Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
March 24, 2025 at 2:54 PM
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology
Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...
www.nature.com
May 26, 2025 at 9:37 AM
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
Amazing chemical biology/structural biology work on K29/K48 branching E3 Ufd4/TRIP12 www.nature.com/articles/s41...
Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination - Nature Communications
The K29/K48 hetero-polyubiquitin signal has been reported to be an enhanced degradation signal, but the enzymatic mechanism of this ubiquitin chain formation is unclear. Here, the authors reveal how t...
www.nature.com
May 10, 2025 at 12:05 PM
Amazing chemical biology/structural biology work on K29/K48 branching E3 Ufd4/TRIP12 www.nature.com/articles/s41...
@rudi-k48.bsky.social
Der nächste der es geil findet auf #armutsbetroffene einzutreten!
#Blockempfehlung
Der nächste der es geil findet auf #armutsbetroffene einzutreten!
#Blockempfehlung
May 21, 2026 at 12:05 PM
@rudi-k48.bsky.social
Der nächste der es geil findet auf #armutsbetroffene einzutreten!
#Blockempfehlung
Der nächste der es geil findet auf #armutsbetroffene einzutreten!
#Blockempfehlung
Need to download and print the K48 V8 Honda engine that was never finished
August 26, 2026 at 2:56 PM
Need to download and print the K48 V8 Honda engine that was never finished
Thrilled to share our work on the role of Ataxin-3 in lysosome regeneration published in @embojournal.org . Here we show that Atxn3 targets K48-K63 branched ubiquitin chains on damaged lysosomes and mediates restoration of lysosomal function via microautophagy.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
August 1, 2025 at 2:10 PM
Thrilled to share our work on the role of Ataxin-3 in lysosome regeneration published in @embojournal.org . Here we show that Atxn3 targets K48-K63 branched ubiquitin chains on damaged lysosomes and mediates restoration of lysosomal function via microautophagy.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Le réacteur compact « K48 » des SNA de type Rubis
December 22, 2024 at 6:43 PM
Le réacteur compact « K48 » des SNA de type Rubis
If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications:
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome - Nature Communications
K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the hum...
doi.org
October 15, 2025 at 6:53 PM
If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications:
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome https://www.biorxiv.org/content/10.1101/2025.01.13.632666v1
January 13, 2025 at 9:46 PM
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome https://www.biorxiv.org/content/10.1101/2025.01.13.632666v1
New work out by @hemmo-lab.bsky.social @icce-unidue.bsky.social @kulathu.bsky.social and others on how ATXN3 restores lysosome integrity after damage by targeting K48- and K63-branched ubiquitin chains. Full story: www.embopress.org/doi/full/10....
@unidue.bsky.social @crc1430.bsky.social @dfg.de
@unidue.bsky.social @crc1430.bsky.social @dfg.de
August 5, 2025 at 5:42 AM
New work out by @hemmo-lab.bsky.social @icce-unidue.bsky.social @kulathu.bsky.social and others on how ATXN3 restores lysosome integrity after damage by targeting K48- and K63-branched ubiquitin chains. Full story: www.embopress.org/doi/full/10....
@unidue.bsky.social @crc1430.bsky.social @dfg.de
@unidue.bsky.social @crc1430.bsky.social @dfg.de
💖大家好！我會參加今年的CWT-K48第二天！💖
詳細資訊如下，如果時間允許的話歡迎大家一起參與～
🌟9/7 新光三越高雄左營店 10F - B49&50🌟
詳細資訊如下，如果時間允許的話歡迎大家一起參與～
🌟9/7 新光三越高雄左營店 10F - B49&50🌟
September 3, 2025 at 6:51 AM
💖大家好！我會參加今年的CWT-K48第二天！💖
詳細資訊如下，如果時間允許的話歡迎大家一起參與～
🌟9/7 新光三越高雄左營店 10F - B49&50🌟
詳細資訊如下，如果時間允許的話歡迎大家一起參與～
🌟9/7 新光三越高雄左營店 10F - B49&50🌟
A new paper reports the structure of the E4 enzyme Ufd2, which mediates K48 branched ubiquitination on K29diUb and K29triUb, identifying Ufd2’s core region as a K29diUb binding domain and a dimeric conformation for distal ubiquitin stabilization
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains - Nature Chemical Biology
Tong et al. chemically trapped the structure of the E4 enzyme Ufd2, which mediates K48 branched ubiquitination on K29diUb and K29triUb, identifying Ufd2’s core region as a K29diUb binding domain and a...
