#JCSciliaSI
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marinebrunet.bsky.social
Exciting news: the new review from @centriolelab.bsky.social is out in the amazing #JCSciliaSI! 🎉
I had the pleasure of working alongside Olivier Mercey, Paul Guichard and Virginie Hamel on this one.
Cherry on top: our #UExM image was selected for the cover of the issue! 🤩
Advances in high-resolution imaging of centrioles and cilia
Summary: A review of the progressive advances in light and electron microscopy that have revealed unprecedented structural and molecular insights into centrioles and cilia, and reshaped our view of th...
journals.biologists.com
November 3, 2025 at 2:47 PM
theracilproject.bsky.social
💥 Check the Cilia special issue #JCSciliaSI from @jcellsci.bsky.social co-edited by @lottepedersen.bsky.social and with several exciting papers by other @theracilproject.bsky.social members - congrats Bernhard Schermer @cilib.bsky.social Ronald Roepman Soren Christensen John Sayer and co-authors 💥
jcellsci.bsky.social Journal of Cell Science @jcellsci.bsky.social · Nov 4
Our #JCSciliaSI is complete

Explore our ToC: journals.biologists.com/jcs/issue/13...

Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
JCS Cover: Human tracheal epithelial cells (hTECs) from an air–liquid interface culture imaged using ultrastructural expansion microscopy (U-ExM). Cells are labelled for tubulin (magenta), mCLING (cyan) and DNA (blue, DAPI). Image from Olivier Mercey and Marine Brunet in the Guichard-Hamel lab. See article by O. Mercey et al. (jcs264260).
November 6, 2025 at 10:32 AM
focalplane.bsky.social
We’re excited for the UK Cilia and Centrosome Network e-symposium this afternoon featuring the #JCSciliaSI!

To discover more about the research in this issue, check out these JCS snapshots, video highlights from authors about their research: focalplane.biologists.com/2025/11/24/j...
JCS snapshots: the cilia and flagella edition - FocalPlane
JCS snapshots: the cilia and flagella edition - News
focalplane.biologists.com
November 25, 2025 at 12:29 PM
focalplane.bsky.social
While trying to steer clear of the ‘best organelle’ debate, we’re delighted to highlight #JCSciliaSI, guest edited by @cilialab.bsky.social & @lottepedersen.bsky.social.

And, we hope that even the most ardent fans of other organelles can agree that cilia are certainly beautiful to image!
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - FocalPlane
JCS Special Issue - 'Cilia and Flagella: from Basic Biology to Disease' - News
focalplane.biologists.com
November 13, 2025 at 11:26 AM
jcellsci.bsky.social
New JCS snapshot - Asymmetries in the three-dimensional beat of Chlamydomonas reinhardtii flagella revealed by holographic microscopy

Laurence Wilson presents the key findings from their recent JCS paper with Martin Bees.
#JCSciliaSI

journals.biologists.com/jcs/article/...
November 26, 2025 at 12:57 PM
jcellsci.bsky.social
New JCS snapshot - Characterisation of a primary ciliary dyskinesia model generated from BMI1-transduced basal epithelial cells
Melis Dalbay presents the key findings from their recent JCS paper with Stephen Hart and colleagues.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 25, 2025 at 2:20 PM
jcellsci.bsky.social
New JCS snapshot - ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and reveals a role for ARL13B in spermatogenesis

Alyssa Long presents the key findings from their recent JCS paper with Tamara Caspary and colleagues.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 24, 2025 at 3:53 PM
jcellsci.bsky.social
To hear more about Rudolfo’s research, published in #JCSciliaSI, join us at the 53rd BSCB GenSoc UK Cilia and Centrosome Network e-symposium.
www.eventbrite.co.uk/e/bscb-genso...
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series
www.eventbrite.co.uk
November 17, 2025 at 3:06 PM
jcellsci.bsky.social
New JCS snapshot - Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease

Rudolfo Karl presents the key findings from their recent JCS paper with Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social & team.
#JCSciliaSI

