We're pleased to present a new collection on #Interferons in infection and disease. Explore JEM articles highlighting the latest advances in our understanding of the dynamic nature of interferons in immunity and disease.
👉 rupress.org/jem/collecti...
👉 rupress.org/jem/collecti...
November 5, 2026 at 3:15 PM
We're pleased to present a new collection on #Interferons in infection and disease. Explore JEM articles highlighting the latest advances in our understanding of the dynamic nature of interferons in immunity and disease.
👉 rupress.org/jem/collecti...
👉 rupress.org/jem/collecti...
Xbp1 controls the reparative function of intestinal #ILC2s during #colitis. From Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Shiyang Li (Shandong University) and colleagues: rupress.org/jem/article/...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
November 5, 2026 at 4:15 PM
Xbp1 controls the reparative function of intestinal #ILC2s during #colitis. From Yanyan Cui, Zixiao Zhao, Jing Shen, Yatai Chen, Qiuheng Tian, Shiyang Li (Shandong University) and colleagues: rupress.org/jem/article/...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
Not all #antibodies protect us. @ki.se researchers reveal how #autoantibodies against type I interferons can weaken antiviral defenses, potentially contributing to severe viral infections. A fascinating reminder that disease severity depends on both the #virus & our #immunesystem. lnkd.in/p/epDWRXXW
November 4, 2026 at 1:57 PM
Not all #antibodies protect us. @ki.se researchers reveal how #autoantibodies against type I interferons can weaken antiviral defenses, potentially contributing to severe viral infections. A fascinating reminder that disease severity depends on both the #virus & our #immunesystem. lnkd.in/p/epDWRXXW
The rise in prevalence of #autoantibodies neutralizing type I #interferons reaches a plateau in centenarians. New study from Nanna Mørk, Julie A. Jensen, Trine H. Mogensen @au.dk and colleagues:
rupress.org/jhi/article/...
#Autoimmunity #cytokines
rupress.org/jhi/article/...
#Autoimmunity #cytokines
November 3, 2026 at 2:45 PM
The rise in prevalence of #autoantibodies neutralizing type I #interferons reaches a plateau in centenarians. New study from Nanna Mørk, Julie A. Jensen, Trine H. Mogensen @au.dk and colleagues:
rupress.org/jhi/article/...
#Autoimmunity #cytokines
rupress.org/jhi/article/...
#Autoimmunity #cytokines
Here's one potential danger in medicine/pharma of freezer systems that can be hacked & disabled remotely. Apart from drugs based on antibodies (which is a *lot* of newer drugs, esp for cancer treatment) it would also include things like Interferons, viral & mRNA vaccines, RNA therapeutics etc etc.
Some most definitely are in terms of alarm systems at least. Unsure whether the software could be accessed to change temperature. Not sure academic labs would be much of a target, but biotech/pharma almost certainly. Imagine KOing an entire company stock of a biologic, for example. Very bad.
November 4, 2026 at 8:05 PM
Here's one potential danger in medicine/pharma of freezer systems that can be hacked & disabled remotely. Apart from drugs based on antibodies (which is a *lot* of newer drugs, esp for cancer treatment) it would also include things like Interferons, viral & mRNA vaccines, RNA therapeutics etc etc.
pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection. From Elena Hernández-García, Miguel Galán, @salva-iborra.bsky.social and colleagues: rupress.org/jem/article/...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
November 6, 2026 at 4:15 PM
pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection. From Elena Hernández-García, Miguel Galán, @salva-iborra.bsky.social and colleagues: rupress.org/jem/article/...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
📘 Part of #Interferons in Infection and Disease: rupress.org/jem/collecti...
Even without interferons, Drosophila still manages an awful lot of antiviral immunity
cGAS-STING dependent immunity in insects: insights from Drosophila flies
#Drosophila
#Drosophila
cGAS-STING dependent immunity in insects: insights from Drosophila flies
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 1, 2026 at 4:17 PM
Even without interferons, Drosophila still manages an awful lot of antiviral immunity
Fièvre, courbatures, fatigue : après une injection, certains ne ressentent rien, quand d'autres sont terrassés pendant deux jours. Intrigués par cette loterie biologique, des chercheurs de l'Université de Genève ont identifié le rôle clé des interférons, des molécules qui agissent comme une ...
