile cancer: Trop-2 is highly expressed in HPV-positive tumors, supporting sacituzumab govitecan as a promising targeted therapy. Nectin-4 expression is limited—biopsy of metastases is key before treatment.
Read the paper 👉 bit.ly/4kebgFC
#IPVSPaperOfTheWeek #cancerresearch
Read the paper 👉 bit.ly/4kebgFC
#IPVSPaperOfTheWeek #cancerresearch
May 9, 2025 at 6:50 AM
New hope for penile cancer: Trop-2 is highly expressed in HPV-positive tumors, supporting sacituzumab govitecan as a promising targeted therapy. Nectin-4 expression is limited—biopsy of metastases is key before treatment.
Read the paper 👉 bit.ly/4kebgFC
#IPVSPaperOfTheWeek #cancerresearch
Read the paper 👉 bit.ly/4kebgFC
#IPVSPaperOfTheWeek #cancerresearch
New prospective evidence suggests that on-treatment HPV ctDNA could help identify patients with HPV-positive oropharyngeal cancer who may be suitable for de-intensified therapy.
🔗https://www.nature.com/articles/s41467-026-72984-7
#IPVSPaperOfTheWeek
🔗https://www.nature.com/articles/s41467-026-72984-7
#IPVSPaperOfTheWeek
September 18, 2026 at 1:53 PM
New prospective evidence suggests that on-treatment HPV ctDNA could help identify patients with HPV-positive oropharyngeal cancer who may be suitable for de-intensified therapy.
🔗https://www.nature.com/articles/s41467-026-72984-7
#IPVSPaperOfTheWeek
🔗https://www.nature.com/articles/s41467-026-72984-7
#IPVSPaperOfTheWeek