January 1, 2026 at 10:14 AM
The 4-valent and 9-valent HPV vaccines essentially eliminated HPV 16/18 in Denmark: “prevalence of [HPV16/18] in the samples decreased to < 1% in 2021 from 15–17% before vaccination
This is amazing. HPV16/18 are the most common high risk subtypes to cause cervical cancer. #meded #oncsky #radonc 🧪
This is amazing. HPV16/18 are the most common high risk subtypes to cause cervical cancer. #meded #oncsky #radonc 🧪
👧🏽 Since 2008, vaccination against human papillomavirus #HPV is free for girls in Denmark
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
Vaccines work: Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
In 2008, Denmark started to offer free vaccination against human papillomavirus (HPV) with the 4-valent HPV vaccine to teenage girls around the age of 14. New data from a cohort study presenting resul...
www.eurekalert.org
July 11, 2025 at 2:33 PM
#ScienceSunday
#Vaccines
Here is another example where scientists have generated systemic immunity against human papilloma virus using nasal delivery of a cationic nanogel containing the HPV16 E7 protein as an antigen. In addition, an anti-tumor effect was seen. Game-changing!
Vaccines save lives.
#Vaccines
Here is another example where scientists have generated systemic immunity against human papilloma virus using nasal delivery of a cationic nanogel containing the HPV16 E7 protein as an antigen. In addition, an anti-tumor effect was seen. Game-changing!
Vaccines save lives.
Cationic nanogel–based nasal therapeutic HPV vaccine prevents the development of cervical cancer
Cationic nanogel–based nasal therapeutic vaccine induces cancer-specific immune responses and inhibits cancer development in cervical tissue.
www.science.org
November 16, 2025 at 12:07 PM
#ScienceSunday
#Vaccines
Here is another example where scientists have generated systemic immunity against human papilloma virus using nasal delivery of a cationic nanogel containing the HPV16 E7 protein as an antigen. In addition, an anti-tumor effect was seen. Game-changing!
Vaccines save lives.
#Vaccines
Here is another example where scientists have generated systemic immunity against human papilloma virus using nasal delivery of a cationic nanogel containing the HPV16 E7 protein as an antigen. In addition, an anti-tumor effect was seen. Game-changing!
Vaccines save lives.
5. NIH researchers identified the particles in HPV that cause cancer. The resulting vaccine has shown to be 100% effective in preventing HPV16 and HPV18, the two deadliest forms of the virus. In the coming decades, this work will prevent millions of people from developing cancer.
March 3, 2025 at 2:29 PM
5. NIH researchers identified the particles in HPV that cause cancer. The resulting vaccine has shown to be 100% effective in preventing HPV16 and HPV18, the two deadliest forms of the virus. In the coming decades, this work will prevent millions of people from developing cancer.
Denmark is on track to wipe out the most dangerous strains of HPV. New data shows the vaccine has all but wiped out HPV16 and HPV18. It's a powerful proof point for what widespread, equitable vaccine coverage can do. buff.ly/3do5Sfo
#ShareGoodNewsToo
#ShareGoodNewsToo
Denmark close to wiping out leading cancer-causing HPV strains after vaccine roll-out
A nationwide study suggests infections with human papillomavirus (HPV) types 16 and 18 have been virtually eliminated since vaccination began in 2008 – protecting even unvaccinated women.
buff.ly
September 15, 2025 at 12:50 PM
Denmark is on track to wipe out the most dangerous strains of HPV. New data shows the vaccine has all but wiped out HPV16 and HPV18. It's a powerful proof point for what widespread, equitable vaccine coverage can do. buff.ly/3do5Sfo
#ShareGoodNewsToo
#ShareGoodNewsToo
"Results of the first randomized controlled trial of single-dose HPV vaccine, published in Lancet Global Health in March 2024, showed greater than 97% efficacy against the HPV16 and HPV18 strains at 36 months among women in Kenya."
Imagine virtually ending cervical cancer.
Imagine virtually ending cervical cancer.
Now that the World Health Organization has endorsed a one-dose vaccine, global health groups are amping up their effort to inoculate the world's girls. How are they doing?
Whatever happened to ... the global effort to wipe out cervical cancer with a vaccine?