« Certaines personnes naissent avec un système immunitaire déjà en alerte » : pourquoi nous ne sommes pas égaux face aux effets secondaires des vaccins
ebx.sh
November 7, 2026 at 12:33 PM
Fièvre, courbatures, fatigue : après une injection, certains ne ressentent rien, quand d'autres sont terrassés pendant deux jours. Intrigués par cette loterie biologique, des chercheurs de l'Université de Genève ont identifié le rôle clé des interférons, des molécules qui agissent comme une ...
Congrats to Yimei Li with this interesting preprint! The impact of viral RNA on the innate immune response depends on the immune context and may lead to local immune suppression to stimulate viral growth: www.biorxiv.org/content/10.6...
Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics
Type I interferons (IFN) help clear a viral infection, but IFN levels can then decline to reset the antiviral state and avoid innate immune dysregulation. Such dysregulation can occur following infect...
www.biorxiv.org
November 1, 2026 at 5:46 PM
Congrats to Yimei Li with this interesting preprint! The impact of viral RNA on the innate immune response depends on the immune context and may lead to local immune suppression to stimulate viral growth: www.biorxiv.org/content/10.6...
The Uncovered Role of Interferons in Sepsis: From Pathogenesis to Precision Immunotherapy
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
October 29, 2026 at 9:17 PM
The Uncovered Role of Interferons in Sepsis: From Pathogenesis to Precision Immunotherapy
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
CCR Journal Watch
https://criticalcarereviews.com/latest-evidence/journal-watch
Are there type I IFN auto-antibodies in centenarians ?...
The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians rupress.org/jhi/article/...
The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians rupress.org/jhi/article/...
The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians
Mørk et al. investigated neutralizing IFN-I auto-Abs in centenarians from Denmark, Colombia, Australia, and Japan and found that the prevalence of auto-Abs
rupress.org
October 27, 2026 at 7:26 PM
Are there type I IFN auto-antibodies in centenarians ?...
The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians rupress.org/jhi/article/...
The rise in prevalence of autoantibodies neutralizing type I interferons reaches a plateau in centenarians rupress.org/jhi/article/...
Rémi Bru, Océane Paris, Guillaume Bossis, Stephanie Boireau, Mar Naranjo-Gomez, Mireia Pelegrin: Differential Effects of Distinct Type I Interferons and IFN Inducers on Fc Receptor landscape and myeloid cell function https://hal.science/hal-05841901v1 [sdv.mhep.mi]
October 29, 2026 at 3:00 AM
Rémi Bru, Océane Paris, Guillaume Bossis, Stephanie Boireau, Mar Naranjo-Gomez, Mireia Pelegrin: Differential Effects of Distinct Type I Interferons and IFN Inducers on Fc Receptor landscape and myeloid cell function https://hal.science/hal-05841901v1 [sdv.mhep.mi]
Additionally, recent studies highlight that a minority of patients naturally harbor pre-existing neutralizing autoantibodies against type I interferons, making them silently vulnerable to severe infections despite therapeutic supplementation
October 28, 2026 at 7:29 AM
Additionally, recent studies highlight that a minority of patients naturally harbor pre-existing neutralizing autoantibodies against type I interferons, making them silently vulnerable to severe infections despite therapeutic supplementation
🦠subvariants actively suppress the host’s natural type I/I interferon (IFN) response to evade early detection and replicate unchecked.
Administering exogenous interferons aims to bypass this roadblock and jumpstart the immune system
Administering exogenous interferons aims to bypass this roadblock and jumpstart the immune system
October 28, 2026 at 7:29 AM
🦠subvariants actively suppress the host’s natural type I/I interferon (IFN) response to evade early detection and replicate unchecked.
