Congratulations to Simon Grassmann @simongrassmann.bsky.social on his latest paper describing how Stat3 can act as a rheostat of inflammation, integrating distinct cytokine signals to qualitatively tune NK cell responses depending on viral burden @mskcc.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells
STAT3 acts as a cytokine-sensing switch in NK cells, integrating IL-15 and type I interferon signals to shape antiviral responses.
www.science.org
October 27, 2026 at 4:01 AM
Congratulations to Simon Grassmann @simongrassmann.bsky.social on his latest paper describing how Stat3 can act as a rheostat of inflammation, integrating distinct cytokine signals to qualitatively tune NK cell responses depending on viral burden @mskcc.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Check out this new review about "Cytokine circuits in CNS homeostasis and disease" from Burkhard Becher @becherlab.bsky.social, Donatella De Feo and Melanie Greter: www.nature.com/articles/s41...
Cytokine circuits in CNS homeostasis and disease - Nature Immunology
In their Review, Becher et al. discuss how selected cytokine networks preserve, destabilize and restore central nervous system integrity.
www.nature.com
October 26, 2026 at 1:15 PM
Check out this new review about "Cytokine circuits in CNS homeostasis and disease" from Burkhard Becher @becherlab.bsky.social, Donatella De Feo and Melanie Greter: www.nature.com/articles/s41...
cytokineちん❗️おシル真ん中にして❗️😡
October 28, 2026 at 12:13 PM
cytokineちん❗️おシル真ん中にして❗️😡
Review @natimmunol.nature.com
Cytokine circuits in CNS homeostasis and disease
www.nature.com/articles/s41...
Cytokine circuits in CNS homeostasis and disease
www.nature.com/articles/s41...
October 23, 2026 at 4:52 PM
Review @natimmunol.nature.com
Cytokine circuits in CNS homeostasis and disease
www.nature.com/articles/s41...
Cytokine circuits in CNS homeostasis and disease
www.nature.com/articles/s41...
More weekend reading: New review explores cytokine circuits in CNS homeostasis; "CNS cytokine circuits may also be shaped by systemic immune & metabolic cues, whose influence on local cytokine production & responsiveness remains incompletely understood"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 24, 2026 at 10:59 AM
More weekend reading: New review explores cytokine circuits in CNS homeostasis; "CNS cytokine circuits may also be shaped by systemic immune & metabolic cues, whose influence on local cytokine production & responsiveness remains incompletely understood"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC https://www.biorxiv.org/content/10.64898/2026.10.22.760671v1
October 26, 2026 at 2:46 AM
Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC https://www.biorxiv.org/content/10.64898/2026.10.22.760671v1
Immune explores two fortuitous discoveries: caspase inhibitors that hitch a ride through gasdermin D pores to selectively block proinflammatory cytokine secretion, and human monoclonal antibodies against malaria repurposed to block allergic antibody binding to red meat allergens in α-gal syndrome.
Immune 109: Allergic to red meat? Scientists discover a potential new treatment
YouTube video by MicrobeTV
youtu.be
October 27, 2026 at 2:23 PM
Immune explores two fortuitous discoveries: caspase inhibitors that hitch a ride through gasdermin D pores to selectively block proinflammatory cytokine secretion, and human monoclonal antibodies against malaria repurposed to block allergic antibody binding to red meat allergens in α-gal syndrome.