Now that the World Health Organization has endorsed a one-dose vaccine, global health groups are amping up their effort to inoculate the world's girls. How are they doing?
www.npr.org
September 12, 2024 at 9:28 PM
"Results of the first randomized controlled trial of single-dose HPV vaccine, published in Lancet Global Health in March 2024, showed greater than 97% efficacy against the HPV16 and HPV18 strains at 36 months among women in Kenya."
Imagine virtually ending cervical cancer.
Imagine virtually ending cervical cancer.
#Vaccines winning vs HPV and cervical cancer.
"Based on the data gathered during the study period, HPV16/18 has been almost eliminated among vaccinated women in Denmark: prevalence of these two types in the samples decreased to < 1% in 2021 from 15–17% before vaccination of girls."
#Vaccineswork
"Based on the data gathered during the study period, HPV16/18 has been almost eliminated among vaccinated women in Denmark: prevalence of these two types in the samples decreased to < 1% in 2021 from 15–17% before vaccination of girls."
#Vaccineswork
👧🏽 Since 2008, vaccination against human papillomavirus #HPV is free for girls in Denmark
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
Vaccines work: Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
In 2008, Denmark started to offer free vaccination against human papillomavirus (HPV) with the 4-valent HPV vaccine to teenage girls around the age of 14. New data from a cohort study presenting resul...
www.eurekalert.org
July 12, 2025 at 12:01 PM
#Vaccines winning vs HPV and cervical cancer.
"Based on the data gathered during the study period, HPV16/18 has been almost eliminated among vaccinated women in Denmark: prevalence of these two types in the samples decreased to < 1% in 2021 from 15–17% before vaccination of girls."
#Vaccineswork
"Based on the data gathered during the study period, HPV16/18 has been almost eliminated among vaccinated women in Denmark: prevalence of these two types in the samples decreased to < 1% in 2021 from 15–17% before vaccination of girls."
#Vaccineswork
Before vaccination, the prevalence of HPV16/18 was between 15 and 17%, which has decreased in vaccinated women to less than 1% by 2021
Wow 👏🏽👏🏽
Wow 👏🏽👏🏽
September 9, 2025 at 1:17 AM
Before vaccination, the prevalence of HPV16/18 was between 15 and 17%, which has decreased in vaccinated women to less than 1% by 2021
Wow 👏🏽👏🏽
Wow 👏🏽👏🏽
A new study explores how host immune pressure may shape HPV16 evolution, with implications for viral persistence and disease outcomes.
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
September 25, 2026 at 10:15 AM
A new study explores how host immune pressure may shape HPV16 evolution, with implications for viral persistence and disease outcomes.
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
Full paper link: www.nature.com/articles/s41...
#IPVSPaperOfTheWeek
@chasewnelson.bsky.social
@lisamirabello.bsky.social
@nature.com
@einsteinmededu.bsky.social
A therapeutic HPV vaccine could eliminate precancerous cervical lesions @AACR #Oncology #News #HPV #vaccine #Cancer
"Treatment with Vvax001 is safe, feasible, and shows preliminary clinical effectiveness in patients with HPV16-associated CIN3 lesions."
aacrjournals.org/clincancerre...
"Treatment with Vvax001 is safe, feasible, and shows preliminary clinical effectiveness in patients with HPV16-associated CIN3 lesions."
aacrjournals.org/clincancerre...
January 24, 2025 at 10:16 AM
Buz Adam Ötzi..
En meşhur atalarımızdan
Bulan iki dağcı, Erica ve Helmut, Alp Dağlarında 1991’de tesadüfen karşılaştılar..
Detaylı şekilde yeniden okuyorum
Çünkü onda HPV16- kanser yapan virüs bulundu ..
5300 yaşında..
Ve bedeninde 69 dövme..
HPV’nin izine düşünce..
En meşhur atalarımızdan
Bulan iki dağcı, Erica ve Helmut, Alp Dağlarında 1991’de tesadüfen karşılaştılar..
Detaylı şekilde yeniden okuyorum
Çünkü onda HPV16- kanser yapan virüs bulundu ..
5300 yaşında..
Ve bedeninde 69 dövme..
HPV’nin izine düşünce..
February 16, 2026 at 9:27 AM
Buz Adam Ötzi..
En meşhur atalarımızdan
Bulan iki dağcı, Erica ve Helmut, Alp Dağlarında 1991’de tesadüfen karşılaştılar..