www.nature.com
August 18, 2025 at 4:44 PM
A new paper reports the structure of the E4 enzyme Ufd2, which mediates K48 branched ubiquitination on K29diUb and K29triUb, identifying Ufd2’s core region as a K29diUb binding domain and a dimeric conformation for distal ubiquitin stabilization
www.nature.com/articles/s41...
www.nature.com/articles/s41...
As seen at the truly excellent National Museum in Seoul.
May 11, 2026 at 2:38 PM
As seen at the truly excellent National Museum in Seoul.
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at high temporal resolution after intracellular delivery of ubiquitinated proteins. This reveals a degradation code for ubiquitin chains varying by linkage, length, and topology.
dlvr.it
April 7, 2025 at 7:14 PM
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Je constate que ça rage parce que j'ai réussi à récupérer un K48 qui traînait pour faire la tambouille.
November 20, 2024 at 6:53 AM
Je constate que ça rage parce que j'ai réussi à récupérer un K48 qui traînait pour faire la tambouille.
Amazing structures and more by my colleague Sascha Amann explaining how the 26S proteasome interacts with K48 and K48-K11 branched ubiquitin chains. I think that this is a crucial puzzle piece in understanding substrate engagement by the proteasome.
It was a pleasure seeing this project unfold 🚀
It was a pleasure seeing this project unfold 🚀
New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann
Let me walk you through it 🧵 1/9
Let me walk you through it 🧵 1/9
Structural basis for the ubiquitin chain recognition of the human 26S proteasome
Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...
www.biorxiv.org
April 9, 2025 at 8:34 PM
Amazing structures and more by my colleague Sascha Amann explaining how the 26S proteasome interacts with K48 and K48-K11 branched ubiquitin chains. I think that this is a crucial puzzle piece in understanding substrate engagement by the proteasome.
It was a pleasure seeing this project unfold 🚀
It was a pleasure seeing this project unfold 🚀
#proteostasis UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains: Molecular Cell www.cell.com/molecular-ce...
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
July 9, 2025 at 5:54 PM
#proteostasis UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains: Molecular Cell www.cell.com/molecular-ce...
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
Nature Communications - K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin...
rdcu.be
October 15, 2025 at 10:16 AM
Excited to share our Nature Communications paper 🎉 rdcu.be/eK7wG
We uncovered by cryoEM how the human proteasome recognizes branched K11/K48 ubiquitin chains through a new K11-binding site in the RPN2 subunit, revealing how the proteasome precisely identifies targets for rapid turnover. #cryoEM
Deconstructing destruction: A rapid route to proteasomal fate
Deconstructing destruction: A rapid route to proteasomal fate
In this issue of Molecular Cell, Kiss et al. introduce UbiREAD, a technology that deciphers ubiquitin chain-mediated degradation in living cells, revealing a hierarchy where K48 chains of at least three ubiquitins drive rapid proteasomal degradation and branched K48/K63 chains follow substrate-anchored rules.
dlvr.it
April 9, 2025 at 3:20 PM
Deconstructing destruction: A rapid route to proteasomal fate
Differential ubiquitin modifications of ESCRT-I subunits VPS37-1 and VPS28-2 by XBAT35.2 positively regulate plant immunity. Nice example of K48 vs K63 polyubiquitination by the same E3. It's all about E2s 😜. nph.onlinelibrary.wiley.com/doi/10.1111/...