Administering exogenous interferons aims to bypass this roadblock and jumpstart the immune system
Administering exogenous interferons aims to bypass this roadblock and jumpstart the immune system
Beyond interferons, current research focus centers on inhibiting human proteins that the virus hijacks to enter, replicate, and exit host cells
🔥 Interferon therapeutics are highly timing-dependent. Early administration (within 7 days of symptom onset) suppresses viral loads
🔥 Interferon therapeutics are highly timing-dependent. Early administration (within 7 days of symptom onset) suppresses viral loads
October 28, 2026 at 7:29 AM
Beyond interferons, current research focus centers on inhibiting human proteins that the virus hijacks to enter, replicate, and exit host cells
🔥 Interferon therapeutics are highly timing-dependent. Early administration (within 7 days of symptom onset) suppresses viral loads
🔥 Interferon therapeutics are highly timing-dependent. Early administration (within 7 days of symptom onset) suppresses viral loads
and lowers hospitalization risks. However, administering interferons during late-stage, severe COVID can be dangerous, exacerbating hyper-inflammation and contributing to "cytokine storms"
www.news-medical.net/news/2026071...
www.news-medical.net/news/2026071...
Study identifies immune response causing severe COVID-19 susceptibility
Although the COVID-19 pandemic has largely subsided, scientists continue to investigate why the virus proved so deadly, causing at least three million deaths worldwide, according to the latest estimat...
www.news-medical.net
October 28, 2026 at 7:29 AM
and lowers hospitalization risks. However, administering interferons during late-stage, severe COVID can be dangerous, exacerbating hyper-inflammation and contributing to "cytokine storms"
www.news-medical.net/news/2026071...
www.news-medical.net/news/2026071...
And what tx was Applegate receiving for MS? Because those injection and infusion interferons are a BITCH. Who knows what long term damage those meds/toxins could have caused. *sigh* What if she had Lyme Disease and only needed abx? #ChristinaApplegate #MS #MyelinDamage
October 25, 2026 at 6:11 PM
And what tx was Applegate receiving for MS? Because those injection and infusion interferons are a BITCH. Who knows what long term damage those meds/toxins could have caused. *sigh* What if she had Lyme Disease and only needed abx? #ChristinaApplegate #MS #MyelinDamage
Researchers found that STAT3 acts as an immune switch in mice infected with cytomegalovirus.
Depending on inflammation and signals from IL-15 and interferons, it can either strengthen or suppress natural killer (NK) cell responses.
www.science.org/doi/10.1126/...
Depending on inflammation and signals from IL-15 and interferons, it can either strengthen or suppress natural killer (NK) cell responses.
www.science.org/doi/10.1126/...
STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells
STAT3 acts as a cytokine-sensing switch in NK cells, integrating IL-15 and type I interferon signals to shape antiviral responses.
www.science.org
October 23, 2026 at 12:59 PM
Researchers found that STAT3 acts as an immune switch in mice infected with cytomegalovirus.
Depending on inflammation and signals from IL-15 and interferons, it can either strengthen or suppress natural killer (NK) cell responses.
www.science.org/doi/10.1126/...
Depending on inflammation and signals from IL-15 and interferons, it can either strengthen or suppress natural killer (NK) cell responses.
www.science.org/doi/10.1126/...
Long COVID is associated with reduced circulating levels of the neurotransmitter serotonin.
Serotonin depletion occurs when SARS-CoV-2 viral RNA induces type I interferons (IFNs), a type of immune signal molecule.
Serotonin depletion occurs when SARS-CoV-2 viral RNA induces type I interferons (IFNs), a type of immune signal molecule.
October 19, 2026 at 2:30 PM
Long COVID is associated with reduced circulating levels of the neurotransmitter serotonin.
Serotonin depletion occurs when SARS-CoV-2 viral RNA induces type I interferons (IFNs), a type of immune signal molecule.
Serotonin depletion occurs when SARS-CoV-2 viral RNA induces type I interferons (IFNs), a type of immune signal molecule.
#Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance. New study from Signe Bedsted Clemmensen, Nanna Mørk, Trine H. Mogensen @au.dk and colleagues:
rupress.org/jhi/article/...
