Which FDA-approved vaccines had randomized, placebo-controlled trials?
ALL OF THEM.
Polio?
Measles, mumps, rubella?
Haemophilus influenzae B?
Diphtheria, tetanus, pertussis?
Meningococcus?
Varicella?
Pneumococcus?
Rotavirus?
RSV?
Hepatitis B?
Influenza?
HPV?
COVID-19?
Shingles?
YEP.
A thread🧵
1/
ALL OF THEM.
Polio?
Measles, mumps, rubella?
Haemophilus influenzae B?
Diphtheria, tetanus, pertussis?
Meningococcus?
Varicella?
Pneumococcus?
Rotavirus?
RSV?
Hepatitis B?
Influenza?
HPV?
COVID-19?
Shingles?
YEP.
A thread🧵
1/
May 5, 2025 at 12:20 AM
Which FDA-approved vaccines had randomized, placebo-controlled trials?
ALL OF THEM.
Polio?
Measles, mumps, rubella?
Haemophilus influenzae B?
Diphtheria, tetanus, pertussis?
Meningococcus?
Varicella?
Pneumococcus?
Rotavirus?
RSV?
Hepatitis B?
Influenza?
HPV?
COVID-19?
Shingles?
YEP.
A thread🧵
1/
ALL OF THEM.
Polio?
Measles, mumps, rubella?
Haemophilus influenzae B?
Diphtheria, tetanus, pertussis?
Meningococcus?
Varicella?
Pneumococcus?
Rotavirus?
RSV?
Hepatitis B?
Influenza?
HPV?
COVID-19?
Shingles?
YEP.
A thread🧵
1/
7. Haemophilus influenzae (Hib)
1 Hib + diphtheria saline placebo-controlled trial – PMID 3497990 - see above.
1990 Alaska native saline placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/2233906/
1 adjuvant placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/1903846/
1 Hib + diphtheria saline placebo-controlled trial – PMID 3497990 - see above.
1990 Alaska native saline placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/2233906/
1 adjuvant placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/1903846/
Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine Study Group - PubMed
We found no evidence that the PRP-D vaccine provides significant protection, at least for Alaska Native infants, against invasive diseases caused by H. influenzae type b. The ineffectiveness of the va...
pubmed.ncbi.nlm.nih.gov
June 13, 2025 at 5:26 AM
7. Haemophilus influenzae (Hib)
1 Hib + diphtheria saline placebo-controlled trial – PMID 3497990 - see above.
1990 Alaska native saline placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/2233906/
1 adjuvant placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/1903846/
1 Hib + diphtheria saline placebo-controlled trial – PMID 3497990 - see above.
1990 Alaska native saline placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/2233906/
1 adjuvant placebo-controlled trial: pubmed.ncbi.nlm.nih.gov/1903846/
Haemophilus influenzae type b (Hib), a vaccine preventable disease, is making a comeback. Hitting hardest among vulnerable adults facing housing instability, smoking, and substance use. 🏡 🚬
Progress isn't permanent. Let’s protect it.
Keep preventable diseases-prevented. 💉 💪
Progress isn't permanent. Let’s protect it.
Keep preventable diseases-prevented. 💉 💪
Clusters of Invasive Haemophilus influenzae Type b Disease Among Adult
This report describes two clusters of invasive of Haemophilus influenzae type b among adults with special risk factors in Alaska, Oregon, and Washington.
www.cdc.gov
April 17, 2026 at 1:19 AM
Haemophilus influenzae type b (Hib), a vaccine preventable disease, is making a comeback. Hitting hardest among vulnerable adults facing housing instability, smoking, and substance use. 🏡 🚬
Progress isn't permanent. Let’s protect it.
Keep preventable diseases-prevented. 💉 💪
Progress isn't permanent. Let’s protect it.
