On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem:
🔗 www.jbc.org/article/S002...
Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime
🔗 www.jbc.org/article/S002...
Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime
Writers and Readers of Sialylation in Immunoregulation in Cancer
Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape
cell-cell interactions, and are strongly implicated in regulating immune recognition
and tissue homeostasis. In ca...
www.jbc.org
February 5, 2026 at 4:07 AM
On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem:
🔗 www.jbc.org/article/S002...
Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime
🔗 www.jbc.org/article/S002...
Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime
With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
April 3, 2026 at 9:09 PM
With the potential to limit T cell activity locally, a new drug called ImmTAAI may enable targeted immunoregulation treatment for type 1 diabetes.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/3NQusPc
Hong Kong Baptist University researchers review how natural killer cells shape brain disease, from clearing virus infected cells and autoreactive immune cells to driving inflammation.
The key may be targeting the right NK cell subset.
onlinelibrary.wiley.com/doi/10.1002/...
The key may be targeting the right NK cell subset.
onlinelibrary.wiley.com/doi/10.1002/...
Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. W...
onlinelibrary.wiley.com
September 28, 2026 at 12:16 PM
Hong Kong Baptist University researchers review how natural killer cells shape brain disease, from clearing virus infected cells and autoreactive immune cells to driving inflammation.
The key may be targeting the right NK cell subset.
onlinelibrary.wiley.com/doi/10.1002/...
The key may be targeting the right NK cell subset.
onlinelibrary.wiley.com/doi/10.1002/...
Due to alternative splicing that removes the TM–encoding exon, CD137 exists in both soluble and membrane forms, both expressed by Treg & critical for immunoregulation in #T1D @jem.org @medicalcollegeofwi.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
July 7, 2026 at 8:24 PM
Due to alternative splicing that removes the TM–encoding exon, CD137 exists in both soluble and membrane forms, both expressed by Treg & critical for immunoregulation in #T1D @jem.org @medicalcollegeofwi.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice
Reference
www.sciencedirect.com/science/arti...
Reference
www.sciencedirect.com/science/arti...
Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice
Malaria, a pervasive and devastating disease, is characterized by systemic complications and dysregulated host immune responses to Plasmodium infectio…
www.sciencedirect.com
September 9, 2025 at 6:25 AM
Single-cell profiling reveals immunoregulation of artemisinin on CD8+GZMB+ T cells via JAK2-STAT3 in malaria-infected mice
Reference
www.sciencedirect.com/science/arti...
Reference
www.sciencedirect.com/science/arti...
the Laboratory of Immunoregulation patch goes hard ngl
December 25, 2024 at 4:34 AM
the Laboratory of Immunoregulation patch goes hard ngl
Promising study for engineering stem cells to reverse Type-1 #Diabetes by boosting immunoregulation. Holds hope for treating other #autoimmune diseases. #science #immunoengineering
Engineered stem cells reversed new-onset type 1 diabetes in mice by changing the immune response. The cells cleared quickly, but the immune shift lasted beyond their presence. doi.org/hb6vjh
Engineered stem cells reverse new-onset type 1 diabetes in mice
A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset type 1 diabetes (T1D) in a mouse model of the disease.
medicalxpress.com
June 7, 2026 at 12:42 PM
Promising study for engineering stem cells to reverse Type-1 #Diabetes by boosting immunoregulation. Holds hope for treating other #autoimmune diseases. #science #immunoengineering
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections | Genes & Immunity
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections | Genes & Immunity
Eukaryotic cells regulate gene expression through multiple checkpoints, including post-transcriptional mechanisms mediated by microRNAs (miRNAs). These small non-coding RNAs inhibit translation by binding to target mRNAs, often within a complex regulatory network involving other RNA species such...
www.nature.com
January 21, 2026 at 11:01 AM
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections | Genes & Immunity
An Observational Study on the Analysis of Vitamin D Deficiency in COVID-19 Patients With No Comorbidities: A Retrospective Analysis www.cureus.com/articles/317...
An Observational Study on the Analysis of Vitamin D Deficiency in COVID-19 Patients With No Comorbidities: A Retrospective Analysis
Introduction: Vitamin D deficiency is an important problem when facing a viral disease. Vitamin D deficiency is widely prevalent in India and plays an important role in immunoregulation. The deficienc...
www.cureus.com
December 1, 2024 at 11:49 PM
An Observational Study on the Analysis of Vitamin D Deficiency in COVID-19 Patients With No Comorbidities: A Retrospective Analysis www.cureus.com/articles/317...
