Authors used Anti-BAIAP2 / IRSP53 from #SBio(LifeSpan) in their study. Including #RRIDs will make this less ambiguous.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing

Mechanisms of active wetting and fluidification in epithelial cell collectives

go.nature.com/3Pxjq1E

For example Baiap2; which encodes an abundant scaffolding protein (Irsp53) in the postsynaptic density. We observed no differential expression, only differential splicing, resulting in loss of the C-terminal PDZ binding motif, needed for postsynaptic density localization.

De novo missense variants in BAIAP2 identified in six patients with severe DEEs, featuring refractory epilepsy, developmental delays, and intellectual disability.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #BAIAP2 #IRSp53 #DEE #intellectualdisability #wholeexomesequencing

Here's another celebration for @jasonsynaptic.bsky.social lab today. Our two rock stars grad students Alicia Ravens and Kaelan Sullivan pre-print is out. This is just a beautiful project. Please check out our lates Arc pre-print
www.biorxiv.org/content/10.1...

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis. https://www.biorxiv.org/content/10.1101/2024.01.30.578027v1

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis. https://www.biorxiv.org/content/10.1101/2024.01.30.578027v1

Interesting paper from Zurzolo Lab on #tunnellingnanotubes
🧪
"Tunnelling nanotube formation is driven by Eps8/IRSp53-dependent linear actin polymerization"

www.embopress.org/doi/full/10....

A very interesting study on one of my favorite topics. IRSp53 acts as a sensor for membrane curvature upon mechanical stress and promotes a recovery of plasma membrane shape.

doi.org/10.7554/eLif...