This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
November 24, 2024 at 3:20 AM
This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
For people in the Boston area, this new long Covid clinical trial is now recruiting — testing Abrocitinib, a selective JAK1 inhibitor @postviraltrials.bsky.social
clinicaltrials.gov/study/NCT065...
clinicaltrials.gov/study/NCT065...
ClinicalTrials.gov
clinicaltrials.gov
January 10, 2025 at 5:43 PM
For people in the Boston area, this new long Covid clinical trial is now recruiting — testing Abrocitinib, a selective JAK1 inhibitor @postviraltrials.bsky.social
clinicaltrials.gov/study/NCT065...
clinicaltrials.gov/study/NCT065...
June 29, 2025 at 1:25 PM
@fitzbear.bsky.social @leroytoon.bsky.social keep temping me and teasing me to make my new sona Juno ether a Pookoo or a Ottsel and its scaryly working Dx ahhhh make them stahhhp!!
Jak And Daxter Jak1 Transformation XD
ALT: Jak And Daxter Jak1 Transformation XD
static.klipy.com
June 12, 2026 at 5:58 PM
@fitzbear.bsky.social @leroytoon.bsky.social keep temping me and teasing me to make my new sona Juno ether a Pookoo or a Ottsel and its scaryly working Dx ahhhh make them stahhhp!!
Not that we need it per se, but a little bit more evidence that IL-6 can drive pathological inflammation in lungs...
(here in mouse model of post allo-HSCT)
@jidjournal.bsky.social
#immunosky #medsky
(here in mouse model of post allo-HSCT)
@jidjournal.bsky.social
#immunosky #medsky
Interleukin-6 is significantly increased in severe pneumonia after allo-HSCT and might induce lung injury via IL-6/sIL-6R/JAK1/STAT3 pathway
Interleukin-6 elevated in severe pneumonia after allo-HSCT and plays a role in lung injury via the IL-6/sIL-6R/JAK1/STAT3 pathway.
academic.oup.com
January 23, 2025 at 11:25 PM
Not that we need it per se, but a little bit more evidence that IL-6 can drive pathological inflammation in lungs...
(here in mouse model of post allo-HSCT)
@jidjournal.bsky.social
#immunosky #medsky
(here in mouse model of post allo-HSCT)
@jidjournal.bsky.social
#immunosky #medsky
The FDA has approved brepocitinib as a TYK2/JAK1 inhibitor from Roivant/Priovant
Huge shout out to the #PfizerChemistry team who discovered the molecule - it was a large project team and when I joined the mol had already been identified and…
#ChemSky 1/…
Huge shout out to the #PfizerChemistry team who discovered the molecule - it was a large project team and when I joined the mol had already been identified and…
#ChemSky 1/…
August 28, 2026 at 4:29 PM
The FDA has approved brepocitinib as a TYK2/JAK1 inhibitor from Roivant/Priovant
Huge shout out to the #PfizerChemistry team who discovered the molecule - it was a large project team and when I joined the mol had already been identified and…
#ChemSky 1/…
Huge shout out to the #PfizerChemistry team who discovered the molecule - it was a large project team and when I joined the mol had already been identified and…
#ChemSky 1/…
The first account was of #filgotinib, and this is of #upadacitinib. Both are Janus tyrosine kinase type 1 (JAK1) inhibitors.
November 21, 2024 at 7:29 PM
The first account was of #filgotinib, and this is of #upadacitinib. Both are Janus tyrosine kinase type 1 (JAK1) inhibitors.
JAK1 Degradation by HMPV SH Protein Impairs Host IL-6 Signaling
www.thailandmedical.news/news/jak1-de...
www.thailandmedical.news/news/jak1-de...
JAK1 Degradation by HMPV SH Protein Impairs Host IL-6 Signaling - Thailand Medical News
www.thailandmedical.news
January 5, 2025 at 7:57 AM
JAK1 Degradation by HMPV SH Protein Impairs Host IL-6 Signaling
www.thailandmedical.news/news/jak1-de...
www.thailandmedical.news/news/jak1-de...
