#JAXResearch
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trowbridgelab.bsky.social
Our Stem Cells & Developmental Biology program is live! We've built something rare: an integrated community of basic & translational scientists, innovative technologies & humanized models — all aimed at improving human health. @jax.org
🔗 go.jax.org/stem-cell-research
#JAXresearch #JAXstemcellsdev
Stem Cells & Developmental Biology
At JAX, we investigate how genetic and epigenetic programs govern stem cell fate, tissue growth and patterning, and regeneration—and how these processes can be restored in disease—by integrating devel...
go.jax.org
May 21, 2026 at 3:45 PM
trowbridgelab.bsky.social
The Jackson Laboratory is a wonderful, collaborative place to pursue basic & translational science. On the faculty job market? I strongly encourage you to consider joining us in Bar Harbor, Maine!
Apply: go.jax.org/276n55

#JAXresearch #JAXstemcellsdev
Faculty Positions - Now Accepting Applications
The Jackson Laboratory is inviting applications for Assistant and Associate Professors at our Mammalian Genetics campus in Bar Harbor, Maine.
go.jax.org
September 21, 2026 at 7:27 PM
trowbridgelab.bsky.social
A huge congratulations to the newest graduate of the Trowbridge lab at The Jackson Laboratory @jax.org, Dr. Shawn David!! Shawn did a fantastic job defending his thesis today. So proud! 🎉 👏 🎊 #JAXGenomicEducation #UMaineGSBSE #JAXresearch #JAXstemcellsdev
August 5, 2026 at 11:49 PM
jax.org
📕 New in Leukemia from Springer Nature Group, "Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition" with Eric Wang: www.nature.com/articles/s41... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition - Leukemia
Leukemia - Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
www.nature.com
September 16, 2024 at 12:55 PM
trowbridgelab.bsky.social
It's Day 1 of #ISSCR2026! Big day for @jax.org:

🍽️ 12:30 pm — JAX-NYSCF Innovation Showcase: scalable iPSC platforms for neurodegeneration | Room 510a (lunch provided)

🎤 3:10 pm — Daniel Paull: scaling iPSC models for drug discovery | Room 510a

#JAXresearch #JAXstemcellsdev
July 8, 2026 at 2:33 PM
trowbridgelab.bsky.social
With mixed emotions, we said farewell to our @jax.org summer student Eva Rios. She was a JOY to have in the lab - thoughtful, engaged, creative, a dot-connector and with a great sense of humor and desire to learn and be challenged 🤩 #SSP26 #JAXGenomicEducation #JAXresearch #JAXstemcellsdev
August 7, 2026 at 12:21 PM
trowbridgelab.bsky.social
Excited to welcome Dr. Laura Bennett to JAX and our Stem Cells & Developmental Biology group this fall! Trained with Nancy Speck at UPenn, Laura's rigorous & translationally-minded program on HSC development is a perfect fit. Details below! #JAXresearch #JAXstemcellsdev
May 28, 2026 at 1:57 PM
trowbridgelab.bsky.social
3/3 A highlight was sitting down with Dr. Laura Bennett to discuss her upcoming lab launch @jax.org. Her arrival is a major addition to our Stem Cells & Developmental Biology program, and a sign of exciting things ahead! #JAXresearch #JAXstemcellsdev
June 3, 2026 at 6:19 PM
jax.org
📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell:

🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience

doi.org/10.1016/j.ne...
scientific illustration
May 30, 2024 at 12:53 PM
jax.org
📔 New in Advanced Functional Materials from Wily, "Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model" with Mikail Dogan & Derya Unutmaz: onlinelibrary.wiley.com/doi/10.1002/...
#jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing
August 19, 2024 at 1:51 PM
jax.org
Read the full story 👇

#jaxstemcelldev #jaxresearch #bloodcancer #newpub #newpaper #science #stemcells
Pre-cancerous blood cells may fuel disease risk by prematurely aging the bone marrow
New JAX research shows mutant blood cells reshape the bone marrow environment in ways that promote disease progression, opening new avenues for prevention.
www.jax.org
August 7, 2026 at 6:01 PM
trowbridgelab.bsky.social
Congrats to Basile Tarchini & team, part of our Stem Cells & Development program @jax.org, on their new paper! Auditory hair cells self-correct their orientation after birth, even without the proteins thought to control it. journals.biologists.com/dev/article/...

#JAXresearch #JAXstemcellsdev
Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling
Summary: Misoriented mouse auditory hair cells can spontaneously correct their orientation after birth, revealing unexpected plasticity and a partnership between core planar cell polarity proteins and...
journals.biologists.com
June 17, 2026 at 4:31 PM
jax.org
📓 New in the European Journal of Human Genetics from Nature Portfolio, "Speech and language classification in the human phenotype ontology" with Ben Coleman & Peter Robinson: www.nature.com/articles/s41...
#jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing
Speech and language classification in the human phenotype ontology - European Journal of Human Genetics
European Journal of Human Genetics - Speech and language classification in the human phenotype ontology
www.nature.com
August 12, 2024 at 5:53 PM
trowbridgelab.bsky.social
Day 3 of #ISSCR2026 🔬 JAX stem cells & development colleagues present new translational work on diabetes and vision loss! 👇 Final day tomorrow, and something special for JAX. Stay tuned. 🏆

#JAXresearch #JAXstemcellsdev
July 10, 2026 at 11:44 AM
jax.org
📙 New in @plos.bsky.social Computational Biology, "Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline" with Joshua Mitchell, Yuanye Chi, Maheshwor Thapa & Shuzhao Li:

