🧬 Can engineered Tregs stay stable under inflammation? Deleting a regulatory element near IRF4 helped preserve their suppressive function in preclinical experiments. Patient benefit remains unproven.
doi.org/10.1038/s415...
#Immunology #CellTherapy
doi.org/10.1038/s415...
#Immunology #CellTherapy
Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate - Nature Immunology
Tang and colleagues identify a distal IRF4 chromatin regulatory region that governs human Treg cell stability.
doi.org
September 24, 2026 at 5:18 AM
🧬 Can engineered Tregs stay stable under inflammation? Deleting a regulatory element near IRF4 helped preserve their suppressive function in preclinical experiments. Patient benefit remains unproven.
doi.org/10.1038/s415...
#Immunology #CellTherapy
doi.org/10.1038/s415...
#Immunology #CellTherapy
#ASH24 myeloma, IRF4 in myeloma, identified genes regulating ITF3, AiRID1a and IRF4 bind the same region, MED12 impairs both MYC and IRF4, great science
December 9, 2024 at 6:43 PM
#ASH24 myeloma, IRF4 in myeloma, identified genes regulating ITF3, AiRID1a and IRF4 bind the same region, MED12 impairs both MYC and IRF4, great science
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
April 15, 2025 at 5:13 PM
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
Schrier used that event to announce her run for the seat
www.youtube.com/watch?v=IRF4...
Holding events when the elected won’t show up has power
7/
www.youtube.com/watch?v=IRF4...
Holding events when the elected won’t show up has power
7/
Dr. Kim Schrier for Congress Announcement
YouTube video by Dr. Kim Schrier
www.youtube.com
February 20, 2025 at 10:18 PM
Schrier used that event to announce her run for the seat
www.youtube.com/watch?v=IRF4...
Holding events when the elected won’t show up has power
7/
www.youtube.com/watch?v=IRF4...
Holding events when the elected won’t show up has power
7/
Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate @natimmunol.nature.com @ucsfmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 21, 2026 at 2:14 PM
Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate @natimmunol.nature.com @ucsfmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting #IRF4 could open a new path for #MultipleMyeloma therapy.
G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER
#GenesAndDiseases: doi.org/10.1016/j.ge...
G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER
#GenesAndDiseases: doi.org/10.1016/j.ge...
September 26, 2026 at 1:30 PM
Targeting #IRF4 could open a new path for #MultipleMyeloma therapy.
G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER
#GenesAndDiseases: doi.org/10.1016/j.ge...
G1126 suppresses myeloma growth, reduces lenalidomide-resistant cells and enhances #chemotherapy response while sparing normal stem cells. @ECNUER
#GenesAndDiseases: doi.org/10.1016/j.ge...
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 @cp-cellreports.bsky.social @luoweicool.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
July 13, 2025 at 4:17 PM
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 @cp-cellreports.bsky.social @luoweicool.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Epigenetics Update - Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate u.epigenome.us/2JRq9uPW
Patrick Ho and Qizhi Tang (ucsanfrancisco.bsky.social) in natimmunol.nature.com
#Epigenetics #Inflammation #Chromatin
---
epigenometech.com
Patrick Ho and Qizhi Tang (ucsanfrancisco.bsky.social) in natimmunol.nature.com
#Epigenetics #Inflammation #Chromatin
---
epigenometech.com
September 24, 2026 at 6:01 AM
Epigenetics Update - Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate u.epigenome.us/2JRq9uPW
Patrick Ho and Qizhi Tang (ucsanfrancisco.bsky.social) in natimmunol.nature.com
#Epigenetics #Inflammation #Chromatin
---
epigenometech.com
Patrick Ho and Qizhi Tang (ucsanfrancisco.bsky.social) in natimmunol.nature.com
#Epigenetics #Inflammation #Chromatin
---
epigenometech.com
Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
March 10, 2025 at 5:35 PM
Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
@cp-cellreports.bsky.social
Whipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder:
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease | Journal of Human Immunity | Rockefeller University Press
We report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency.
rupress.org
November 11, 2025 at 3:39 PM
Whipple's disease was an inflammatory condition for decades, it became an infectious disease some years ago, and it is now becoming a genetic disorder:
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
IRF4 haploinsufficiency in a multiplex family with Whipple’s disease url: rupress.org/jhi/article/...