Detaylı şekilde yeniden okuyorum
Çünkü onda HPV16- kanser yapan virüs bulundu ..
5300 yaşında..
Ve bedeninde 69 dövme..
HPV’nin izine düşünce..
En meşhur atalarımızdan
Bulan iki dağcı, Erica ve Helmut, Alp Dağlarında 1991’de tesadüfen karşılaştılar..
Detaylı şekilde yeniden okuyorum
Çünkü onda HPV16- kanser yapan virüs bulundu ..
5300 yaşında..
Ve bedeninde 69 dövme..
HPV’nin izine düşünce..
and maybe a year to get my strength back. I won't know for another 3 months whether the treatment has worked.
I posted this because my cancer was caused by the HPV16 virus, for which we now have a safe and effective vaccine.
Get your kids vaccinated.
I posted this because my cancer was caused by the HPV16 virus, for which we now have a safe and effective vaccine.
Get your kids vaccinated.
February 25, 2026 at 7:16 PM
and maybe a year to get my strength back. I won't know for another 3 months whether the treatment has worked.
I posted this because my cancer was caused by the HPV16 virus, for which we now have a safe and effective vaccine.
Get your kids vaccinated.
I posted this because my cancer was caused by the HPV16 virus, for which we now have a safe and effective vaccine.
Get your kids vaccinated.
Painful, powerful post from @Jaberwock22, who is one of the most insightful observers of #$TSLA anywhere. Bottom line, his agony was caused by the HPV16 virus, for which there is now a vaccination. As he urges, please, get your child vaccinated with the Gardisal-9 vaccine.
I recently completed a course of 35 radiation treatments for tonsil cancer. I was diagnosed last November, the first step was to have a tracheostomy to provide me with a means of breathing in case my throat became blocked. That was 17 days in hospital, I tested positive for COVID. The radiation ....
February 25, 2026 at 10:44 PM
Painful, powerful post from @Jaberwock22, who is one of the most insightful observers of #$TSLA anywhere. Bottom line, his agony was caused by the HPV16 virus, for which there is now a vaccination. As he urges, please, get your child vaccinated with the Gardisal-9 vaccine.
cn krebsvorstufe
die ärztin hat angerufen. cin 3, der gleiche befund wie beim letzten mal. hpv16 (stamm bei mir nachgewiesen), ist wohl sehr aggressiv und auch die impfung (zwei dosen schon drin) wird daran auch nicht viel ändern können. aber, eine weitere konisation medizinisch vertretbar \o/
die ärztin hat angerufen. cin 3, der gleiche befund wie beim letzten mal. hpv16 (stamm bei mir nachgewiesen), ist wohl sehr aggressiv und auch die impfung (zwei dosen schon drin) wird daran auch nicht viel ändern können. aber, eine weitere konisation medizinisch vertretbar \o/
May 19, 2026 at 3:17 PM
cn krebsvorstufe
die ärztin hat angerufen. cin 3, der gleiche befund wie beim letzten mal. hpv16 (stamm bei mir nachgewiesen), ist wohl sehr aggressiv und auch die impfung (zwei dosen schon drin) wird daran auch nicht viel ändern können. aber, eine weitere konisation medizinisch vertretbar \o/
die ärztin hat angerufen. cin 3, der gleiche befund wie beim letzten mal. hpv16 (stamm bei mir nachgewiesen), ist wohl sehr aggressiv und auch die impfung (zwei dosen schon drin) wird daran auch nicht viel ändern können. aber, eine weitere konisation medizinisch vertretbar \o/
A review of 274 studies confirms HPV vaccine is safe and effective.
🔹 66% lower cervical cancer risk (80% if vaccinated ≤16 yrs)
🔹 90% reduction in persistent HPV16/18 infection at 12 months
🔹 No link to serious adverse events
Study is here: vaxintegrity.cidrap.umn.edu/sites/defaul...
🔹 66% lower cervical cancer risk (80% if vaccinated ≤16 yrs)
🔹 90% reduction in persistent HPV16/18 infection at 12 months
🔹 No link to serious adverse events
Study is here: vaxintegrity.cidrap.umn.edu/sites/defaul...
May 21, 2026 at 6:01 PM
A review of 274 studies confirms HPV vaccine is safe and effective.