Gurkirat Wadhwa
When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
https://arxiv.org/abs/2610.33750
When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
https://arxiv.org/abs/2610.33750
October 28, 2026 at 6:37 AM
Gurkirat Wadhwa
When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
https://arxiv.org/abs/2610.33750
When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
https://arxiv.org/abs/2610.33750
Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation https://pubmed.ncbi.nlm.nih.gov/42929886/
October 27, 2026 at 10:41 AM
Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation https://pubmed.ncbi.nlm.nih.gov/42929886/
Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation https://pubmed.ncbi.nlm.nih.gov/42929886/
October 26, 2026 at 9:41 PM
Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation https://pubmed.ncbi.nlm.nih.gov/42929886/
An exciting study reveals that a juice with lycopene from tomatoes and isoflavones from soy significantly lowered key pro-inflammatory cytokine levels in just 4 weeks. As an inflammation reducer, it may broadly help prevent chronic conditions like dementia. For more search for DOI 10.1002/mnfr.70420
October 27, 2026 at 12:45 AM
An exciting study reveals that a juice with lycopene from tomatoes and isoflavones from soy significantly lowered key pro-inflammatory cytokine levels in just 4 weeks. As an inflammation reducer, it may broadly help prevent chronic conditions like dementia. For more search for DOI 10.1002/mnfr.70420
Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC https://www.biorxiv.org/content/10.64898/2026.10.22.760671v1
October 26, 2026 at 2:46 AM
Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC https://www.biorxiv.org/content/10.64898/2026.10.22.760671v1
📚 New Arxiv Paper
Title: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
Authors: Gurkirat Wadhwa
Read more: https://arxiv.org/abs/2610.33750
Title: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
Authors: Gurkirat Wadhwa
Read more: https://arxiv.org/abs/2610.33750
October 27, 2026 at 8:02 AM
📚 New Arxiv Paper
Title: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
Authors: Gurkirat Wadhwa
Read more: https://arxiv.org/abs/2610.33750
Title: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction
Authors: Gurkirat Wadhwa
Read more: https://arxiv.org/abs/2610.33750
This collection covers genetic susceptibility to infectious disease, environmental & evolutionary tuning of innate immune responses, neuroimmune regulation of tissue function, metabolic & transcriptional cell-fate control, & #cytokine-mediated tissue protection & repair 👉 rupress.org/jem/collecti...
October 23, 2026 at 8:03 PM
This collection covers genetic susceptibility to infectious disease, environmental & evolutionary tuning of innate immune responses, neuroimmune regulation of tissue function, metabolic & transcriptional cell-fate control, & #cytokine-mediated tissue protection & repair 👉 rupress.org/jem/collecti...
Gurkirat Wadhwa: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction https://arxiv.org/abs/2610.33750 https://arxiv.org/pdf/2610.33750 https://arxiv.org/html/2610.33750
October 27, 2026 at 6:49 AM
Gurkirat Wadhwa: When Protection Hurts: A Cytokine Storm Theory of Supply Chain Overreaction https://arxiv.org/abs/2610.33750 https://arxiv.org/pdf/2610.33750 https://arxiv.org/html/2610.33750
NKG2C+ NK cell-like TCRαβ+ CD8 T cells exhibit effective antitumor control in mice while mitigating cytokine release syndrome @jci.org @mskcancercenter.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
October 22, 2026 at 2:45 AM
NKG2C+ NK cell-like TCRαβ+ CD8 T cells exhibit effective antitumor control in mice while mitigating cytokine release syndrome @jci.org @mskcancercenter.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
What if some of the most interesting drug targets are simply the proteins we haven't systematically tested?
A new preprint maps human immune-cell responses across the cytokine repertoire and finds that GDF9 can mimic certain IL-2-like activities.
www.biorxiv.org/content/10.6...
A new preprint maps human immune-cell responses across the cytokine repertoire and finds that GDF9 can mimic certain IL-2-like activities.
www.biorxiv.org/content/10.6...
Decoding & manipulating human intercellular signaling via scalable cell-free protein synthesis
Intercellular protein signals underpin human health and influence disease outcomes. Millions of patients are treated annually with signaling inhibitors and activators, generating billions in sales. Ho...
www.biorxiv.org
October 28, 2026 at 1:12 PM
What if some of the most interesting drug targets are simply the proteins we haven't systematically tested?
A new preprint maps human immune-cell responses across the cytokine repertoire and finds that GDF9 can mimic certain IL-2-like activities.
www.biorxiv.org/content/10.6...
A new preprint maps human immune-cell responses across the cytokine repertoire and finds that GDF9 can mimic certain IL-2-like activities.
www.biorxiv.org/content/10.6...