Keep preventable diseases-prevented. 💉 💪
Created a new file in my "Global History of Health" folder today for Haemophilus influenzae type b (Hib) as a "new" emerging disease. (Friends, it's an ancient disease, and we were just on the verge of getting it under control: link.springer.com/article/10.1...) #histmed #aDNA 🧪🗃️
April 3, 2026 at 5:13 PM
Created a new file in my "Global History of Health" folder today for Haemophilus influenzae type b (Hib) as a "new" emerging disease. (Friends, it's an ancient disease, and we were just on the verge of getting it under control: link.springer.com/article/10.1...) #histmed #aDNA 🧪🗃️
In medical school and residency, I learned about haemophilus influenzae meningitis that killed and maimed babies and toddlers.
But I never saw a case.
Why? Because the vaccine was approved a few years before I started my pediatric residency.
www.meningitis.org/meningitis/c...
But I never saw a case.
Why? Because the vaccine was approved a few years before I started my pediatric residency.
www.meningitis.org/meningitis/c...
Haemophilus Influenzae type b (Hib) meningitis
www.meningitis.org
December 13, 2024 at 3:34 PM
In medical school and residency, I learned about haemophilus influenzae meningitis that killed and maimed babies and toddlers.
But I never saw a case.
Why? Because the vaccine was approved a few years before I started my pediatric residency.
www.meningitis.org/meningitis/c...
But I never saw a case.
Why? Because the vaccine was approved a few years before I started my pediatric residency.
www.meningitis.org/meningitis/c...
Pediatricians are reporting increased cases of life-threatening illnesses among children as anti-vaccine sentiment surges, including:
—Rotavirus
—Haemophilus influenzae
—Streptococcus pneumoniae
—Rotavirus
—Haemophilus influenzae
—Streptococcus pneumoniae
June 2, 2026 at 2:56 PM
Pediatricians are reporting increased cases of life-threatening illnesses among children as anti-vaccine sentiment surges, including:
—Rotavirus
—Haemophilus influenzae
—Streptococcus pneumoniae
—Rotavirus
—Haemophilus influenzae
—Streptococcus pneumoniae
Guess what Florida will make great again?
Measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b, Respiratory syncytial virus, influenza, Covid-19, hepatitis A & B, varicella, Human papillomavirus, Meningococcal meningitis & rotavirus
Measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b, Respiratory syncytial virus, influenza, Covid-19, hepatitis A & B, varicella, Human papillomavirus, Meningococcal meningitis & rotavirus
September 5, 2025 at 12:23 AM
Guess what Florida will make great again?
Measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b, Respiratory syncytial virus, influenza, Covid-19, hepatitis A & B, varicella, Human papillomavirus, Meningococcal meningitis & rotavirus
Measles, mumps, rubella, tetanus, diphtheria, pertussis, polio, Haemophilus influenzae type b, Respiratory syncytial virus, influenza, Covid-19, hepatitis A & B, varicella, Human papillomavirus, Meningococcal meningitis & rotavirus
Yes Pierre. Vaccines being so bad. Who can forget polio, smallpox, diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type B (Hib), rotavirus, hepatitis B, measles, mumps, rubella, chickenpox, pneumococcal and meningococcal diseases. Are those mandates evil too?
January 21, 2025 at 1:20 PM
Yes Pierre. Vaccines being so bad. Who can forget polio, smallpox, diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type B (Hib), rotavirus, hepatitis B, measles, mumps, rubella, chickenpox, pneumococcal and meningococcal diseases. Are those mandates evil too?
1/3 During my training, I never saw measles, Haemophilus influenzae b, or syphilis—because effective public health strategies had nearly eliminated these threats. But what I once took for granted, those public health victories, are sliding backward
April 12, 2025 at 12:33 AM
1/3 During my training, I never saw measles, Haemophilus influenzae b, or syphilis—because effective public health strategies had nearly eliminated these threats. But what I once took for granted, those public health victories, are sliding backward
Polio, diphtheria, measles, and Haemophilus influenzae type b (Hib)—you have a friend in Tallahassee.
December 13, 2025 at 12:53 AM
Polio, diphtheria, measles, and Haemophilus influenzae type b (Hib)—you have a friend in Tallahassee.
Hospitals warned about rare infection emerging in Calgary
8 cases of Haemophilus influenzae type b (Hib) so far: government #Alberta
www.cbc.ca/news/canada/...