Health Rising: “From Severe ME/CFS to Healed: Jen’s Remarkable Rinvoq ME/CFS Recovery Story”
‘To encourage further research into Rinvoq and JAK1 inhibitors in ME, Jen plans to publish a comprehensive case study soon’
www.healthrising.org/blog/2024/11...
‘To encourage further research into Rinvoq and JAK1 inhibitors in ME, Jen plans to publish a comprehensive case study soon’
www.healthrising.org/blog/2024/11...
www.healthrising.org
November 20, 2024 at 8:55 PM
Health Rising: “From Severe ME/CFS to Healed: Jen’s Remarkable Rinvoq ME/CFS Recovery Story”
‘To encourage further research into Rinvoq and JAK1 inhibitors in ME, Jen plans to publish a comprehensive case study soon’
www.healthrising.org/blog/2024/11...
‘To encourage further research into Rinvoq and JAK1 inhibitors in ME, Jen plans to publish a comprehensive case study soon’
www.healthrising.org/blog/2024/11...
Good Sundsy to all who worm! Today's semi-inspirational reading is from The Book of Delbert
youtube.com/watch?v=jak1...
Never Been Rocked Enough - Delbert McClinton (Delbert McClinton)
youtube.com/watch?v=jak1...
Never Been Rocked Enough - Delbert McClinton (Delbert McClinton)
Delbert McClinton - Never Been Rocked Enough
YouTube video by amenhop
youtube.com
September 20, 2026 at 10:47 AM
Good Sundsy to all who worm! Today's semi-inspirational reading is from The Book of Delbert
youtube.com/watch?v=jak1...
Never Been Rocked Enough - Delbert McClinton (Delbert McClinton)
youtube.com/watch?v=jak1...
Never Been Rocked Enough - Delbert McClinton (Delbert McClinton)
Thank you for all who hung out today while I flew through Jak1 and starting Jak 2, and thank you @luiroi.bsky.social for the raid and bringing your community to mine ;w;
Hope you all had a amazing time!
Hope you all had a amazing time!
January 27, 2025 at 11:19 PM
Thank you for all who hung out today while I flew through Jak1 and starting Jak 2, and thank you @luiroi.bsky.social for the raid and bringing your community to mine ;w;
Hope you all had a amazing time!
Hope you all had a amazing time!
RNA dicing promotes the expression of an oncogenic JAK1 isoform
RNA dicing promotes the expression of an oncogenic JAK1 isoform
van der Kammen et al. describe RNA dicing, a mechanism in which post-transcriptional mRNA cleavage at alternative polyadenylation (APA) sites generates uncapped transcripts that enable translation of truncated protein isoforms. In JAK1, RNA dicing produces an independent JH1 kinase domain that alters signaling, promotes proliferation, and creates opportunities for therapy.
dlvr.it
May 3, 2026 at 7:50 PM
RNA dicing promotes the expression of an oncogenic JAK1 isoform
That daxter model is not mine, incase if you’re about to ask
I just took his model from Jak1 and did some tweaks
I just preferred how he looked in that game vs how he looked in Jak2 and onward’s cutscenes, his exaggerated expressions just worked better for him as a character in my opinion
I just took his model from Jak1 and did some tweaks
I just preferred how he looked in that game vs how he looked in Jak2 and onward’s cutscenes, his exaggerated expressions just worked better for him as a character in my opinion
April 25, 2026 at 11:20 PM
That daxter model is not mine, incase if you’re about to ask
I just took his model from Jak1 and did some tweaks
I just preferred how he looked in that game vs how he looked in Jak2 and onward’s cutscenes, his exaggerated expressions just worked better for him as a character in my opinion
I just took his model from Jak1 and did some tweaks
I just preferred how he looked in that game vs how he looked in Jak2 and onward’s cutscenes, his exaggerated expressions just worked better for him as a character in my opinion
For me it’s the first Jak & Daxter game. The first game I felt like I was good at even though I never completed it. Plus riding the Flut Flut was always fun xD
Jak And Daxter Jak1
ALT: Jak And Daxter Jak1
static.klipy.com
September 20, 2026 at 8:52 PM
For me it’s the first Jak & Daxter game. The first game I felt like I was good at even though I never completed it. Plus riding the Flut Flut was always fun xD
Barcelona researchers analyzed human lung, kidney, and nasal tissues and found SARS-CoV-2 uses different entry pathways in different organs.
