Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
November 15, 2024 at 6:11 PM
Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons"
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
Now on BioRxiv www.biorxiv.org/content/10.1...
Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social
💗piR-45962 exacerbates autophagic apoptosis in aged myocardial ischemia-reperfusion injury through modulation of the HNRNPH1/GATA5 signaling axis
www.sciengine.com/ABBS/doi/10....
#aged myocardial ischemia-reperfusion injury
#autophagic apoptosis
#piR-45962
www.sciengine.com/ABBS/doi/10....
#aged myocardial ischemia-reperfusion injury
#autophagic apoptosis
#piR-45962
September 30, 2026 at 4:55 AM
💗piR-45962 exacerbates autophagic apoptosis in aged myocardial ischemia-reperfusion injury through modulation of the HNRNPH1/GATA5 signaling axis
www.sciengine.com/ABBS/doi/10....
#aged myocardial ischemia-reperfusion injury
#autophagic apoptosis
#piR-45962
www.sciengine.com/ABBS/doi/10....
#aged myocardial ischemia-reperfusion injury
#autophagic apoptosis
#piR-45962
Like hummingbirds, certain infovores metabolize data so quickly that they require a near-constant stream of input. If starved, their brains gasp, shrivel, hallucinate; demonic visions tapdance in the autophagic froth
September 1, 2025 at 4:01 AM
Like hummingbirds, certain infovores metabolize data so quickly that they require a near-constant stream of input. If starved, their brains gasp, shrivel, hallucinate; demonic visions tapdance in the autophagic froth
This week’s selection of articles and @biorxivpreprint.bsky.social preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Autophagic stress activates distinct compensatory secretory pathways in neurons www.biorxiv.org/content/10.1...
Highlight: Autophagic stress activates distinct compensatory secretory pathways in neurons www.biorxiv.org/content/10.1...
biomed.news
November 24, 2024 at 8:06 AM
This week’s selection of articles and @biorxivpreprint.bsky.social preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Autophagic stress activates distinct compensatory secretory pathways in neurons www.biorxiv.org/content/10.1...
Highlight: Autophagic stress activates distinct compensatory secretory pathways in neurons www.biorxiv.org/content/10.1...
can everywhere please stop becoming a ritually autophagic nazi state for 2 seconds im trying to believe humanity is redeemable
July 25, 2025 at 7:15 AM
can everywhere please stop becoming a ritually autophagic nazi state for 2 seconds im trying to believe humanity is redeemable
Excited to hear some #proteostasis research at #MBP2026 by @cnaumann123.bsky.social who talks about a new plant-specific component of the autophagic network - see also her latest preprint
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 17, 2026 at 7:58 AM
Excited to hear some #proteostasis research at #MBP2026 by @cnaumann123.bsky.social who talks about a new plant-specific component of the autophagic network - see also her latest preprint
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
autophagic autocracies
August 2, 2025 at 12:23 AM
autophagic autocracies
Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ https://www.biorxiv.org/content/10.64898/2026.01.07.698105v1
January 8, 2026 at 2:31 PM
Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ https://www.biorxiv.org/content/10.64898/2026.01.07.698105v1
Look!
Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution
biorxiv.org/cgi/content/...
Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution
biorxiv.org/cgi/content/...
Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution
Autophagy is a highly conserved catabolic pathway to remove deleterious cytosolic material to maintain cellular homeostasis and cell survival. Upon autophagy induction, a unique double-membraned struc...
biorxiv.org
December 24, 2024 at 8:30 PM
Look!
Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution
biorxiv.org/cgi/content/...
Mechanistic studies of autophagic cargo recruitment and membrane expansion through in vitro reconstitution
biorxiv.org/cgi/content/...
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 24, 2025 at 7:09 PM
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#Autophagy #Senescence #MitralValveDisease
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
June 23, 2025 at 7:07 PM
#Autophagy #Senescence #MitralValveDisease
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
Senescent 🐶#ValvularInterstitialCell▶️⏬Autophagic flux
Autophagic p62-dependent degradation of p21 & p16 in canine VICs▶️⏬Senescence & SASP (MMP9 IL6 TGFB1)
#Autophagy 2025
www.tandfonline.com/doi/full/10....
The ideology is fascism. No need to fear the word.
Fascists kill fascists too. They're very violence oriented. They're autophagic.
It's right wing extremism. When the moderate right loses too much battles, this type emerges from the youngest
Happened before
Fascists kill fascists too. They're very violence oriented. They're autophagic.
It's right wing extremism. When the moderate right loses too much battles, this type emerges from the youngest
Happened before
September 25, 2025 at 4:33 AM
The ideology is fascism. No need to fear the word.
Fascists kill fascists too. They're very violence oriented. They're autophagic.
It's right wing extremism. When the moderate right loses too much battles, this type emerges from the youngest
Happened before
Fascists kill fascists too. They're very violence oriented. They're autophagic.