8 cases of Haemophilus influenzae type b (Hib) so far: government #Alberta
www.cbc.ca/news/canada/...
Hospitals warned about rare infection emerging in Calgary | CBC News
Health officials are warning emergency wards about the circulation of Haemophilus influenzae type b (Hib) among homeless adults living in Calgary.
www.cbc.ca
December 25, 2025 at 12:11 AM
Hospitals warned about rare infection emerging in Calgary
8 cases of Haemophilus influenzae type b (Hib) so far: government #Alberta
www.cbc.ca/news/canada/...
8 cases of Haemophilus influenzae type b (Hib) so far: government #Alberta
www.cbc.ca/news/canada/...
Einigen sagte HiB nichts. Dabei war Haemophilus influenzae Typ B vor Einführung der Impfung Anfang der 90er der häufigste Erreger der eitrigen Hirnhautentzündung bei Kindern bis fünf Jahre. So erfolgreich sind Impfungen. #ImpfenSchützt
February 18, 2025 at 5:28 PM
Einigen sagte HiB nichts. Dabei war Haemophilus influenzae Typ B vor Einführung der Impfung Anfang der 90er der häufigste Erreger der eitrigen Hirnhautentzündung bei Kindern bis fünf Jahre. So erfolgreich sind Impfungen. #ImpfenSchützt
Hib ist quasi aus unserer Wahrnehmung verschwunden. Dabei war Haemophilus influenzae Typ B vor Einführung der Impfung Anfang der 90er der häufigste Erreger der eitrigen Hirnhautentzündung bei Kindern bis fünf Jahre. So erfolgreich sind Impfungen. #ImpfenSchützt
A deadly bacterial disease is returning, doctors warn, as vaccination rates fall.
www.yahoo.com/news/article...
www.yahoo.com/news/article...
A deadly bacterial disease is returning, doctors warn, as vaccination rates fall
Hib, a deadly bacterial infection that causes meningitis, is making a comeback, doctors warn. They say the rise in cases is changing the way they practice medicine.
www.yahoo.com
April 4, 2026 at 4:01 PM
Hib ist quasi aus unserer Wahrnehmung verschwunden. Dabei war Haemophilus influenzae Typ B vor Einführung der Impfung Anfang der 90er der häufigste Erreger der eitrigen Hirnhautentzündung bei Kindern bis fünf Jahre. So erfolgreich sind Impfungen. #ImpfenSchützt
Haemophilus influenzae sobbing
May 2, 2025 at 1:07 AM
Haemophilus influenzae sobbing
MAKE Wissen über Infektionserreger GREAT AGAIN - #Bildungsauftrag:
Corynebacterium diphtheriae (Diphtherie), Clostridium tetani (Tetanus), Bordetella pertussis (Pertussis) und Haemophilus influenzae Typ b (Hib) wird von Bakterien, der Rest von den gleichnamigen Viren verursacht.
Corynebacterium diphtheriae (Diphtherie), Clostridium tetani (Tetanus), Bordetella pertussis (Pertussis) und Haemophilus influenzae Typ b (Hib) wird von Bakterien, der Rest von den gleichnamigen Viren verursacht.
February 16, 2025 at 6:48 AM
MAKE Wissen über Infektionserreger GREAT AGAIN - #Bildungsauftrag:
Corynebacterium diphtheriae (Diphtherie), Clostridium tetani (Tetanus), Bordetella pertussis (Pertussis) und Haemophilus influenzae Typ b (Hib) wird von Bakterien, der Rest von den gleichnamigen Viren verursacht.
Corynebacterium diphtheriae (Diphtherie), Clostridium tetani (Tetanus), Bordetella pertussis (Pertussis) und Haemophilus influenzae Typ b (Hib) wird von Bakterien, der Rest von den gleichnamigen Viren verursacht.
Facts. Gone due to vaccines.
We are now 2+ generations of children largely spared the dread of meningitis due to Haemophilus influenzae type B; Streptococcus pneumoniae; and (increasingly) Neisseria meningitidis. These are dreaded conditions that stalked the nightmares of parents.
