Here's another celebration for @jasonsynaptic.bsky.social lab today. Our two rock stars grad students Alicia Ravens and Kaelan Sullivan pre-print is out. This is just a beautiful project. Please check out our lates Arc pre-print
www.biorxiv.org/content/10.1...

Mechanisms of active wetting and fluidification in epithelial cell collectives

go.nature.com/3Pxjq1E

Authors used Anti-BAIAP2 / IRSP53 from #SBio(LifeSpan) in their study. Including #RRIDs will make this less ambiguous.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing

For example Baiap2; which encodes an abundant scaffolding protein (Irsp53) in the postsynaptic density. We observed no differential expression, only differential splicing, resulting in loss of the C-terminal PDZ binding motif, needed for postsynaptic density localization.

Interesting paper from Zurzolo Lab on #tunnellingnanotubes
🧪
"Tunnelling nanotube formation is driven by Eps8/IRSp53-dependent linear actin polymerization"

www.embopress.org/doi/full/10....

De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis. https://www.biorxiv.org/content/10.1101/2024.01.30.578027v1

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis. https://www.biorxiv.org/content/10.1101/2024.01.30.578027v1

A very interesting study on one of my favorite topics. IRSp53 acts as a sensor for membrane curvature upon mechanical stress and promotes a recovery of plasma membrane shape.

doi.org/10.7554/eLif...