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ResearchPublishing

doi.org/10.1371/jour...
Common data models to streamline metabolomics processing and annotation, and implementation in a Python pipeline
To standardize metabolomics data analysis and facilitate future computational developments, it is essential to have a set of well-defined templates for common data structures. Here we describe a colle...
doi.org
June 25, 2024 at 12:27 PM
jax.org
📓 New review in Frontiers in Immunology, "Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential" with Derya Unutmaz:

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #immunosky #ScientificResearchPublishing

www.frontiersin.org/journals/imm...
Frontiers | Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential
Mucosal-associated invariant T (MAIT) cells play diverse roles in cancer, infectious diseases, and immunotherapy. This review explores their intricate involv...
www.frontiersin.org
April 11, 2024 at 4:13 PM
jax.org
📗 New in GeroScience from Springer Nature Group, "Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice" with Alison Lu: link.springer.com/article/10.1... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing
Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice - GeroScience
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these studies and reduce the need for veterinary interventi...
link.springer.com
August 27, 2024 at 1:23 PM
trowbridgelab.bsky.social
Congrats to our Stem Cells & Development colleague Stefan Semrau! Support from the Michael J. Fox Foundation will launch human stem cell models of Parkinson's disease to be shared with the research community. More details below! #JAXresearch #JAXstemcellsdev
jax.org The Jackson Laboratory @jax.org · Jun 9
🧪 🧬 🧠 - We are excited to announce that we have received $1.8 million from the Michael J. Fox Foundation to address a critical gap in Parkinson’s research – the limited availability of standardized, scalable human cell model systems for understanding Parkinson’s.
The Jackson Laboratory secures grant from The Michael J. Fox Foundation to advance Parkinson’s disease research through the JAX–NYSCF Collaborative
New human stem cell platform will expand access to standardized disease models, support Parkinson’s disease research and therapeutic discovery efforts.
www.jax.org
June 10, 2026 at 2:06 PM
jax.org
New in Genetics from Oxford Journals, "Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse" by Richard Baldarelli, Cynthia Smith, Martin Ringwald, Joel Richardson, Carol Bult & MGI Mouse:

#jaxresearch 🧪🤝🖥️ 🧬 ⑂

doi.org/10.1093/gene...
Mouse Genome Informatics: an integrated knowledgebase system for the laboratory mouse
Abstract. Mouse Genome Informatics (MGI) is a federation of expertly curated information resources designed to support experimental and computational inves
doi.org
April 23, 2024 at 1:14 PM
jax.org
📘 New in the Journal of Neuropathology & Experimental Neurology, "Testing SIPA1L2 as a modifier of CMT1A using mouse models" with @georgecmurray.bsky.social, Timothy Hines, Abigail Tadenev & Robert Burgess:

#jaxresearch #raredisease #ScientificResearchPublishing
🧪🤝🖥️ 🧬

t.co/uxSGsnVrX3
Testing SIPA1L2 as a modifier of CMT1A using mouse models
Abstract. Charcot-Marie-Tooth disease type 1A (CMT1A) is a demyelinating peripheral neuropathy caused by the duplication of peripheral myelin protein 22 (P
t.co
April 1, 2024 at 3:47 PM
jax.org
📘 New in Redox Biology, "Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics" with Susan McClatchy & Gary Churchill:

doi.org/10.1016/j.re...

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing
scientific image showing phenotype processing
July 16, 2024 at 1:50 PM
trowbridgelab.bsky.social
📣 ISSCR 2026 is almost here (July 8–11, Montréal)! Our JAX Stem Cells & Developmental Biology colleagues (www.jax.org/research-and...) have talks and posters across the meeting, plus a JAX-NYSCF Innovation Showcase and Booth #605. Here's the full picture 👇 #ISSCR2026 #JAXresearch #JAXstemcellsdev
Stem Cells & Developmental Biology
By studying how cells are born, integrate, and regenerate, JAX researchers are uncovering the foundations of human health.
www.jax.org
June 30, 2026 at 1:18 PM
jaxeducation.bsky.social
We were pleased to welcome high school students w/ the Senior Doctors Academy of Health Career Opportunity Programs at @uconn.bsky.social Health to @jacksonlab.bsky.social.

Students got an overview of #JAXResearch & completed a hands-on genetic variation exercise. Thanks for visiting! 👏

#SciEd
Students pose for a group photo at The Jackson Laboratory in Farmington, Connecticut. Two students practice pipetting into a gel electrophoresis tray at a table. Four students laugh as they practice pipetting into small plastic tubes at a table. Three students practice pipetting into small plastic tubes at a table.
April 9, 2024 at 11:43 AM
jax.org
📘 New in Bioinformatics from Oxford University Press, "FastHPOCR: Pragmatic, fast and accurate concept recognition using the Human Phenotype Ontology" with Peter Robinson: doi.org/10.1093/bioi...

#jaxresearch 🧪🤝🖥️ 🧬 ⑂
FastHPOCR: pragmatic, fast, and accurate concept recognition using the human phenotype ontology
AbstractMotivation. Human Phenotype Ontology (HPO)-based phenotype concept recognition (CR) underpins a faster and more effective mechanism to create patie
doi.org
July 8, 2024 at 2:28 PM
jax.org
📕 From AACR Journals: "A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis" with Brian White, Carol Bult, Jeffrey Chuang and team: aacrjournals.org/cancerres/ar... #jaxresearch 🧪🤝🖥️ 🧬 #scientificresearchpublishing
A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
A pan-cancer repository of >1,000 patient-derived xenograft hematoxylin and eosin–stained images will facilitate cancer biology investigations through histopathological analysis and contributes import...
aacrjournals.org
September 9, 2024 at 12:18 PM