We are now 2+ generations of children largely spared the dread of meningitis due to Haemophilus influenzae type B; Streptococcus pneumoniae; and (increasingly) Neisseria meningitidis. These are dreaded conditions that stalked the nightmares of parents.
By the time I finished residency, I was so good at lumbar punctures. Squeezing down on a crying infants head and pushing them into a ball and then slipping in the spinal needle. On a typical admission night I might do 2 or 3. All gone now. I haven’t done one in years. They want to bring this back.
Day 2 of vaccine preventable disease education. Don’t forget that we don’t need these to come back… #vaccineswork #MedSky #PedSky
February 16, 2025 at 2:45 AM
Facts. Gone due to vaccines.
We are now 2+ generations of children largely spared the dread of meningitis due to Haemophilus influenzae type B; Streptococcus pneumoniae; and (increasingly) Neisseria meningitidis. These are dreaded conditions that stalked the nightmares of parents.
We are now 2+ generations of children largely spared the dread of meningitis due to Haemophilus influenzae type B; Streptococcus pneumoniae; and (increasingly) Neisseria meningitidis. These are dreaded conditions that stalked the nightmares of parents.
New tools for the important opportunistic human bacterial pathogen Haemophilus influenzae #MicroSky: www.biorxiv.org/content/10.1...
CRISPRi-seq in Haemophilus influenzae reveals genome-wide and medium-specific growth determinants
Work in the human pathobiont Haemophilus influenzae has pioneered functional genomics in bacteria such as genome-wide transposon mutagenesis combined with deep sequencing. These approaches unveiled a ...
www.biorxiv.org
August 7, 2025 at 4:33 PM
New tools for the important opportunistic human bacterial pathogen Haemophilus influenzae #MicroSky: www.biorxiv.org/content/10.1...
In youngest US kids, vaccine uptake drops for flu, hepatitis B, rotavirus, pneumococcal, & Haemophilus influenzae type b vaccines.
Read more on the report: ow.ly/qmZh50YzXsM
Read more on the report: ow.ly/qmZh50YzXsM
March 27, 2026 at 9:42 PM
In youngest US kids, vaccine uptake drops for flu, hepatitis B, rotavirus, pneumococcal, & Haemophilus influenzae type b vaccines.
Read more on the report: ow.ly/qmZh50YzXsM
Read more on the report: ow.ly/qmZh50YzXsM
Ask a grey-haired pediatrician about how many lumbar punctures they used to have to do in a shift for infants that then ended up having Hib (Haemophilus influenzae type b) meningitis.
Also, if you did not vaccinate your kids, PLEASE do not lie about it if they need care. It is critical information.
Also, if you did not vaccinate your kids, PLEASE do not lie about it if they need care. It is critical information.
I treated very young kids in my ER who had a fever today.
They're too young to realize how lucky they are to be vaccinated.
Their parents were reminded by me of how wise their choices were, though.
Their being vaccinated meant we had to do FAR less testing and extensive treatments than otherwise.
They're too young to realize how lucky they are to be vaccinated.
Their parents were reminded by me of how wise their choices were, though.
Their being vaccinated meant we had to do FAR less testing and extensive treatments than otherwise.
November 17, 2024 at 5:01 AM
Ask a grey-haired pediatrician about how many lumbar punctures they used to have to do in a shift for infants that then ended up having Hib (Haemophilus influenzae type b) meningitis.
Also, if you did not vaccinate your kids, PLEASE do not lie about it if they need care. It is critical information.
Also, if you did not vaccinate your kids, PLEASE do not lie about it if they need care. It is critical information.
My dad died of a vaccine preventable illness. He died of h-flu or heamophilus influenzae. We vaccinate children against this illness and while protection often wanes over the course of a lifetime, there would be lower levels of it in the population if everyone opted for the vaccine.
September 4, 2025 at 8:10 PM
My dad died of a vaccine preventable illness. He died of h-flu or heamophilus influenzae. We vaccinate children against this illness and while protection often wanes over the course of a lifetime, there would be lower levels of it in the population if everyone opted for the vaccine.