🔹 66% lower cervical cancer risk (80% if vaccinated ≤16 yrs)
🔹 90% reduction in persistent HPV16/18 infection at 12 months
🔹 No link to serious adverse events
Study is here: vaxintegrity.cidrap.umn.edu/sites/defaul...
🔹 66% lower cervical cancer risk (80% if vaccinated ≤16 yrs)
🔹 90% reduction in persistent HPV16/18 infection at 12 months
🔹 No link to serious adverse events
Study is here: vaxintegrity.cidrap.umn.edu/sites/defaul...
Looking at the scientific #evidence
The #vaccine against human papillomavirus #HPV has been effective in reducing infections with vaccine-covered HPV types (HPV16/18), the HPV types responsible for over 70% of #cervicalcancer
#Medsky🧪 #IDsky #immunosky #pedsky #publichealth 🛟🧫 #STISky #CancerSky
The #vaccine against human papillomavirus #HPV has been effective in reducing infections with vaccine-covered HPV types (HPV16/18), the HPV types responsible for over 70% of #cervicalcancer
#Medsky🧪 #IDsky #immunosky #pedsky #publichealth 🛟🧫 #STISky #CancerSky
👧🏽 Since 2008, vaccination against human papillomavirus #HPV is free for girls in Denmark
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
🔎 Researchers looked at 16,955 cervical cell samples from 8,659 women over a 7-year study period
📉 #vaccination has effectively reduced infections with cancerogenic HPV 16/18 types
#IDSky #MedSky #STISky 🧪🩺
Vaccines work: Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
In 2008, Denmark started to offer free vaccination against human papillomavirus (HPV) with the 4-valent HPV vaccine to teenage girls around the age of 14. New data from a cohort study presenting resul...
www.eurekalert.org
September 23, 2025 at 7:38 AM
Looking at the scientific #evidence
The #vaccine against human papillomavirus #HPV has been effective in reducing infections with vaccine-covered HPV types (HPV16/18), the HPV types responsible for over 70% of #cervicalcancer
#Medsky🧪 #IDsky #immunosky #pedsky #publichealth 🛟🧫 #STISky #CancerSky
The #vaccine against human papillomavirus #HPV has been effective in reducing infections with vaccine-covered HPV types (HPV16/18), the HPV types responsible for over 70% of #cervicalcancer
#Medsky🧪 #IDsky #immunosky #pedsky #publichealth 🛟🧫 #STISky #CancerSky
…precancers or even cancers. Again, it’s a preliminary Phase II clinical trial, but it’s such a hopeful study given the data and the biological plausibility. aacrjournals.org/clincancerre...
Vvax001, a Therapeutic Vaccine for Patients with HPV16-positive High-grade Cervical Intraepithelial Neoplasia: a Phase II Trial
Abstract. Purpose: Human papillomavirus (HPV) infection is the major cause of (pre)malignant cervical lesions. We previously demonstrated that Vvax001, a replication-incompetent Semliki Forest virus (...
aacrjournals.org
January 27, 2025 at 1:08 AM
…precancers or even cancers. Again, it’s a preliminary Phase II clinical trial, but it’s such a hopeful study given the data and the biological plausibility. aacrjournals.org/clincancerre...
OUT NOW in Nat Commns @natcomms.nature.com: HPV16 causes the majority of the 1,800 cervical cancers diagnosed every single day, but most infections are controlled by the immune system.
Our study shows that these disparate outcomes are shaped by genetic variation in both host and virus. 🧬 1/9
Our study shows that these disparate outcomes are shaped by genetic variation in both host and virus. 🧬 1/9
July 27, 2026 at 3:47 PM
OUT NOW in Nat Commns @natcomms.nature.com: HPV16 causes the majority of the 1,800 cervical cancers diagnosed every single day, but most infections are controlled by the immune system.
Our study shows that these disparate outcomes are shaped by genetic variation in both host and virus. 🧬 1/9
Our study shows that these disparate outcomes are shaped by genetic variation in both host and virus. 🧬 1/9
Endocervical adenocarcinoma in situ (AIS). While HPV16 is the most frequent subtype detected in AIS, it shows a stronger association with HPV18 relative to high grade squamous lesions.
#pathsky #medsky #pathology #gynpath
#pathsky #medsky #pathology #gynpath
November 14, 2024 at 2:18 PM
Endocervical adenocarcinoma in situ (AIS). While HPV16 is the most frequent subtype detected in AIS, it shows a stronger association with HPV18 relative to high grade squamous lesions.