#Infections #Autoimmunity
rupress.org/jhi/article/...
#Infections #Autoimmunity
October 16, 2026 at 1:45 PM
#Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance. New study from Signe Bedsted Clemmensen, Nanna Mørk, Trine H. Mogensen @au.dk and colleagues:
rupress.org/jhi/article/...
#Infections #Autoimmunity
rupress.org/jhi/article/...
#Infections #Autoimmunity
Type III Interferons (lambda) in Parasitic Infections: Balancing Mucosal Defense and Immune Modulation pubmed.ncbi.nlm.nih.gov/42880679/
October 16, 2026 at 1:24 PM
Type III Interferons (lambda) in Parasitic Infections: Balancing Mucosal Defense and Immune Modulation pubmed.ncbi.nlm.nih.gov/42880679/
#Autoantibodies neutralizing type I interferons in #COVID19 patients from Southern Brazil. New study from Renan César Sbruzzi, Fernanda S.L. Vianna @ufrgs.br and colleagues:
rupress.org/jhi/article/...
#Infections #Phenocopies
@casanovalab.bsky.social
rupress.org/jhi/article/...
#Infections #Phenocopies
@casanovalab.bsky.social
October 13, 2026 at 1:30 PM
#Autoantibodies neutralizing type I interferons in #COVID19 patients from Southern Brazil. New study from Renan César Sbruzzi, Fernanda S.L. Vianna @ufrgs.br and colleagues:
rupress.org/jhi/article/...
#Infections #Phenocopies
@casanovalab.bsky.social
rupress.org/jhi/article/...
#Infections #Phenocopies
@casanovalab.bsky.social
The increase in prevalence of type I IFN neutralizing auto-Abs in the elderly might not be genetically driven, making its study more challenging 😉
Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance rupress.org/jhi/article/...
Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance rupress.org/jhi/article/...
Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance
Here, Clemmensen et al. investigated the heredity of IFN-I auto-Abs in adults in a large Danish twin cohort of 1,318 twin pairs. Overall, the data do not s
rupress.org
October 9, 2026 at 7:09 PM
The increase in prevalence of type I IFN neutralizing auto-Abs in the elderly might not be genetically driven, making its study more challenging 😉
Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance rupress.org/jhi/article/...
Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance rupress.org/jhi/article/...
🔬 “You are what you eat” counts even for immuncells!
From cDC1 cross-presentation and macrophage plasticity to type I interferons and γδ CAR-T cells, Session V at #SFB1160 covered quite some ground!
Thanks to Caetano Reis e Sousa, Sebastian Baach, Lidia Bosurgi, Andreas Wack & Marina Zintchenko!
From cDC1 cross-presentation and macrophage plasticity to type I interferons and γδ CAR-T cells, Session V at #SFB1160 covered quite some ground!
Thanks to Caetano Reis e Sousa, Sebastian Baach, Lidia Bosurgi, Andreas Wack & Marina Zintchenko!
October 9, 2026 at 6:09 PM
🔬 “You are what you eat” counts even for immuncells!
From cDC1 cross-presentation and macrophage plasticity to type I interferons and γδ CAR-T cells, Session V at #SFB1160 covered quite some ground!
Thanks to Caetano Reis e Sousa, Sebastian Baach, Lidia Bosurgi, Andreas Wack & Marina Zintchenko!
From cDC1 cross-presentation and macrophage plasticity to type I interferons and γδ CAR-T cells, Session V at #SFB1160 covered quite some ground!
Thanks to Caetano Reis e Sousa, Sebastian Baach, Lidia Bosurgi, Andreas Wack & Marina Zintchenko!
Differential Effects of Distinct Type I Interferons and IFN Inducers on Fc Receptor landscape and myeloid cell function https://www.biorxiv.org/content/10.64898/2026.10.01.756027v1
October 7, 2026 at 2:18 PM
Differential Effects of Distinct Type I Interferons and IFN Inducers on Fc Receptor landscape and myeloid cell function https://www.biorxiv.org/content/10.64898/2026.10.01.756027v1