It's right wing extremism. When the moderate right loses too much battles, this type emerges from the youngest
Happened before
In case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) evades immune detection partly via autophagic capture and lysosomal degradation of major histocompatibility complex class I (MHC-I). Why MHC-I is susceptible to ...
www.biorxiv.org
December 12, 2024 at 4:49 AM
In case you missed it.. New preprint! Our latest study identifying how MHC-I is captured by autophagy and targeted for degradation in #PDAC - It all happens at the ER ! Congrats to co-first authors Marine Berquez, Alex Li & Matthew Luy.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
New in Nature Comms: Autophagic EVs (AEVs) are a distinct vesicle subtype, not just #exosomes!
Mao et al. used proteomics to identify unique markers (autophagic cargos, ESCRT III components, Rab13) for these <100nm vesicles released via amphisomes.
www.nature.com/articles/s41...
#Proteomics
Mao et al. used proteomics to identify unique markers (autophagic cargos, ESCRT III components, Rab13) for these <100nm vesicles released via amphisomes.
www.nature.com/articles/s41...
#Proteomics
Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections - Nature Communications
The authors identify a subtype of small extracellular vesicles, termed autophagic extracellular vesicles. This type of vesicle exhibits biomarkers different from exosomes and plays a crucial role in v...
www.nature.com
January 25, 2026 at 4:22 PM
New in Nature Comms: Autophagic EVs (AEVs) are a distinct vesicle subtype, not just #exosomes!
Mao et al. used proteomics to identify unique markers (autophagic cargos, ESCRT III components, Rab13) for these <100nm vesicles released via amphisomes.
www.nature.com/articles/s41...
#Proteomics
Mao et al. used proteomics to identify unique markers (autophagic cargos, ESCRT III components, Rab13) for these <100nm vesicles released via amphisomes.
www.nature.com/articles/s41...
#Proteomics
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
www.biorxiv.org
February 14, 2026 at 1:34 PM
Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis
Out now 👇 www.biorxiv.org/content/10.6...
Our First preprint 🌱 about a new Component of the Autophagic Network identified in Pi-deprived root tips is online ❣️ All I wished for Valentine's day 😀 #proudPI#autophagy#rootPiSensing#plantproteolysis
CAN1-mediated autophagosome size regulation fine-tunes phosphate starvation tolerance in Arabidopsis thaliana https://www.biorxiv.org/content/10.64898/2026.02.12.705259v1
February 14, 2026 at 1:04 PM
Our First preprint 🌱 about a new Component of the Autophagic Network identified in Pi-deprived root tips is online ❣️ All I wished for Valentine's day 😀 #proudPI#autophagy#rootPiSensing#plantproteolysis
Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...
Autophagic stress activates distinct compensatory secretory pathways in neurons
Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...
www.biorxiv.org
November 13, 2024 at 3:26 PM
Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...
Cold plunges actually change your cells
University of Ottawa
Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better.
www.sciencedaily.com/releases/202...
University of Ottawa
Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better.
www.sciencedaily.com/releases/202...
March 31, 2025 at 1:09 AM
Cold plunges actually change your cells
University of Ottawa
Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better.
www.sciencedaily.com/releases/202...
University of Ottawa
Cold water immersion for seven days significantly improves cellular resilience and autophagic function, helping cells manage stress better.
www.sciencedaily.com/releases/202...
Next is Christin Naumann a jr. PI at the IPB in Halle on the identification of a new plant-specific component of the
Autophagic Network
#MBP2026
Autophagic Network
#MBP2026
March 17, 2026 at 7:58 AM
Next is Christin Naumann a jr. PI at the IPB in Halle on the identification of a new plant-specific component of the
Autophagic Network
#MBP2026
Autophagic Network
#MBP2026
not cannibal capitalism but the autophagic society
April 4, 2025 at 6:45 AM
not cannibal capitalism but the autophagic society
New Article: "Vacuolar sorting receptors coordinate lytic vacuolar and autophagic transport for plant effector-triggered immunity" rdcu.be/eBbOG
VSRs orchestrate the vacuolar sorting of immune-related proteins and autophagic degradation of bacterial effectors in ETI.
VSRs orchestrate the vacuolar sorting of immune-related proteins and autophagic degradation of bacterial effectors in ETI.
August 18, 2025 at 10:51 AM
New Article: "Vacuolar sorting receptors coordinate lytic vacuolar and autophagic transport for plant effector-triggered immunity" rdcu.be/eBbOG
VSRs orchestrate the vacuolar sorting of immune-related proteins and autophagic degradation of bacterial effectors in ETI.
VSRs orchestrate the vacuolar sorting of immune-related proteins and autophagic degradation of bacterial effectors in ETI.
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in #PancreaticCancer 🧪 www.nature.com/articles/s41...
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer - Cell Death & Differentiation
Cell Death & Differentiation - USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer
www.nature.com
December 4, 2024 at 4:49 PM
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in #PancreaticCancer 🧪 www.nature.com/articles/s41...
Very excited to share my postdoc work- out now at PNAS!
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
July 7, 2025 at 7:38 PM
Very excited to share my postdoc work- out now at PNAS!
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways
Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...
Bacterial lipid effectors subvert host autophagic flux by inducing lysosomal dysfunction https://www.biorxiv.org/content/10.64898/2026.09.18.752599v1
September 22, 2026 at 12:30 PM
Bacterial lipid effectors subvert host autophagic flux by inducing lysosomal dysfunction https://www.biorxiv.org/content/10.64898/2026.09.18.752599v1