#pathsky #medsky #pathology #gynpath
#pathsky #medsky #pathology #gynpath
PDS Biotech's PDS0101 combined with Merck's Keytruda reached 39.3 months median overall survival in Phase 2 HPV16-positive head and neck cancer. VERSATILE-002 results now in JAMA Oncology.
PDS Biotech's PDS0101 combo shows 39-month survival in HNSCC trial
VERSATILE-002 Phase 2 results, published in JAMA Oncology, showed 39.3 months median overall survival in HPV16-positive head and neck cancer, more than
biotech.disruptsmedia.com
September 27, 2026 at 6:30 PM
PDS Biotech's PDS0101 combined with Merck's Keytruda reached 39.3 months median overall survival in Phase 2 HPV16-positive head and neck cancer. VERSATILE-002 results now in JAMA Oncology.
Analyzing 4704 HPV16 genomes reveals 56 codons under positive selection. Host immunity shapes viral evolution more than thought. HLA class I's role is crucial! PMID:42230578, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73531-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
HPV16 genetic variation provides evidence of positive natural selection driven by HLA class I | Nature Communications
Human papillomavirus type 16 (HPV16) causes more cancer than any other virus. However, most HPV16 infections are controlled by the host’s immune system and it remains unclear how viral and host genetic variation contribute to infection outcomes. Here, we analyze 4704 HPV16 whole genomes to identify 56 viral codons putatively under positive natural selection to change their amino acids, with evidence including dN/dS > 1, evolutionary convergence, and structural importance in the protein. We find that codons under positive selection disproportionately overlap known HPV16 immune epitopes recognized by cytotoxic T lymphocytes, particularly those restricted by the previously reported risk allele HLA-B*07:02 (odds ratio [OR] = 4.9; 95%CI = 2.1–10.3; PFisher = 0.00015), exemplified by position 10 of the E6 oncoprotein. Positively selected codons also disproportionately overlap 158 nucleotide sites at which the evolutionary sub/lineages of HPV16 have diverged (OR = 19.1; 95%CI = 10.5–34.7;
doi.org
July 4, 2026 at 10:00 AM
Alt text: post by Kevin Fenton @profkevinfenton
BREAKING:
Denmark has effectively eliminated the main cancer-causing HPV strains
HPV16 and HPV18
infections are now under one percent after vaccination.
This is why vaccination matters.
BREAKING:
Denmark has effectively eliminated the main cancer-causing HPV strains
HPV16 and HPV18
infections are now under one percent after vaccination.
This is why vaccination matters.
January 2, 2026 at 3:19 AM
Alt text: post by Kevin Fenton @profkevinfenton
BREAKING:
Denmark has effectively eliminated the main cancer-causing HPV strains
HPV16 and HPV18
infections are now under one percent after vaccination.
This is why vaccination matters.
BREAKING:
Denmark has effectively eliminated the main cancer-causing HPV strains
HPV16 and HPV18
infections are now under one percent after vaccination.
This is why vaccination matters.
First-author paper representing years of work on HPV16 — the most carcinogenic human papillomavirus — has been officially ACCEPTED at Nature Communications! So excited to share our findings once it’s out. These folks truly make the world go ‘round 💕
May 6, 2026 at 10:53 AM
First-author paper representing years of work on HPV16 — the most carcinogenic human papillomavirus — has been officially ACCEPTED at Nature Communications! So excited to share our findings once it’s out. These folks truly make the world go ‘round 💕
Dutch study demonstrates high HPV vaccine effectiveness against HPV16 and HPV18 infections up to 14 years after a two-dose and three-dose schedule, with no signs of waning and significant indirect effects academic.oup.com/jid/advance-...
The long-term effect of two and three doses of bivalent HPV vaccination against HPV infections: a comparison between two observational cohort studies
Long-term effectiveness of 2-dose and 3-dose bivalent HPV vaccination in the Netherlands was high against incident and persistent HPV16/18 infections, with
academic.oup.com
March 19, 2026 at 4:23 PM
Dutch study demonstrates high HPV vaccine effectiveness against HPV16 and HPV18 infections up to 14 years after a two-dose and three-dose schedule, with no signs of waning and significant indirect effects academic.oup.com/jid/advance-...