The US has 15 vaccines for kids <18:
MMR
DTaP
Pneumococcal
Rotavirus
Varicella
Hepatitis B
Hepatitis A
Polio
Haemophilus influenzae B
Meningococcal
Human Papillomavirus
Influenza
COVID-19
RSV
NOT 72.
Not even 72 total DOSES from birth to age 18 (it’s ~35)
Stop letting people lie.
MMR
DTaP
Pneumococcal
Rotavirus
Varicella
Hepatitis B
Hepatitis A
Polio
Haemophilus influenzae B
Meningococcal
Human Papillomavirus
Influenza
COVID-19
RSV
NOT 72.
Not even 72 total DOSES from birth to age 18 (it’s ~35)
Stop letting people lie.
November 14, 2024 at 8:06 PM
The US has 15 vaccines for kids <18:
MMR
DTaP
Pneumococcal
Rotavirus
Varicella
Hepatitis B
Hepatitis A
Polio
Haemophilus influenzae B
Meningococcal
Human Papillomavirus
Influenza
COVID-19
RSV
NOT 72.
Not even 72 total DOSES from birth to age 18 (it’s ~35)
Stop letting people lie.
MMR
DTaP
Pneumococcal
Rotavirus
Varicella
Hepatitis B
Hepatitis A
Polio
Haemophilus influenzae B
Meningococcal
Human Papillomavirus
Influenza
COVID-19
RSV
NOT 72.
Not even 72 total DOSES from birth to age 18 (it’s ~35)
Stop letting people lie.
- Mumps
- Pertussis (Whooping Cough) – Not fully eliminated but significantly reduced.
- Haemophilus influenzae type b (Hib) Disease - nearly eliminated
- Varicella – Dramatically reduced
- Pneumococcal Disease (Certain Serotypes) – nearly eliminated in vaccinated populations.
- Pertussis (Whooping Cough) – Not fully eliminated but significantly reduced.
- Haemophilus influenzae type b (Hib) Disease - nearly eliminated
- Varicella – Dramatically reduced
- Pneumococcal Disease (Certain Serotypes) – nearly eliminated in vaccinated populations.
March 3, 2025 at 10:19 PM
- Mumps
- Pertussis (Whooping Cough) – Not fully eliminated but significantly reduced.
- Haemophilus influenzae type b (Hib) Disease - nearly eliminated
- Varicella – Dramatically reduced
- Pneumococcal Disease (Certain Serotypes) – nearly eliminated in vaccinated populations.
- Pertussis (Whooping Cough) – Not fully eliminated but significantly reduced.
- Haemophilus influenzae type b (Hib) Disease - nearly eliminated
- Varicella – Dramatically reduced
- Pneumococcal Disease (Certain Serotypes) – nearly eliminated in vaccinated populations.
is 15 a lot? brain worms yes. vaccines no.
November 19, 2024 at 4:02 PM
is 15 a lot? brain worms yes. vaccines no.
Haemophilus influenzae
type b (Hib) is a serious bacterial infection that primarily affects children under 5, causing severe diseases like meningitis, bloodstream infections, and pneumonia...Hib can lead to permanent disabilities or death, though it is now rare due to routine childhood vaccination.
type b (Hib) is a serious bacterial infection that primarily affects children under 5, causing severe diseases like meningitis, bloodstream infections, and pneumonia...Hib can lead to permanent disabilities or death, though it is now rare due to routine childhood vaccination.
April 2, 2026 at 11:27 PM
Haemophilus influenzae
type b (Hib) is a serious bacterial infection that primarily affects children under 5, causing severe diseases like meningitis, bloodstream infections, and pneumonia...Hib can lead to permanent disabilities or death, though it is now rare due to routine childhood vaccination.
type b (Hib) is a serious bacterial infection that primarily affects children under 5, causing severe diseases like meningitis, bloodstream infections, and pneumonia...Hib can lead to permanent disabilities or death, though it is now rare due to routine childhood vaccination.