A new paper reports identification of a binder of IRF4 and development of a selective degrader that exhibits strong cytotoxicity against multiple myeloma cell lines
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma - Nature Chemical Biology
Identification of a binder of interferon regulatory factor 4 (IRF4) enabled development of a selective degrader, dIRF4-2, that exhibited strong cytotoxicity in multiple myeloma cell lines, offering an...
www.nature.com
June 3, 2026 at 4:02 PM
A new paper reports identification of a binder of IRF4 and development of a selective degrader that exhibits strong cytotoxicity against multiple myeloma cell lines
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
April 16, 2025 at 1:17 PM
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
April 16, 2025 at 7:58 AM
Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @plosbiology.org 🧪 plos.io/43TnG0L
Delta IRF4 Formula Race Car
Delta IRF4 Formula Race Car
Bid for the chance to own a Delta IRF4 Formula Race Car at auction with Bring a Trailer, the home of the best vintage and classic cars online. Lot #243,765.
bringatrailer.com
May 14, 2026 at 9:50 PM
Delta IRF4 Formula Race Car
Blimp-1–IRF4 axis regulates IL-5 and IL-13 production in ILC2s, driving either worm expulsion or eosinophilia during allergic lung inflammation @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
April 1, 2026 at 2:22 AM
Blimp-1–IRF4 axis regulates IL-5 and IL-13 production in ILC2s, driving either worm expulsion or eosinophilia during allergic lung inflammation @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
May 19, 2026 at 12:00 PM
@cp-immunity.bsky.social preview of IRF4-driven circuit that reshapes alveolar macrophage identity and positions them as contributors to allergic pathophysiology
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
January 13, 2026 at 6:01 PM
@cp-immunity.bsky.social preview of IRF4-driven circuit that reshapes alveolar macrophage identity and positions them as contributors to allergic pathophysiology
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
In a @natchembio.nature.com study, @danafarber.bsky.social researchers report the first selective IRF4 degrader, a promising preclinical strategy against multiple myeloma. Read more: bit.ly/4va1HfQ
Dana-Farber Investigators Formulate First IRF Degrader with Potential for Multiple Myeloma
RESEARCH SUMMARYStudy Title: Pharmacological Targeting of IRF4 as a Therapeutic Strategy for Multiple MyelomaPublication: Nature Chemical BiologyDana-Farber Cancer Institute authors: Irene Ghobrial, MD, Jun Qi, PhD
bit.ly
July 1, 2026 at 7:00 PM
In a @natchembio.nature.com study, @danafarber.bsky.social researchers report the first selective IRF4 degrader, a promising preclinical strategy against multiple myeloma. Read more: bit.ly/4va1HfQ
Congratulations to Dr. Endi Santosa @endicytosis.bsky.social on his latest study on cooperativity of IRF4 and IRF8 in antiviral NK cells!
On a side note, this is the 10th paper I’ve published in @jimmunol.bsky.social throughout my career - very proud to support @aai.org and our society journal!
On a side note, this is the 10th paper I’ve published in @jimmunol.bsky.social throughout my career - very proud to support @aai.org and our society journal!
Cutting Edge: Cooperative interferon regulatory factor network shapes the NK-cell antiviral response
Abstract. Natural killer (NK) cells are innate lymphocytes that exhibit adaptive traits particularly evident during cytomegalovirus (CMV) infection. Follow
academic.oup.com
April 5, 2025 at 1:40 PM
Congratulations to Dr. Endi Santosa @endicytosis.bsky.social on his latest study on cooperativity of IRF4 and IRF8 in antiviral NK cells!
On a side note, this is the 10th paper I’ve published in @jimmunol.bsky.social throughout my career - very proud to support @aai.org and our society journal!
On a side note, this is the 10th paper I’ve published in @jimmunol.bsky.social throughout my career - very proud to support @aai.org and our society journal!
New in Blood Cancer Discovery: IRF4 Shapes the #Lymphoma TME buff.ly/7wbtXW8
Elevated IRF4 expression in #follicularlymphoma cells may contribute to immune evasion and aggressive disease features by impairing B-cell antigen presentation, altering cytokine signaling, and rewiring metabolism.
Elevated IRF4 expression in #follicularlymphoma cells may contribute to immune evasion and aggressive disease features by impairing B-cell antigen presentation, altering cytokine signaling, and rewiring metabolism.
IRF4 Promotes Immune Evasion and Shapes the Tumor Microenvironment in Follicular Lymphoma
Elevated IRF4 expression in follicular lymphoma cells may contribute to immune evasion and aggressive disease features by impairing B-cell antigen presentation, altering cytokine signaling, and…
buff.ly
November 25, 2025 at 5:07 PM
New in Blood Cancer Discovery: IRF4 Shapes the #Lymphoma TME buff.ly/7wbtXW8
Elevated IRF4 expression in #follicularlymphoma cells may contribute to immune evasion and aggressive disease features by impairing B-cell antigen presentation, altering cytokine signaling, and rewiring metabolism.
Elevated IRF4 expression in #follicularlymphoma cells may contribute to immune evasion and aggressive disease features by impairing B-cell antigen presentation, altering cytokine signaling, and rewiring metabolism.
Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon https://www.biorxiv.org/content/10.64898/2026.06.15.732353v1
June 19, 2026 at 4:16 PM
Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon https://www.biorxiv.org/content/10.64898/2026.06.15.732353v1
Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/...
@esidsociety.bsky.social
#InbornErrorsOfImmunity
@esidsociety.bsky.social
#InbornErrorsOfImmunity
November 11, 2025 at 5:02 PM
Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/...
@esidsociety.bsky.social
#InbornErrorsOfImmunity
@esidsociety.bsky.social
#InbornErrorsOfImmunity
