Gastrointestinal symptoms are common in patients undergoing hemodialysis (HD) and closely associated with mesenteric ischemia, a life-threatening condition with high mortality. Nonocclusive mesenteric...

- A new manuscript published in the Journal of Vascular Surgery sheds light on the alarming prevalence of silent, severe coronary ischemia in patients with diabetic foot ulcers (DFU). The study, “High Prevalence of Silent, Severe Coronary Ischemia in Patients with Diabetic Foot Ulcers,” demonstrates that a significant proportion of DFU patients—without overt history of coronary artery A new manuscript published in the Journal of Vascular Surgery sheds light on the alarming prevalence of silent, severe coronary ischemia in patients with diabetic foot ulcers (DFU). The study, “High Prevalence of Silent, Severe Coronary Ischemia in Patients with Diabetic Foot Ulcers,” demonstrates that a significant proportion of DFU patients—without overt history of coronary artery A new manuscript published in the Journal of Vascular Surgery sheds light on the alarming prevalence of silent, severe coronary ischemia in patients with diabetic foot ulcers (DFU). The study, “High Prevalence of Silent, Severe Coronary Ischemia in Patients with Diabetic Foot Ulcers,” demonstrates that a significant proportion of DFU patients—without overt history of coronary artery - -

Background: Cardiac surgery patients are at particular risk of postoperative acute respiratory distress syndrome (ARDS), with an estimated incidence of 5% to 10%. Cardiopulmonary bypass (CPB), ischemia-reperfusion injury, and blood product transfusions are well-recognized contributing factors. Asymptomatic carriage of respiratory viruses has been hypothesized to prime the lungs and potentiate ARDS development when combined with the pulmonary insults of cardiac surgery. However, no #Study has directly assessed the relationship between preoperative asymptomatic viral carriage and postoperative ARDS. Objective: The VIRUS-ATTAC #Study aims to determine whether asymptomatic carriage of influenza or other respiratory viruses is independently associated with postoperative ARDS following elective cardiac surgery under CPB. Methods: VIRUS-ATTAC is a prospective, multicenter, low-interventional clinical #Study conducted across 5 French university hospitals and sponsored by Rennes University Hospital. Adult patients scheduled for elective cardiac surgery under CPB are eligible. A nasopharyngeal flocked swab is collected at anesthesia induction and tested using a multiplex reverse transcription polymerase chain reaction assay detecting 16 respiratory viruses. Results are kept blinded to the clinical team. The primary outcome is ARDS within 7 postoperative days, defined using the Berlin criteria and adjudicated by an independent blinded committee. Secondary outcomes include reintubation, postoperative pulmonary complications, pneumonia, ventilator-free days, intensive care unit–free days, hospital-free days, and 28-day mortality. The primary analysis uses a causal inference framework with a directed acyclic graph for confounder selection and g-computation to estimate the average treatment effect of viral carriage on ARDS risk. A sample size of 1250 patients (including 250 asymptomatic influenza carriers) provides 80% power to detect a 5% absolute risk increase in ARDS (2-sided α=.05). Results: The VIRUS-ATTAC #Study received ethics approval from the Comité de Protection des Personnes Sud-Est VI, and recruitment was initiated in February 2021 across 5 French university hospitals. Data collection was completed on March 10, 2023. Of the 1258 patients assessed as eligible, 1204 provided written informed consent and were enrolled. The #Study database was locked on April 9, 2026. Statistical analysis began after database lock, and the results are expected to be reported in a separate publication in 2027. Conclusions: VIRUS-ATTAC is the first prospective multicenter #Study to directly evaluate the association between preoperative asymptomatic respiratory viral carriage and postoperative ARDS in cardiac surgery patients. If confirmed, this association would provide a rationale for evaluating preventive strategies, such as systematic preoperative vaccination or postponement of elective surgery in carriers, in future interventional studies aiming to reduce postoperative respiratory complications. Trial Registration: ClinicalTrials.gov NCT04562207; https://clinicaltrials.gov/#Study/NCT04562207 International Registered Report Identifier (IRRID): DERR1-10.2196/103466

- Thanks to Magdalena Antoszewska for her wizardry in putting together this video. Here's to working to #ActAgainstAmputation For more on this blog (there's quite a lot) see below for a sample. 3 rings of risk WIFI plus Function Evolution of WIfI: Expansion of WIfI Notation After Intervention #ActAgainstAmputation @alpslimb @vascularsvs @USC_vascular @UCSFVascular @jmills1955 @VirginiePhD_POD @rowe_vincent Thanks to Magdalena Antoszewska for her wizardry in putting together this video. Here's to working to #ActAgainstAmputation For more on this blog (there's quite a lot) see below for a sample. 3 rings of risk WIFI plus Function Evolution of WIfI: Expansion of WIfI Notation After Intervention #ActAgainstAmputation @alpslimb @vascularsvs @USC_vascular @UCSFVascular @jmills1955 @VirginiePhD_POD @rowe_vincent Thanks to Magdalena Antoszewska for her wizardry in putting together this video. Here's to working to #ActAgainstAmputation For more on this blog (there's quite a lot) see below for a sample. 3 rings of risk WIFI plus Function Evolution of WIfI: Expansion of WIfI Notation After Intervention #ActAgainstAmputation @alpslimb @vascularsvs @USC_vascular @UCSFVascular @jmills1955 @VirginiePhD_POD @rowe_vincent - -

Interactions between brain-resident and peripheral infiltrated immune cells are thought to contribute to neuroplasticity after cerebral ischemia. However, conventional bulk sequencing makes it challen...

The human heart is a tireless pump, but it is also a machine that can be damaged by its own restart. When a blockage cuts off blood flow to the heart, the…

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Theory: MAP >65. Bedside: high norepi to hit 65 can cause limb ischemia. Prioritize perfusion over fixed MAP in severe shock. https://bexyhub.in

Read the full paper: Neuroprotective effect of a selective peroxisome proliferator-activated receptor alpha modulator in murine cerebral ischemia

We developed a postmortem protocol for temporal bone extraction and dissection in organ donors, enabling atraumatic bilateral temporal bone retrieval within 1–2 h of ischemia, followed by stepwise mi...