Epithelial Zonation of 👦🐭small intestine
scRNAseq

5 (instead of 3) zones▶️Nutrient metabolism

3 Lgr5+ #IntestinalStemCell populations▶️a Hoxb7/8/9+ subset

ChEA3+SCENIC▶️transcrptional control of intestinal domains

#NatureCellBio 2024
www.nature.com/articles/s41...

Crosstalk between #CircadianRhythms, cell cycle regulators, and Wnt, #Notch, and Hippo pathways governs #IntestinalStemCell fate and regeneration, offering new precision therapeutic avenues in #IntestinalBiology.
#OpenAccess: doi.org/10.1016/j.ge...

I've been away from social media for some time, but I'm very happy to share that we just got a paper out describing how a network of bHLH transcription factors simultaneously regulates #Drosophila #IntestinalStemCell self-renewal and bipotential differentiation
www.sciencedirect.com/science/arti...

#Treg-derived IFNγ and #IL10 synergistically activate #mTORC1 and Myc pathways to promote epithelial repair, with combined #cytokine signaling supporting #IntestinalStemCell growth after therapy-induced #GutInjury. @tum.de @univparissaclay.bsky.social

#STTT: doi.org/10.1038/s413...