Matrix viscoelasticity amplifies pro-fibrotic crosstalk between cardiac fibroblasts and macrophages
Matrix viscoelasticity amplifies pro-fibrotic crosstalk between cardiac fibroblasts and macrophages
Matrix viscoelasticity governs cardiac fibroblast-macrophage crosstalk, with soft, viscous environments amplifying profibrotic signaling through dynamic paracrine feedback. Atcha et al. examine how mechanical cues and sequential immune activation synergize to recapitulate post-infarction fibrosis, identifying cytokine networks that may serve as therapeutic targets in cardiac remodeling.
dlvr.it
October 26, 2026 at 12:35 PM
Matrix viscoelasticity amplifies pro-fibrotic crosstalk between cardiac fibroblasts and macrophages
Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation @insight.jci.org @cannalab.bsky.social @childrensphila.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
October 22, 2026 at 3:00 AM
Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation @insight.jci.org @cannalab.bsky.social @childrensphila.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
STAT3 is a cytokine-sensitive switch regulating NK cell differentiation in a mouse model of antiviral response.
Learn more in #ScienceImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression. https://scim.ag/4ymYbAe
Learn more in #ScienceImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression. https://scim.ag/4ymYbAe
STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells
STAT3 acts as a cytokine-sensing switch in NK cells, integrating IL-15 and type I interferon signals to shape antiviral responses.
scim.ag
October 20, 2026 at 3:00 PM
STAT3 is a cytokine-sensitive switch regulating NK cell differentiation in a mouse model of antiviral response.
Learn more in #ScienceImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression. https://scim.ag/4ymYbAe
Learn more in #ScienceImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression. https://scim.ag/4ymYbAe
HOIP is the main catalytic subunit of LUBAC, the main Met1-Ub ligase complex, which is required for efficient inflammatory signalling downstream of numerous TNF receptor superfamily members, cytokine and pattern recognition receptors. 3/12
October 28, 2026 at 1:01 PM
HOIP is the main catalytic subunit of LUBAC, the main Met1-Ub ligase complex, which is required for efficient inflammatory signalling downstream of numerous TNF receptor superfamily members, cytokine and pattern recognition receptors. 3/12
The authors included RRIDs in their in JCI Insight paper! We value the author's support of reproducibility. #STMpublishing #BetterScience #OpenResearch
Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation
Read the full paper: Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation
doi.org
October 25, 2026 at 7:00 AM
The authors included RRIDs in their in JCI Insight paper! We value the author's support of reproducibility. #STMpublishing #BetterScience #OpenResearch
Presented my research at #DC2026 on how blocking a tumor-derived cytokine alters Dendritic Cells to promote anti-tumor immunity! Fortunately, this picture was taken BEFORE the power-outage. Should have brought a flashlight ;)
Thank you to the organizers for hosting a wonderful conference!
Thank you to the organizers for hosting a wonderful conference!
October 23, 2026 at 4:55 AM
Presented my research at #DC2026 on how blocking a tumor-derived cytokine alters Dendritic Cells to promote anti-tumor immunity! Fortunately, this picture was taken BEFORE the power-outage. Should have brought a flashlight ;)
Thank you to the organizers for hosting a wonderful conference!
Thank you to the organizers for hosting a wonderful conference!
Raghav Paladugu, Fardina Fathmiul Alam: Computational De Novo Design of Miniprotein Candidate Neutralizers Targeting the IL-23 Cytokine Subunit p19 https://arxiv.org/abs/2610.32779 https://arxiv.org/pdf/2610.32779 https://arxiv.org/html/2610.32779
October 26, 2026 at 6:59 AM
Raghav Paladugu, Fardina Fathmiul Alam: Computational De Novo Design of Miniprotein Candidate Neutralizers Targeting the IL-23 Cytokine Subunit p19 https://arxiv.org/abs/2610.32779 https://arxiv.org/pdf/2610.32779 https://arxiv.org/html/2610.32779