Here is a paper from 2023 from Graham Rook himself referring to it as the Old Friends hypothesis:
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
The old friends hypothesis: evolution, immunoregulation and essential microbial inputs
In wealthy urbanised societies there have been striking increases in chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel diseases. There has also been an increase in ...
pmc.ncbi.nlm.nih.gov
April 13, 2025 at 10:57 PM
Here is a paper from 2023 from Graham Rook himself referring to it as the Old Friends hypothesis:
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
PD-L1–expressing NK cells restrain cytotoxic CD8+ T cells in the submandibular gland, providing insights into disrupted immunoregulation contributing to immune-related adverse events
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1
PD-L1–expressing NK cells restrain cytotoxic CD8+ T cells in the SMG, providing insights into disrupted immunoregulation contributing to irAEs.
www.science.org
December 20, 2024 at 7:10 PM
PD-L1–expressing NK cells restrain cytotoxic CD8+ T cells in the submandibular gland, providing insights into disrupted immunoregulation contributing to immune-related adverse events
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
Researchers at Ege University reviewed over 100 studies and found that miRNAs like miR-21, miR-146a, miR-150, and miR-155 control immune responses in SARS-CoV-2, HBV, HIV, and HSV by targeting core pathways like NF-κB and JAK-STAT.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections - Genes & Immunity
Genes & Immunity - Decoding miRNA-Mediated Immunoregulation in SARS-CoV-2, HBV, HIV, and HSV Infections
www.nature.com
January 20, 2026 at 2:17 PM
Researchers at Ege University reviewed over 100 studies and found that miRNAs like miR-21, miR-146a, miR-150, and miR-155 control immune responses in SARS-CoV-2, HBV, HIV, and HSV by targeting core pathways like NF-κB and JAK-STAT.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Review @cp-trendsimmuno.bsky.social
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy
www.cell.com/trends/immun...
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy
www.cell.com/trends/immun...
February 13, 2025 at 7:45 PM
Review @cp-trendsimmuno.bsky.social
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy
www.cell.com/trends/immun...
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy
www.cell.com/trends/immun...
Yes! "Old Friends" paper is here, and a worthwhile read.
The old friends hypothesis: evolution, immunoregulation and essential microbial inputs
In wealthy urbanised societies there have been striking increases in chronic inflammatory disorders such as allergies, autoimmunity and inflammatory bowel diseases. There has also been an increase in the prevalence of individuals with systemically ...
pmc.ncbi.nlm.nih.gov
November 19, 2025 at 3:30 PM
Yes! "Old Friends" paper is here, and a worthwhile read.
If you are interested in a postdoc opportunity in Europe, consider the EU Marie Curie Postdoctoral Fellowship:
ec.europa.eu/info/funding...
I am happy to host if the human thymus, immunoregulation, myasthenia gravis or allogeneic HSCT are topics that interest you. DMs are open! ImmunoSky MedSky 🦠🧪
ec.europa.eu/info/funding...
I am happy to host if the human thymus, immunoregulation, myasthenia gravis or allogeneic HSCT are topics that interest you. DMs are open! ImmunoSky MedSky 🦠🧪
ec.europa.eu
March 31, 2025 at 8:16 PM
If you are interested in a postdoc opportunity in Europe, consider the EU Marie Curie Postdoctoral Fellowship:
ec.europa.eu/info/funding...
I am happy to host if the human thymus, immunoregulation, myasthenia gravis or allogeneic HSCT are topics that interest you. DMs are open! ImmunoSky MedSky 🦠🧪
ec.europa.eu/info/funding...
I am happy to host if the human thymus, immunoregulation, myasthenia gravis or allogeneic HSCT are topics that interest you. DMs are open! ImmunoSky MedSky 🦠🧪
I’ve never seen such a level of ignorance as I’ve seen with Covid. Ppl weren’t able to think for themselves and politicians made up every reason not to mask up…and ppl believed these charlatans. They even threatened a doctor in charge of immunoregulation…
truthout.org/articles/don...
truthout.org/articles/don...
Don’t Forget the History of COVID in Prison: An Interview With Victoria Law
The pandemic bared the cruelty of prison in new ways. It was a lost opportunity to move away from mass incarceration.
truthout.org
March 12, 2025 at 5:16 PM
I’ve never seen such a level of ignorance as I’ve seen with Covid. Ppl weren’t able to think for themselves and politicians made up every reason not to mask up…and ppl believed these charlatans. They even threatened a doctor in charge of immunoregulation…
truthout.org/articles/don...
truthout.org/articles/don...