@newphyt.bsky.social
@newphyt.bsky.social
Differential ubiquitin modifications of <fc>ESCRT</fc>‐I subunits <fc>VPS37</fc>‐1 and <fc>VPS28</fc>‐2 positively regulate plant immunity
The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2-mediated plant immunity against bacterial pathogens by modifying the ESCRT-I subunits VPS28-2 and VPS37-1 with distinct ubiqui...
nph.onlinelibrary.wiley.com
September 29, 2026 at 6:15 PM
Differential ubiquitin modifications of ESCRT-I subunits VPS37-1 and VPS28-2 by XBAT35.2 positively regulate plant immunity. Nice example of K48 vs K63 polyubiquitination by the same E3. It's all about E2s 😜. nph.onlinelibrary.wiley.com/doi/10.1111/...
@newphyt.bsky.social
@newphyt.bsky.social
K48 รังจิ้งจอก พร้อมให้บริการแล้วววว
ตื่นเต้นmax เป็นปีแรกที่จัดบูธเสร็จก่อนเวลา 55
#เจ้าชายบรรณาการของจอมมาร
#จันทร์กระจ่างต้องเกลียวคลื่น
#FoxxTrot
#CQ8
ตื่นเต้นmax เป็นปีแรกที่จัดบูธเสร็จก่อนเวลา 55
#เจ้าชายบรรณาการของจอมมาร
#จันทร์กระจ่างต้องเกลียวคลื่น
#FoxxTrot
#CQ8
March 16, 2025 at 2:46 AM
K48 รังจิ้งจอก พร้อมให้บริการแล้วววว
ตื่นเต้นmax เป็นปีแรกที่จัดบูธเสร็จก่อนเวลา 55
#เจ้าชายบรรณาการของจอมมาร
#จันทร์กระจ่างต้องเกลียวคลื่น
#FoxxTrot
#CQ8
ตื่นเต้นmax เป็นปีแรกที่จัดบูธเสร็จก่อนเวลา 55
#เจ้าชายบรรณาการของจอมมาร
#จันทร์กระจ่างต้องเกลียวคลื่น
#FoxxTrot
#CQ8
Check out our latest study @natsmb.nature.com: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases: #cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains!
❕ www.nature.com/articles/s41...
@samuelmaiwald.bsky.social @unileiden.bsky.social
❕ www.nature.com/articles/s41...
@samuelmaiwald.bsky.social @unileiden.bsky.social
May 26, 2025 at 2:36 PM
Check out our latest study @natsmb.nature.com: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases: #cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains!
❕ www.nature.com/articles/s41...
@samuelmaiwald.bsky.social @unileiden.bsky.social
❕ www.nature.com/articles/s41...
@samuelmaiwald.bsky.social @unileiden.bsky.social
Der @rudi-k48.bsky.social macht bei mir gerade einen Abgang. #Blockempfehlung
May 21, 2026 at 12:42 PM
Der @rudi-k48.bsky.social macht bei mir gerade einen Abgang. #Blockempfehlung
window words #76: David Hoffmann
Literatur am Fenster
(k48 #240)
Foto: Oliver Hangl
www.oliverhangl.com/projects/int...
Literatur am Fenster
(k48 #240)
Foto: Oliver Hangl
www.oliverhangl.com/projects/int...
July 8, 2026 at 6:02 PM
window words #76: David Hoffmann
Literatur am Fenster
(k48 #240)
Foto: Oliver Hangl
www.oliverhangl.com/projects/int...
Literatur am Fenster
(k48 #240)
Foto: Oliver Hangl
www.oliverhangl.com/projects/int...
Müzik hediyelerine devam. Sıra @sleepingdeath.bsky.social'a gelmiştir zannediyorum. Kendisini Stravinsky'nin neoklasik balesi Apollon Musagete'nin ilk bölümü ile selamlıyoruz.
www.youtube.com/watch?v=Kx9L...
www.youtube.com/watch?v=Kx9L...
Stravinsky: Apollon musagète, K48: I. Birth of Apollo (1947 Version)
YouTube video by Berliner Philharmoniker - Topic
www.youtube.com
June 14, 2026 at 3:31 PM
Müzik hediyelerine devam. Sıra @sleepingdeath.bsky.social'a gelmiştir zannediyorum. Kendisini Stravinsky'nin neoklasik balesi Apollon Musagete'nin ilk bölümü ile selamlıyoruz.
www.youtube.com/watch?v=Kx9L...
www.youtube.com/watch?v=Kx9L...