youtu.be/RDr146QtTx4
JCS snapshot - Renal tissue-resident macrophages promote cystogenesis in polycystic kidney disease
YouTube video by The Company of Biologists
youtu.be
November 17, 2025 at 3:06 PM
jcellsci.bsky.social
In their Perspective article, Muyang Ren, Siham Jaleel, Stephen King & Girish Mali @dyneinassembly.bsky.social highlight the structural diversity of the axonemal dynein assembly factors & their emerging roles in the biology of motile cilia.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Schematic of the dynein assembly pathway and putative roles of DNAAFs that work within it. Axonemal dynein arm motor subunits (heavy chains, intermediate chains and light chains) are assembled in a multi-step dynein assembly pathway involving steps of folding, assembly and transport. DNAAFs are thought to operate at distinct steps. HSP70 proteins likely engage nascent dynein heavy chain, intermediate chain and light chain subunits as they emerge from the ribosome exit tunnel. Specific DNAAFs then likely hand over semi-folded subunits to the HSP90 chaperone and its co-chaperone R2TP complex for further folding and assembly. Many DNAAFs are proposed to function at this step with RUVBL1/2. Pre-assembled ODA motors are finally packaged into an inhibited closed conformation by DNAAF9 (Shulin) for stable attachment to IFT trains for ciliary import. IDAs might undergo similar packaging for IFT transport via currently unknown factors. Genetic variants that block any step of assembly can cause severe motile ciliopathies such as PCD. PTM, post-translational modification.
November 17, 2025 at 12:09 PM
jcellsci.bsky.social
Timothy Ogden, Bendert de Graaf and Tonia Hymers discuss how effective collaboration between researchers & patient-led rare disease organizations is necessary, possible & powerful, building on the authors' experiences leading patient groups for Bardet–Biedl syndrome.
#JCSciliaSI
Engaging patient-led rare disease organizations to advance research – through the lens of Bardet–Biedl syndrome
Summary: This Perspective discusses how effective collaboration between researchers and patient-led rare disease organizations is necessary, possible and powerful, building on the authors' experiences...
journals.biologists.com
November 17, 2025 at 9:38 AM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Rudolfo Karl: journals.biologists.com/jcs/article/...
#JCSciliaSI
Rudolfo Karl
November 14, 2025 at 2:14 PM
jcellsci.bsky.social
Rudolfo Karl, Elvira Mass, Dagmar Wachten @wachtenlab.bsky.social and colleagues discover that renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that tissue-resident macrophages promote cytogenesis in an in vitro 3D model system.
November 14, 2025 at 2:14 PM
jcellsci.bsky.social
Tiago Dantas @dantas-lab.bsky.social @icvs-uminho.bsky.social, Carla Abreu @carlamcabreu.bsky.social and colleagues @i3suporto.bsky.social find that dynein-2 requires HSP90 chaperone activity to ensure robust retrograde IFT and ciliogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that HSP90 inhibition results in IFT particle accumulation in the ciliary shaft due to reduced frequency of retrograde IFT.
November 13, 2025 at 9:45 AM
jcellsci.bsky.social
In their Perspective article, Ruxandra Bachmann-Gagescu, and John Sayer explore how ciliary specialisation might explain the high variability of ciliopathies and propose priority research directions.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Cartoon showing organ and cell-type-specific functions and pathways of primary cilia. Here, we show examples of renal, retinal and CNS ciliated cells, indicating some of the known resident ciliary proteins required for their specific sensory function.
November 12, 2025 at 3:04 PM
jcellsci.bsky.social
Melanie Eschment, Ruxandra Bachmann-Gagescu and colleagues discover that CEP290 deficiency disrupts ciliary axonemal architecture in human iPSC-derived brain organoids.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
November 12, 2025 at 1:46 PM
jcellsci.bsky.social
Akisato Marumo, Hiroto Ishii, Shin Yamaguchi, Junichiro Yajima and colleagues characterise the 3D beating pattern of the ciliary tip in the live ciliate Tetrahymena.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
November 12, 2025 at 9:44 AM
jcellsci.bsky.social
Dagmar Wachten @wachtenlab.bsky.social & Søren Tvorup Christensen @sorentc.bsky.social explore the primary cilium as a master regulator of cellular communication that integrates diverse signalling pathways in development & homeostasis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
JCS poster - Primary cilia signalling at a glance
November 11, 2025 at 3:04 PM
jcellsci.bsky.social
Melis Dalbay, Stephen Hart @ucl.ac.uk and colleagues develop and characterise a robust human PCD airway cell model via BMI1 transduction, which will enable therapeutic and mechanistic studies.
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 11, 2025 at 10:27 AM
jcellsci.bsky.social
In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Graphical summary representing strategies for deciphering temporal–spatial phosphoproteomic outcomes of primary cilia signaling in different biological contexts.
November 10, 2025 at 3:03 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Mark Lee: journals.biologists.com/jcs/article/...
#JCSciliaSI
Mark Lee
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Mark Lee @guacamarklee.bsky.social and Keren Hilgendorf @uofubiochem.bsky.social discover that prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Figure showing that EP4 localizes to primary cilia of ASCs.
November 10, 2025 at 9:01 AM
jcellsci.bsky.social
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Conserved MIPs. (A) 16 common MIPs that are conserved across almost all examined species. (B) Cross-section view of the location of the conserved MIPs within a DMT. (C) Longitudinal view of the eight conserved MIPs at the outer junction and seam region. (D) Longitudinal view of the six conserved MIPs at the inner junction. The figures are generated based on structure of DMTs from human respiratory epithelium cilia (PDB: 8J07). Black arrow indicates the position of the seam.
November 7, 2025 at 3:02 PM
jcellsci.bsky.social
Read more about this research in our ‘First person’ interview with Alyssa Long: journals.biologists.com/jcs/article/...
#JCSciliaSI
Alyssa Long
November 7, 2025 at 1:02 PM
jcellsci.bsky.social
Alyssa Long, Tamara Caspary and colleagues discover that ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and uncover a role for ARL13B in spermatogenesis.
#JCSciliaSI
journals.biologists.com/jcs/article/...
Micrographs showing that pancreatic islets appear normal in Arl13bhnn/hnn;Arl13b-Cerulean mice.
November 7, 2025 at 1:02 PM