Blocking IL1R1 reduced lung infection while JAK1/2 inhibition strongly reduced kidney infection.
www.biorxiv.org/content/10.6...
Blocking IL1R1 reduced lung infection while JAK1/2 inhibition strongly reduced kidney infection.
www.biorxiv.org/content/10.6...
www.biorxiv.org
May 9, 2026 at 11:59 AM
Barcelona researchers analyzed human lung, kidney, and nasal tissues and found SARS-CoV-2 uses different entry pathways in different organs.
Blocking IL1R1 reduced lung infection while JAK1/2 inhibition strongly reduced kidney infection.
www.biorxiv.org/content/10.6...
Blocking IL1R1 reduced lung infection while JAK1/2 inhibition strongly reduced kidney infection.
www.biorxiv.org/content/10.6...
Researchers found that IL6 suppresses mitochondrial function via the JAK1/STAT1/3-HIF1α/ERRα pathway.
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
Xu et al. show that IL6, not TNF-α, suppresses mitochondrial function. When PGC1 is
low, IL6 increases HIF1A transcription and stabilizes HIF1α protein via ERRα. HIF1α
reciprocally suppresses ERRα, co...
www.cell.com
March 8, 2025 at 12:25 AM
Researchers found that IL6 suppresses mitochondrial function via the JAK1/STAT1/3-HIF1α/ERRα pathway.
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
When PGC1 levels are low, IL6 stabilizes HIF1α, which inhibits ERRα, reducing mitochondrial activity.
Boosting PGC1 reverses this effect.
www.cell.com/cell-reports...
@jem.org a new type I IFN–dependent psoriasis subtype resulting from rare heterozygous variants in ADAR1 and associated with a specific response to JAK1 and TYK2 inhibitors @inserm.fr
rupress.org/jem/article-...
rupress.org/jem/article-...
July 15, 2026 at 6:03 PM
@jem.org a new type I IFN–dependent psoriasis subtype resulting from rare heterozygous variants in ADAR1 and associated with a specific response to JAK1 and TYK2 inhibitors @inserm.fr
rupress.org/jem/article-...
rupress.org/jem/article-...
oh yeah since sly2 was pretty long, I'm taking a break from doing sly3 and now I'm playing Jak1
September 8, 2025 at 3:05 PM
oh yeah since sly2 was pretty long, I'm taking a break from doing sly3 and now I'm playing Jak1
und -aktivitäten regulieren –, die als Kennzeichen von Long COVID gelten. Patienten mit Long COVID zeigten Anzeichen chronischer Entzündungen, einer Schwächung des Immunsystems und Störungen des Zellstoffwechsels, die bei Patienten, die sich vollständig von COVID-19 erholt
January 3, 2026 at 6:04 PM
und -aktivitäten regulieren –, die als Kennzeichen von Long COVID gelten. Patienten mit Long COVID zeigten Anzeichen chronischer Entzündungen, einer Schwächung des Immunsystems und Störungen des Zellstoffwechsels, die bei Patienten, die sich vollständig von COVID-19 erholt
Janus Kinaz 1 (JAK1) ve JAK2 adlı inflamasyonla ilişkili iki sinyal proteinini inhibe eden ruxolitinib adlı ilaç, yalnızca JAK1 veya JAK2'yi inhibe eden diğer ilaçlardan daha üstünmüş.
March 8, 2024 at 6:55 PM
Janus Kinaz 1 (JAK1) ve JAK2 adlı inflamasyonla ilişkili iki sinyal proteinini inhibe eden ruxolitinib adlı ilaç, yalnızca JAK1 veya JAK2'yi inhibe eden diğer ilaçlardan daha üstünmüş.