‘Our study identified dysregulation of Autoantibodies against various receptors involved in the autonomous nervous system (ANS), vaso-, and immunoregulation and their correlation with symptom severity, pointing to their role in the pathogenesis of [Long Covid].’
January 8, 2025 at 4:43 PM
‘Our study identified dysregulation of Autoantibodies against various receptors involved in the autonomous nervous system (ANS), vaso-, and immunoregulation and their correlation with symptom severity, pointing to their role in the pathogenesis of [Long Covid].’
This is AWESOME. Using engineered cells to program T Cells to match the effects of Chimeric T-Cell inside the body to promote immunoregulation, eliminating the "remove from the body, separate, and modify" current process. Suddenly #autoimmune disorders could hypothetically be treated with a shot
December 15, 2025 at 12:50 AM
This is AWESOME. Using engineered cells to program T Cells to match the effects of Chimeric T-Cell inside the body to promote immunoregulation, eliminating the "remove from the body, separate, and modify" current process. Suddenly #autoimmune disorders could hypothetically be treated with a shot
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
www.mdpi.com
April 20, 2025 at 6:17 PM
IL-10 in Systemic Lupus Erythematosus: Balancing Immunoregulation and Autoimmunity
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
🔑involved in inflammatory and immune processes in SLE.
🔹IL-10 did not correlate with disease activity, organ in-
volvement, or treatment response.
www.mdpi.com/1422-0067/26...
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse https://www.biorxiv.org/content/10.1101/2024.11.12.623303v1
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse https://www.biorxiv.org/content/10.1101/2024.11.12.623303v1
B7 costimulatory family member Butyrophilin 2A2 (BTN2A2) is predominantly expressed by antigen prese
www.biorxiv.org
November 16, 2024 at 12:17 AM
Butyrophilin 2A2 promotes T cell immunoregulation by enhancing CD45 phosphatase activity within the immune synapse https://www.biorxiv.org/content/10.1101/2024.11.12.623303v1
Congrats to Brunkow, Ramsdell, and Sakaguchi! Their discoveries about immunoregulation and how the immune system avoids autoimmunity should lead to new treatments for not just cancer but autoimmune disease. #science #immunity #autoimmune #cancer
October 6, 2025 at 12:05 PM
Congrats to Brunkow, Ramsdell, and Sakaguchi! Their discoveries about immunoregulation and how the immune system avoids autoimmunity should lead to new treatments for not just cancer but autoimmune disease. #science #immunity #autoimmune #cancer
"whole mitochondria can act as intercellular signals, facilitating tissue homeostasis, repair, immunoregulation, and even influencing tumor progression through cell-to-cell transfer"
September 1, 2024 at 1:34 PM
"whole mitochondria can act as intercellular signals, facilitating tissue homeostasis, repair, immunoregulation, and even influencing tumor progression through cell-to-cell transfer"
Big news for @vcumassey.bsky.social: the first multi‑platform digital atlas of oral tissues. Grateful for the leadership of researchers like Jinze Liu, Ph.D., of #VCUPublicHealth, whose biostatistical expertise helped map fibroblast‑driven immunoregulation.
www.masseycancercenter.org/news/2026/ma...
www.masseycancercenter.org/news/2026/ma...
Massey researchers lead international collaboration of first-ever, multi-platform digital atlas of oral tissues
Research & Innovation
www.masseycancercenter.org
March 25, 2026 at 12:33 AM
Big news for @vcumassey.bsky.social: the first multi‑platform digital atlas of oral tissues. Grateful for the leadership of researchers like Jinze Liu, Ph.D., of #VCUPublicHealth, whose biostatistical expertise helped map fibroblast‑driven immunoregulation.
www.masseycancercenter.org/news/2026/ma...
www.masseycancercenter.org/news/2026/ma...
TGF-β and IL-4 dampen initial inflammation in the lung during mouse-adaptive SARS-CoV-2 infection, suggesting that promotion of immunoregulation could help patients in early stages of disease
www.biorxiv.org/content/10.1...
@stephrstephr.bsky.social
www.biorxiv.org/content/10.1...
@stephrstephr.bsky.social
May 16, 2025 at 1:50 AM
TGF-β and IL-4 dampen initial inflammation in the lung during mouse-adaptive SARS-CoV-2 infection, suggesting that promotion of immunoregulation could help patients in early stages of disease
www.biorxiv.org/content/10.1...
@stephrstephr.bsky.social
www.biorxiv.org/content/10.1...
@stephrstephr.bsky.social