April Arthritis & Rheumatology Clinical Connections
•Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to JAK1/2 Inhibitors
•Clinical Characteristics of Anti-Synthetase Syndrome: Analysis from the CLASS Project
acr.tw/426RTql
#Medsky #Rheumsky
•Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to JAK1/2 Inhibitors
•Clinical Characteristics of Anti-Synthetase Syndrome: Analysis from the CLASS Project
acr.tw/426RTql
#Medsky #Rheumsky
March 31, 2025 at 8:10 PM
April Arthritis & Rheumatology Clinical Connections
•Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to JAK1/2 Inhibitors
•Clinical Characteristics of Anti-Synthetase Syndrome: Analysis from the CLASS Project
acr.tw/426RTql
#Medsky #Rheumsky
•Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to JAK1/2 Inhibitors
•Clinical Characteristics of Anti-Synthetase Syndrome: Analysis from the CLASS Project
acr.tw/426RTql
#Medsky #Rheumsky
New Jersey doctors report 3 cases, 2 with autism and 1 without, where long COVID worsened neuropsychiatric symptoms. All improved within weeks after treatment with upadacitinib, a JAK1 inhibitor blocking interferon pathways.
bmcneurol.biomedcentral.com/articles/10....
bmcneurol.biomedcentral.com/articles/10....
Favorable responses to upadacitinib, a JAK1 inhibitor, in long COVID patients with predominant neuropsychiatric symptoms: case reports in 2 autistic patients and one typically developing patient - BMC...
The long-term impact of coronavirus disease 2019 (COVID-19) has become evident over the past 3–4 years, with the recognition of post-COVID long-term sequelae, often referred to as long COVID. Neuropsy...
bmcneurol.biomedcentral.com
August 20, 2025 at 3:58 PM
New Jersey doctors report 3 cases, 2 with autism and 1 without, where long COVID worsened neuropsychiatric symptoms. All improved within weeks after treatment with upadacitinib, a JAK1 inhibitor blocking interferon pathways.
bmcneurol.biomedcentral.com/articles/10....
bmcneurol.biomedcentral.com/articles/10....
Shanghai researchers found that EGCG, a green tea compound, blocked IFN-β-triggered mucus overproduction in airway cells by inhibiting JAK1, which in turn shut down STAT1 and ERK signaling linked to MUC5AC expression.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Epigallocatechin gallate inhibited IFN-β induced MUC5AC overexpression in airway epithelial cells by modulating JAK1 mediated STAT1 and ERK pathways activation
The overexpression of mucin 5AC (MUC5AC) induced by interferon-beta (IFN-β) plays a critical role in airway mucus hypersecretion and contributes to th…
www.sciencedirect.com
July 4, 2025 at 12:50 PM
Shanghai researchers found that EGCG, a green tea compound, blocked IFN-β-triggered mucus overproduction in airway cells by inhibiting JAK1, which in turn shut down STAT1 and ERK signaling linked to MUC5AC expression.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
So glad this is finally shared. It’s a remarkable story.
Severe ME/CFS to Healed: Jen's Remarkable Rinvoq ME/CFS Recovery Story - Health Rising
www.healthrising.org/blog/2024/11...
Severe ME/CFS to Healed: Jen's Remarkable Rinvoq ME/CFS Recovery Story - Health Rising
www.healthrising.org/blog/2024/11...
From Severe ME/CFS to Healed: Jen's Remarkable Rinvoq ME/CFS Recovery Story - Health Rising
Jen quickly recovers from a long and severe case of chronic fatigue syndrome eg. ME/CFS using a JAK1 inhibitor called Rinvoq.
www.healthrising.org
November 20, 2024 at 9:54 PM
So glad this is finally shared. It’s a remarkable story.
Severe ME/CFS to Healed: Jen's Remarkable Rinvoq ME/CFS Recovery Story - Health Rising
www.healthrising.org/blog/2024/11...
Severe ME/CFS to Healed: Jen's Remarkable Rinvoq ME/CFS Recovery Story - Health Rising
www.healthrising.org/blog/2024/11...
A report by Muhammad Junejo et al., "JAK1 Inhibition is Sufficient for the Treatment of Granuloma Annulare" https://doi.org/10.1016/j.jid.2025.04.030 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky
December 15, 2025 at 11:35 AM
A report by Muhammad Junejo et al., "JAK1 Inhibition is Sufficient for the Treatment of Granuloma Annulare" https://doi.org/10.1016/j.jid.2025.04.030 #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermsky